Current through Register Vol. 48, No. 51, June 17, 2024
Part 4717.8100 - TABLE OF CHRONIC HRVS The heading for each item contains the chemical name and, in parenthesis, the CAS RN. Each item lists the chronic HRV, the equation used to develop the chronic HRV, and the variables necessary for the equation. The equations used to develop the chronic HRV are designated as follows: "A" means calculating the NOAEL[HEC] or LOAEL[HEC] or BMC[HEC] under part 4717.8300, subpart 3, and applying the general equation under part 4717.8300, subpart 2; "B" means calculating the NOAEL[HEC] or LOAEL[HEC] or BMC[HEC] under part 4717.8300, subpart 4, and applying the general equation under part 4717.8300, subpart 2; "C" means calculating the NOAEL[HEC] or LOAEL[HEC] or BMC[HEC] under part 4717.8300, subpart 5, and applying the general equation under part 4717.8300, subpart 2; "D" means calculating the NOAEL[HEC] or LOAEL[HEC] or BMC[HEC] under part 4717.8300, subpart 6, and applying the general equation under part 4717.8300, subpart 2; and "E" means applying the equation under part 4717.8400, subpart 2. The endpoint of concern is listed for use in determining a cancer index under part 4717.8550 or a hazard index under part 4717.8600. The unit risk for carcinogens is expressed as risk per ( µg/m3).
TABLE OF CHRONIC HRVs
A. Acetaldehyde (75-07-0) | Chronic HRV ( µg/m3) | 5 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 2.2E-6 |
B. Acetonitrile (75-05-8) | Chronic HRV ( µg/m3) | 60 |
| Endpoint of concern | Mortality |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 6E1 |
| Uncertainty factor | 1,000 |
C. Acrylonitrile (107-13-1) | Chronic HRV ( µg/m3) | 0.1 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 6.8E-5 |
D. Ammonia (7664-41-7) | Chronic HRV ( µg/m3) | 80 |
| Endpoint of concern | Upper and lower respiratory system |
| Equation | C |
| NOAEL[HEC] (mg/m3) | 2.3 |
| Uncertainty factor | 30 |
E. Antimony trioxide (1309-64-4) | Chronic HRV ( µg/m3) | 0.2 |
| Endpoint of concern | Lower respiratory system |
| Equation | A |
| BMC[HEC] (mg/m3) | 7.4E-2 |
| Uncertainty factor | 300 |
F. Arsenic (7440-38-2) | Chronic HRV ( µg/m3) | 0.002 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 4.3E-3 |
G. Benzene (71-43-2) | Chronic HRV ( µg/m3) | 1.3 - 4.5 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 2.2E-6 to 7.8E-6 |
H. Benzidine (92-87-5) | Chronic HRV ( µg/m3) | 0.0002 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 6.7E-2 |
I. Beryllium (7440-41-7) | Chronic HRV ( µg/m3) | 0.004 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 2.4E-3 |
J. Bis(chloromethyl)ether (542-88-1) | Chronic HRV ( µg/m3) | 0.0002 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 6.2E-2 |
K. Bromomethane (74-83-9) | Chronic HRV ( µg/m3) | 5 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| LOAEL[HEC] (mg/m3) | 4.8E-1 |
| Uncertainty factor | 100 |
L. 1,3-Butadiene (106-99-0) | Chronic HRV ( µg/m3) | 0.04 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 2.8E-4 |
M. Cadmium (7440-43-9) | Chronic HRV ( µg/m3) | 0.006 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 1.8E-3 |
N. Carbon disulfide (75-15-0) | Chronic HRV ( µg/m3) | 700 |
| Endpoint of concern | Nervous system |
| Equation | D |
| BMC[HEC] (mg/m3) | 1.97E1 |
| Uncertainty factor | 30 |
O. 2-Chloroacetophenone (532-27-4) | Chronic HRV ( µg/m3) | 0.03 |
| Endpoint of concern | Upper and lower respiratory system |
| Equation | C |
| LOAEL[HEC] (mg/m3) | 3E-2 |
| Uncertainty factor | 1,000 |
P. Chromium VI (18540-29-9) | Chronic HRV ( µg/m3) | 0.0008 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 1.2E-2 |
Q. Coke oven emissions (8007-45-2) | Chronic HRV ( µg/m3) | 0.02 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 6.2E-4 |
R. 1,2-Dibromoethane (106-93-4) | Chronic HRV ( µg/m3) | 0.05 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 2.2E-4 |
S. Dichloromethane (75-09-2) | Chronic HRV ( µg/m3) | 20 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 4.7E-7 |
T. 1,3-Dichloropropene (542-75-6) | Chronic HRV ( µg/m3) | 20 |
| Endpoint of concern | Upper respiratory system |
| BMC[HEC] (mg/m3) | 7.2E-1 |
| Equation | C |
| Uncertainty factor | 30 |
U. Dichlorvos (62-73-7) | Chronic HRV ( µg/m3) | 0.5 |
| Endpoint of concern | Nervous system |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 5E-2 |
| Uncertainty factor | 100 |
V. Diesel particulates (*) | Chronic HRV ( µg/m3) | 5 |
| Endpoint of concern | Lower respiratory system |
| Equation | A |
| NOAEL[HEC] (mg/m3) | 1.55E-1 |
| Uncertainty factor | 30 |
W. N,N-dimethylformamide (68-12-2) | Chronic HRV ( µg/m3) | 30 |
| Endpoint of concern | Gastrointestinal system and hepatic system |
| Equation | D |
| LOAEL[HEC] (mg/m3) | 7.9 |
| Uncertainty factor | 300 |
X. Epichlorohydrin (106-89-8) | Chronic HRV ( µg/m3) | 8 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 1.2E-6 |
Y. 1,2-Epoxybutane (106-88-7) | Chronic HRV ( µg/m3) | 20 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| LOAEL[HEC] (mg/m3) | 4.8 |
| Uncertainty factor | 300 |
Z. Ethylene glycol monobutyl ether (111-76-2) | Chronic HRV ( µg/m3) | 13,000 |
| Endpoint of concern | Hematologic system |
| Equation | D |
| BMC[HEC] (mg/m3) | 3.8E2 |
| Uncertainty factor | 30 |
AA. Formaldehyde (50-00-0) | Chronic HRV ( µg/m3) | 0.8** |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 1.3E-5 |
BB. 1,6-Hexamethylene diisocyanate (822-06-0) | Chronic HRV ( µg/m3) | 0.01** |
| Endpoint of concern | Upper and lower respiratory system |
| Equation | C |
| NOAEL[HEC] (mg/m3) | 1E-3 |
| Uncertainty factor | 100 |
CC. n-Hexane (110-54-3) | Chronic HRV ( µg/m3) | 2,000 |
| Endpoint of concern | Nervous system and upper respiratory system |
| Equation | D |
| LOAEL[HEC] (mg/m3) | 7.3E1 |
| Uncertainty factor | 30 |
DD. Hydrazine/Hydrazine sulfate (302-01-2) | Chronic HRV ( µg/m3) | 0.002 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 4.9E-3 |
EE. Hydrogen chloride (7647-01-0) | Chronic HRV ( µg/m3) | 20 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| LOAEL[HEC] (mg/m3) | 6.1 |
| Uncertainty factor | 300 |
FF. Hydrogen cyanide (74-90-8) | Chronic HRV ( µg/m3) | 3 |
| Endpoint of concern | Endocrine system and nervous system |
| Equation | D |
| LOAEL[HEC] (mg/m3) | 2.5 |
| Uncertainty factor | 1,000 |
GG. Manganese (7439-96-5) | Chronic HRV ( µg/m3) | 0.2 |
| Endpoint of concern | Nervous system |
| Equation | B |
| BMC[HEC] (mg/m3) | 1.9E-2 |
| Uncertainty factor | 100 |
HH. Methyl methacrylate (80-62-6) | Chronic HRV ( µg/m3) | 700** |
| Endpoint of concern | Upper and lower respiratory system |
| Equation | C |
| BMC[HEC] (mg/m3) | 7.2 |
| Uncertainty factor | 10 |
II. Methylene diphenyl diisocyanate (MDI) and polymeric MDI (101-68-8 and 9016-87-9) | Chronic HRV ( µg/m3) | 0.6** |
| Endpoint of concern | Upper and lower respiratory system |
| Equation | A |
| BMC[HEC] (mg/m3) | 6E-2 |
| Uncertainty factor | 100 |
JJ. Nickel refinery dust (*) | Chronic HRV ( µg/m3) | 0.04 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 2.4E-4 |
KK. Nickel subsulfide (12035-72-2) | Chronic HRV ( µg/m3) | 0.02 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 4.8E-4 |
LL. 2-Nitropropane (79-46-9) | Chronic HRV ( µg/m3) | 20 |
| Endpoint of concern | Hepatic system |
| Equation | D |
| LOAEL[HEC] (mg/m3) | 1.6E1 |
| Uncertainty factor | 1,000 |
MM. Propylene oxide (75-56-9) | Chronic HRV ( µg/m3) | 3 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 3.7E-6 |
NN. Styrene (100-42-5) | Chronic HRV ( µg/m3) | 1000 |
| Endpoint of concern | Nervous system |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 3.4E1 |
| Uncertainty factor | 30 |
OO. Toluene (108-88-3) | Chronic HRV ( µg/m3) | 400 |
| Endpoint of concern | Nervous system and upper respiratory system |
| Equation | D |
| LOAEL[HEC] (mg/m3) | 1.19E2 |
| Uncertainty factor | 300 |
PP. 2,4-/2,6-Toluene diisocyanate (26471-62-5) | Chronic HRV ( µg/m3) | 0.08** |
| Endpoint of concern | Lower respiratory system |
| Equation | D |
| NOAEL[HEC] (mg/m3) | 2.3E-3 |
| Uncertainty factor | 30 |
QQ. Vinyl acetate (108-05-4) | Chronic HRV ( µg/m3) | 200 |
| Endpoint of concern | Upper respiratory system |
| Equation | C |
| NOAEL[HEC] (mg/m3) | 5 |
| Uncertainty factor | 30 |
RR. Vinyl chloride (75-01-4) | Chronic HRV ( µg/m3) | 1 |
| Endpoint of concern | Cancer |
| Equation | E |
| Unit risk | 8.8E-6 |
* This HRV is for a chemical mixture which, therefore, does not have a chemical-specific number assigned by the Chemical Abstracts Service.
** This HRV may not provide protection for individuals who have been previously sensitized to this chemical.
Statutory Authority: MS s 144.12