Current through Register Vol. 48, No. 51, June 17, 2024
Part 4717.8200 - TABLE OF ACUTE HRVS The heading for each item contains the chemical name and, in parenthesis, the CAS RN. Each item lists the acute HRV, the equation used to develop the acute HRV, and the variables necessary for the equation. The equations used to develop the acute HRV are designated as follows: "A" means calculating the NOAEL or LOAEL or BMC[ADJ] under part 4717.8500, subpart 3, and applying the general equation under part 4717.8500, subpart 2; "B" means calculating the NOAEL[ADJ] or LOAEL[ADJ] or BMC [ADJ] under part 4717.8500, subpart 4, and applying the general equation under part 4717.8500, subpart 2; "C" means calculating the BMC or BMC[ADJ] under part 4717.8500; and "D" means applying the equation under part 4717.8500, subpart 5. The endpoint of concern is listed for use in determining a hazard index under part 4717.8600.
TABLE OF ACUTE HRVs
A. Ammonia (7664-41-7) | Acute HRV ( µg/m3) | 3,200 |
| Endpoint of concern | Irritant - eye, respiratory system |
| Equation | C |
| BMC (mg/m3) | 9.5 |
| Uncertainty factor | 3 |
B. Arsine (7784-42-1) | Acute HRV ( µg/m3) | 200 |
| Endpoint of concern | Hematologic* |
| Equation | A |
| NOAEL[ADJ] (mg/m3) | 1.6E1 |
| Uncertainty factor | 100 |
C. Benzene (71-43-2) | Acute HRV ( µg/m3) | 1,000 |
| Endpoint of concern | Reproductive/developmental |
| Equation | D |
| NOAEL (mg/m3) | 1.3E2 |
| Uncertainty factor | 100 |
D. Carbon disulfide (75-15-0) | Acute HRV ( µg/m3) | 6,000 |
| Endpoint of concern | Reproductive/developmental |
| Equation | D |
| NOAEL (mg/m3) | 6.2E2 |
| Uncertainty factor | 100 |
E. Chlorine (7882-50-5) | Acute HRV ( µg/m3) | 290 |
| Endpoint of concern | Irritant - respiratory system |
| Equation | A |
| NOAEL (mg/m3) | 2.9 |
| Uncertainty factor | 10 |
F. Chloroform (67-66-3) | Acute HRV ( µg/m3) | 150 |
| Endpoint of concern | Reproductive/developmental |
| Equation | D |
| LOAEL (mg/m3) | 1.5E2 |
| Uncertainty factor | 1,000 |
G. Dichloromethane (75-09-2) | Acute HRV ( µg/m3) | 10,000 |
| Endpoint of concern | Nervous system |
| Equation | A |
| NOAEL[ADJ] (mg/m3) | 6.8E2 |
| Uncertainty factor | 60 |
H. 1,4-Dioxane (123-91-1) | Acute HRV ( µg/m3) | 3,000 |
| Endpoint of concern | Irritant - eye and nasal |
| Equation | A |
| LOAEL[ADJ] (mg/m3) | 1.8E2 |
| Uncertainty factor | 60 |
I. Ethyl benzene (100-41-4) | Acute HRV ( µg/m3) | 10,000 |
| Endpoint of concern | Reproductive/developmental |
| Equation | D |
| NOAEL (mg/m3) | 4.3E2 |
| Uncertainty factor | 30 |
J. Ethyl chloride (75-00-3) | Acute HRV ( µg/m3) | 100,000 |
| Endpoint of concern | Reproductive/developmental |
| Equation | D |
| NOAEL (mg/m3) | 4E3 |
| Uncertainty factor | 30 |
K. Ethylene glycol monoethyl ether (110-80-5) | Acute HRV ( µg/m3) | 400 |
| Endpoint of concern | Reproductive/developmental |
| Equation | D |
| NOAEL (mg/m3) | 3.7E1 |
| Uncertainty factor | 100 |
L. Ethylene glycol monoethyl ether acetate (111-15-9) | Acute HRV ( µg/m3) | 100 |
| Endpoint of concern | Reproductive/developmental |
| Equation | D |
| LOAEL (mg/m3) | 1.4E2 |
| Uncertainty factor | 1,000 |
M. Ethylene glycol monomethyl ether (EGME) (109-86-4) or 2-methoxyethanol | Acute HRV ( µg/m3) | 90 |
| Endpoint of concern | Reproductive/developmental |
| Equation | D |
| NOAEL (mg/m3) | 9.3 |
| Uncertainty factor | 100 |
N. Formaldehyde (50-00-0) | Acute HRV ( µg/m3) | 94 |
| Endpoint of concern | Irritant - eye and respiratory system |
| Equation | C |
| BMC (mg/m3) | 9.4E-1 |
| Uncertainty factor | 10 |
O. Hydrogen chloride (7647-01-1) | Acute HRV ( µg/m3) | 2,700 |
| Endpoint of concern | Irritant - eye and respiratory system |
| Equation | A |
| NOAEL (mg/m3) | 2.7 |
| Uncertainty factor | 1 |
P. Hydrogen cyanide (74-90-8) | Acute HRV ( µg/m3) | 700 |
| Endpoint of concern | Nervous system* |
| Equation | A |
| NOAEL (mg/m3) | 6.8E1 |
| Uncertainty factor | 100 |
Q. Hydrogen fluoride (7664-39-3) | Acute HRV ( µg/m3) | 240 |
| Endpoint of concern | Irritant - respiratory system |
| Equation | A |
| NOAEL[ADJ] (mg/m3) | 2.4 |
| Uncertainty factor | 10 |
R. Methanol (67-56-1) | Acute HRV ( µg/m3) | 25,000 |
| Endpoint of concern | Nervous system |
| Equation | A |
| NOAEL[ADJ] (mg/m3) | 2.5E2 |
| Uncertainty factor | 10 |
S. Methyl bromide (74-83-9) | Acute HRV ( µg/m3) | 2,000 |
| Endpoint of concern | Nervous system* |
| Equation | A |
| LOAEL[ADJ] (mg/m3) | 1.4E2 |
| Uncertainty factor | 60 |
T. Methyl ethyl ketone (78-93-3) | Acute HRV ( µg/m3) | 10,000 |
| Endpoint of concern | Irritant - eye and respiratory system |
| Equation | A |
| LOAEL[ADJ] (mg/m3) | 8E2 |
| Uncertainty factor | 60 |
U. Nickel and nickel compounds (**) | Acute HRV ( µg/m3) | 11 |
| Endpoint of concern | Irritant - respiratory system |
| Equation | A |
| LOAEL (mg/m3) | 6.7E-2 |
| Uncertainty factor | 6 |
V. Nitric acid (7697-37-2) | Acute HRV ( µg/m3) | 130 |
| Endpoint of concern | Irritant - respiratory system |
| Equation | A |
| NOAEL (mg/m3) | 1.29E-1 |
| Uncertainty factor | 1 |
W. Phenol (108-95-2) | Acute HRV ( µg/m3) | 5,800 |
| Endpoint of concern | Irritant - eye and respiratory system |
| Equation | B |
| NOAEL[ADJ] (mg/m3) | 5.8E1 |
| Uncertainty factor | 10 |
X. Phosgene (75-44-5) | Acute HRV ( µg/m3) | 4 |
| Endpoint of concern | Irritant - respiratory system* |
| Equation | A |
| NOAEL[ADJ] (mg/m3) | 4E-1 |
| Uncertainty factor | 100 |
Y. Sodium hydroxide (1310-93-2) | Acute HRV ( µg/m3) | 8 |
| Endpoint of concern | Irritant - eye, skin, and respiratory system |
| Equation | A |
| LOAEL[ADJ] (mg/m3) | 5E-1 |
| Uncertainty factor | 60 |
Z. Styrene (100-42-5) | Acute HRV ( µg/m3) | 21,000 |
| Endpoint of concern | Irritant - eye and respiratory system |
| Equation | A |
| NOAEL[ADJ] (mg/m3) | 2.1E2 |
| Uncertainty factor | 10 |
AA. Tetrachloroethylene or perchlorethylene (127-18-4) | Acute HRV ( µg/m3) | 20,000 |
| Endpoint of concern | Irritant - eye and respiratory and nervous systems |
| Equation | B |
| LOAEL[ADJ] (mg/m3) | 1.2E3 |
| Uncertainty factor | 60 |
BB. Toluene (108-88-3) | Acute HRV ( µg/m3) | 37,000 |
| Endpoint of concern | Irritant - eye and respiratory and nervous systems |
| Equation | B |
| NOAEL[ADJ] (mg/m3) | 3.7E2 |
| Uncertainty factor | 10 |
CC. 1,1,1-Trichloroethane or methyl chloroform (71-55-6) | Acute HRV ( µg/m3) | 140,000 |
| Endpoint of concern | Nervous system |
| Equation | A |
| NOAEL (mg/m3) | 1.37E3 |
| Uncertainty factor | 10 |
DD. Trichloroethylene (79-01-6) | Acute HRV ( µg/m3) | 2,000 |
| Endpoint of concern | Reproductive/developmental |
| Equation | D |
| LOAEL (mg/m3) | 5.4E2 |
| Uncertainty factor | 300 |
EE. Triethylamine (121-44-8) | Acute HRV ( µg/m3) | 2,800 |
| Endpoint of concern | Irritant - eye; transient corneal edema |
| Equation | B |
| NOAEL[ADJ] (mg/m3) | 2.8E1 |
| Uncertainty factor | 10 |
FF. Vanadium pentoxide (1314-62-1) | Acute HRV ( µg/m3) | 30 |
| Endpoint of concern | Irritant - respiratory system |
| Equation | B |
| LOAEL[ADJ] (mg/m3) | 3E-1 |
| Uncertainty factor | 10 |
GG. Xylenes (1330-20-7) | Acute HRV ( µg/m3) | 43,000 |
| Endpoint of concern | Irritant - eye and respiratory and nervous systems |
| Equation | A |
| NOAEL (mg/m3) | 4.3E2 |
| Uncertainty factor | 10 |
* This HRV is for a chemical where there is little magnitude difference between the level where mild irritancy occurs and levels where more severe adverse health effects occur.
** This HRV is for a chemical mixture which, therefore, does not have a chemical-specific number assigned by the Chemical Abstracts Service.
Statutory Authority: MS s 144.12