006.06.21 Ark. Code R. 010

Current through Register Vol. 49, No. 10, October, 2024

Rule 006.06.21-010 - Thoroughbred Rule 1217.5 Uniform Guidelines for Foreign Substances and Recommended Penalties Model Rule

Uniform Classiflcation Guidelines for Foreign Substances and Recommended Penalties.

Uniform Classification Guidelines for Foreign Substances And Recommended Penalties Model Rule.

December, 2020 (V.14.4)

© ASSOCIATION OF RACING COMMISSIONERS INTERNATIONAL - 2020.

Association of Racing Commissioners International 2365 Harrodsburg Road, Suite B-450, Lexington, Kentucky USA 40504 www.arci.com

Preamble to the Uniform Classification Guidelines of Foreign Substances

The Preamble to the Uniform Classification Guidelines was approved by the RC1 Drug Testing and Quality Assurance Program Committee (now the Drug Testing Standards and Practices Program Committee) on August 26, 1991. Minor revisions to the Preamble were made by the Drug Classification subcommittee (now the Veterinary Pharmacologists Subcommittee) on September 3, 1991.

''The Uniform Classification Guidelines printed on the following pages are intended to assist stewards, hearing officers and racing commissioners in evaluating the seriousness of alleged violations of medication and prohibited substance rules in racing jurisdictions. Practicing equine veterinarians, state veterinarians, and equine pharmacologists are available and should be consulted to explain the pharmacological effects of the drugs listed in each class prior to any decisions with respect to penalities to be imposed. The ranking of drugs is based on their pharmacology, their ability to influence the outcome of a race, whether or not they have legitimate therapeutic uses in the racing horse, or other evidence that they may be used improperly. These classes of drugs are intended only as guidelines and should be employed only to assist persons adjudicating facts and opinions in understanding the seriousness of the alleged offenses. The facts of each case are always different and there may be mitigating circumstances which should always be considered. These drug classifications will be reviewed frequently and new drugs will be added when appropriate."

Notes Regarding Classification Guidelines

* Where the use of a drug is specifically permitted by a jurisdiction, then the jurisdiction's rule supersedes these penalty guidelines.

* Regulators should be aware that a laboratory report may identify a drug only by the name of its metabolite. The metabolite might not be listed here, but the parent compound may be.

* These classes of drugs are intended only as guidelines and should be employed only to assist persons adjudicating facts and opinions in understanding the seriousness of the alleged offenses.

* The facts of each case are different and there may be mitigating circumstances that should be considered.

* These drug classifications will be reviewed periodically. New drugs will be added or some drugs may be reclassified when appropriate.

* Racing Commissioners International (RCI) and/or the Racing Medication and Testing Consortium (RMTC) should be consulted for found substances or drugs not included in these guidelines and treated as Class 1 violations warranting a Class A penalty unless otherwise advised.

Classification Criteria

The RCI Drug Classification Scheme is based on 1) pharmacology, 2) drug use patterns, and 3) the appropriateness of a drug for use in the racing horse. Categorization is decided using the following general guidelines:

* Pharmacology. Drugs that are known to be potent stimulants or depressants are placed in higher classes, while those that have (or would be expected to have) little effect on the outcome of a race are placed in lower classes.

* Drug Use Patterns Some consideration is given to placement of drugs based on practical experience with their use and the nature of positive tests. For example, procaine positives have in the past been associated primarily with the administration of procaine penicillin, and this has been taken into consideration in the placement of procaine into Class 3 instead of Class 2 with other injectable local anesthetics.

* Appropriateness of Drug Use. Drugs that clearly are intended for use in equine therapeutics are placed in lower classes. Drugs that clearly arc not intended for use in the horse are placed in higher classes, particularly if they might affect the outcome of a race. Drugs that are recognized as legitimately useful in equine therapeutics but could affect the outcome of a race are placed in the middle or higher classes.

The list includes most drugs that have been reported as detected by racing authority laboratories in the United States, Canada, the United Kingdom and other Association of Official Racing Chemists (AORC) laboratories, but does not include those which would seem to have no effect on the performance of the horse or drug detectability. For example, it does not include antibiotics, sulfonamides, vitamins, anthelmintics, or pangamic acid, all of which have been reported.

The list contains many drugs that have never been reported as detected. Usually, these are representatives of chemical classes that have the potential for producing an effect, and in many cases, for which at least one drug in that chemical class has been reported.

Most drugs have numerous effects, and each was judged on an individual basis. There are instances where there is a rather fine distinction between drugs in one category' and those in the next. This is a reflection of a nearly continuous spectrum of effects from the most innocuous drug on the list to the drug that is the most offensive.

Classification Definitions

* Class 1: Stimulant and depressant drugs that have the highest potential to affect performance and that have no generally accepted medical use in the racing horse. Many of these agents are Drug Enforcement Agency (DEA) schedule II substances. These include the following drugs and their metabolites: Opiates, opium derivatives, synthetic opioids and psychoactive drugs, amphetamines and amphetamine-like drugs as well as related drugs, including but not limited to apomorphine, nikethamide, mazindol, pemoline, and pentylenetetrazol. Though not used as therapeutic agents, all DEA Schedule 1 agents are included in Class 1 because they are potent stimulant or depressant substances with psychotropic and often habituative actions. This class also includes all erythropoietin stimulating substances and their analogues.

* Class 2: Drugs that have a high potential to affect performance, but less of a potential than drugs in Class 1. These drugs are 1) not generally accepted as therapeutic agents in racing horses, or 2) they are therapeutic agents that have a high potential for abuse. Drugs in this class include: psychotropic drugs, certain nervous system and cardiovascular system stimulants, depressants, and neuromuscular blocking agents. Injectable local anesthetics are included in this class because of their high potential for abuse as nerve blocking agents.

* Class 3: Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacology of which suggests less potential to affect performance than drugs in Class 2. Drugs in this class include bronchodilators, anabolic steroids and other drugs with primary effects on the autonomic nervous system, procaine, antihistamines with sedative properties and the high-ceiling diuretics.

* Class 4: This class includes therapeutic medications that would be expected to have less potential to affect performance than those in Class 3. Drugs in this class includes less potent diuretics; corticosteroids; antihistamines and skeletal muscle relaxants without prominent central nervous system (CNS) effects; expectorants and mucolytics; hemostatics; cardiac glycosides and anti-arrhythmics; topical anesthetics; antidiarrheals and mild analgesics. This class also includes the non-steroidal anti-inflammatory drugs (NSAIDs), at concentrations greater than established limits.

* Class 5: This class includes those therapeutic medications that have very localized actions only, such as anti-ulcer drugs, and certain anti-allergic drugs. The anticoagulant drugs are also included.

* Prohibited Practices:

A) The possession and/or use of a drug, substance or medication, specified below, on the premises of a facility under the jurisdiction of the regulatory body for which a recognized analytical method has not been developed to detect and confirm the administration of such substance; or the use of which may endanger the health and welfare of the horse or endanger the safety of the rider or driver; or the use of which may adversely affect the integrity of racing:

1) Erythropoietin

2) Darbepoetin

3) Oxyglobin

4) Hemopure

B) The possession and/or use of a drag, substance, or medication on the premises of a facility under the jurisdiction of the regulatory body that has not been approved by the United States Food and Drug Administration (FDA) for use in the United States.

C) The practice, administration, or application of a treatment, procedure, therapy or method identified below, which is performed on the premises of a facility under jurisdiction of a regulatory' body and which may endanger the health and welfare of the horse or endanger the safety of the rider or driver, or the use of which may adversely affect the integrity of racing:

Drug Classification Scheme

* Class 1: Opiates, opium derivatives, synthetic opioids, psychoactive drugs, amphetamines, and all DEA Schedule 1 substances (see http://www.deadiversion.usdoi.gov/schedules/#list). and many DEA Schedule II drugs. Also found in this class are drugs that are potent stimulants of the CNS. Drugs in this class have no generally accepted medical use in the racing horse and their pharmacologic potential for altering the performance of a racing horse is very' high. This class also includes all erythropoietin stimulating substances and their analogues.

* Class 2: Drugs placed in this category have a high potential for affecting the outcome of a race. Most are not generally accepted as therapeutic agents in the racing horse. Many are products intended to alter consciousness or the psychic state of humans, and have no approved or indicated use in the horse. Some, such as injectable local anesthetics, have legitimate use in equine medicine, but should not be found in a racing horse. The following groups of drugs are placed in this class:

A) Opiate partial agonists, or agonist-antagonists.

B) Non-opiate psychotropic drags. These drugs may have stimulant, depressant, analgesic or neuroleptic effects.

C) Miscellaneous drugs, which might have a stimulant effect on the CNS.

D) Drugs with prominent CNS depressant action.

E) Anti-depressant and antipsychotic drugs, with or without prominent CNS stimulatory or depressant effects.

F) Muscle blocking drugs - those that have a direct neuromuscular blocking action.

G) Local anesthetics that have a reasonable potential for use as nerve-blocking agents (except procaine).

H) Snake venoms and other biologic substances that may be used as nerve-blocking agents.

* Class 3: Drugs placed in this class may or may not have an accepted therapeutic use in the horse. Many are drugs that affect the cardiovascular, pulmonary and autonomic nervous systems. They all have the potential of affecting the performance of a racing horse. The following groups of drugs are placed in this class:

A) Drugs affecting the autonomic nervous system that do not have prominent CNS effects, but which do have prominent cardiovascular or respiratory system effects. Bronchodilators are included in this class.

B) A local anesthetic that has nerve-blocking potential but also has a high potential for producing urine residue levels from a method of use not related to the anesthetic effect of the drug (procaine).

C) Miscellaneous drugs with mild sedative action, such as the sleep-inducing antihistamines.

D) Primary vasodilating/hypotensive agents.

E) Potent diuretics affecting renal function and body fluid composition.

F) Anabolic and/or androgenic steroids and other drugs.

* Class 4: Drugs in this category comprise primarily therapeutic medications routinely used in racehorses. These may influence performance, but generally have a more limited ability to do so. Groups of drugs assigned to this category include the following:

A) Non-opiate drugs that have a mild central antipyretic effect.

B) Drugs affecting the autonomic nervous system that do not have prominent CNS, cardiovascular, or respiratory effects:

1) Drugs used solely as topical vasoconstrictors or decongestants.

2) Drugs used as gastrointestinal antispasmodics.

3) Drugs used to void the urinary bladder.

4) Drugs with a major effect on CNS vasculature or smooth muscle of visceral organs.

C) Antihistamines that do not have a significant CNS depressant effect. This does not include the H2 blocking agents, which are in Class 5.

D) Mineralocorticoid drugs.

E) Skeletal muscle relaxants.

F) Anti-inflammatory' drugs. These drugs may reduce pain as a consequence of their anti-inflammatory action.

1) Non-steroidal anti-inflammatory drugs (NSAlDs). (Aspirin-like drugs).

2) Corticosteroids (glucocorticoids).

3) Miscellaneous anti-inflammatory agents.

G) Less potent diuretics.

H) Cardiac glycosides and antiarrhythmic agents.

1. Cardiac glycosides.

2. Antiarrhythmic agents (exclusive of lidocaine, bretylium, and propranolol).

3. Miscellaneous cardiotonic drugs.

I Topical Anesthetics - agents not available in injectable formulations.

J) Anti diarrheal drugs.

K) Miscellaneous drugs:

1. Expectorants with little or no other pharmacologic action.

2. Stomachics.

3. Mucolytic agents.

* Class 5: Drugs in this category are therapeutic medications that have very localized actions only, such as anti-ulcer drugs, and certain antiallergic drugs. The anticoagulant drugs are also included.

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
[DELTA]-l-androstene-3, 17diol	3	A
[DELTA]-l-and rostene-3, 17dione	3	A
[DELTA]-1-dihydrotestosterone	3	A
1-and rostenediol (5a and rost-1-ene-3[BETA], 17[BETA]diol)	3	B	Steroid - endogenous weak androgen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA) and of estrone.	Endogenous AAS
l-and rostenedione (5a and rost-1-ene-3, 17dione)	3	B	Steroid - endogenous weak androgen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA) and of estrone.	Endogenous AAS
1-testosterone (17[BETA]hydroxy-5a-androst-len-3-one)	3	A	Steroid - chemically related to anabolic steroids.	AAS lacking FDA approval
19-Nor and rostenediol	3	B
19-Nor and rostened ione	3	B
19-noretiocholanolone.	3	B	Nandrolene Link - a metabolite of nandrolone (19-nortestosterone) and bolandione (19norandrostenedione).	Metabolite of a B substance
2-Aminoheptane	Tuamine	4	B
3-Methoxytyramine	3-MT	2	A
3,4-methylenedioxypyprova lerone	MDPV, "bath salts''	1	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
4-androstene-3,6,17 trione (6-oxo)	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines -Aromatase inhibitors.	Testolactone has B classification
4-androstenediol (androst-4-ene-3[BETA],17[BETA]diol)	3	B	Testosterone Link -androstenediol that is converted to testosterone.	Metabolized to a B substance
4-Hydroxytestosterone	3	B
5-androstenedione (androst-5- ene-3,17dione)	3	B	Testosterone Link -prohormone of testosterone.	Metabolized to a B substance
5[ALPHA]-androstane-3[ALPHA],17[ALPHA]diol	3	B	Testosterone Link -testosterone metabolite.	Metabolite of a B substance
5[ALPHA]-androstane-3[ALPHA],17[BETA]diol	3	B	Testosterone Link -testosterone metabolite.	Metabolite of a B substance
5[ALPHA]-androstane-3[BETA],17[ALPHA]diot	3	B	Testosterone Link -testosterone metabolite.	Metabolite of a B substance
5[ALPHA]-androstane-3[BETA],17[BETA]diol	3	B	Testosterone Link -testosterone metabolite.	Metabolite of a B substance
5[BETA]-androstane-3[ALPHA], 17[BETA]diol, androst-4-ene3[ALPHA], 17[ALPHA]-diol	3	B	Testosterone Link -androstenediol that is converted to testosterone.	Metabolized to a B substance
7-keto-dhea;19-	3	B	DHEA Link - a steroid produced by metabolism of the prohormone dehydroepiandrosterone (DHEA).	Metabolite of a B substance
7[ALPHA]-hydroxy-dhea	3	B	DHEA Link - naturally occurring steroid and a major metabolite of dehydroepiandrosterone (DHEA).	Metabolite of a B substance
7[BETA]-hydroxy-dhea	3	B	DHEA Link - naturally occurring steroid and a major metabolite of dehydroepiandrosterone (DHEA).	Metabolite of a B substance
a-Cobratoxin	1	A
Acebutolol	Sectral	3	B

Drug/Substance	Trade Namc(s)	Drug Class	Penalty Class	Special Notation	Note.
Acecarbromal	2	A
Acenocoumarol	5	C
Acepromazine	Atrove/, Notensil, PromAce®	3	B
Acetaminophen (Paracetamol)	Tylenol, Tenipra, etc.	4	C
Acetanilid	4	B
Acetazolamide	Diamox, Vetamox	4	C
Acetophenazine	Titidal	2	A
Acetophenetidin (Phenacetin)	4	B
Acetylcysteine	4	C
Acetylsalicylic acid (Aspirin)	4	C
Activators of the AM Pactivated protein kinase (AMPK) -E.g, AlCAR, and Peroxisome Proliferator Activated Receptor 6 (pparti) agonists (e.g, GW 1516).	AICAR	2	A	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines.	PPARs are experimental drugs without FDA approval
Adinazolam	2	A
Adrenochrome monosemicarbazone salicylate	4	B
Albuterol (Salbutamol)	Provenlit, Ventolin	3	B	NOTE: "A" penalty for quarter horse races.
Alclofenac	2	B
Alclometasone	Adovate	4	C
Alcuronium	Alloferin	2	A
Aldosterone	AIdocortin, Eleclrocortin	4	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Alfentanil	Alfenta	1	A
Alm ot riptan	Axert	3	A
Alphaprodine	Nisentil	2	A
Alpha-pyrrolidinovalerophenone (also known as Alpha PVP)	1	A	Known as bath salts in humans
Alpidem	Anaxyt	2	A
Alprazolam	Xanax	2	A
Alprenolol	2	A
Althcsin	Saffan	2	A
Altrenogest	Regumate	4	C	*Classification for geldings, colts, adult intact males, spayed females only.
Ambenoniuni	Mytelase, Myeuran	3	B
Ambroxol	Ambrit, de.	4	B
Amcinonide	Cyclocort	4	C
AmiIoride	Moduretic: Midanior	4	B
Aminocaproic acid	Amicar, Caprocid	4	C
Aminoglutethimide	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines.	Testolactone has B classification
Aminophylline	Aminophyllin, de.	3	B
Aminopyrine	4	B
Aminorex	Aminoxafen, Aminoxaphen, Apiquel, McN-742, Menocil	1	A
Amiodarone	4	B
Amisometradine	Rolictron	4	B
Amisulpride	Solian	2	A
Amitraz	Mitaban	3	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Amitriptyline	Elavil, Amilril, Endep	2	A
Amlodipine	Ammivin, Norvasc	3	B
Amobarbital	Amytal	2	A
Amoxapine	Asendin	2	A
Amperozide	2	A
Amphetamine	1	A
Amrinonc	4	B
Amyl nitrite	2	A
Anastrozole	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines -Aromatase inhibitors.	Testolactone lias B classification
Andarine	2	A	SARM
And rost-4-ene-3[ALPHA],17[BETA]diol	3	B	Testosterone Link - an androstenediol that is converted to testosterone.	Metabolized to a B substance
Androst-4-ene-3[BETA],17[ALPHA]diol	3	B	Testosterone Link - an androstenediol that is converted to testosterone.	Metabolized to a B substance
Androst-5-ene-3[ALPHA], 17[ALPHA]diol	3	B	Testosterone Link -androstenediol that is converted to testosterone.	Metabolized to a B substance
Androst-5-ene-3[ALPHA],17[BETA]diol	3	B	Testosterone Link -prohormone of testosterone.	Metabolized to a B substance
Androst-5-ene-3[BETA],17[ALPHA]diol	3	B	Testosterone Link -prohormone of testosterone.	Metabolized to a B substance
Androsta-1,4,6-triene-3,17-dione (androstatrienedione)	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines -Aromatase inhibitors.	Testolactone has B classification

Drug/Substance	Trade Namc(s)	Drug Class	Penalty Class	Special Notation	Note.
And rostenediol (androst-5-ene-3[BETA], 17[BETA]diol)	3	B	Steroid: weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydropiandrosterone (DHEA)	Metabolite of a B substance
And rostenedione (androst-4-ene-3, 17dione)	3	B	Steroid: endogenous weak androgen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA) and of estrone.	Endogenous AAS
Androsterone (3 [BETA]hydroxy-5 [ALPHA] -androstan-17-one)	3	B	Testosterone Link - a metabolite oftestosterone and dihydrotestosterone (DHT).	Metabolite of a B substance
Anileridine	Leritine	1	A
Anilopam	Anisine	2	A
Anisindione	5	D
Anisotropinc	Valpin	4	B
Antipyrine	4	B
Apazone (Azapropazone)	Rheumox	4	B
Apomorphine		1 4	A B
Aprindine
Aprobarbital	Aliirate	2	A
ARA-290	1	A	Erythropoietin Link - a nonerythropoietic peptide engineered from erythropoietin.	Blood doping agent
Arecoline	3	A
Arformoterol	3	B
Aripiprazole	Ability	2	A
Arsenic	3	B	Arsenic is present in pressure-treated lumber designated for non-residential use. Cribbing or wood chewing may result in expsoure sufficient to result in concentrations in excess of the screening limit. Findings for arsenic warrant investigation into the route of exposure with mitigation to 3/C recommended when there is compelling evidence for environmental exposure rather than deliberate administration.

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Aromatase inhibitors listed:
Articaine	Septocaine; Ultracaine,	2	B
Asialo EPO	Tenormin	1	A	Erythropoietin Link -desialylated form of human glycoprotein hormone erythropoietin (EPO), which has been reported to be neuro-, cardio-, and renoprotective in animal models of organ injuries.	Blood doping agent
Atenolol		3	B
Atipamazole	2	B
Atomoxetine	Slrattera	2	A
Atracurium	Tracrium	2	A
Atropine	3	B
Azacylonol	Frenque	2	A
Azaperone	Slresnil, Snicalm, Fentaz (with Fentanyl)	2	A
Baclofen	Lioresal	4	B
Barbital	Veronal	2	A
Barbiturates	2	A
Beclomethasone	Propaderm	4	C
Bemegride	Megimide, Mikedimide	2	A
Benazepril	Lotrel, Lotensin	3	A
Bend roflumethiazide	Naturetin	4	B
Benoxaprofen	2	B
Benoxinate	Dorsacaine	4	C

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Benperidol	Anquil	2	A
Bentazepam	Tiadipona	2	A
Benzactizine	Deprol, Bronchodiletten	2	A
Benzocaine	4	B
Benzoctamine	2	A
Benzodiazepines	2	A
Benzonatate	Tessalon, Tessalon Perles, Zonaluss	2	A
Benzphetamine	Didrex	2	A
Benzthiazide	4	B
Benztropine	Cogentin	2	A
Benzylpiperazine (BZP)	1	A
Bepridil	Bepadin	4	B
Betamethasone	Betasone, etc.	4	C
Betaxolol	Kerlone	3	B
Bethanechol	Urecholine, Duvoid	4	C
Bethanidine	Esbatal	3	A
Biperiden	Akineton	3	A
Biriperone	2	A
Bisoprolol	Zebeta, Bisobloc, etc.	3	B
Bisphosphonates (any)	3	A
Bitolterol	Effectin	3	A
Bolandiol (cstr-4-ene3[BETA], 17[BETA]-diol)	3	A	Steroid	AAS lacking FDA approval

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Bolasterone	3	A
Boldenone	Equipoise	3	B
Boldione	3	A
Botulinum toxin	2	A
Bretylium	Bretylol	3	B
Brimonidine	Alphagem	2	A
Bromazepam	Lexotan, Lectopam	2	A
Bromfenac	Duract	3	A
Bromhexine	Oletor, etc.	4	B
Bromisovalum	Diffucord, etc.	2	A
Bromocriptine	Parlodel	2	A
Bromodiphenhydramin	3	B
Bromperidol	Bromidol	2	A
Brompheniramine	Dimetane, Disomer	3	B
Brotizolam	Brotocol	2	A
Budesonide	Puhnacort, Rhinocort	4	C
Bufexamac	3	A
Bumetanide	Bumex	3	B
Bupivacaine	Marcaine	2	A
Buprenorphine	Temgesic	2	A
Bupropion	Wellbutrin	2	A
Buspirone	Buspar	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Butabarbital (Secbutobarbitone)	Butacaps, Butasol, etc.	2	A
Butacaine	Butyn	2	A
Butalbital (Talbutal)	Fiorinal	2	A
Butamben (butyl aminobenzoate)	Butesin	4	C
Butanilicaine	Hostacain	2	A
Butaperazine	Repoise	2	A
Butoctamide	Listomih	2	A
Butorphanol	Sladol, Torbugesic	3	B
Butoxycaine	Stadacain	4	B
Caffeine	2	B
Calusterone	Methosorb	3	A
Camazepam	Paxor	2	A
Camphor	4	C
Candesartan	Atcand	3	B
Cannabidiol (CBD)1	Anti-epileptic, analgesic	2	B
Canrenone	4	C	Metabololite of a C substance - steroidal antimineralocorticoid, active metabolite of spironolactone (a diuretic).
Capsaicin	2	B
Captodiame	Covatine	2	A
Captopril	Capolen	3	B
Carazolol	Carbacel, Conducton	3	A
Carbachol	Lentin, Doryl	3	B
Carbamezapine	Tegretol	3	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Carbamylated EPO	1	A	Eiythropoietin Link - may be a beneficial tissueprotective cytokine.	Blood doping agent
Carbazochrome	4	B
Carbidopa + levodopa	Sinemet	2	A
Carbinoxamine	Clistin	3	B
Carbromol	Mifudorm	2	A
Cardarine (GW-501516)	2	A	No legit use in the racehorse. Lacks FDA approval
Carfentanil	1	A
Carisoprodol	Rela, Soma	2	B
Carphenazine	Proketazine	2	A
Carpip raminc	Prazinil	2	A
Carprofen	Rimadyl	4	B
Carteolol	Cartrol	3	B
Carticaine (see articaine)	Septocaine: Uhracaine, etc.	2	B
Carvedilol	Coreg	3	B
Cathinone	khat, kat, qat, quat, chat, catha, Abyssinian tea, African tea	1	A
Celecoxib	Celebrex	3	B
Cetirizine	Zyrtec	4	C
Chloral betaine	Beta-Chlor	2	A
Chloral hydrate	Nactec, Oridrate, etc.	2	A
Chloraldehyde (chloral)	2	A
Chloralose (AlphaChloralose)	2	A

Drug/Substance	Trade Nanie(s)	Drug Class	Penalty Class	Special Notation	Note.
Chlordiazepoxide	l.ibrium	2	A
Chlorhexidol	2	A
Chlormerodrin	Neohydrin	4	B
Chlormczanone	Trancopal	2	A
Chloroform	2	A
Chlorophenesin	Maolate	4	C
Chloroprocaine	Nesacaine	2	A
Chloroquine	Avlodor	4	C
Chlorothiazide	Diuril	4	B
Chlorpheniramine	Chlortriemton, etc.	4	B
Chlorp roethazine	Newiplege	2	A
Chlorpromazine	Thorazine, Largactit	1	A
Chlorprothixene	Taractan	2	A
Chlorthalidone	Hydroton	4	B
Chlorzoxazone	ParaJlex	4	B
Chorionic Gonadotropin (CG)	3	B	Hormone and behavioral effects - a water soluble glycoprotein derived from human pregnancy urine. Used for behavior modification in colts / horses. There should be no restriction/regulation in fillies and mares.
Ciclesonide	4	C
Cilostazol	Pletal	4	B
Cimeterol	3	A
Cimetidine	Tagamet	5	D
Cinchocaine	Nupercaine	2	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Citalopram	Celex	2	A
Clanobutin	4	B
Clemastine	Tavist	3	B
Clenbuterol	Ventipulmin	3	B	NOTE: "A" penalty for quarter horse races.
Clibucaine	Batrax	2	A
(.'lid in iu ni	Ouarezan, Clindex, etc.	3	B
Clobazam	Urbanyl	2	A
Clobetasol	Temovate	4	C
Clocapramine	2	A
Clocortolone	Cloderm	4	C
Clodronate	OsPhos	3	A	Bisphosphonate
Clofenamide	4	B
Cloniethiazole (Chlormethiazole)	2	A
Clomiphene	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines -Estrogen modulator.	Testolactone has B classification
Clomipramine	Anafranil	2	A
Clonazepam	Klonopin	2	A
Clonidine	Catapres	3	B
Clorazepate	Tranxene	2	A
Clormecaine	Placacid	2	A
Clostebol	3	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Clothiapine	Entermin	2	A
Clotiazepam	Trecahno, Rize	2	A
Cloxazolam	Enadd, Sepazon, Tolestan	2	A
Clozapine	Clozaril, Leponex	2	A
CATO 530	1	A	Erythropoietin Link - a biopharmaceutical consisting of a novel peptide that mimics the actions of erythropoietin, CNTO 530 produced sustained increases in red blood cell parameters.	Blood doping agent
Cobalt (check note)	3	Bl	For cobalt concentrations of less than 25 parts per billion (ppb) of blood serum or plasma no penalty is recommended. For concentrations of 25 ppb or greater but less than 50 ppb of blood plasma or serum the recommended penalty is a written warning, the placement of the horse on the Veterinarians List with removal from list only after a blood test confirms that the concentration is below 25 ppb of blood plasma or serum. Testing shall be paid by the owner(s) of the horse. Concentrations of 50 ppb or greater in blood plasma or serum have a recommended "B" penalty.
Cocaine	1	A3	If it is determined by the State Veterinarian/Equine Medical Director; the Stewards, or the Racing Authority that the finding of cocaine or morphine was unintentional and not based upon an attempt to affect the outcome of a race, the Stewards or Racing Authority may elect to assign a Class B penalty to the trainer.
Codeine	1	A
Colchicine	4	B
Conorphone	2	A
Corticaine	Ultracain	2	A
Corticotrophind	3	B	Peptide hormone involved in the stress response.
Cortisone	Cortone, etc.	4	C
Cromolyn	Intel	5	D

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Crotetamide	2	A
Cyamemazine	Tertian	2	A
Cyclandclate	("yclospasmol	3	A
Cyclizine	Merazine	3	B
Cyclobarbital	Phanodorm	2	A
Cyclobenzaprine	Flexeril	4	B
Cvclofenil	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines -selective estrogen receptor modulator (SERM).	Testolactone has B classification
Cyclomethycaine	Surfacaine	4	C
Cyclothiazide	Anhydron, Renazide	4	B
Cycrimine	Pagitane	3	B
Cyproheptadine	Periactin	3	B
Danazol	Danocrine	3	B
Dantrolene	Dantrium	4	C
Da rbepoetin	Aranesp	1	A
Darbepoctin (dcpo)	1	A	Erythropoietin Link - Bone marrow stimulant (Erythropoiesisstimulating agents are medications which stimulates the bone marrow to make red blood cells).	Blood doping agent
Decamethonium	Syncurine	2	A
Dehydrochloromethylte stosterone	3	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Dembroxol (Denibrexine)	Sputolysin	4	C
Dcmoxepam	2	A
Deoxycorticosterone	Percortin, DOCA, Descotone, Dorcostrin	4	C
Dcracoxib	Deremaxx	3	B
Dermorphin	1	A
Desipraminc	Norpromine, Pertofrane	2	A
Desonide	Des Owen	4	C
Dcsoximetasonc	Topicort	4	C
Desoxymethyltestosterone	3	A
Detomidine	Dormosedan	3	B
Dexamethasone	Azium, etc.	4	C
Dextromethorphan	4	B
Dextromoramide	Palfium, Narcolo	I	A
Dextropropoxvphcne	Darvon	3	B
Dezocine	Dalgan	2	A
Diamorphine	1	A
Diazepam	Valium	2	B
Diazoxidc	Proglycem	3	B
Dibucaine	Nupercainal, Cinchocaine	2	B
Dichloralphcnazone	Febenol, lsocom	2	A
Dichlorphenamide	Daramide	4	C
Diclofenac	Voltaren, Vollarol	4	C

Drug/Suhstance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Dicumarol	Dicumarol	5	D
Diethylpropion	Tepanil, etc.	2	A
Diethylthiamhutene	Themalon	2	A
Diflorasone	Florone, Maxiflor	4	C
Diflucortolone	Flu-Cortinest, etc.	4	C
Diflunisal	3	B
Digitoxin	Crystodigin	4	B
Digoxin	Lanoxin	4	B
Diisopropy famine	2	B	Consistent with nitroglycerine
Dihydrocodeine	Parcodin	2	A
Dihydroergotamine	4	B
Dihyd rotestosterone (17[BETA]-hydroxy-5aand rostan-3-one)	3	B	Steroid - endogenous androgen sex steroid and hormone.	Endogenous AAS
Di lorazepam	Briantum	2	A
Diltiazem	Cardizem	4	B
Dimefline	3	A
Dimethisoquin	Qnolane	4	B
Diniethvlsulfoxide (DMSO)	Domoso	4	C
Diphenadione	5	C
Diphenhydramine	Benadryl	3	B
Diphenoxylate	Difenoxin, Lomotil	4	B
Diprenorphine	M50 50	2	A
Dipyridamole	Persantine	3	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Dipyrone	Novin, Methatnpyrone	4	C
Disopyramide	Norpace	4	B
Divalproex	Depakote	3	A
Dixyrazine	Esucos	2	A
Dobutamine	Dob utrex	3	B
Donepezil	Aricepl	1	A
Dopamine	Intropin	2	A
Doxacurium	Nnromax	2	A
Doxapram	Dopram	2	A
Doxazosin	3	A
Doxefazepain	Doxans	2	A
Doxepin	Adapin, Sinequan	2	A
Doxylaniine	Decapryn	3	B
Dromostanolone	Drolban	3	B
Droperidol	lnapsine, Droleptan, Innovar-Vet (with Fentanyl)	2	A
Drostanolone	3	A	Steroid	AAS lacking FDA approval
Duloxctine	2	A
Dyclonine	Dydone	4	C
Dyphylline	3	B
Ed rophonium	Tensilon	3	B
Eletripan	Relpax	3	A
Eltenac	4	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Enalapril (metabolite enaloprilat)	Vasotec	3	A
Enciprazine	2	A
Endorphins	1	A
Enkephalins	1	A
Ephedrine	2	A
Epi-dihydrotestosterone	3	B	Testosterone Link -androgenic metabolite of testosterone.	Metabolite of a B substance
Epibatidine	2	A
Epinephrine	2	A
Epitestosterone	3	B	Testosterone Link -endogenous steroid and an epimer of the androgen sex hormone testosterone.	Endogenous, stereoisomer of a B substance.
EPO-Fc	1	A	Erythropoietin Link -fusion protein in human blood.	Blood doping agent
EPO-mimetic peptides (EMP):	1	A
Ergoloid mesylates (dihyd roergoco mine mesylate, dihydroergocristine mesylate, and dihyd roergocryptine mesylate)	2	A
Ergonovine	Ergotrate	4	C
Ergotamine	Gynergen, Cafergot, etc.	4	B
Erthrityl tetranitrate	Cardilate	3	A
Erythropoietin (EPO)	Epogen, Procrit, etc.	1	A
Esmolol	Brevibloc	3	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Esomeprazole	Nexium	5	D
Estazolam	Domnamid, Eurodin, Nudalon	2	A
Eszopiclone	2	A
Etacrynic acid	3	C
Etamiphylline	3	B
Etanercept	Enbrel	4	B
Ethacrynic acid	Edecrin	3	B
Ethamivan	2	A
Ethanol	2	A
Ethchlorvynol	Placidyl	2	A
Ethinamate	lahnid	2	A
Ethoheptazine	Zadane	2	A
Ethopropazine	Parsidol	2	A
Ethosuximidc	Zarontin	3	A
Ethotoin	Peganone	4	B
Ethoxzolamidc	('a rdrase, Etham ide	4	C
Ethylaminobenzoate (Benzocaine)	Semets, etc.	4	C
Ethylestrenol	Maxibolin, Organon	3	B
Ethylisobutrazine	Diquel	2	A
Ethylmorphine	Dionin	1	A
Ethylnorepinephrine	Bronkephrine	3	A
Ethylphenidate	1	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Etidocaine	Duranest	2	A
Etifoxin	Stresam	2	A
Etiocholanolone	3	B	Testosterone Link -etiocholane steroid as well as an endogenous 17-ketosteroid that is produced from the metabolism of testosterone.	Metabolite of a B substance
Etizolam	Depas, Pasaden	2	A
Ethamsylate	4	B
Etodolac	l.odine	3	B
Etodroxizine	Indunox	2	A
Etofenamate	4	B	Consistent with other nonFDA approved NSAIDs
Etomidate	2	A
Etorphine HCI	M99	I	A
Exemestane	Aromatase inhibitors	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines -Aromatase inhibitors.	Testolactone has B classification
Famotidine	Caster, etc.	5	D
Felbamate	Felbatol	3	B
Felodipine	Plendil	4	B
Fenarbamate	Tymium	2	A
Fenbufen	C.incopal	3	B
Fenclozic acid	Myalex	2	B
Fenfluramine	Pondimin	2	A
Fenoldopam	Corlopam	3	B
Fenoprofen	Nalfon	3	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Fenoterol	Berotec	3	B
Fenspiride	Respiride, Respan, etc	3	B
Fentanyl	Sublimaze	1	A
Fentiazac	3	B
Fexofenadine	Allegro	4	C
Fibroblast Growth Factors (fgfs), Hepatocyte Growth Factor (HGF), Insulinlike Growth Facto r-1 (IGF-1) and its analogues, Mechano Growth Factors (mgfs), Platelet-Derived Growth Factor (PDGF), Vascular-Endothelial Growth Factor (VEGF) and any other growth factor affecting muscle, tendon or ligament protein synthesis/degradation, vascularization, energy utilization, regenerative capacity or fiber type switching.	3	A	Cardiac, Muscle effects - a family of peptide cytokines that are important in the regulation of many tissues.	Lack FDA approval; no legitimate use in race horse.
Firocoxib	4	C
Flecainide	Idalon	4	B
Floctafenine	Idalon, Idarac	4	B
Fluanisone	Sedalande	2	A
Fludiazepam	Erispam	2	A
Fludrocortisone	Alforone, etc.	4	C
Flufcnamic acid	4	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Flumethasone	Flucort, etc.	4	C
Flumethiazide	Ademol	4	B
Flunarizine	Sibelium	4	B
Flunisolide	Bronilide, etc.	4	C
Flunitrazepam	Rohypnol, Narcozep, Darkene, Hypnodorm	2	A
Flunixin	Banamine	4	c*
Fluocinolone	Syncdar	4	C
Fluocinonide	I. icon, Lidex	4	C
Fluopromazine	Psyquil, Siquil	2	A
Fluoresone	Caducid	2	A
FluoromethoIone	FML	4	C
Fluoroprednisolone	4	B
Fluoxetine	Prozac	2	A
Fluoxvmesterone	Halotestin	3	B
Flupcnthixol	Depixol, Fluanxol	2	A
Fluphenazine	Prolixin, Permitil, Anatensol, etc.	2	B
Flupirtine	Katadolone	3	A
Fluprednisolone	Alphadrol	4	C
Flurandrenolide	Cordran	4	C
Flurazepam	Dahnane	2	A
Flurbiprofen	Froben	3	B
Fluspirilene	Imap, Redeptin	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Fluticasone	Flixonase, Flutide	4	C
Flutoprazepam	Restas	2	A
Fluvoxamine Formebolonc	Dumirox, Faverin, etc.	2 3	A A
Formestane	Aromatase inhibitors	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines -Aromatase inhibitors.	Testolactone has B classification
Formoterol	Ahram	3	B
Fosinopril	Monopril	3	A
Fosphenytoin	Cerebyx	3	B
Fulvestrant	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines - Estrogen receptor antagonist antineoplastic agent.	Testolactone has B classification
Furazabol	3	A
Furosemide	Lasix	N/A
Gabapentin	Neurontin	3	B
Galantamine	Reminyl	2	A
Gallamine	Flaxedil	2	A
Gamma Aminobutryic Acid (GABA)	Carolina Gold	3	B
Gepirone	2	A
Gestrinone	3	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
GH-Releasing Peptides (ghrps), e.g., alexamorelin, G1IRP-6, hexarelin and pralmorelin (GHRP-2)	3	A	Anabolic Effects - a synthetic GH secretagogue.	Anabolic agent lacking FDA approval
Glutethimide	Doriden	2	A
Glycopyrrolate	Robinid	4	C
Growth Hormone Releasing Hormone (GHRH) and its analogues, e.g., CJC-1295, sermorelin and tesamorelin	3	A	Anabolic Effects - peptide analogue of growth hormone-releasing hormone which is used as a diagnostic agent to assess growth hormone secretion for the purpose of diagnosing growth hormone deficiency.	Anabolic agent lacking FDA approval
Growth Hormone Secretogogues (GHS), e.g., glirelin andghrelin mimetics, e.g., anamorelin and ipamorelin	3	A	Anabolic Effects - hunger hormone, appetiteenhancing and anabolic effects.	Anabolic agent lacking FDA approval
Guaifenesin (glycerol guiacolate)	Gecolate	4	C
Guanabenz	Wylensin	3	B
Guanadrel	Hylorel	3	A
Guanethidine	Ismelin	3	A
Halazepam	Paxipam	2	A
I la lei non ide	Halog	4	C
Halobetasol	Ultravale	4	C
Haloperidol	Haldol	2	A
Haloxazolam	Somelin	2	A
Harpagoside	4	B	Devil's Claw Plant

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Hemoglobin glutamers	Oxyglobin Hemopure	2	A
Heptaminol	Corofundol	3	B
Heroin	1	A
Hexafluorenium	Myalexen	2	A
Ilexobarbital	Evipal	2	A
Hexocyclium	Tral	4	B
Hexylcaine	Cydaine	2	B
HIF activators (e.g. Argon, xenon)	3	A	Cardiovascular Effects - a key mediator of oxygen homeostasis that was first identified as a transcription factor that is induced and activated by decreased oxygen tension.	Blood doping agent
Homatropine	Homapin	3	B
Homophenazine	Pelvichlhol	2	A
Hydralazine	Apresoline	3	B
Hydrochlorthiazide	Hydrodiuril	4	B
Hydrocodone (dihydrocodienone)	Hycodan	1	A
Hydrocortisone (Cortisol)	Cortef etc.	4	C
Hydroflumethiazide	Saluron	4	B
Hydromorphone	Dilaudid	1	A
Hvdroxyamphetamine	Paradrine	1	A
Hydroxyzine	Atarax	2	B
Hypoxia-inducible factor (HIF) activators	1	A	Blood doping agent
Hypoxia-inducible factor (HIF) stabilizers (e.g. IOX-2)	I	A	Blood doping agent
Ibomal	Nodal	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Ibuprofen	Motrin, Advil, Nurpin, etc.	4	C
Ibutilide	Corvert	3	B
IIoprost	Ventavis	3	A
Imipramine	Imavate, Presamine, Tofranil	2	A
Indapamide	Diuretic	3	C
Indomethacin	Indodn	3	B
Infliximab	Remicade	4	B
Insulins	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines - protein hormone that is used as a medication to treat high blood sugar.
Ipratropium	3	B
Irbesarten	Avapro	3	A
Isapirone	2	A
Isocarboxazid	Marplan	2	A
Isoetharinc	Rronkosol	3	B
Isoflupredone	Predef 2x	4	C
Isomethadone	2	A
Isomethcptene	Octin, Octon	4	B
Isopropamide	Darkid	4	B
Isoproterenol	lsoprel	2	A
Isosorbide dinitrate	Isordil	3	B
Isoxicam	Maxicam	2	B
Isoxsuprine	Vasodilan	4	D
Isradipine	DynaCirc	4	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Kebuzone	3	B
Ketamine	Ketalar, Ketaset, Vetalar	2	B
Ketazolam	Anxon, Laftram, Solalran, Loftran	2	A
Ketoprofen	Orudis	4	C*
Ketorolac	Toradol	3	A
Labetalol	Normodyne	3	B
Lamotrigine	Lamictal	3	A
Lansoprazole	5	D
Lenperone	Elanone-V	2	A
Letosteine	Viscotiol, Visiolal	4	B
Letrozole	3	A
Levantisole	2	B
Levobunolol	lielagan	3	B
Levomethorphan	2	A
Levorphanol	Levo-Dremoran	I	A
Lidocaine	Xylocaine	2	B
Ligandrol	2	A	SARM
Lisinopril	Prinivil, Zestril	3	A
Lithium	Lithizine, Duralith, etc.	2	A
Lobeline	2	A
Lofentanil	1	A
Loflazepate, Ethyl	Victan	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Loperamide	Imodium	3	B
Loprazolam	Dormonort, Havlane	2	A
Loratidine	Claritin	4	C
Lorazepam	Ativan	2	A
Lormetazepam	Noctamid	2	A
Losartan	Hyzaar	3	B
Loxapine	Laxitane	2	A
Luteinizing Hormone (LH)	3	B	Hormone and behavioral effects - a hormone produced by gonadotropic cells in the anterior pituitary gland. In females, an acute rise of LH triggers ovulation and development of the corpus luteum. Used for behavior modification in colts / horses. There should be no restriction/regulation in fillies and mares.
Mabuterol	3	A
Maprotiline	LudiomiL	2	A
Mazindol	Sanorex	1	A
Mebutamate	Axilen, Dormale, Capta	2	A
Mecamylamine	Inversine	3	B
Meclizine	Antivert, Bonine	3	B
Mcclofenamic acid	ArgueI	4	C
Meclofenoxate	Lucidiril, etc.	2	A
Medazepam	Nobrium, etc.	2	A
Medetomidine	Damintor	3	B
Medroxyprogesterone	3	B	Classification for all genders
Medrysone	Medriusar, etc.	4	C
Mefenamic acid	Ponslei	3	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Meldonium	Mildronate, el al	1	A
Meloxicani	Mobic	4	B
Melperone	Eunerpan	2	A
Memantine	Namenda	2	A
Meparfynol	Oblivon	2	A
Mepazine	Pacatai	2	A
Mcpenzolate	Cantil	3	B
Meperidine	Demerol	1	A
Mephenesin	Tolserol	4	B
Mephenoxalone	Control, etc.	2	A
Mephentermine	Wyamine	1	A
Mephenytoin	Mesantoin	2	A
Mephobarbital (Methylphenobarbital)	Mebaral	2	A
Mcpivacaine	Carbocaine	2	B
Meprobamate	Equanil, Miltown	2	A
Meralluride	Mercuhydrin	4	B
Merbaphen	Novasural	4	B
Mercaptomerin	Thiomerin	4	B
Mercumatilin	Cumertilin	4	B
Mersalyl	Salyrgan	4	B
Mesalamine	Asacol	5	C
Mesoridazine	Serentil	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Mestanolone	3	A
Mesterolone	3	A
Metaclazepam	Talis	2	A
Metandienonc	3	A	Steroid	AAS lacking FDA approval
Metaproterenol	Alupent, Metaprel	3	B
Metaraminol	Aramine	1	A
Metaxalone	Skelaxin	4	B
Metazocine	2	A
Metenolone	3	A	Steroid	AAS lacking FDA approval
Metformin	2	B
Methacholine	3	A
Methadone	Dolophine	1	A
Methamphetamine	Desoxyn	1	A4	Recommended Penalty B if testing can prove presence of only levo-methamphetamine is present in sample.
Methandriol (Methyland rostenediol)	Probotic	3	A
Methand rostenolone	Dianobal	3	A
Methantheline	Banthine	3	B
Methapyrilene	Histadyl, etc.	3	B
Methaqualone	Ouaalude	1	A
Metharbital	Gemonil	2	A
Methasterone	3	A
Methazolamide	Naptazane	4	C
Methcathinone	1	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Methdilazine	Tacaryl	3	B
Methcnolone	Primobolan	3	A
Methixene	Trest	3	A
Methocarbamol	Rohaxin	4 2	C
Methohexital	Brevital		A
Methotrexate	Folex, Nexale, etc.	4	B
Methotrimeprazine	Levoprome, Neurocil, etc.	2	A
Mcthoxaniine	Vasoxyl	3	A
Methoxy phenamine	Orthoxide	3	A
Methoxypolyethylene glycol-epoetin beta (CERA)	1	A	Erythropoietin Link - an erythropoiesis-stimulating agent (ESA) indicated for the treatment of anemia associated with chronic kidney disease (CKD in adult patients on dialysis and patients not on dialysis.	Blood doping agent
Methscopolamine	Pamine	4	B
Methsuximide	Celontin	4	B
Methyclothiazide	Enduron	4	B
Methyl- 1-testosterone		3	A
Methylatropine		3	B
MethyldienoIone	Aldomet	3	A
Methyldopa		3	A
Methylergonovine	Methergine Geranamine	4 I	C
Methylhexanamine (Methylhexaneamine)			A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Methylnortestosterone (Trcstolone)	3	A
Methylphenidate	Ritalin	1	A
Methylprednisolone	Medrol	4	C
Methyltestosterone	Metandren	3	B
Methyprylon	NoIndar	2	A
Methysergide	Sansert	4	B
Metiamide	4	B
Metoclopramide	Region	4	C
Metocurine	Metubine	2	A
Metolazone	3	B
Metomidate	Hypnodil	2	A
Metopon (methydihydromorphin one)	1	A
Metoprolol	Lopressor	3	B
Metribolone	3	A	Steroid	AAS lacking FDA approval
Mexazolam	Melex	2	A
Mexiletine	Mexitil	4	B
Mibefradil	Posicor	3	B
Mibolerone	3	B
Midazolam	Versed	3	B
Midodrine	Pro-Amiline	3	B
Milrinone	4	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Minoxidil	Loniten	3	B
Mirtazepine	Remeron	2	A
Misoprostol	Cytotec	5	D
Mitragynine	Kratom	1	A
Mivacuriuni	Mivacron	2	A
Modafinil	Provigil	2	A
Moexipril (metabolite, moexiprilat)	Uniretic	3	B
Molidustat	I	A	Blood doping agent
Molindone	Mohan	2	A
Mometasone	Elocon	4	C
Montclukast	Singulair	4	C
Moperone	Luvalren	2	A
Morphine	1	A6	If it is determined by the State Veterinarian/Equine Medical Director; the Stewards, or the Racing Authority that the finding of cocaine or morphine was unintentional and not based upon an attempt to affect the outcome of a race, the Stewards or Racing Authority may elect to assign a Class B penalty to the trainer.
Mosapriminc	2	A
Muscarine	3	A
myo-inositol trispyrophosphate (ITPP)	1	A
N-Buty (scopolamine	4	C
Nabumetone	Anthraxan, Relafen, Reliflex	3	A
Nadol	Corgard	3	B
Naepaine	Amylsine	2	A
Nalbuphine	Nubain	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Nalorphine	Nalline, Lethidrone	2	A
Naloxone	Narcan	3	B
Naltrexone	Revia	3	B
Nandrolone	Nandrolin, l.aurabolin, Durabolin	3	B
Naphazoline	Privine	4	B
Naproxen	Equiproxen, Naprosyn	4	C
Naratriptan	Amerge	3	B
Nebivolol	3	A
Nedocromil	Tilade	5	D
Nefazodone	Serzone	2	A
Nefopam	3	A
Neostigmine	Prostigmine	3	B
Nicardipine	Cardine	4	B
Nifedipine	Procardia	4	B
Niflumic acid	Nifluril	3	B
Nikethamide	('oramine	1	A
Nimesulide	3	B
Nimetazepam	Erimin	2	A
Nimodipine	Nemotop	4	B
Nitrazepam	Mogadon	2	A
Nitroglycerin	2	B
Nizatidine	Axid	5	D

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Norandrosterone	3	B	Nandrolene Link - a detectable metabolite of nandrolone, an anabolic-androgenic steroid.	Metabolite of a B substance
Norbolethone/Norbolet one	3	A
Norclostebol	3	A
Nordiazepam	Calmday, Nordaz, etc.	2	A
Norethisterone (norethindrone)	4	B all genders	No known use in the horse
Norepineph line	2	A
No rethand rolone	3	A
Nortestosterone	3	B
Nortriptyline	Avenlyl, Pamelor	2	A
Nv lid rine	Arlidin	3	A
Olanzepine	Zyprexa	2	A
Olicerdine	1	A	FDA approved opioid for humans
Olmesartan	Benicar	3	A
Olsalazine	Dipentum	5	C
Omeprazole	Prilosec, Losec	5	D
Oripavine	2	A
Orphenad line	Norlfex	4	B
Ostarine	2	A	SARM
Oxabolone	3	A
Oxand rolone	Anavar	3	B
Oxaprozin	Daypro, Deflam	4	B
Oxazepam	Serax	2	A
Oxazolam	Serenal	2	A
Oxcarbazepine	Trileptal	3	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Oxilofrine (hydroxyephedrine)	2	A
Oxprcnolol	Trasicor	3	A
Oxycodone	Percodan	1	A
Oxvmesterone	3	A
Oxymetazoline	Afrin	4	B
OxymethoIone	Adroyd, Anadrol	3	B
Oxymorphone	Numorphan	1	A
Oxvperitine	Forit, Jntegrin	2	A
Oxyphenbutazone	Tandearil	4	C
Oxyphencyclimine	Daricon	4	B
Oxyphenonium	Antrenyl	4	B
Paliperidone	2	A
Pancuronium	Pavilion	2	A
Pantoprazole	Protonix	5	D
Papaverine	Pavagen, etc.	3	A
Parecoxib	4	B
Paraldehyde	Paral	2	A
Paramethadione	Paradione	3	A
Paramethasone	Haldrone	4	C
Pargyline	Eulonyl	3	A
Paroxetine	Paxil, Seroxat	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Peginesatide	1	A	Erythropoietin Link - an eiythropoiesis-stimulating agent (ESA) indicated for the treatment of anemia due to chronic kidney disease (CKD) in adult patients on dialysis.	Blood doping agent
Pemoline	Cylert	1	A
Penbutolol	Levatol	3	B
Penfluridol	Cyperon	2	A
Pentaerythritol tetranitrate	Duolrale	3	A
Pentazocine	Tahvin	3	B
Pentobarbital	Nembutal	2	A
Pentoxyfylline	Trental, Vazofirin	4	D
Pentylenetetrazol	Metrazol, Nioric	1	A
Perazine	Taxilan	2	A
Perfluorocarbons	2	A
Perfluorodecahydronop hthalene	2	A
Pcrfluorodecolin	2	A
Perfluorooctylbromide	2	A
Perfluorotripropylamin e	2	A
Pergolide	Permax	3	B
Periciazine	Alodept, etc.	2	A
Perindopril	Hiprel	3	A
Perlapine	Hypnodin	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Perphenazine	Trilafon	2	A
Phenacemide	Phenurone	4	B
Phenaglycodol	Acalo, Alcamid, etc.	2	A
Phenazocine	Narphen	1	A
Phencyclidine (PCP)	Sernylan	1	A
Phendimetrazine	Bontril, etc.	1	A
Phenelzine	Nardelzine, Nardil	2	A
Phenindione	Hedidin	5	D
Phenmetrazine	Preludin	1	A
Phenobarbital	Luminal	2	A
Phenoxy benzamine	Dibenzyline	3	B
Phenprocoumon	Liquamar	5	D
Phensuximide	Milontin	4	B
Phentermine	Jomamin	2	A
Phentolamine	Regitine	3	B
Phenylbutazone	Butazolidin	4	C*
Phenylephrine	Isophrin, Neo-Synephrine	3	B
Phenylpropanolamine	Propadrine	3	B
Phenytoin	Dilantin	4	B
Physostigmine	Eserine	3	A
Picrotoxin	1	A
Piminodine	Alvodine, Cimadon	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Pimobendan	2	B
Pimozide	Orap	2	A
Pinazepam	Domar	2	A
Pindolol	Viskin	3	B
Pipam perone	Dipiperon	2	A
Pipecuronium	Arduan	2	A
Pipequaline	2	A
Piperacetazine	Psymod, Quids	2	A
Piperocaine	Metycaine	2	A
Pipotiazine	Lonseren, Piportil	2	A
Pipradrol	Da taril, Gerondyl, etc.	2	A
Piquindone	2	A
Pirbuterol	Maxair	3	B
Pirenzepine	Gastrozepin	5	C
Piretanide	Arelix, Tauliz	3	B
Piritramide	1	A
Piroxicam	Peldene	4	B
Plasma expanders (c.g. Bycerol; intravenous administration of albumin, dextran, hydroxyethvl starch and mannitol)	3	A	No legit use in the racehorse. Lacks FDA approval.
Polyethylene glycol	5	D
Polythiazide	Renese	4	B

Drug/Substancc	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Pramoxine	Tronothaine	4	C
Prasterone (dehyd roepiand rostero ne, DHEA, 30[BETA]hyd roxyand rost-5-en17-one)	3	B	Steroid - inactive endogenous steroid.	Endogenous AAS
Prazepam	Verslran, ('entrax	2	A
Prazosin	Minipress	3	B
Prednisolone	Delta-Cortef, etc.	4	C
Prednisone	Meticorten, etc.	4	C
Pregabalin	l.yrica	3	B	Gabapentanoid
Prilocaine	Citanest	2	B
Primidone	Mysoline	3	B
Probenecid	4	C
Procainamide	Pronestyl	4	B
Procaine	3	B
Procaterol	Pro Air	3	A
Prochlorperazine	Darbazine, ('ompazine	2	A
Procyclidine	Kemadrin	3	B
Promazine	Sparine	3	B
Promethazine	Phenergan	3	B
Propafenone	Rythmol	4	B
Propanidid	2	A
Propantheline	Pro-Banihine	3	B
Proparacaine	Ophthaine	4	C

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Propentophylline	Karsivan	3	B
Propiomazine	Largon	2	A
Propionylpromazine	Tranvet	2	A
Propiram	2	A
Propofol	Diprivan, Disoprivan	2	A
Propoxvcaine	Ravocaine	2	A
Propranolol	Inderal	3	B
Propylhexedrine	Benzedrex	4	B
Prostanazol	3	A
Prothipendyl	Dominal	2	A
Protokylol	Ventaire Concordin, Triptil	3	A
Protriptyline		2	A
Proxibarbital	Axeen, Centralgot	2	A
Pseudoephed line	Cenafed, Novafed	3	B
Pyridostigmine	Mestinon, Regonol	3	B
Pyrilamine	Neoantergan, Equihist	3	B
Pyrithyldione	Hybersulfan, Sonodor	2	A
Quazipam	Doral	2	A
Quetiapine	Seroquel	2	A
Quinapril, Quinaprilat	Accupril	3	A
Quin bolone	3	A
Quinidine	Ouinidex, Quinicardine	4	B

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Rabeprazole	Aciphex	5	D
Racemethorphan	2	A
Racemorphan	2	A
Raclopride	2	A
Ractopamine	Paylean	2	A
Raloxifene	3	B	Estrogen effects, same classification as Testolactone on Human Olympic Guidelines -selective estrogen receptor modulators-SERMs.	Testolactone has B classification
Ramipril, metabolite Ramiprilat	Altace	3	A
Ranitidine	Zantac	5	D
Remifentanil	Ultiva	1	A
Remoxipride	Roxiam	2	A
Reserpine	Serpasil	2	B
Rilmazafone	2	A
Risperidone	2	A
Ritanserin	2	A
Ritodrine	Yutopar	3	B
Rivastigminc	Exelon	2	A
Rizatriptan	Maxalt	3	B
Rocuronium	Zemnron	2	A
Rofecoxib	Vioxx	2	B
Romifidine	Sedivel	3	B

Drug/Substance	Trade Nanie(s)	Drug Class	Penalty Class	Special Notation	Note.
Ropivacaine	Naropin	2	A
Roxadustat (FG-4592)	1	A	Erythropoietin Link - HIF prolyl-hydroxylase inhibitor and thereby increases endogenous production of erythropoietin, which stimulates production of hemoglobin and red blood cells.	Blood doping agent
Salicylamide	4	C
Salicylate	4	C
Salmeterol	3	B
Scopolamine (Hyoscine)	Triptone	4	C
Secobarbital (Quinalbarbitone)	Seconal	2	A
Selective Androgen Receptor Modulators (SARMs)	2	A
Selegiline	Eldepryl, Jiunex, etc.	2	A
Sertraline	Lustrat, Zoloft	2	A
Sibutramine	Meridia	3	B
Sildenafil	Viagra	3	A
Snake Venoms	1	A
Somatrem	Protropin	2	A
Somatropin	Nutropin	2	A
Sotalol	Hetapace, Sotacor	3	B
Spiclomazinc	2	A
Spiperone	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Spirapril, metabolite Spiraprilat	Renomax	3	A
Spironalactonc	Alduelone	4	B
Spironolactone	Diuretic	3	C
Stanozolol	Winslrol-V	3	B
Stenbolone	3	A
Strychnine	1	A
Succinylcholine	Sucostrin, Quelin, etc.	2	A
Sufentanil	Sufenta	1	A
Sulfasalazine	Azuljidine, Azaline	4	C
Sulfondiethylmethane	2	A
Sulfonmethane	2	A
Sulforidazine	lnofal	2	A
Sulindac	Clinoril	3	B
Sulpiride	Aiglonyl, Sulpitil	2	A
Suitopride	Barnetd	2	A
Sumatriptan	hnitrex	3	B
Synthetic cannabis	Spice, K2, Kronic	1	A
Tadalasil	Cialis	3	A
Talbutal	Lolusale	2	A
Tamoxifen	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines -Estrogen receptor antagonist antineoplastic agent.	Testolactone has B classification

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Tandospirone	2	A
Tapentadol	Nucynta	1	A
TCO2	3	B
Tclmisartin	Micardis	3	B
Temazepam	Restoril	2	A
Tenoxicam	Alganex, etc.	3	B
Tepoxalin	3	B
Terazosin	Hytrin	3	A
Terbutaline	Rrethine, Bricanyt	3	B
Terfenadine	Seldane, Tritudan	4	C
Testolactone	Testae	3	B
Testolone	2	A	SARM
Testosterone	3	B
Tetrabenazine	Nilotnan	2	A
Tetracaine	Ponto caine	2	A
Tetrahyd rogestrinone	3	A
Tetrahydrozoline	Tyzine	4	B
Tetrazepam	Musarit, Myotastin	2	A
THC (tetrahydrocannabinol)2	Drug of human abuse	1	A	Drug of human abuse.
Thebaine	2	A
Theobromine	4	B
Theophylline	Aqualphyllin, etc.	3	B
Thialbarbital	Kemithal	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Thiamylal	Surital	2	A
Thiethylperazine	Torecan	2	A
Thiopental	Penlothal	2	A
Thiopropazate	Darial	2	A
Thioproperazine	Majeptil	2	A
Thioridazine	Mellaril	2	A
Thiosalicylate	4	B
Thiothixene	Navane	2	A
Thiphenamil	Trocinate	4	B
Thyroxine and thyroid modulators/hormones, including but not limited to those containing T4 (tetraiodothyronine/thy roxine), T3 (triiodothyronine), or combinations thereof.	Levothyroxine	3	C	FDA approvad but has (limited) racehorses.	legitimate use in care of
Tiapride	Italprid, Luxoben, etc.	2	A
Tiaprofenic acid	Surgam	3	B
Tibolonc	3	A	Steroid - synthetic steroid.	AAS lacking FDA approval
Tildronate Sodium	Tildren	3	A	Bisphosphonate
Tiletamine	Component of Telazol	2	A
Timiperone	Tolopelon	2	A
Timolol	Blocardrin	3	B
Tocainide	Tonocard	4	B
Tofisopam	Grandaxain, Seriel	2	A

Drug/Substance	Trade Namc(s)	Drug Class	Penalty Class	Special Notation	Note.
Tolazoline	Priscoline	3	B
Tolfenamic Acid	4	B
Tolmetin	Tolectin	3	B
Topirimate	Topamax	2	A
Toremifene	3	B	Hormone and Metabolic effects, Testolactone on Human Olympi estrogen receptor modulator.	same classification as c Guidelines - Selective
Torsemide (Torasemide)	Demadex	3	A
Tramadol	Ullram	2	B
Trandolapril (and metabolite, trandolaprilat)	Tarka	3	B
Tranexamic acid	4	C
Tranylcypromine	Parnate	2	A
Trazodone	Desyrel	2	A
Trcnbolone	Finoplix	3	B
Tretoquinol	Inolin	2	A
Triamcinolone	Velalog, etc.	4	C
Triamterene	Dyrenimn	4	B
Triazolam	Halcion	2	A
Tribromethanol	2	A
Tricaine methanesulfonate	Finquel	2	A
Trichlormcthiazide	Naqua, Naquasone	4	C
Trichloroethanol	2	A
Tricholoethylene	Trilene, Trimar	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Triclofos	Tridos	2	A
Tridihexethyl	Pathilon	4	B
Trifluomeprazine	NorIran	2	A
Trifluoperazine	Stelazine	2	A
Trifluperidol	Triperidol	2	A
Triflupromazine	Felame, Vesprin	2	A
Trihexylphenidyl	Ariane	3	A
Trimeprazine	Temaril	4	B
Trimetazidine	3	B	Hormone and Metabolic effects, same classification as Testolactone on Human Olympic Guidelines - a drug for angina pectoris, the first cytoprotective anti- ischemic agent.
Trimethadione	Tridione	3	B
Trimethaphan	Arfonad	3	A
Trimipraminc	Surmontil	2	A
Tripelennamine	PBZ	3	B
Triprolidinc	Actidil	3	B
Trometaniol (Also known as tris hydroxymethyl aminomethane [THAM[)	3	B
Tubocurarine (Curare)	Metubin	2	A
Tybamate	Benvil, Nospan, etc.	2	A
Urethane	2	A
Valdeeoxib	4	B	Corrected to be consistent with all NSAIDS
Valerenie aeid	3	A
Valnoetamide	Nirvanyl	2	A
Valsartan	Diovan	3	B
Vardenafil	Levitra	3	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Vedaprofen	4	B
Venlafaxine	Efflemr	2	A
Veralipride	Accional, Veralipril	2	A
Verapamil	('alan, Isoplin	4	B
Vercuronium	Norcuron	2	A
Viloxazine	Calatrot, Vivalan, etc.	2	A
Vinbarbital	Delvinol	2	A
Vinylbital	Optanox, Speda	2	A
Warfarin	Coumadin, Coufarin	5	D
Xylazine	Rompun, Bay Va 1470	3	B
Xylometazoline	Olrivin	4	B
Yohimbine	2	B
Zafirlukast	Accolate	4	C
Zaleplon	Sonata	2	A
Zeranol	Ralgro	4	C
Ziconotide	1	A
Zileuton	Zyflo	4	C
Zilpaterol hydrochloride	Zilpaterol	2	A
Ziprasidone	Geoden	2	A
Zolazepam	2	A
Zolmitriptan	Zotnig	3	B
Zolpidem	Ambien, Stilnox	2	A

Drug/Substance	Trade Name(s)	Drug Class	Penalty Class	Special Notation	Note.
Zomepirac	Zotnax	2	B
Zonisamide	Zonegran	3	B
Zopiclone	lmovan	2	A
Zotcpinc	Lodopin	2	A
Zuclopenthixol	Ciatyl, Cesordinol	2	A

UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES

Version 14.4 (December, 2020)

PENALTY GUIDELINES

© ASSOCIATION OF RACING COMMISSIONERS INTERNATIONAL - 2020.

Association of Racing Commissioners International

2365 Harrodsburg Road, B-450, Lexington, Kentucky, United States

www.arci.com

PENALTY CATEGORY "A"

The following are recommended penalties for violations due to the presence of a drug carrying a Category "A" penalty and for violations of ARCI-011-015 and ARCI-025-015: Prohibited Practices:

LICENSED TRAINER:
1st Offense	2nd LIFETIME offense in any jurisdietion	3rd LIFETIME offense in any jurisdietion
* Minimum one-year suspension absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum of a three-year suspension AND * Minimum fine of $10,000 or 10% of total purse (greater of the two) absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum of $25,000 or 25% of purse (greater of the two). AND * May be referred to the Commission for any further action deemed necessary by the Commission.	* Minimum three-year suspension absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum of license revocation with no reapplication for a three-year period. AND * Minimum fine of $25,000 or 25% of total purse (greater of the two) absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum of $50,000 or 50% purse (greater of the two). AND * May be referred to the Commission for any further action deemed necessary by the Commission.	* Minimum five-year suspension absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum of license revocation with no reapplication for a five-year period. AND * Minimum fine of $50,000 or 50% of total purse (greater of the two) absent mitigating circumstances. The preence of aggravating factors could be used to impose a maximum of $100,000 or 100% purse (greater of the two). AND * May be referred to the Commission for any further action deemed necessary by the Commission.
LICENSED OWNER:
1st Offense	2nd LIFETIME offense in owner's stable any jurisdietion	3rd LIFETIME offense in owner's stable in any jurisdietion
* Disqualification and loss of purse AND * Horse shall be placed on the Veterinarian's List for 180 days and must pass a commission-approved examination before becoming eligible to be entered.	* Disqualification and loss of purse AND * Horse shall be placed on the Veterinarian's List for 180 days and must pass a commission-approved examination before becoming eligible to be entered.	* Disqualification, loss of purse and $50,000 fine AND * Horse shall be placed on the Veterinarian's List for 180 days and must pass a commission-approved examination before becoming eligible to be entered. AND * Referral to the Commission with a recommendation of a suspension for a minimum of 90 days.

PENALTY CATEGORY "B"

The following are recommended penalties for violations due to the presence of a drug carrying Category "B" penalty, for the detection of two or more NSAIDs in a plasma/serum and/or urine sample, the detection of two or more corticosteroids in a plasma/serum and/or urine sample subject to the provisions set forth in ARCI-01 l-020(E) and ARCI-025-020(E) and for violations of the established levels for total carbon dioxide:

Version 14.4, December 2020

LICENSED TRAINER:
1st Offense	2nd offense (365-day period) in any jurisdiction	3rd offense (365-day period) in any jurisdiction
* Minimum 15-day suspension absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum of a 60-day suspension AND * Minimum fine of$500 absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum fine of SI,000.	* Minimum 30-day suspension absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum of a 180-day suspension AND * Minimum fine of $1,000 absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum fine of $2,500.	* Minimum 60-day suspension absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum of a one-year suspension. * Minimum fine of $2,500 absent mitigating circumstances. The presence of aggravating factors could be used to impose a maximum of $5,000 or 5% purse (greater of the two). AND * May be referred to the Commission for any further action deemed necessary by the Commission.
LICENSED OWNER:
1st Offense	2nd offense (365-day period) in owner's stable any jurisdiction	3rd offense (365-day period) in owner's stable in any jurisdiction
* Disqualification and loss of purse [in the absence of mitigating circumstances]* AND * Horse must pass a commission-approved examination before becoming eligible to be entered.	* Disqualification and loss of purse [in the absence of mitigating circumstances]* AND * Horse must pass a commission-approved examination before becoming eligible to be entered.	* Disqualification, loss of purse, and in the absence of mitigating circumstances a $5,000 fine.* AND * Horse shall be placed on the Veterinarian's List for 45 days and must pass a commission-approved examination before becoming eligible to be entered.

PENALTY CATEGORY "C"

The following are recommended penalties for violations due to the presence of a drug carrying a Category "C" penalty and overages for permitted NSAIDs and furosemide: (All concentrations are for measurements in serum or plasma.)

LICENSED TRAINER	Furosemide (>100 ng/ml) and/or no furosemide when identified as administered	Phenylbutazone (>0.3 mcg/ml) Flunixin (> 5.0 ng/ml) Ketoprofen (> 2.0 ng/ml) and CLASS C Violations
1st Offense (365-day period) in any jurisdiction	Minimum of a written warning to maximum fine of $500	Minimum fine of $1,000 absent mitigating circumstances
2nd Offense (365-day period) in any jurisdiction	Minimum of a written warning to maximum fine of $750	Minimum fine of $1,500 and 15-day suspension absent mitigating circumstances
3rd Offense (365-day period) in any jurisdiction	Minimum fine of $500 to a maximum fine of $1,000	Minimum fine of $2,500 and 30-day suspension absent mitigating circumstances
LICENSED OWNER	Furosemide (>100 ng/ml) and/or no furosemide when identified as administered	Phenylbutazone (>0.3 mcg/ml) Flunixin (> 5.0 ng/ml) Ketoprofen (> 2.0 ng/ml) and CLASS C Violations
1st Offense (365-day period) in any jurisdiction	Horse may be required to pass commission-approved examination before being eligible to run	Disqualification and loss of purse in the absence of mitigating circumstances. Horse must pass commission-approved examination before being eligible to run.
2nd Offense (365-day period) in any jurisdiction	Horse may be required to pass commission-approved examination before being eligible to run	Disqualification and loss of purse in the absence of mitigating circumstances. If same horse, placed on veterinarian's list for 45 days, must pass commission-approved examination before being eligible to run
3rd Offense (365-day period) in any jurisdiction	Disqualification and loss of purse. Horse must pass commission-approved examination before being eligible to run	Disqualification and loss of purse in the absence of mitigating circumstances. Minimum $5,000 fine. If same horse, placed on veterinarian's list for 60 days, must pass commission-approved examination before being eligible to run

After a two-year period, if the licensee has had no further violations, any penalty due to an overage in the 2.0-5.0 category will be expunged from the licensee's record for penalty purposes.

PENALTY CATEGORY "D"

The recommended penalty for a violation involving a drug that carries a Category "D" penalty is a written warning to the trainer and owner. Multiple violations may result in fines and/or suspension.

MMV Point System

Multiple Medication Violation Model Rule. ARCI-011-020(B)(13)

Officials are advised to check a licensee's ARCI regulatory record to see if multiple medication violations should be considered as an aggravating factor in the determination of an appropriate penalty.

(1) Multiple Medication Violations (MMV)

(a) A trainer who receives a penalty for a medication violation based upon a horse testing positive for a Class 1-5 medication with Penalty Class A-C, as provided in the most recent version of the ARCI Uniform Classification Guidelines for Foreign Substances, or similar state regulatory guidelines, shall be assigned points as follows:

Penalty Class	Points If Controlled Therapeutic Substance	Points If Non-Controlled Substance
Class A	N/A	6
Class B	2	4
Class C	1/2 for first violation with an additional 1/2 point for each additional violation within 365 days1	1 for first violation with an additional 1/2 point for each additional violation within 365 days
Class D	0	0

¹ Points for NSAID violations only apply when the primary threshold of the NSAID is exceeded. Points are not to be separately assigned for a stacking violation.

If the Stewards or Commission determine that the violation is due to environmental contamination, they may assign lesser or no points against the trainer based upon the specific facts of the case.

(b) The points assigned to a medication violation by the Stewards or Commission ruling shall be included in the ARCI official database. The ARCI shall record points consistent with Section 13(a) including when appropriate, a designation that points have been suspended for the medication violation. Points assigned by such regulatory ruling shall reflect, in the case of multiple positive tests as described in paragraph (d), whether they constitute a single violation. The Stewards' or Commission Ruling shall be posted on the official website of the Commission and within the official database of the Association of Racing Commissioners International. If an appeal is pending, that fact shall be noted in such Ruling. No points shall be applied until a final adjudication of the enforcement of any such violation.

(c) A trainer's cumulative points for violations in all racing jurisdictions shall be maintained by the ARCI. Once all appeals are waived or exhausted, the points shall immediately become part of the trainer's official ARCI record and shall be considered by the Commission in its determination to subject the trainer to the mandatory enhanced penalties by the Stewards or Commission as provided in this regulation.

(d) Multiple positive tests for the same medication incurred by a trainer prior to delivery of official notice by the commission may be treated as a single violation. In the case of a positive test indicating multiple substances found in a single post-race sample, the Stewards may treat each substance found as an individual violation for which points will be assigned, depending upon the facts and circumstances of the case.

(e) The official ARCI record shall be used to advise the Stewards or Commission of a trainer's past record of violations and cumulative points. Nothing in this administrative regulation shall be construed to confer upon a licensed trainer the right to appeal a violation for which all remedies have been exhausted or for which the appeal time has expired as provided by applicable law.

(f) The Stewards or Commission shall consider all points for violations in all racing jurisdictions as contained in the trainer's official ARCI record when determining whether the mandatory enhancements provided in this regulation shall be imposed.

(g) In addition to the penalty for the underlying offense, the following enhancements shall be imposed upon a licensed trainer based upon the cumulative points contained in his/her official ARCI record:

Points	Suspension in days
5-5.5	15 to 30
6-8.5	30 to 60
9-10.5	90 to 180
11 or more	180 to 360

MMV penalties are not a substitute for the current penalty system and are intended to be an additional uniform penalty when the licensee:

(i) Has had more than one medication violation for the relevant time period, and

(ii) Exceeds the permissible number of points.

The Stewards and Commission shall consider aggravating and mitigating circumstances, including the trainer's prior record for medication violations, when determining the appropriate penalty for the underlying offense. The MMP is intended to be a separate and additional penalty for a pattern of violations.

(h) The suspension periods as provided in Section 13(g) shall run consecutive to any suspension imposed for the underlying offense.

(i) The Stewards' or Commission Ruling shall distinguish between the penalty for the underlying offense and any enhancement based upon a Stewards or Commission review of the trainer's cumulative points and regulatory record, which may be considered an aggravating factor in a case.

(j) Points shall expire as follows:

Penalty Classification	Time to Expire
A	3 years
B	2 years
C	1 year

In the case of a medication violation that results in a suspension, any points assessed expire on the anniversary date of the date the suspension is completed.

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REVISIONS TO ARCI UNIFORM CLASSIFICATION GUIDELINES FOR FOREIGN SUBSTANCES

Version	Date	Drug/Substance	Notes
14.2	September 2020	Medroxyprogesterone	Replaced methoxyprogesterone as probable typo
14.2	September 2020	Medroxyprogesterone	Added as Drug Class 3, Penalty Class B.
14.2	September 2020	Methoxyprogesterone	Removed as drug does not exist 14.2 September 2020
Methoxyprogesterone	Removed Asterisk Language on Permitted Nsaids
"*If the trainer has not had more than one violation within the previous two years, the Stewards/Judges are encouraged to issue a warning in lieu of a fine provided the reported level is below 3.0 mcg/inl absent of aggravating factors."
14.3	September 2020	Medroxyprogesterone	Moved to correct location alphabetically
14.4	December 2020	Alpha pyrrolidinovaleroph	enon e Added as Drug Class 1, Penalty Class A
14.4	December 2020	Aripiprazole	Added as Drug Class 2, Penalty Class A
14.4	December 2020	Arsenic	Added as Drug Class 3, Penalty Class B
14.4	December 2020	Diisopropylamine	Added as Drug Class 2, Penalty Class B
14.4	December 2020	Etofenamate	Added as Drug Class 4, Penalty Class B
14.4	December 2020	Flufenamic Acid	Changed to Drug Class 4, Penalty B
14.4	December 2020	Harpagoside	Added as Drug Class 4, Penalty B
14.4	December 2020	Hypoxia-inducible factor	(HIF) activators Changed from Drug Class 3, Penalty A to Drug Class 1,
Penalty A
14.4	December 2020	Hypoxia-inducible factor	(HIF) stabilizers (e.g. IOX-2) Added as Drug Class 1, Penalty A
14.4	December 2020	Molidustat	Added as Drug Class 1, Penalty A
14.4	December 2020	Norethisterone(norethindr	one) Added as Drug Class 4, Penalty B
14.4	December 2020	Oliceridine	Added as Drug Class 1, Penalty A
14.4	December 2020	Oripavine	Added as Drug Class 2, Penalty A
14.4	December 2020	Parecoxib	Added as Drug Class 4, Penalty B
14.4	December 2020	Pregabalin	Added as Drug Class 3, Penalty B
14.4	December 2020	Tapentadol	Added as Drug Class 1, Penalty A
14.4	December 2020	Trometamol (Also known	as THAM) Added as Drug Class 3, Penalty B
14.4	December 2020	Valdecoxib	Changed from Drug Class 2, Penalty B to Drug Class 4, Penalty B

006.06.21 Ark. Code R. 010

Adopted by Arkansas Register Volume MMXXI Number 12, Effective 11/30/2021