Packing group | Oral toxicity LD50(mg/kg) | Dermal toxicity LD50 (mg/kg) | Inhalation toxicity by dusts and mists LC50(mg/L) |
I | [LESS THAN EQUAL TO]5.0 | [LESS THAN EQUAL TO]50 | [LESS THAN EQUAL TO]0.2 |
II | >5.0 and [LESS THAN EQUAL TO]50 | >50 and [LESS THAN EQUAL TO]200 | >0.2 and [LESS THAN EQUAL TO]2.0 |
III | >50 and [LESS THAN EQUAL TO]300 | >200 and [LESS THAN EQUAL TO]1000 | >2.0 and [LESS THAN EQUAL TO]4.0 |
Packing Group | Vapor concentration and toxicity |
I (Hazard Zone A) | V [GREATER THAN EQUAL TO] 500 LC50and LC50[LESS THAN EQUAL TO] 200 mL/M3. |
I (Hazard Zone B) | V [GREATER THAN EQUAL TO] 10 LC50; LC50[LESS THAN EQUAL TO] 1000 mL/m3; and the criteria for Packing Group I, Hazard Zone A are not met. |
II | V [GREATER THAN EQUAL TO] LC50; LC50[LESS THAN EQUAL TO] 3000 mL/m3; and the criteria for Packing Group I, are not met. |
III | V [GREATER THAN EQUAL TO] .2 LC50; LC50[LESS THAN EQUAL TO] 5000 mL/m3; and the criteria for Packing Groups I and II, are not met. |
Note 1: V is the saturated vapor concentration in air of the material in mL/m3at 20 °C and standard atmospheric pressure.
Note 2: A liquid in Division 6.1 meeting criteria for Packing Group I, Hazard Zones A or B stated in paragraph (a)(2) of this section is a material poisonous by inhalation subject to the additional hazard communication requirements in §§172.203(m), 172.313 and table 1 of §172.504(e) of this subchapter.
where
fi = mole fraction of the ith component substance of the liquid.
LC50i = mean lethal concentration of the ith component substance in mL/m3
where:
Pi = partial pressure of the i th component substance in kPa at 20 °C and one atmospheric pressure. Pi may be calculated according to Raoult's Law using appropriate activity coefficients. Where activity coefficients are not available, the coefficient may be assumed to be 1.0.
Packaging group (hazard zone) | Ratio of volatility and LC50 |
I (Hazard Zone A) | R [GREATER THAN EQUAL TO] 500 and LC50(mixture) [LESS THAN EQUAL TO] 200 mL/m3. |
I (Hazard Zone B) | R [GREATER THAN EQUAL TO] 10 and LC50(mixture) [LESS THAN EQUAL TO] 1000 mL/m3; and the criteria for Packing Group I, Hazard Zone A are not met. |
II | R [GREATER THAN EQUAL TO] 1 and LC50(mixture) [LESS THAN EQUAL TO] 3000 mL/m3; and the criteria for Packing Group I, Hazard Zones A and B are not met. |
III | R [GREATER THAN EQUAL TO] 1/5 and LC50(mixture) [LESS THAN EQUAL TO] 5000 mL/m3; and the criteria for Packing Group I, Hazard Zones A and B and Packing Group II are not met. |
49 C.F.R. §173.133