Current through Register Vol. 48, No. 51, June 17, 2024
Part 4717.8150 - TABLE OF SUBCHRONIC HRVS The heading for each item contains the chemical name and, in parenthesis, the CAS RN. Each item lists the subchronic HRV, the equation used to develop the subchronic HRV, and the variables necessary for the equation. The equations used to develop the subchronic HRV are designated as follows: "A" means calculating the NOAEL[HEC] or LOAEL[HEC] or BMC[HEC] under part 4717.8300, subpart 3, and applying the general equation under part 4717.8300, subpart 2; "B" means calculating the NOAEL[HEC] or LOAEL[HEC] or BMC[HEC] under part 4717.8300, subpart 4, and applying the general equation under part 4717.8300, subpart 2; "C" means calculating the NOAEL[HEC] or LOAEL[HEC] or BMC[HEC] under part 4717.8300, subpart 5, and applying the general equation under part 4717.8300, subpart 2; and "D" means calculating the NOAEL[HEC] or LOAEL[HEC] or BMC [HEC] under part 4717.8300, subpart 6, and applying the general equation under part 4717.8300, subpart 2. The endpoint of concern is listed for use in determining a hazard index under part 4717.8600.
TABLE OF SUBCHRONIC HRVs
A. Acrolein (107-02-8) | Subchronic HRV ( µg/m3) | 0.2 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| LOAEL[HEC] (mg/m3) | 2E-2 |
| Uncertainty factor | 100 |
B. Acrylic acid (79-10-7) | Subchronic HRV ( µg/m3) | 3 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| LOAEL[HEC] (mg/m3) | 3.3E-1 |
| Uncertainty factor | 100 |
C. Allyl chloride (107-05-1) | Subchronic HRV ( µg/m3) | 10 |
| Endpoint of concern | Nervous system |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 3.6 |
| Uncertainty factor | 300 |
D. Arsine (7784-42-1) | Subchronic HRV ( µg/m3) | 0.1 |
| Endpoint of concern | Hematologic system |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 1.4E-2 |
| Uncertainty factor | 100 |
E. Chlordane (12789-03-6) | Subchronic HRV ( µg/m3) | 7 |
| Endpoint of concern | Hepatic system |
| Equation | B |
| NOAEL[HEC] (mg/m3) | 6.5E-1 |
| Uncertainty factor | 100 |
F. Chlorine dioxide (10049-04-4) | Subchronic HRV ( µg/m3) | 0.6 |
| Endpoint of concern | Lower respiratory system |
| Equation | C |
| LOAEL[HEC] (mg/m3) | 6.4E-1 |
| Uncertainty factor | 1,000 |
G. Chromic acid mists and dissolved Cr (VI) aerosols (18540-29-9) | Subchronic HRV ( µg/m3) | 0.02 |
| Endpoint of concern | Upper and lower respiratory system |
| Equation | C |
| LOAEL[ADJ] (mg/m3) | 7.1E-4 |
| Uncertainty factor | 30 |
H. Cr (VI) particulates (18540-29-9) | Subchronic HRV ( µg/m3) | 1 |
| Endpoint of concern | Lower respiratory system |
| Equation | A |
| BMC[HEC] (mg/m3) | 3.5E-2 |
| Uncertainty factor | 30 |
I. Cumene (98-82-8) | Subchronic HRV ( µg/m3) | 4,000 |
| Endpoint of concern | Renal system and endocrine system |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 4.35E2 |
| Uncertainty factor | 100 |
J. 1,2-Dibromo-3-chloropropane (96-12-8) | Subchronic HRV ( µg/m3) | 2 |
| Endpoint of concern | Male reproductive system |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 1.7E-1 |
| Uncertainty factor | 100 |
K. 1,4-Dichlorobenzene (106-46-7) | Subchronic HRV ( µg/m3) | 800 |
| Endpoint of concern | Hepatic system |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 7.5E1 |
| Uncertainty factor | 100 |
L. 1,2-Dichloropropane (78-87-5) | Subchronic HRV ( µg/m3) | 10 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| LOAEL[HEC] (mg/m3) | 1.3 |
| Uncertainty factor | 100 |
M. Dicyclopentadiene (77-73-6) | Subchronic HRV ( µg/m3) | 3 |
| Endpoint of concern | Renal system |
| Equation | D |
| LOAEL[HEC] (mg/m3) | 9.6E-1 |
| Uncertainty factor | 300 |
N. 2-Dimethylamino ethanol (101-01-0) | Subchronic HRV ( µg/m3) | 70 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| NOAEL[HEC] (mg/m3) | 1.96 |
| Uncertainty factor | 30 |
O. Ethylene glycol monomethyl ether (EGME) or 2-methoxyethanol (109-86-4) | Subchronic HRV ( µg/m3) | 60 |
| Endpoint of concern | Male reproductive and hematologic systems |
| Equation | D |
| NOAEL[HEC](mg/m3) | 1.7E1 |
| Uncertainty factor | 300 |
P. Hydrogen sulfide (7783-06-4) | Subchronic HRV ( µg/m3) | 10 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| NOAEL[HEC] (mg/m3) | 1.01 |
| Uncertainty factor | 100 |
Q. Phosphine (7803-51-2) | Subchronic HRV ( µg/m3) | 3 |
| Endpoint of concern | Decreased body weight |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 2.5E-1 |
| Uncertainty factor | 100 |
R. Propylene glycol monomethyl ether (107-98-2) | Subchronic HRV ( µg/m3) | 20,000 |
| Endpoint of concern | Nervous system |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 6.58E2 |
| Uncertainty factor | 30 |
S. Triethylamine (121-44-8) | Subchronic HRV ( µg/m3) | 70 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| NOAEL[HEC] (mg/m3) | 1.95E1 |
| Uncertainty factor | 300 |
Statutory Authority: MS s 144.12