Ex Parte XIONG et alDownload PDFPatent Trial and Appeal BoardFeb 8, 201912986477 (P.T.A.B. Feb. 8, 2019) Copy Citation UNITED STA TES p A TENT AND TRADEMARK OFFICE APPLICATION NO. FILING DATE FIRST NAMED INVENTOR 12/986,477 01/07/2011 RENQIANG XIONG 545 7590 02/12/2019 K&L GATES LLP-New York 599 Lexington A venue 33rd Floor New York, NY 10022-6030 UNITED STATES DEPARTMENT OF COMMERCE United States Patent and Trademark Office Address: COMMISSIONER FOR PATENTS P.O. Box 1450 Alexandria, Virginia 22313-1450 www .uspto.gov ATTORNEY DOCKET NO. CONFIRMATION NO. 0813715.10101 6470 EXAMINER PEO,KARAM ART UNIT PAPER NUMBER 1777 NOTIFICATION DATE DELIVERY MODE 02/12/2019 ELECTRONIC Please find below and/or attached an Office communication concerning this application or proceeding. The time period for reply, if any, is set in the attached communication. Notice of the Office communication was sent electronically on above-indicated "Notification Date" to the following e-mail address(es): USpatentmail@klgates.com PTOL-90A (Rev. 04/07) UNITED STATES PATENT AND TRADEMARK OFFICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Ex parte RENQIANG XIONG and JOHN MICHAEL BERNARD Appeal2017-004848 Application 12/986,477 Technology Center 1700 Before TERRY J. OWENS, MONTE T. SQUIRE, and BRIAND. RANGE, Administrative Patent Judges. RANGE, Administrative Patent Judge. DECISION ON APPEAL SUMMARY Appellants 1 appeal under 35 U.S.C. § 134(a) from the Examiner's decision rejecting claims 1-5, 7-12, and 24--33. We have jurisdiction. 35 U.S.C. § 6(b). An oral hearing was held on February 6, 2019. 2 We REVERSE. 1 According to Appellants, the real party in interest is Microfluidics International Corporation. Appeal Br. 2. 2 A written transcript of the oral hearing will be entered into the record when the transcript is made available. Appeal2017-004848 Application 12/986,477 STATEMENT OF THE CASE3 Appellants describe the invention as relating to a high pressure mixing chamber that could be used, for example, to process and mix liquid drugs. Spec. ,r 2. In particular, the chamber seeks to use fewer components of smaller size to reduce holdup volume thereby saving resources. Id. at ,r 11. Claim 1, reproduced below with formatting modified for readability and emphasis added to key recitations, is illustrative of the claimed subject matter: 1. A compact interaction chamber assembly comprising: (a) a first housing with a first central axis, the first housing including: ( 1) a first opening at a bottom face of the first housing, the first opening having a generally cylindrical shape of a first opening diameter and sharing the first central axis; and (2) a first protrusion extending from a top face of the first housing including a first flow path, the first flow path extending from the first opening through the first protrusion and sharing the first central axis; (b) a second housing having a generally cylindrical shape with a second central axis, the second housing including: (1) a second opening at a bottom face of the second housing, the second opening having a generally cylindrical shape and sharing the second central axis; and (2) a second protrusion of a second diameter extending from a top face of the second housing including a second flow path, the second flow path extending from the second opening through the second protrusion and sharing the second central 3 In this Decision, we refer to the Final Office Action dated April 27, 2016 ("Final Act."), the Appeal Brief filed September 26, 2016 ("Appeal Br."), the Examiner's Answer dated December 21, 2016 ("Ans."), and the Reply Brief filed February 3, 2017 ("Reply Br."). 2 Appeal2017-004848 Application 12/986,477 axis, the second housing configured to be fastened to the first housing such that: (A) the second central axis is collinear with the first central axis of the first housing; and (B) the second protrusion is configured to extend into the first opening when the first housing is fastened to the second housing; ( c) a first mixing chamber element and a second mixing chamber element, the first and second mixing chamber elements configured to reside within the first opening of the first housing, and be radially secured within the first opening by hoop stress of the first housing applied with thermal expansion and contraction without using a tube member that is stretched axially to hold the first and second mixing chamber elements radially, an outer surface of each of the first and second mixing chamber elements configured to make contact with an inner surface of the first opening of the first housing such that the first and second mixing chamber elements are compressed axially to cause a fluid tight seal between the outer surface of each of the first and second mixing chamber elements and an inner surface of the first opening of the first housing, wherein the axial compression is greater than or equal to 30,000 pounds per square inch, wherein, the first mixing chamber element is squeezed together with the second mixing chamber element so that a bottom face of the first mixing chamber element makes fluid tight contact with a top face of the second mixing chamber element; and ( d) at least one retaining member configured to reside within the first opening of the first housing, and configured to retain the first and second mixing chamber elements. Appeal Br. 27 (Claims App.). Claim 25 similarly recites, for example, "first and second mixing chamber elements configured to reside within the first opening of the housing, and be radially secured within the first opening by 3 Appeal2017-004848 Application 12/986,477 hoop stress of the first housing applied with thermal expansion and contraction." Id. at 29--30. REFERENCES The Examiner relies upon the prior art below in rejecting the claims on appeal: Yang Onodera et al. ("Onodera") Bocazzi et al. ("Bocazzi") us 5,664,938 us 5,984,519 US 2005/0089993 Al Sept. 9, 1997 Nov. 16, 1999 Apr. 28, 2005 Ehrfeld et al. US 2007/0291581 Al Dec. 20, 2007 ("Ehrfeld") Panagiotou et al. US 2009/0269250 Al Oct. 29, 2009 ("Panagiotou") Basic Microfluidic Concepts, http://faculty.washington.edu/yagerp/ microfluidicstutorial/basicconcepts.htm ( visited June 24, 2014) ("Schilling"). Microchannel, http://Wikipedia, en. wikipedia.org/wiki/Microchannel (microtechnology) (visited June 24, 2014) ("Microchannel"). REJECTIONS The following rejections are before us on appeal: Rejection 1. Claims 1-3, 24--26, and 33 under 35 U.S.C. § 103 as unpatentable over Onodera in view of Boccazzi. Ans. 3. Rejection 2. Claims 4, 5, 7-9, and 27-30 under 35 U.S.C. § 103 as unpatentable over Onodera in view of Boccazzi as evidenced by Microchannel and Schilling. Id. at 8. Rejection 3. Claim 10 under 35 U.S.C. § 103 as unpatentable over Onodera in view ofBoccazzi and in further view of Yang. Id. at 9. 4 Appeal2017-004848 Application 12/986,477 Rejection 4. Claims 11 and 31 under 35 U.S.C. § 103 as unpatentable over Onodera in view of Boccazzi and in further view of Ehrfeld. Id. at 10. Rejection 5. Claims 12 and 32 under 35 U.S.C. § 103 as unpatentable over Onodera in view of Boccazzi and in further view of Panagiotou. Id. at 1 1. ANALYSIS The Examiner has the initial burden of establishing a prima facie case of obviousness based on an inherent or explicit disclosure of the claimed subject matter under 35 U.S.C. § 103. In re Oetiker, 977 F.2d 1443, 1445 (Fed. Cir. 1992) ("[T]he examiner bears the initial burden, on review of the prior art or on any other ground, of presenting a prima facie case of unpatentability."). To establish a prima facie case of obviousness, the Examiner must show that each and every limitation of the claim is described or suggested by the prior art or would have been obvious based on the knowledge of those of ordinary skill in the art or the inferences and creative steps a person of ordinary skill in the art would have employed. KSR Int 'l Co. v. Teleflex Inc., 550 U.S. 398,417 (2007); In re Fine, 837 F.2d 1071, 1074 (Fed. Cir. 1988). We first focus on independent claims 1 and 25. The Examiner determines that claims 1 and 25 are obvious over Onodera in view of Boccazzi. Ans. 3. The Examiner finds that Onodera teaches a volume interaction chamber assembly having most elements of the independent claims. Id. at 4 (citing Onodera). The Examiner finds that Onodera uses a tube member stretched axially to hold the first and second mixing chamber elements radially. Id. at 7. With respect to the claims' recitation of "the first and second mixing chamber elements configured to ... be radially secured 5 Appeal2017-004848 Application 12/986,477 within the first opening by hoop stress of the first housing applied with thermal expansion and contraction," the Examiner explains that some hoop stress is inherent and that Onodera's ceramics are capable of thermal expansion and contraction: The first and second mixing chamber elements are radially secured within the first opening by hoop stress of the first housing creating a fluid tight seal (C20/L27-38); since the first and second mixing chamber elements are within the first opening there will inherently be hoop stress created by the inner surface of the first opening and the outer surface of the mixing chamber elements. Hoop stress is the normal stress in the tangential direction (https://en.wikipedia.org/wiki/ Cylinder stress). The limitation "applied with thermal expansion and contraction" ( claim 1, line 27) is considered a product by process limitation and said limitations are not given patentable weight in product claims. The material of Onodera used for the first and second mixing chamber and first housing is capable of thermal expansion and contraction ( ceramic; C4/L 11-15). Ceramic materials are capable of thermal expansion and contraction; ceramics are known to have a coefficient of thermal expansion. A ceramic material is capable of exhibiting some level of expansion and contraction. Id. at 5---6 ( emphases added). The Examiner relies on Bocazzi as teaching "clips, spring clamps, threaded holes, and pins" that, according to the Examiner, could be substituted for Onodera's threaded fastening means. Ans. 7 ( citing Bocazzi). Appellants argue that the prior art does not disclose the recitation "radially secured within the first opening by hoop stress of the first housing applied with thermal expansion and contraction." Appeal Br. 18 ( emphasis omitted). On the present record, we agree with Appellants that the Examiner has not adequately explained how the prior art teaches or suggests this recitation. 6 Appeal2017-004848 Application 12/986,477 We begin our analysis with claim construction. Claims 1 and 25 both recite that the first and second mixing chamber elements must be "configured to" both "reside within the first opening of the first housing" and "be radially secured within the first opening by hoop stress of the first housing applied with thermal expansion and contraction." Appeal Br. 27, 30-31 (Claims App.). The "configured to" recitation requires that the first and second mixing chamber elements be capable of achieving the recited "be radially secured within the first opening by first opening by hoop stress of the first housing applied with thermal expansion and contraction." The Examiner finds that Onodera's mixing chamber elements will inherently have hoop stress and that a ceramic material "is capable of exhibiting some level of expansion and contraction." Ans. 6. The Examiner, however, does not address how the prior art teaches or suggests first and second mixing chamber elements capable of being radially secured "by hoop stress of the first housing applied with thermal expansion and contraction." Rather, the mixing chamber elements must have specific dimensions relative to the first opening in order to achieve hoop stress applied with thermal expansion and contraction. Spec. ,r 26. The Examiner does not address why it would have been obvious to reach these dimensions in view of the prior art. Accordingly, we do not sustain the Examiner's rejection of claims 1 and 25. Because the Examiner's treatment of the dependent claims (including the Examiner's use of additional references) does not cure this error, we also do not sustain the Examiner's rejection of those claims. 7 Appeal2017-004848 Application 12/986,477 DECISION For the above reasons, we reverse the Examiner's rejections of claims 1-5, 7-12, and 24--33. No time period for taking any subsequent action in connection with this appeal may be extended under 37 C.F.R. § 1.136(a). REVERSED 8 Copy with citationCopy as parenthetical citation