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Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

73 Fed. Reg. 73329 (Dec. 2, 2008)

Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

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Federal RegisterDec 2, 2008
73 Fed. Reg. 73329 (Dec. 2, 2008)

AGENCY:

Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS).

ACTION:

Request for comments on the proposed substances to be evaluated for Set 23 toxicological profiles.

SUMMARY:

This notice announces the list of proposed substances that will be evaluated for CERCLA Set 23 toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public nominations from the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the evaluation of any additional substances that may have public health implications.

DATES:

Nominations must be submitted by December 24th, 2008.

ADDRESSES:

Nominations may be submitted electronically, by mail, or by facsimile. Refer to the section Submission of Nominations (below) for specific addresses and/or the facsimile number.

FOR FURTHER INFORMATION:

Contact Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Mailstop F-32, 1600 Clifton Road, NE., Atlanta, Georgia 30333, telephone (770) 488-3313.

SUPPLEMENTARY INFORMATION:

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601 et seq.] amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) [42 U.S.C. 9601 et seq.] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances that are most commonly found at facilities on the CERCLA National Priorities List (NPL). Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This list has identified 275 hazardous substances that ATSDR and EPA determined pose the most significant potential threat to human health. The availability of the revised list of the 275 priority substances was announced in the Federal Register on March 6, 2008 (73 FR 12178). For previous versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7, 2005 (70 FR 70284).

Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

Each year, ATSDR develops a list of priority substances that will be evaluated for toxicological profile development. This list was compiled, on the basis of ATSDR's Priority List of Hazardous Substances, with consideration of the amount of relevance of newly published scientific literature. The following 80 substances will be evaluated:

  Name CAS
1 MERCURY 007439-97-6
  METHYLMERCURY 022967-92-6
  MERCURIC CHLORIDE 007487-94-7
2 POLYCHLORINATED BIPHENYLS 001336-36-3
  AROCLOR 1254 011097-69-1
  AROCLOR 1260 011096-82-5
  AROCLOR 1248 012672-29-6
  AROCLOR 1242 053469-21-9
  AROCLOR 012767-79-2
  AROCLOR 1221 011104-28-2
  AROCLOR 1016 012674-11-2
  AROCLOR 1232 011141-16-5
  AROCLOR 1240 071328-89-7
  TETRACHLOROBIPHENYL 026914-33-0
3 POLYCYCLIC AROMATIC HYDROCARBONS 130498-29-2
  BENZO(A)PYRENE 000050-32-8
  BENZO(B)FLUORANTHENE 000205-99-2
  DIBENZO(A,H)ANTHRACENE 000053-70-3
  BENZO(A)ANTHRACENE 000056-55-3
  BENZO(K)FLUORANTHENE 000207-08-9
  BENZOFLUORANTHENE 056832-73-6
  FLUORANTHENE 000206-44-0
  CHRYSENE 000218-01-9
  ACENAPHTHENE 000083-32-9
  INDENO(1,2,3-CD)PYRENE 000193-39-5
  BENZOPYRENE 073467-76-2
  PHENANTHRENE 000085-01-8
  PYRENE 000129-00-0
  FLUORENE 000086-73-7
  ANTHRACENE 000120-12-7
  BENZO(A)FLUORANTHENE 000203-33-8
  BENZO(GHI)PERYLENE 000191-24-2
  ACENAPHTHYLENE 000208-96-8
  BENZO(J)FLUORANTHENE 000205-82-3
  BENZO(E)PYRENE 000192-97-2
  BENZOPERYLENE 011057-45-7
  BENZO(B)ANTHRACENE 000092-24-0
  DIBENZ(A,J)ANTHRACENE 000224-41-9
  BENZO(GHI)FLUORANTHENE 000203-12-3
  1-METHYLPYRENE 002381-21-7
4 CHLOROFORM 000067-66-3
5 DDT, P,P′- 000050-29-3
  DDE, P,P′- 000072-55-9
  DDD, P,P′- 000072-54-8
  DDT, O,P′- 000789-02-6
  DDD, O,P′ -000053-19-0
  DDE, O,P′- 003424-82-6
6 TRICHLOROETHYLENE 000079-01-6
7 DIELDRIN 000060-57-1
  ALDRIN 000309-00-2
8 CHLORDANE 000057-74-9
  CIS-CHLORDANE 005103-71-9
  TRANS-CHLORDANE 005103-74-2
  OXYCHLORDANE 027304-13-8
  GAMMA-CHLORDENE 056641-38-4
  CHLORDANE, TECHNICAL 012789-03-6
  ALPHA-CHLORDENE 056534-02-2
  NONACHLOR, TRANS- 039765-80-5
  NONACHLOR, CIS- 005103-73-1
  CHLORDENE 003734-48-3
9 HEXACHLOROBUTADIENE 000087-68-3
10 COAL TAR CREOSOTE 008001-58-9
  COAL TARS 008007-45-2
  COAL TAR PITCH 065996-93-2
11 BENZIDINE 000092-87-5
12 TOXAPHENE 008001-35-2
13 TETRACHLOROETHYLENE 000127-18-4
14 1,2-DIBROMOETHANE 000106-93-4
15 DISULFOTON 000298-04-4
16 3,3′-DICHLOROBENZIDINE 000091-94-1
17 ENDRIN 000072-20-8
  ENDRIN KETONE 053494-70-5
  ENDRIN ALDEHYDE 007421-93-4
18 BERYLLIUM 007440-41-7
19 1,2-DIBROMO-3-CHLOROPROPANE 000096-12-8
  DIBROMOCHLOROPROPANE 067708-83-2
20 PENTACHLOROPHENOL 000087-86-5
21 DI-N-BUTYL PHTHALATE 000084-74-2
22 ENDOSULFAN 000115-29-7
  ENDOSULFAN SULFATE 001031-07-8
  ENDOSULFAN, ALPHA 000959-98-8
  ENDOSULFAN, BETA 033213-65-9
23 METHOXYCHLOR 000072-43-5
24 METHANE 000074-82-8
25 TOLUENE 000108-88-3
26 2-HEXANONE 000591-78-6
27 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN 001746-01-6
  HEXACHLORODIBENZO-P-DIOXIN 034465-46-8
  HEPTACHLORODIBENZO-P-DIOXIN 037871-00-4
  TETRACHLORODIBENZO-P-DIOXIN 041903-57-5
  PENTACHLORODIBENZO-P-DIOXIN 036088-22-9
  1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN 035822-46-9
  OCTACHLORODIBENZO-P-DIOXIN 003268-87-9
  1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN 057653-85-7
  1,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN 039227-28-6
  1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN 019408-74-3
  1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN 040321-76-4
28 DI(2-ETHYLHEXYL)PHTHALATE 000117-81-7
29 1,1-DICHLOROETHENE 000075-35-4
30 METHYLENE CHLORIDE 000075-09-2
31 BROMODICHLOROETHANE 000683-53-4
32 1,2-DICHLOROETHANE 000107-06-2
33 2,4,6-TRICHLOROPHENOL 000088-06-2
  TETRACHLOROPHENOL 025167-83-3
  2,4-DICHLOROPHENOL 000120-83-2
  2,4,5-TRICHLOROPHENOL 000095-95-4
  2-CHLOROPHENOL 000095-57-8
  2,3,4,5-TETRACHLOROPHENOL 004901-51-3
  2,3,5,6-TETRACHLOROPHENOL 000935-95-5
  2,3,4,6-TETRACHLOROPHENOL 000058-90-2
  4-CHLOROPHENOL 000106-48-9
  CHLOROPHENOL 025167-80-0
34 2,4-DINITROPHENOL 000051-28-5
35 BIS(2-CHLOROETHYL) ETHER 000111-44-4
36 ASBESTOS 001332-21-4
  CHRYSOTILE ASBESTOS 012001-29-5
  AMOSITE ASBESTOS 012172-73-5
37 HEXACHLOROBENZENE 000118-74-1
38 2,4-DINITROTOLUENE 000121-14-2
  DINITROTOLUENE 025321-14-6
  2,6-DINITROTOLUENE 000606-20-2
39 RADIUM-226 013982-63-3
  RADIUM 007440-14-4
  RADIUM-228 015262-20-1
  RADIUM-224 013233-32-4
40 ETHION 000563-12-2
41 THORIUM 007440-29-1
  THORIUM-230 014269-63-7
  THORIUM-228 014274-82-9
42 4,6-DINITRO-O-CRESOL 000534-52-1
42 CHLOROBENZENE 000108-90-7
44 N-NITROSODI-N-PROPYLAMINE 000621-64-7
45 1,2,3-TRICHLOROBENZENE 000087-61-6
46 POLONIUM-210 013981-52-7
47 CHLORPYRIFOS 002921-88-2
48 NEPTUNIUM-237 013994-20-2
49 CHLORDECONE 000143-50-0
  MIREX 002385-85-5
50 S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE 000078-48-8
51 BROMINE 007726-95-6
52 DICOFOL 000115-32-2
53 PARATHION 000056-38-2
54 SELENIUM 007782-49-2
55 TRICHLOROFLUOROETHANE 027154-33-2
56 TRIFLURALIN 001582-09-8
57 4,4′-METHYLENEBIS(2-CHLOROANILINE) 000101-14-4
58 PENTACHLOROBENZENE 000608-93-5
59 1,3-BUTADIENE 000106-99-0
60 1,1-DICHLOROETHANE 000075-34-3
61 1,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN 039001-02-0
  HEPTACHLORODIBENZOFURAN 038998-75-3
  2,3,4,7,8-PENTACHLORODIBENZOFURAN 057117-31-4
  HEXACHLORODIBENZOFURAN 055684-94-1
  PENTACHLORODIBENZOFURAN 030402-15-4
  2,3,7,8-TETRACHLORODIBENZOFURAN 051207-31-9
  DIBENZOFURANS, CHLORINATED 042934-53-2
  1,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN 067562-39-4
  1,2,3,7,8,9-HEXACHLORODIBENZOFURAN 072918-21-9
  TETRACHLORODIBENZOFURAN 030402-14-3
  1,2,3,6,7,8-HEXACHLORODIBENZOFURAN 057117-44-9
  1,2,3,4,7,8-HEXACHLORODIBENZOFURAN 070648-26-9
  2,3,4,6,7,8-HEXACHLORODIBENZOFURAN 060851-34-5
  1,2,3,7,8-PENTACHLORODIBENZOFURAN 057117-41-6
  1,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN 055673-89-7
62 1,1,2-TRICHLOROETHANE 000079-00-5
63 HEXACHLOROCYCLOPENTADIENE 000077-47-4
64 1,2-DIPHENYLHYDRAZINE 000122-66-7
65 1,2-DICHLOROETHENE, TRANS- 000156-60-5
  1,2-DICHLOROETHYLENE 000540-59-0
  1,2-DICHLOROETHENE, CIS- 000156-59-2
66 CARBON DISULFIDE 000075-15-0
67 PALLADIUM 007440-05-3
68 CHLOROETHANE 000075-00-3
98 ACETONE 000067-64-1
70 DIBENZOFURAN 000132-64-9
71 2,4-DIMETHYLPHENOL 000105-67-9
72 CARBON MONOXIDE 000630-08-0
73 CHLOROMETHANE 000074-87-3
74 BUTYL BENZYL PHTHALATE 000085-68-7
75 VANADIUM 007440-62-2
76 N-NITROSODIMETHYLAMINE 000062-75-9
77 1,2,4-TRICHLOROBENZENE 000120-82-1
78 N-NITROSODIPHENYLAMINE 000086-30-6
79 2-BUTANONE 000078-93-3
80 FLUORINE 007782-41-4
  HYDROGEN FLUORIDE 007664-39-3
  FLUORIDE ION 016984-48-8

Submission of Nominations for the Evaluation Set 23 Proposed Substances: Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the full name, title, affiliation, e-mail address and telephone number of the nominator.

ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances that will be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the Selection Criteria announced in the Federal Register on May 7th, 1993 (87 FR 27288).

Please submit nominations by one of the following methods:

  • E-mail jxt1@cdc.gov.
  • Fax 770.488.4178.
  • Mail CDR Jessilynn Taylor, 1600 Clifton Rd, NE., MS F32, Atlanta, GA 30333.

Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time permits.

Dated: November 26, 2008.

Ken Rose,

Director, Office of Policy, Planning, and Evaluation National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.

[FR Doc. E8-28551 Filed 12-1-08; 8:45 am]

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