DE LA CHAPELLE et al.v.KOLODNER et al.

Board of Patent Appeals and Interferences

Apr 16, 2004

08160295 (B.P.A.I. Apr. 16, 2004)

The opinion being written in support of the decision being entered today is not binding precedent of the Board. Paper No. 140 UNITED STATES PATENT AND TRADEMARK OFFICE BEFORE THE BOARD OF PATENT APPEALS ANDINTERFERENCES ALBERT DE LA CHAPELLE, BERT VOGELSTEIN and KENNETH W. KINZLER Junior party, (Application 08/160,295) V. RICHARD D. KOLODNER, ROBERT A.G. REENAN and RICHARD FISHEL Senior party, (Application 08/465,251) 2,'VE Patent Interference No. 104,063 ý'ý! FINAL HEARING: DECEMBER 19,2003 Before CAROFF, ELLIS, and LORIN, Administrative Patent Judges. FINAL DECISION (Under 37 CFR § 1.658) Per Curiam This interference involves an application of the junior party, de la Chapelle et al. (Chapelle), and an application of the senior party, Kolodner et al (Kolodner). According Interference No. 104,063 to the record before us, the Chapelle application is jointly assigned to Johns Hopkins University and Albert de la Chapelle (Paper No. 8); and the Kolodner application is jointly assigned to Dana-Farber Cancer Institute, and University of Vermont and State Agricultural College (Paper No. 5). The subject matter in issue relates to an isolated DNA sequence of a human gene associated with hereditary non-polyposis colon cancer (HNPCC) and other cancers. According to the specification disclosure of each party, the detection of a defect or alteration in this sequence can be diagnostic of a predisposition to HNPCC or other cancers. The isolated DNA molecule of interest is more particularly defined by the sole count in issue, count 1, as follows: Count 1 An isolated DNA molecule having the sequence of SEQ I D NO: 1 (as set forth in 08/160,295) or SEQ I D NO:8 (as set forth in 08/465,251). The claims of the parties which have been designated as corresponding to this count are: Chapelle Claims 1-6, 27-31 and 38-45 Kolodner Claims 28-30, 32, 34-36, and 41-54 During the preliminary motion stage of this interference, each party filed a number of motions. In all, twenty motions were filed including a motion by Chapelle to 2 Interference No. 104,063 deny Kolodner benefit of the filing date of application 08/154,792 (motion 11: Paper No. 27).1 In his decision on motions (Paper No. 97), the APJ denied motion 11. As a consequence of that denial, the APJ issued an order to show cause against Chapelle since junior party Chapelle did not allege any date in its preliminary statement prior to the effective filing date accorded to Kolodner, the senior party. Although the parties have raised issues in their briefs relating to a number of preliminary motions, we shall first review the APJ's decision regarding motion 11 since that decision, if upheld, is dispositive of many, if not all, of the other issues before us. Each of the parties have submitted exhibits, filed briefs and appeared, through counsel, at final hearing. Only Kolodner has filed a record .2 No issue of interference-in-fact has been raised in this proceeding. Final hearing was had before a merits panel consisting of Judges Caroff, Ellis and Lorin. Each of these three judges write separately. Judges Caroff and Lorin concur that motion 11 should be denied or dismissed. Judge Ellis dissents. ' We shall refer to each motion in accordance with the numbering system used by the Administrative Patent Judge (APJ) in his decision on motions to identify individual motions. 2 The record, exhibits, briefs, opposition briefs and reply briefs will be respectively referred to in our decision, as appropriate, by the abbreviations R, X, B, OB, RIB, preceded by a letter representing the name of the submitting party (C or K), and followed by a pertinent page or exhibit number. It is noted that both parties also have filed proposed findings of fact and conclusions of law, which will be respectively referred to, if appropriate, by the abbreviations PFF and PCL. 3 Interference No. 104,063 The concurring opinions of Judge Caroff and Judge Lorin, and the dissenting opinion of Judge Ellis, follow. Judgment is in order based on the concurring opinions of Judge Caroff and Lorin. A statement of the Judgment follows the judge's separate opinions. CAROFF, Administrative Patent Judge, Concurring. With regard to motion 11, having thoroughly evaluated all the evidence of record in light of the opposing positions taken by each party, I agree with the APJ's holding in Paper No. 97 that the motion should be denied. First of all, I note that Chapelle, as the moving party, has the burden of proof as the proponent of the proposition that Kolodner should be denied benefit of the filing date of application 08/154,792. That proposition must be supported by a preponderance of the evidence. 37 CFR § 1.637(a); Behr v. Talbo , 27 USPQ2d 1401, 1405 (Bd. Pat. App. & Int. 1992). Chapelle has failed to sustain its burden of proof. In particular, Chapelle proposes that Kolodner be denied benefit of the filing date of its earliest filed application because that application allegedly does not contain an adequate written description of the DNA molecule defined by the count and, therefore, allegedly fails to satisfy the "description requirement" of 35 U.S.C. § 112, first paragraph. As I see it, the specification of Kolodner's'792 benefit application attempts to describe an isolated DNA molecule within the scope of the count (SEQ ID NO: 8), both in terms of its actual nucleotide sequence (Figure), and in terms of an example 4 Interference No. 104,063 describing the isolation of a clone designated as pDHA 11, which is said to have the cDNA sequence identified as SEQ ID NO: 8 (Example 3, pp.76-80). The disclosed nucleotide sequence is admitted to contain four nucleotide errors out of about 3,000 nucleotides (KR-30, para 6; KR-36, para. 42). A plasmid containing clone pDHA 11 was later deposited with the ATCC on January 26, 1994, approximately two months after the filing date of the '792 application. That deposit is referred to on page 79 of Kolodner's involved application 08/465,251. 1 agree with Chapelle that the error-prone nucleotide sequence disclosed in the '792 application is insufficient by itself to constitute an accurate and complete description of either of the specific sequences defined by the count within the purview of the first paragraph of 35 U.S.C. § 112. As noted by Chapelle, there is nothing in the '792 application itself which suggests that there are any errors in the disclosed sequence, or where any errors might be (KR-55,11. 13-20). While the errors may be few in number, their effect on the encoded protein would no doubt be significant since the cloning and identification of specific genes involved in cancer development is admittedly difficult and unpredictable ('792 application: p. 4, first full paragraph). Apparently, there is no way a skilled artisan would recognize that there were any errors in the disclosed sequence unless comparative sequencing or homology studies were conducted and discrepancies thereby discovered by serendipity (KR 52-53; KR 158, para. 8). However, as explained by Chapelle (CB 19-24), this type of extrinsic 5 Interference No. 104,063 discovery and identification of errors is not a proper basis for validating an otherwise deficient description of the subject matter at issue .3 Be that as it may, the inquiry does not end here. Yet to be determined is whether Kolodner may rely upon the isolation of a clone, as described in a working example included in its '792 application, in conjunction with a post-filing date deposit of that clone, to satisfy the "written description" requirement of 35 U.S.C. § 112. This issue is governed by the principles enunciated in Enzo Biochem Inc. v. Gen-Probe Inc., 296 F.3d 1316, 1325, 63 USPQ2d 1609, 1613 (Fed. Cir. 2002), and In re Lundak, 773 F.2d 1216, 227 USPQ 90 (Fed. Cir. 1985). Again it should be noted that Chapelle, as the moving party, has the burden of establishing by a preponderance of the evidence that Kolodner's '792 application does not constitute a constructive reduction to practice of the invention defined by the count. 37 CFR § 1.637(f),(g). Consequently, Chapelle has the burden of proof with regard to the issue at hand. There is no question that the precedent and legal principles set forth by our reviewing court, The United States Court of Appeals for the Federal Circuit, must be 3 This is not to say that the errors in the disclosed sequence in the '792 application could not have been rendered harmless and later corrected on the basis of other information contained in the specification itself. Thus, as I endeavor to point out, infLa, the isolation of clone pDHA 11, as described in Example 3, coupled with later deposit of the clone in a public depository, provide sufficient descriptive support under 35 U.S.C. § 112 and could serve as a basis for correcting the disclosed sequence. In effect, the correction of sequence data in the specification has been made in subsequently filed "CIP" applications in the chain of pendency linking the '792 application with the Kolodner application now directly involved in this interference. 6 Interference No. 104,063 followed. See Rivise and Caesar, Interference Law and Practice, Vol. IV, § 784 (Michie Co. 1948). In Enzo, the court essentially held that a reference in a specification to a deposit of biological material in a public depository, which makes its contents accessible to the public, constitutes an adequate description of the deposited material sufficient to comply with the written description requirement of 35 U. S.C. § 112. Enzo, supra. As here, the subject matter at issue in Enzo concerned nucleotide sequences. In effect, the court held that a reference to a deposi of a nucleotide sequence was equivalent to a description of that sequence for purposes of satisfying the written description requirement. This holding was justified by the court "[I]n light of the history of biological deposits for patent purposes, the goals of the patent law, and the practical difficulties of describing unique biological materials in a written description." Enzo, supra. It is particularly noteworthy that the court apparently did not ascribe any particular criticality to the question of whether or not the specific structures of the nucleotide sequences at issue could have been accurately and completely described in the specification if a reasonable effort had been made to obtain them. In this regard, the court stated: Although the structures of those sequences, i.e., the exact nucleotide base pairs, are not expressly set forth in the specification, those structures Day not have been reasonably obtainable and in any event were not known to Enzo when it filed its application in 1986. See '659 patent, col. 3,11. 40-46 (noting severe time constraints in sequencing DNA) [underlining added for emphasis] Enzo, supra, at 1614. In Lundak, the court held that where a deposit of a biological material with an 7 Interference No. 104,063 independent depository is required to satisfy the enablement requirement of 35 U.S.C. § 112, the deposit can be made after filing of an application, but prior to issuance of a patent. Based upon my reading of the Lundak and Enzo decisions, in my opinion Kolodner may rely upon the isolation of clone pDHA1 1, as described in Example 3 in its '792 application, in conjunction with the post-filing date deposit of that clone, to satisfy the written description requirement of 35 U.S.C. § 112, and thereby be accorded benefit of the '792 application filing date. In my view, this result is consistent with, and logically follows from, the principles enunciated by the court in Lundak and Enzo. It is true, as noted by Chapelle, that Enzo does not address the specific question of whether a post-filing date deposit can be relied upon to satisfy the written description requirement. However, the parallel question of satisfying the enablement requirement via a post-filing date deposit was answered in the affirmative in Lundak. As I read Lundak, the rationale for acceptance of a post-filing date deposit applies equally as well to situations, as here and in Enzo, where deposits also are relied upon for purposes of satisfying the "description requirement." I agree with Kolodner that, with respect to deposits, there is no basis for distinction between the written description and enablement requirements of 35 U.S.C. § 112, first paragraph. They must both be satisfied at the time of filing. If a biological material was in existence prior to the filing date, is referenced in the application, and is subsequently deposited with the appropriate assurances (37 CFR 1.804(b)), one can rely upon that later deposit to satisfy the requirements of 35 U.S.C. § 112, first 8 Interference No. 104,063 paragraph. As held in Lundak, the act of later depositing that biological material did not change what is in the application because all that need be disclosed was already present in the application at the time it was filed. Lundak, supra, at 96. (KOB 12-19, particularly pages 17-18). In this case, the'792 application describes an existing material in a working example in terms of its isolation as a clone referred to as pDHA 11. A plasmid containing that clone was later deposited with the ATCC; the deposit being referred to in Kolodner's involved application. As I previously noted (see footnote 3), the'792 application is linked in a chain of pendency with Kolodner's involved application which, in my opinion, satisfies the Lundak caveat that the deposit must be made prior to issuance of a patent, and referred to in the specification. Thus, I find that the rationale stated in Lundak and in Enzo establishes a symmetry4between the enablement and description requirements of 35 U.S.C. § 112 in respect to reliance upon a deposit of a biological material. This symmetry leads me to conclude that the practice of making a post-filing date deposit, which is looked upon with favor in Lundak, is equally acceptable for purposes of complying with the written description requirement. Chapelle has not convinced me that the history of biological 4 The symmetry to which I refer relates to the fact that both the written description and enablement requirements must be satisfied at the time of filing, and may be satisfied by making a deposit of the requisite biological material. In this particular regard, there is no distinction between the two. Therefore, if the enablement requirement can be satisfied under specified circumstances by a post-filing date deposit (Lundak) so, too, should the description requirement under corresponding circumstances. 9 Interference No. 104,063 deposits for patent purposes, the exigencies of the patent law, or the practical difficulties associated with describing unique biological materials require a different conclusion. I now address two ancillary points raised by Chapelle for the first time in its reply brief. First, according to Chapelle, Kolodner has not satisfied the procedural requirement of 37 CFR § 1.804(b) which mandates that a corroborating statement (regarding the deposit of a biological material specifically identified in an application) must be "promptly" submitted. Chapelle points out that the statement relied on by Kolodner for this purpose (KR-41, paragraph 75) was filed during the preliminary motion stage of this interference, over four years from the time the deposit was made. I am not convinced by this argument since I am unaware of any precise definition of "promptly" which would preclude acceptance of Kolodner's statement as complying with the requirements of 37 CFR § 1.804(b). Indeed, in my view Kolodner followed acceptable procedure in a timely fashion especially when the statement in question is taken in conjunction with the much earlier reference in Kolodner's involved application (page 79) to the deposit itself: A plasmid containing this human cDNA clone [pDHA 11] has been deposited with the American Type Culture Collection (ATCC) on January 26, 1994 in accordance with the Budapest Treaty as ATCC number 75647. Certainly, both Kolodner's statement (KR-41) and the statement in involved application '251 (page 79) were submitted prior to issuance of any patent and, therefore, are within 10 Interference No. 104,063 the letter and spirit of the guidelines provided in Lundak (227 USPQ at 95). Second, Chapelle urges that an inventor's statement for purposes of satisfying 37 CFR § 1.804(b) requires corroboration by a third party non-inventor, in analogy to the corroboration requirement for establishing prior inventorship. Chapelle cites no authority in support of this particular proposition. In interference proceedings, the requirement for corroboration by a third party non-inventor has been uniquely applied only in regard to issues directly relating to prior inventorship, viz. conception, diligence and actual reduction to practice. Rivise and Caesar, Interference Law and Practice, Vol. 111, § 539 (Michie Co. 1947). 1 am unaware of any application of the corroboration rule to issues relating to a constructive reduction to practice especially where, as here, the issues directly relate to satisfaction of the patentability standards set forth in the first paragraph of 35 U.S.C. § 112. Evidence regarding patentability generally requires no independent corroboration of the type required in determining prior inventorship. Accordingly, I see no basis for extending the corroboration rule to matters relating to constructive reduction to practice. For all of the foregoing reasons, I hold that motion 11 was properly denied. One final note is in order regarding the dissenting opinion of my colleague, Judge Ellis. For the most part, the concerns expressed in the dissenting opinion have been addressed, supra. However, one item merits further elaboration. My colleague states that: ... the evidence of record; viz, CX 2002, indicates that the nucleolide sequence of the insert contained in the deposited pDHA 11 clone differs 11 Interference No. 104,063 from the nucleotide sequences disclosed in each of Kolodner's four applications. To the contrary, I find that the evidence of record only indicates that the sequence described in CX-2001 is the same as the seauence described in Kolodner's earliest filed application, the '792 application. See original motion 11 (Paper No. 27, page 2); CX-20011; CX-2002; KR-30. My colleague appears to assume, without any concrete proof, that: (a) any clone which may be described in CX-2001 or CX-2002 is the same as the r)DHA 11 clone identified in each of Kolodner's four applications, and/or (b) the nucleotide sequence of the DDHA 11 clone identified in the '792 application differs from the "incorrect" SEQ ID NO: 8 of the'251 application (the invention described in the count). I refrain from making any such assumptions or inferences from the record before us. Rather, it is my position that Chapelle, as the moving party, has the burden of adducing evidence sufficient to establish pertinent facts rather than leaving such matters in the realm of speculation or inference. This burden should not have to be assumed by Kolodner or by a panel of the Board. Chapelle did not adduce evidence sufficient to validate the assumptions of my colleague despite the following: (1) Chapelle had the opportunity to cross-examine Kolodner's witnesses on these particular matters, but did not; and (2) Chapelle was given the opportunity to access the deposited pDHA 11 clone 12 0 Interference No. 104,063 and conduct inter partes testing, yet did not avail itself of that opportunity (see Paper No. 116)'. Chapelle had the burden of making a case with regard to the issues raised in motion 11. In my opinion, it is inappropriate, especially in an inter gartes proceeding, for the Board to substitute speculative commentary for evidence lacking in the record. Other Motions Turning to other motions decided by the APJ, it is initially noted that, of the twenty motions filed during the preliminary motion stage of this interference, only motions 1-6, 11, 14, and 17-20 were raised in the parties' briefs for final hearing. Motions 7-10, 12-13 and 15716 were not raised in the briefs and, accordingly, are regarded as abandoned. Photis v. Lunkenheimer, 225 USPQ 948, 950-51 (Bd. Pat. Int. 1984). Motions 1-5 are all motions for judgment attacking the patentability of Chapelle's involved claims. Those motions, which were originally deferred to final hearing, are now dismissed as moot since it has been determined, supra, that Chapelle has failed to show good cause why judgment should not be entered against Chapelle based on a failure to allege any date in its preliminary statement prior to the effective filing date accorded to senior party Kolodner. ' Chapelle filed a motion for additional discovery pursuant to 37 CFR § 1.687(b) and, by virtue of the granting of that motion, was accorded full access to the deposited pDHA 11 clone of Kolodner, as well as the opportunity to introduce into evidence any sequencing data derived from that clone through inter partes testing. 13 Interference No. 104,063 Motion 14, which was originally deferred to final hearing, is now dismissed as moot since it was filed in response to motions 2-5 which have now been dismissed. Motion 18, which is apparently contingent upon the granting of motion 11, is dismissed as moot since the contingency upon which it is based has not occurred. Motions 17, 19 and 20 are now dismissed as moot since they were filed in response to motions 7, 9, and 13, respectively, which were not raised in the briefs and, therefore, regarded as abandoned. In view of the foregoing, the only other motion before us for consideration on the merits (other than motion 11) is motion 6. Motion 6 was brought by Kolodner under 37 CFR § 1.633(c)(2). In the motion, Kolodner sought to amend its claim 49, and to add new claims 54-55 corresponding to the count. The APJ denied the motion because it was not considered to state sufficient reasons to justify granting the relief requested, as required by 37 CFR § 1.637(a). According to Kolodner, the motion was brought to present claims which more nearly comport with Chapelle claim 1 which was held to be patentable. Kolodner also claims that denial of the motion "could" deny Kolodner the ability to present its best case. In my view, motion 6 was properly denied essentially for the reasons presented by Chapelle (COB 33-34) and in the Decision on Motions (Paper No. 97, pages 8-9). In summary, Kolodner has failed to convincingly explain why the requested relief is necessary to resolve the present interference or otherwise materially affect its outcome. As pointed out by Chapelle, it is the count (rather than the claims) which determine 14 Interference No. 104,063 what evidence can be presented to make out a case for priority. Kolodner has presented no motion to add or substitute a count. As the APJ noted in his Decision on Motions (page 9): The mere desire by Kolodner to obtain additional or modified claims corresponding to the count in issue is a matter which can be adequately addressed by the primary examiner upon continuation of ex parte prosecution after termination of the interference, assuming that Kolodner prevails in the interference and, therefore, is not a sufficient basis for relief. An interference proceeding is not an appropriate forum for correcting each and every deficiency which may be found in the parties' involved claims. MARC L. CARO Administrative Patent Judge BOARD OF PATENT APPEALS AND INTERFERENCES 15 Interference No. 104,063 LORIN, Administrative Patent Judge, concurring. Throughout Motion 11 Q.e. de la Chapelle's Preliminary Motion 5; Paper No. 27), De la Chapelle argues that Kolodner's prior 08/154,792 ('792) application does not satisfy the requirements of 35 U.S.C. § 112 forthe subject matter "claimed 116 in Kolodner's interfering 08/465,251 ('251) application. However, Motion 11 was filed under Rule 37 CFR § 1.633(g). A "preliminary motion to attack benefit under § 1.633(g) shall explain, as to each count, why an opponent should not be accorded the benefit of the filing date of the earlier application" [emphasis added], 37 CFR § 1.637(g). The motion nowhere mentions the count. Furthermore, pursuant to 37 CFR § 1.637(a), de la Chapelle was under a burden to show that Kolodner's '792 application does not satisfy the requirements of 35 U.S.C. § 112 for a single species within the scope of the count. Weil v. Fritz, 572 F.2d 856, 866 n.16, 196 USPQ 600, 608 n.16 (CCPA 1978). The count is drawn to an isolated DNA having SEQ ID NO:8 as set forth in Kolodner's interfering '251 application or SEQ ID NO: 1 as set forth in de la Chapelle's interfering application no. 08/160,295 ('295). As they are literally disclosed in the parties' respective applications, Kolodner's SEQ ID NO:8 and de la Chapelle's SEQ ID NO:1 are not the same. Therefore the count is directed to two alternative species. Accordingly, to prevail, de la Chapelle needed to 6 Here are some examples: "There can be no doubt that Kolodner was not in possession of the invention as now claimed. [Emphasis original.] P. 6. "Thus the written description of the '792 application does not fulfill the requirements of § 112 for the claims now presented." P. 7. "Kolodner failed to provide an adequate written description of the invention defined by the claims by failing to teach the nucleotide sequence now claimed." Pp. 11 -12. 16 Interference No. 104,063 explain why Kolodner's'792 application does not satisfy the requirements of 35 U.S.C. § 112 for both species sequences. That was not done. Accordingly, the motion fails to strictly follow the letter of our rules. My colleagues do not object that Motion 11 does not strictly adhere to the rules .7 In my opinion we would have been better served had de la Chapelle done so. Had de la Chapelle consulted the count, we would have a better understanding of how de la Chapelle construed the count in attacking the benefit accorded Kolodner as to the count. As it now stands, it falls on us to both construe the count and determine whether Motion 11 is grounded on a proper construction of the count. I have carefully reviewed the factual record but I find the factual record inadequate for determining the proper construction of the count. The coune could be construed literally. But doing so raises the specter that there may not be an interference-in-fact. When read literally (ýee attached spreadsheet), the alternative sequences of the count are very different. Differences between SEQ ID NOA as disclosed in de la 7 1 presume the reason for this is that, albeit Motion 11 discusses the "claimed" invention, it focuses on no particular claim but solely on SEQ ID NO:8 as disclosed in Kolodner's involved '251 application, which is in fact one of the alternatives of the count. It should also be noted that de la Chapelle narrowly defines Kolodner's "claimed" subject matter as being "directed to nucleic acid molecules as shown in SEQ ID NO:8 of the involved [Kolodner] application Serial No. 08/468,251." Paper No. 27, p. 3, Material Fact No. 10. The reason de la Chapelle has not been required to explain why Kolodner's '792 application does not satisfy the requirements of 35 U.S.C. § 112 for the other alternative of the count, i.e., SEQ ID NO:1 as set forth in de la Chapelle's involved '295 application is, I presume, based on the assumption that de la Chapelle's SEQ ID NO:1 and Kolodners SEQ ID NO:8 are equivalent. 8 The count is: An isolated DNA molecule having the sequence of SEQ ID NO: 1 (as set forth in 08/160,295) or SEQ ID NO:8 (as set forth in 08/465,251). 17 Interference No. 104,063 Chapelle's involved'295 application and SEQ ID NO:8 as disclosed in Kolodner's'251 application exist at four locations: Kolodner'251 Kolodner'251 de la Chapelle'295 de la Chapelle'295 SEQ ID NO:8 SEQ ID NOA SE (nucleotide) SEQ ID NOA (nucleotide) (position) 1-12 See attached spreadsheet. 1 -65 See attached spreadsheet. (i.e., 5'end) (i.e., Vend) 414 T 467 C 968 T 1021 A 2895-3110 See attached 2948+ Unknown - see attached (i.e., 3' spreadsheet. (i.e., Tend) spreadsheet. end) Of particular interest is the difference between the "T" at position 968 of Kolodner's SEQ ID NO:8 and the "A" at position 1021 of de la Chapelle's SEQ ID NOA. As I understand it, the codon encompassing position 968 of Kolodner's SEQ ID NO:8 encodes a valine residue, in contrast to the codon encompassing position 1021 of de la Chapelle's SEQ ID NOA which encodes an glutamic acid. This suggests the difference in nucleotides at that location is a significant one. It further suggests that these two sequences, as literally written, may in fact be independent and distinct from each other, raising the question of whether an interference-in-fact exists. Based on my review of the record, this question has not been answered. I could find nothing in the record showing, in accordance with 37 CFR § 1.601 (n), that Kolodner's SEQ ID NO:8 and de la Chapelle's SEQ ID NOA as literally written are the same patentable invention. What the record does show is that the examiner excused what the examiner considered to be errors in Kolodner's SEQ ID NO:8. The examiner's comments ("Proposed interference count") attached to the Notice declaring the interference, Paper 18 Interference No. 104,063 No. 1, acknowledges the first three differences listed above (but not the last difference). The examiner indicates that, for example, the "T" at position 968 of Kolodners SEQ I D NO:8 is an "editing mistake," as evidenced by Fishel9 (I note that the examiner does not say whether the "error"in de la Chapelle's SEQ ID NO:1 is also an "editing mistake;" see location 467 on the attached spreadsheet.) As far as the examiner is concerned, all the differences between Kolodner's SEQ ID NO:8 as set forth in the count and the actual cIDNA sequence encoding the human MSH2 protein are "non-patentably distinct differences." The implication is that the count, as it is literally written, does not in fact define what the examiner considers to be the interfering subject matter. The examiner would have us read into the count the true cDNA sequence that encodes the human MSH2 protein, i.e., the one disclosed in Fishel (1994) (see attached spreadsheet). The difficulty I have with the examiners comments is that no facts are presented to support the underlying assumptions; that is, 1) Fishel (1994) refers to Kolodner's SEQ ID NO:8 of the count; 2) the differences between Kolodner's SEQ ID NO:8 of the count and Fishel's "corrected" sequence can be accounted for as "editing mistakes" and not something else; and 3) "editing mistakes" are per se "non-patentably distinct differences." Accordingly, in trying to construe the count I am left with two options, to construe it literally or to construe it consistent with the examiners comments. Either way, the 9 Fishel et al., (Fishel 1994), Cell, Vol. 77, No. 1, p. 167, April 8, 1994, is an Erratum providing corrected versions of sequences set forth in Fishel et al., (Fishel 1993), "The Human Mutator Gene Homolog MSH2 and Its Association with Hereditary Nonpolyposis Colon Cancer," Cell, Vol. 75, pp. 1027-1038 (1993), which the Erratum states has "some editing mistakes." See the attached spreadsheet. 19 Interference No. 104,063 construction to be given the count is based on an inadequate factual foundation. Accordingly, I do not find the count can be properly construed. Without an adequate factual record to properly construe the count, we are not in a position to determine whether Motion 11 is grounded on a proper construction of the count. That means even if, as my colleagues have done, we overlook the fact that Motion 11 does not strictly comply with our rules, I do not see that we are in position to decide whether de la Chapelle has met its burden of showing that Kolodner should not be accorded benefit of its earlier'792 application as to the count. Notwithstanding the inadequate factual record to properly construe the count, the fact remains that Junior Party did not address it. On the grounds that Motion 11 does not comply with the rules, I would DISMISS Motion 11. I concur with the reasoning of my colleague Judge Caroff as to the disposition of the other motions before us. Hubert U. Lorin Administrative Patent Judge 20 Interference No. 104,063 Ellis, Administrative Patent Judge, dissenting. The analysis put forth by my colleagues with respect to cle la Chapelle's Preliminary Motion 5 (hereinafter, motion 11),'0 while appearing to have certain merit produces an incongruous result. I do not agree with Judge Caroff that (i) Kolodner's Application No. 08/154,792 (the'792 Application) provides an adequate written description of a nucleotide sequence within the scope of the count and that it [Kolodner] can overcome this deficiency by depositing a clone which contains a DNA encoding a nucleotide sequence not described in any of its four applications; or (ii) that a deposit is required in this case. Nor do I agree with Judge Lorin that motion I I is fatally defective and the count impossible to construe. Therefore, since I would grant the motion, I provide the following dissent. The count in an interference is simply a vehicle for contesting priority. Case ýL. CPC International, Inc., 730 F.2d 745, 749, 221 USPQ 196, 199 (Fed. Cir. 1984). Its purpose is to determine what evidence is relevant to the issue of priority. Scluires v. Corbett, 560 F.2d 424, 433, 194 USPQ 513, 518-519 (CCPA 1977). 1 agree with Judge Lorin that to determine whether any embodiments disclosed in the parties' priority 10 For consistency, I follow the numbering of the motions set forth by the majority. See footnote no. 1, above. 21 Interference No. 104,063 applications are within the scope of the count, the count must first be construed. However, I find no ambiguity in the language of the count, nor has any been pointed out by my colleague. Rather, I find that my colleague's real problem appears to be with the fact that the count is directed to two embodiments of the same invention" and that one of the embodiments contains an error in the nucleotide sequence. This does not mean that the count cannot be "properly construed." In fact, my colleague acknowledges that the count is directed to "two alternative species"; i.e., SEQ ID NO.: 8 as set forth in Kolodners'251 Application or SEQ ID NO.: 1 as set forth in de la Chapelle's '295 Application (page 16, second paragraph). Thus, contrary to Judge 11 1 point out that a count is not ambiguous simply because it is broad enough to encompass both parties' embodiments of an invention, Since a count must encompass the parties' interfering subject matter (37 C.F.R. § 1.601 (f)), it was necessary to create a count which encompasses both the nucleotide sequence set forth in Kolodner's SEQ ID NO.: 8 (claim 28 of the'251 Application) and de la Chapelle's SEQ ID NO.: 1. The positive aspect of the count is that it enables each party to establish benefit based on its own applications and to establish priority based on its own nucleotide sequence data. That is, the count enables both to demonstrate that they were "in possession" of a nucleotide sequence which is said to encode the human MSH2 protein. The present count was constructed in a manner that was intended to ensure that the outcome of the interference would not hinge on inconsequential nucleotide sequence differences such as the silent third position codon change pointed out by the examiner (and Judge Lorin) at position 414 of the Kolodner nucleotide sequence (T, thymine) and position 467 of the de la Chapelle nucleotide sequence (C, cytosine). The difference is inconsequential because both nucleotide sequences code for the same amino acid residue (aspartic acid). (The differences in Kolodner's and de la Chapelle's nucleotide sequences in the regions outside the coding region of the human MSH2 gene are further examples of inconsequential nucleotide sequence differences). The negative aspect of the count is that because SEQ ID NO.: 8 as set forth in the '251 Application contains an error, it [the count] still enables Kolodner to demonstrate "possession" of a species within the scope of the count, even though said sequence is incorrect. 22 Interference No. 104,063 I Lorin's statements, it appears that there is sufficient basis for him to construe the count. In addition to Judge Caroff and myself, I point out that the parties were also able to understand the count because neither filed a motion to have it substituted. The language of the count is given its broadest reasonable interpretation "and should not be given a contrived, artificial, or narrow interpretation which fails to apply to the language of the count in its most obvious sense." Genentech Inc. v. Chiron Corp, 112 F.3d 495, 500, 42 USPQ2d 1608, 1612 (Fed. Cir. 1997), quoting Credel v. Bond, 25 F.3d 1566, 1571, 30 USPQ2d 1911, 1915 (Fed. Cir. 1994). Here, the count is directed, inter alia, to the nucleotide sequence as set forth in SEQ ID NO.: 8 of the '251 Application. That the count is directed to a nucleotide sequence which contains an error does not render it ambiguous. I point out that gWI when a count is ambiguous, may resort be had to extrinsic evidence or to the specification from where it [the count] originated. Genentech Inc. v. Chiron Coa., 112 F.3d at 500, 42 USPQ2d at 1612; Ln Le apjoLa, 975 F.2d 854, 856,24 USPQ2d 1142,1144 (Fed. Cir. 1992); Ln Le Baxte 656 F.2d 679, 686, 210 USPQ 795, 803 (CCPA 1981). Here, I find no statement by Judge Lorin that any of the terms or phrases of the count are ambiguous. Thus, it is not clear to me on what basis he is turning to the examiner's comments attached to the Notice declaring the interference (Paper No. 1) for the "factual foundation" that will enable him properly to construe the count. Even assuming, a[guendo, that Judge Lorin's actions pre appropriate, I point out that findings by, and decisions of, an examiner are not binding on this Board. Sze v. Bloch 458 F.2d 137, 141, 173 USPQ 498, 501 (CCPA 23 Interference No. 104,063 1972). Moreover, construction of the count is a question of law. Genentech Inc. v. Chiron Corp., 112 F.3d at 500, 42 USPQ2d at 1612 (Fed. Cir. 1997). Thus, it is the responsibility of the Board to construe the count, not the examiner. In any event, I find the examiners comments are not directed to the count, but rather they convey his reasons for finding that there is an interference-in-fact despite the differences in the nucleotide sequences of Kolodner's SEQ ID NO.: 8 and de [a Chapelle's SEQ ID NO.: 1. 37 C.F.R. § 1.601(n). The parties appearto agree since neither has filed a motion for no interference-in-fact. I find no basis for my colleague's statement that when the count is literally construed there may not be an interference in fact (page 17, above) or that the sequences of the two parties are not directed to the same invention as set forth in 37 C.F.R. § 1.601 (n) (page 18, above). Both parties are claiming a nucleotide sequence which they contend encodes the same protein, i.e., the human MSH2 protein. The record before us indicates that only one party (de la Chapelle) has "possession" of a correct nucleotide sequence encoding said protein. 12 Hence, my problem with the majority's decision: they render judgment against said party. 12 1 find no evidence in the record to support Judge Lorin's comments on page 19, above, that (I) de la Chapelle's SEQ. ID. NO.: 1 contains an error; and (ii) the nucleotide sequence disclosed in the Erratum in Cell (CX 2002 by Fishel) is the "true" sequence which encodes the human MSH2 protein. Rather, I find that the nucleotide sequence at issue is a human nucleotide sequence. Humans, as a rule, do not breed within families. Consequently, the human population shows many genetic differences known as genetic polymorphisms. De la Chapelle and Kolodner did not obtain their starting material from the same source; i.e., from the same human. Accordingly, it is reasonable to assume that de la Chapelle's SEQ. ID NO.: 1, and the sequence which Kolodner acknowledges is the correct sequence of his isolated clone (CX 2002), are allelic variants, i.e., they are alternate forms of the same gene. 24 Interference No. 104,063 De la Chapelle filed preliminary motion 11 pursuant to 37 C.F.R. § 1.633(g) to deny senior party Kolodner the benefit of the November 17, 1993 filing date of the'792 Application. Paper No. 27. De la Chapelle argues, and Kolodner agrees (KR 30, para. 6), that the nucleotide sequence disclosed in the '792 Application contains four errors. Paper No. 27, p. 2; CB, p. 8. These errors may be small in number, but because they are all present in the portion of the nucleotide sequence which encodes the structural gene they are substantial in their impact. For example, de la Chapelle points out that the first error occurs at nucleotides 16-18 of SEQ ID NO: 8; thus, an ATG codon is misdescribed as an ATC (in SEQ ID NO.: 16). 13 Paper No. 27, pp. 2-3; CB, pp. 8-9. Moreover, because the ATG is the initiating methionine codon, when Kolodner used the incorrect nucleotide sequence to deduce the amino acid sequence for which it encodes, the resultant protein lacked the first twenty-five amino acids. Id. Compare the'792 Application, SEQ ID NO.: 16 and the involved'251 Application, SEQ ID NO.: 16; compare also, Kolodner's original publication (!ýýell, Vol. 75, pp. 1027-1038 (1993), Figure 1 (CX 2001) and the Kolodner.Erratum (Cell, Vol. 77, p. 167 (1994), Figure 1 (CX2002). De la Chapelle further points out that the second error at nucleotide 1019 (a "C" is missing) results in a frameshift rendering amino acids 311-329, incorrect. Id. 13 SEQ ID NO.: 16 discloses the amino acid sequence of the polypeptide encoded by SEQ ID NO.: 8. 25 Interference No. 104,063 De ]a Chapelle still further points out that the third error at nucleotide 1077 (an extraneous "A" is inserted) shifts the reading frame back to the correct sequence, and the fourth error at nucleotide 968 (a "T" instead of an "A") results in the incorrect disclosure of a hydrophobic amino acid- valine at position 318, instead of the acidic amino acid, glutamate (in SEQ ID NO.16). Id. Thus, de la Chapelle contends that Kolodners'792 Application fails to provide an adequate written description of an invention within the scope of the count. 14 14 1 agree with Judge Lorin that de la Chapelle's arguments in motion 11 are directed to Kolodners claimed invention rather than the invention of the count as required by 37 C.F.R. § 1.637(g). However, when the count is identical to one of the claims, it has been the practice of this Board to consider the arguments presented in a motion filed pursuant to 37 C.F.R. § 1.633(g) as being directed to the count, even though the moving party has argued the claim. That is, we consider the substance of the motion, not its form. I recognize that the count and Kolodner's claim 28 are not identical in this case because said claim does not include a DNA molecule having the nucleotide sequence of SEQ ID NO.: 1 set forth in de la Chapelle's involved '295 Application. However, in my view, this does not preclude the panel from considering the merits of de la Chapelle's motion because ofthe manner in which the interference was declared. See, the examiners comments attached to the Notice declaring the interference (Paper No. 1) and the following explanation. I do not agree with Judge Lorin (footnote 7) that the reason de la Chapelle need not establish that Kolodners '792 Application does not satisfy the requirements of 35 U.S.C. § 112 for its SEQ ID NO.A is because the sequences are "equivalent." It is not clear to me, what my colleague means by "equivalent" nucleotide sequences. In my view de [a Chapelle need not explain why Kolodners'792 Application does not provide written descriptive support for SEQ ID NO. 1 of the '251 Application because it was known at the time the interference was declared that the parties' nucleotide sequences were not identical. See, the aforementioned examiner's comments attached to Paper No. 1. That is, in the context of motion 11, which is directed to the issue of written description of the invention, it was known at the time the interference was declared that Kolodner's involved and parent applications do not provide a written description of de la Chapelle's SEQ ID NO.A. Similarly, it was known that de la Chapelle's involved '295 Application does not provide a written description of Kolodner's SEQ ID NO.: 8. Accordingly, I find that de la Chapelle's failure to prove the obvious is also a matter of (continued... 26 Interference No. 104,063 It is well established that de la Chapelle, as the moving party, has the burden of proving by a preponderance of the evidence that it is entitled to the relief sought. 37 C.F.R. § 1.637(a). In my view, de la Chapelle has sustained its burden.'s To be accorded benefit of an earlier-filed application, said application must satisfy the requirements of 35 U.S.C. § 112, first paragraph, for at least one species within the scope of the count. LýLatt v. Boone, 146 F.3d 1348, 1352, 47 USPQ2d 1128, 1130 (Fed. Cir. 1998). Weil v. Fritz, 572 F.2d 856, 865 n.16, 196 USPQ 600, 608 n.16 (CCPA 1978). Thus, the earlier-filed application must contain an adequate written description of the subject matter of the count, and must satisfy the enablement requirement. University of Rochester v. G.D. Searle & Co. Appeal No. 03-1304, (Fed. Cir. 2004); Enzo Biochem. Inc. v. Gen-Probe Incorporated, 296 F.3d 1316, 1324, 63 USPQ2d 1609, 1613 (Fed. Cir. 2002); FlaM ýL Revel, 984 F.2d 1164, 1170-71, 25 USPQ2d 1601, 1606-1607 (Fed. Cir. 1993). To comply with the written description requirement, an applicant "must ... convey with reasonable clarity to those skilled in the art that, as of the filing date sought, he or she was in possession of the invention." Vas Cath Inc. v. Mahurkar, 935 F.2d 1555, 1563-64, 19 USPQ2d 1111, 1117 (Fed. Cir. 1991). With respect to a DNA sequence, our appellate reviewing court has held that an adequate written description usually "requires a precise definition, such as by structure, ... continued) form over substance. 15 Given my colleague's disposition of this case, I have not provided my reasons for finding the arguments in Kolodner's opposition to motion 11 (Paper No. ), unconvincing. Nor have I considered the motions which the majority now dismisses as moot. 27 Interference No. 104,063 formula, chemical name or physical properties." -Enzo Biochem. -Inc. v. Gen-Probe Incorporated, 296 F.3d at 1324, 63 USPQ2d at 1613; University of California v. Eli Lill and Co., 119 F.3d 1559, 1566, 43 USPQ2d 1398, 1404 (Fed. Cir. 1997); E[gmýL. Revel, 984 F.2d at 1170, 25 USPQ2d at 1606. Although in circumstances where a DNA is not available in written form, a reference to a deposit of a nucleotide sequence may provide an adequate written description of said sequence. Enzo Biochem, Inc. v. Gen-Probe Incorporated, supra. Since the count is directed, inter alia, to an isolated DNA molecule having the [nucleotide] sequence of SEQ ID NO.: 8 as set forth in the '251 Application, I find that the evidence of record (i.e., the incorrect nucleotide sequence in the '792 Application) clearly demonstrates that the '792 Application does not provide an adequate written description of said sequence. Rather, the'792 Application misdescribes the aforementioned sequence. Nor do I find that the'792 Application provides an adequate written description of SEQ ID NO.: 1 as set forth in the'295 Application. Accordingly, I find that the '792 Application does not convey to those skilled in the art that the Kolodner inventors were "in possession" of a nucleotide sequence within the scope of the count at the time the application was filed. Cf., Vas-Cath Inc. v. Mahurkar, 935 F.2d at 1563, 19 USPQ at 1117. Judge Caroff acknowledges that (I) the'792 Application does not provide an adequate written description of the nucleotide sequence of SEQ ID NO.: 8 as required by the count; and (ii) one skilled in the art would not recognize the errors in the 28 Interference No. 104,063 nucleotide sequence disclosed therein (page 5, above); but concludes that based on his reading of In re Lundak, 773 F.2d 1216, 227 USPQ 90 (Fed. Cir. 1985) and Enzo Biochem Inc. v. Gen-Probe Inc., 296 F.3d 1316, 63 USPQ2d 1609 (Fed. Cir. 2002), that the deposit of clone pDHA 11 in the involved 08/465,251 (the '251 Application), filed June 5, 1995, is sufficient to satisfy the written description, and presumably the enablement, requirements of 35 U.S.C. § 112, first paragraph, of all of Kolodner's earlier-filed parent applications.'6 According to my colleague, Enzo is controlling in this case because it stands for the proposition that the deposit of biological material in an appropriate public depository is sufficient to satisfy the written description requirement 16 Judge Caroff also suggests that given the deposited pDHA 11 clone, Kolodner could have corrected the nucleotide sequence in the '792 Application. I disagree. Errors in the specification cannot be corrected unless one skilled in the art would recognize (1) the error; and (2) the appropriate correction of said error. In re Oda, 443 F.2d 1200, 1205-06, 170 USPQ 268, 272 (CCPA 1971). Here, since thi kolodner inventors did not know that the nucleotide sequence disclosed in the '792 Application was incorrect, it reasonably follows that one skilled in the art, given the novel DNA sequence over 3,000 nucleotides in length set forth in SEQ I D NO.: 8, would have no way of knowing that there were any errors in the sequence. Moreover, when reading the specification as a whole, one skilled in the art would find that the '792 Application discloses that "the cDNA clone (SEQ ID NO. 8) contains a complete open reading frame capable of encoding 909 amino acids. The encoded amino acid sequence is presented in SEQ ID NO.16" [emphasis added]. The'792 Application, p. 26, lines 7-9. The polypeptide shown in SEQ ID NO.: 16 was deduced from the nucleotide sequence data of SEQ ID NO.: 8 and, therefore, contains the amino acid sequence errors recited above. The specification compares the incorrect sequence shown in SEQ ID NO.: 8 with other cDNAs and concludes that the nucleotide sequence is a human homologue of the E. coli mutS gene. Id., lines 14-17. In addition, the specification discloses that the incorrect polypeptide shown in SEQ ID NO.: 16 is a protein homologue of the E. coli MutS mismatch repair protein and of the yeast protein shown in SEQ ID NO.: 3. Id., lines 17-23. Thus, one skilled in the art, reading the'792 Application would not have any basis for believing that the nucleotide sequence (SEQ ID NO.: 8) and its corresponding amino acid sequence (SEQ ID NO.: 16) were incorrect. 29 Interference No. 104,063 of § 112 for any claim directed to a nucleotide sequence. I disagree. In my view, the court in Enzo did not make such a sweeping generalization with respect to deposits of clones said to encode a particular nucleotide sequence .17 1 find that the court qualified its statement and held that a deposited material in a public depository May constitute an adequate written description of an invention, "when it is not otherwise available in written form " [emphasis added]. Enzo Biochem Inc. v. Gen-Probe Inc., 296 F.3d at 1325, 63 USPQ2d at 1613. Based on the record in this case, I find that the nucleotide sequence of the human mutator gene homolog (hMSH2), which Kolodner's SEQ ID NO.: 8 is said to describe, was obtainable in written form as evinced by the de la Chapelle'295 Application (SEQ ID NO.: 1), and the published sequence in a scientific journal. CX 2001 and CX 2002. Thus, since the fact situation as to when a deposit may satisfy the written description requirement for nucleotide sequence was not present in this case, Enzo is not controlling as precedent. My problems with Judge Caroffs opinion do not end there. Kolodner filed the '792 Application on November 17, 1993, now abandoned. Kolodner filed Application 08/163,449 (the '449 Application) on December 7, 1993, now abandoned, which is said to be a continuation-in-part of the'792 Application. Kolodner filed Application 08/259,310 (the '310 Application) on June 13, 1994, now abandoned, which is said to be a continuation-in-part of the '499 Application. Kolodner filed Application 08/465,251 17 In addition, I find no statement in Enzo that a deposit of a biological material can be used to correct errors in a nucleotide sequence. 30 Interference No. 104,063 (the'251 Application) on June 5, 1995, which is said to be a continuation-in-part of the '310 Application. The errors in the nucleotide/amino acid sequence in the'792 Application are discussed above. The nucleotide and amino acid sequence data were only partially corrected in the '449, '310 and '251 Applications. In these latter applications, an incorrect "T" nucleotide appears at position 968, resulting in a codon coding for valine (GTA), rather than a glutamate (GAA) at amino acid position 318. Thus, SEQ ID NO.: 8 (and, consequently, SEQ ID NO.: 16) in the'449,'310 and'251 Applications is not the correct sequence of human MSH2. In addition, the evidence of record; viz., CX 2002, indicates that the nucleotide sequence of the insert contained in the deposited pDHA 11 clone differs from the nucleotide sequences disclosed in each of Kolodner's four applications." As discussed above, the count is directed, inter alia, to '8 Judge Caroff states that he has not assumed, because there is no proof, that the pDHA 11 clone is the same as "any clone described in CX-2001 or CX-2002." See, page 12, above. I point out that my colleague has stated in footnote 3 that the deposit of clone could serve as a basis for correcting the sequence. The only correct nucleotide sequence of the hMSH2 gene the Kolodner inventors provide is in their Erratum in Cell, CX 2002. Thus, Judge Caroff appears to have assumed that the pDHA 11 clone encodes the correct nucleotide sequence set forth in said publication. In addition, Kolodner states that: pDHA 11 was deposited with the ATCC. That deposit is the same clone as described in the application [the '792 and '449 Applications]. ... The four errors were simple editing errors that resulted from an inadvertent proofreading failure. ... However, the molecule inherently contained the correct sequence and anyone sequencing it would, if done carefully, obtain the correct sequence [Paper No. 51, p. 18, last para.]. Again, the only correct sequence of the hMSH2 gene disclosed by the Kolodner inventors is the nucleotide sequence set forth in the Erratum in Cell. CX 2002. 31 Interference No. 104,063 an isolated DNA molecule having the sequence of SEQ ID NO.: 8 as set forth in the '251 Application, and Judge Caroff states that by virtue of the deposited clone pDHA 11, the '792 Application provides an adequate written description of an invention within the scope of said count. However, it is not clear to me, and my colleague does not explain, of which nucleotide sequence the deposited clone provides an adequate written description. The incorrect SEQ ID NO.: 8 of the'251 Application (the invention described in the count), SEQ ID NO.: 1 as set forth in the '295 Application, or the nucleotide sequence of the hMSH2 gene as set forth in the Erratum in the Cell journal (CX 2002)? 1 find that de la Chapelle clearly demonstrates that the '792 Application does not provide an adequate written description of SEQ ID NO.: 8 as set forth in the '251 Application. That is, anyone reading the'792 Application can plainly see, and Kolodner acknowledges," that (i) the '792 Application contains the four errors pointed out in motion 11 and the accompanying exhibits; and (ii) that three of these four errors were corrected in the '449, '310 and '251 Application. Thus, contrary to Judge Caroffs comments (para. bridging pp. 12-13, above), I find that there is no burden on de [a Chapelle to "test" the deposited pDHA 11 clone or to cross-examine any of Kolodner's witnesses on this issue. '9 See, e.g., Kolodner's Opposition, Paper No. 51, p. 4, second complete para. and p., 12, last para.- p. 15, para. 3. See also, Dr. Kolodner's direct testimony, KR 32, paras. 6, 42 and 54, which are relied upon in said opposition. 32 Interference No. 104,063 As of this writing, the written description and enablement requirements of 35 U.S.C. § 112, first paragraph, are considered by the court to be two separate and distinct issues. Universitv of Rochester v. G.D. Searle & Co., Appeal No. 03-1304 (Fed. Cir. 2004); Enzo Biochem Inc. v. Gen-Probe Inc., 296 F.3d at 1324, 63 USPQ2d at 1612. Written description is a fact-based inquiry; whereas, enablement is a question of law. The purpose of the written description requirement is to "ensure that the scope of the right to exclude, as set forth in the claims, does not overreach the scope of the inventor's contribution to the field of art as described in the patent specification." Reiffin v. Microsoft Corp., 214 F.3d 1342, 1345, 54 USPQ2d 1915, 1917 (Fed. Cir. 2000). Traditionally, a deposit of a biological material in an appropriate depository, when accompanied by additional assurances described below, was considered sufficient to enable one skilled in the art to make and use the claimed invention. In re Lundak, 773 F.2d at 1218-19, 227 USPQ 90 at; Ln Le Araoudelis, 434 F.2d 1390, 1391, 168 USPQ 99, 100 (CCPA 1970). Nevertheless, the court recently held that deposits of microorganisms containing a nucleotide sequence, not otherwise available in written form, may also be used to satisfy the written description requirement of § 112. Enzo Biochern Inc. v. Gen-Probe Inc., 296 F.3d at 1325, 63 USPQ2d at 1613-1614. By the time of Lundak, it had been determined that the words in a specification alone did not always enable one skilled in the art to make and use a claimed invention. 33 Interference No. 104,063 That is, it was determined that certain inventions directed to novel biological materials such as microorganisms, plants, etc., which were not known and readily available to the public could not be made by one skilled in the art based on the teachings in the specification alone, without undue experimentation. For example, an invention directed to a novel microorganism capable of producing an antibiotic or digesting an oil spill, can not be readily isolated ("made") by one skilled in the art because finding a given microorganism in nature is unpredictable. Even the disclosure in a patent application of the precise location where a novel microorganism is located does not ensure that a person skilled in the art would be able "to make and use" the claimed invention. Similarly, with claims to novel plants. Given the unpredictable nature of genetic recombination events, the crossing of two plants using classical plant breeding techniques does not guarantee that one skilled in the art would be able "to make and use" a plant from the description provided in a patent application. Thus, the USPTO permitted an applicant to deposit such inventions in certain recognized depositories, in conjunction with a statement that all restrictions imposed by the depositor would be irrevocably removed upon the granting of the patent,'O to satisfy the enablement " Even, assuming, arquendo, that Judge Caroff is correct with respect to Kolodner being entitled to the benefit of the '792 Application based on a deposit referred to in the involved '251 Application, I do not find that it [Kolodner] has complied with the deposit requirements set forth in 37 C.F.R. §§ 1.801-1.809. Attention is directed to § 1.808(b). In addition to making a deposit in a recognized depository as described in the rules, the depositor must provide a written statement to the USPTO that all restrictions on the availability to the public of the deposited material will be irrevocably removed upon the granting of the patent. See M.P.E.P. § 2410.01; Ex parte (continued... 34 Interference No. 104,063 requirement of § 112. In Lundak, the issue was at what time must a deposit of a human cell line producing hybridomas be made in order for the patent application to be enabling. Since the monoclonal antibody technique generates hybridomas against many different epitopes and with different affinities, a deposit ensured that the particular type of hybridoma claimed in the patent was reproducible and available to the public. The court found that a deposit made after the filing date of the application, and which was in compliance with other USPTO regulations, was sufficient to satisfy the enablement requirement of the patent application at issue. Thus, Lundak has stood for the proposition that provided a deposit is made prior to the issuance of the application in which the deposit is mentioned, said application is considered enabling as of its filing date. The court in Lundak makes no statement as to the deposited cell line satisfying the enablement requirement of an earlier-filed parent application. That is, the court did not, in either Lundak or Enzo, give the claims benefit under 35 U.S.C. § 120 to any earlier-filed applications. Thus, I find no basis for Judge Caroff's presumption that the court would have done so for purposes of both enablement and written description. As set forth above, written description and enablement are two separate requirements of § 112, first paragraph. Written description is a fact-based inquiry. Here, the facts of record irrefutably establish that Kolodner's'792 Application does not provide an adequate written description of an invention within the scope of the count. (.,.continued) Hildebrand, 15 USPQ2d 1662 (Bd. Pat. App. & Int. 1990). This Kolodner has not done. 35 Interference No. 104,063 Rather, the'792 Application misdescribes (i) the human MSH2 gene; and (ii) SEQ ID NO.: 8 as set forth in the'251 Application. Nor does the nucleotide sequence disclosed in the'792 Application provide an adequate written description of SEQ ID NO. :1 as set forth in the'295 Application. Judge Caroff s opinion disregards these facts. According to my colleague, it doesn't matter what nucleotide sequence is disclosed in a specification, as long as the name of the clone containing the sequence is disclosed and the clone is deposited any time an application is pending before the Office. Thus, my colleague appears to believe that those skilled in the art should obtain the deposited clone(s) mentioned in a patent and determine for themselves (even though the inventors themselves might not have been able to) whether the written description of the invention in the patent is correct, or not. Moreover, while Judge Caroff states that his decision based on Lundak and Enzo, he overlooks the fact that his extension of the benefit of the deposited clone to satisfy the written description requirement of earlier-filed applications is inconsistent with 35 U.S.C. § 120 2' and other case law. 35 U.S.C. § 120 requires that each of 21 35 U.S.C. § 120 states, in relevant part: An application for patent for an invention disclosed in the manner orovided -by the first paragrar)h of section 112 of this title in an application previously filed in the United States, ... which is filed by an inventor or inventors named in the previously filed application shall have the same effect, as to such invention, as though filed on the date of the prior application, if filed before the patenting or abandonment of or termination of proceedings on the first application or on an application similarly entitled to the benefit of the filing date of the first application ... [emphasis added]. 36 Interference No. 104,063 Kolodner's earlier-filed applications satisfy the written description requirement for the claims to obtain benefit of their filing dates. Similarly, if one wants to obtain benefit of an earlier-filed application for constructive reduction to practice of an invention within the scope of the count, the earlier-filed application "must describe the subject matter of the count in terms that establish that [the inventor] was in possession of the later-claimed invention, including all of the elements and limitations presented in the count, at the time of the earlier filing." Hyatt v. Boone, 146 F.3d at 1553-54, 47 USPQ2d at 1131 ("it is not a question of whether one skilled in the art might be able to construct the patentee's device from the teachings of the disclosure ... . Rather, it is a question whether the application necessarily discloses that particular device"). Thus, while Judge Caroff contends that Lundak and Enzo establish a symmetry between written description and enablement, he ignores the case law which concerns the compliance of earlier-filed applications with the requirements of § 112, first paragraph, to establish constructive reduction to practice of an invention within the scope of the count, and 35 U.S.C. § 120. The relevant issue here is whether the earlier-filed '792 Application satisfies the requirements of § 112, first paragraph, for an invention within the scope of the count. I submit that it does not. IV. In addition to the foregoing, I find the Judge Caroffs opinion to be misdirected. The deposit issue is really a red herring. I direct attention to 37 C.F.R. §§ 1.802 (b) and 37 Interference No. 104,063 (c) which state, in relevant part: (b) ... Biological material need not be deposited, inter alia, if it is known and readily available to the public or can be made or isolated without undue experimentation. (c) The reference to a biological material in a specification disclosure or the actual deposit of such material by an applicant or patent owner does not create a presumption that such material is necessary to satisfy 35 U.S.C. 112 or that deposit in accordance with these regulations is or was required. A deposit is only necessary when the material is not known and readily available to the public. As discussed above, at least one correct nucleoticle and amino acid sequence of the human mutator gene homolog (hMSH2) were known and readily available in the art. These sequences were published in an "Erratum" in Cell, Vol. 77, p. 167 (1994). CX 2002. In addition, the USPTO does not require a biological deposit when the complete nucleotide sequence of a gene is disclosed in a specification because this information is sufficient to enable one skilled in the art to "make and use" the claimed invention, without undue experimentation. Thus, because the nucleotide sequence of SEQ ID NO.: 8 as set forth in the '251 Application was disclosed in the '449 Application, even though the sequence (in the '449 Application) is incorrect, the '449 Application nevertheless satisfies the written description and enablement requirements of § 112, for the incorrect sequence for the human mutator gene homolog (hMSH2) recited in the count. However, it does not appear that Kolodner wants benefit of an incorrect nucleotide sequence. 38 Interference No. 104,063 V. As the dissenter in this case, I take more liberties in expressing my opinion. To that end, it is my view that the court was too generous in the deference it accorded the USPTO's "Guidelines for Examination of Patent Applications Under the 35 U.S.C. 112, 1 'Written Description' Requirement," 66 Fed. Reg. 1099 (January 5, 2001). Should it not be that a specification having a claim(s) to a nucleotide sequence, or a method(s) of using a nucleotide sequence, contain a written description of said sequence? In the past, specifications having claims directed to a microorganism, cell line, plant, etc. capable of performing a particular function, satisfied the enablement requirement by depositing said microorganism or cell line. However, there was a difference between the claims in past cases and those now before us. Previously, the claims were not directed to the nucleotide sequence within said microorganism/cell line/plant which was responsible for a particular function. For example, the claims were not directed to the gene encoding "antibiotic V or responsible for digesting "petroleum product y.1122 One skilled in the art did not need to know the nucleotide sequence to 22 See, Diamond v. ChakrabaLty, 100 S. Ct. 2204, 206 USPQ 193 (1980). See, also, U.S. Patent No. 4,259,444, claim 1 which reads as follows: 1. A bacterium from the genus Pseudomonas containing therein at least two stable energy-generating plasmids, each of said plasmids providing a separate hydrocarbon degradative pathway. See also, In re Lundak, 773 F.2d 1216, 227 USPQ 90 (Fed. Cir. 1985). Claims 1 and 2, read as follows: 1. An immortal B-cell line WI-L2-729HF2' (continued... 39 Interference No. 104,063 "make and use" the claimed invention because the entire microorganism/cell line/plant or product which it produced was the invention; not a specific nucleotide sequence contained therein. The isolation and characterization (determination of the nucleotide sequence) of a specific gene in those cases would have required undue experimentation by one skilled in the art to make and use the claimed invention based on the mere disclosure of its existence in a microorganism or cell line .13 1 point out that prior to the actual obtention of the nucleotide sequence encoding the human genome by the combined effort of numerous laboratories worldwide, the sequence was "not otherwise available in written form." Enzo Biochem Inc. v. Gen Probe Inc., 296 F.3d at 1325, 63 USPQ2d at 1613. Would it have been possible for ... continued) 2. A hybridoma resulting from the fusion of an immunized lymphocyte and a cell line according to claim 1. 23 Even today, one needs a probe to isolate a novel nucleotide, sequence from cDNA and genomic libraries. DNA probes can only be constructed and employed to isolate genes if a portion of the nucleotide sequence is known. (Under certain circumstances, a DNA probe can also be constructed if part of the amino acid sequence of the protein which the gene encodes is known). Alternatively, if the gene of interest has a known homologue, it [the DNA of the homologuel can be used as a probe. I With cDNA libraries, it is sometimes possible to screen for a gene of interest using a biological assay or an antibody probe which detects the expression of the product which said gene encodes. However, expression of a product will occur only if the cDNA has been inserted into the cloning/expression vector in the proper orientation and in the correct reading frame. Eucaryotic genes, however, often contain introns (intervening segments of "nonsense" DNA which do not encode the gene product). Therefore, when eucaryotic genes are inserted into a vector (for purposes of cloning), it is often not possible to express the protein products which they encode. Thus, genomic libraries (comprising clones of eucaryotic genes) usually cannot be screened using a biological assay to locate the gene of interest. 40 Interference No. 104,063 one to satisfy the written description requirement for a claim directed to the nucleotide sequence of the human genome by depositing several genomic or cDNA clones containing the nucleotide sequence as was done in Enzo? Would such an applicant have been "in possession" of the nucleotide sequence encoding the human genome? I don't think so. In my view, applicants should not be permitted to obtain a patent for a nucleotide sequence based on an isolated, and deposited clone or microorganism an applicant believes, and perhaps even does, contain a DNA sequence which encodes a particular gene. Nor should applicants who incorrectly sequence a gene be rewarded with a patent if they later deposit a microorganism containing the correct sequence. If a nucleotide sequence is what is claimed, the burden is on the applicant to "convey with reasonable clarity to those skilled in the art that, as of the filing date sought, he or she was in possession of the invention"; i.e., "in possession" of the nucleotide sequence. Vas-Cath Inc. v. Mahurkar, 935 F.2d at 1563-64, 19 USPQ2d at 1117. Claiming a nucleotide sequence which one does not or cannot describe, overreaches the scope of an inventors contribution to the field of art. Reiffin v. Microsoft Corp., 214 F.3d at 1345, 54 USPQ2d at 1917. "A patent is not a reward for the search, but compensation for its successful conclusion." Brenner v. Manson, 383 U.S. 519, 536, 148 USPQ 689, 696 (1966). Joan [is istrati istrative Patent Judge JE/eld 41 Interference No. 104,063 Judgment In view of the disposition of all the issues before us, judgment as to the subject matter of the sole count in this interference is in order and, accordingly, judgment is hereby awarded to Kolodner et al, the senior party. Accordingly, de ]a Chapelle et al., the junior party, is not entitled to its claims 1-6, 27-31 and 38-45 corresponding to the count. On the record before us in this interference, Kolodner et al are entitled to their claims 28-30, 32, 34-36 and 41-54 corresponding to the count. However, we note that our decision in no way affects the status of the parties' claims indicated in the initial memorandum forwarded by the primary examiner (Form PTO-850). Thus, it should be noted that the examiner has determined that Chapelle claims 33-37 do not correspond to the count and are patentable. Also, Kolodner claims 31, 33, 37 and 38 have been designated as not corresponding to the count, but have been determined to be unpatentable. Finally, Kolodner claims 29, 32, 35, 36, 41-49 and 53, which correspond to the count, have been determined by the examiner to be unpatentable. Accordingly, the only claims of Kolodner which both correspond to the count and are considered patentable are claims 28, 30, 34, 50-52, and 54. 42 Interference No. 104,063 Attorney for de la Chapelle et a]: Sarah A. Kagan Joseph M. Skerpon Banner & Witcoff Ltd. 1001 G Street, N.W. Washington, DC 2001 Attorney for Kolodner: Ronald 1. Eisenstein, Esq. NIXON, PEABODY, LLP 101 Federal Street Boston, MA 02110 43 Cell Cell Erratum Kolodner K.I.dm Ch.pell. #1 pu- p-ub. 41811 fil, 611W1994 fil, 616M5 ML 1ý1993 fil, 12f7 p.b 12J9193 0&154.792 Owlý,449 OM59310 0&465,251 061160295 SEQ ID bEQ IU NU:b SEQ ID NO 1 SEQ 0 NC:8 SEQ ID NO 1 2 4 5 6 Ah 7 10 2 14 17 z 23 2 T 2 96 ý"A 2 3 3 35 36 T e., 40 41 42 4 5-0 ý52 53 1 A 1 A I A 54 2 T 2 T 2 T 3 T 3 T 3 T 3 56 4 C 4 C 4 C 4 5 G 5 G G ý5, 6 G 6 G 6 G 7 0 7 C 7 C 7 a A 8 8 A 8 , 1 A . . 9- C t 9 C 9 62 10 0 10 1 u 1 10 u 10 6 11 A 11 1 A 11 A 12 G 1 G 12 I-G 1 12 Kclodneý K.I.dna, Call Cell Erratum Kciodner Kolodner I Chapelle #1 I fil 11117/93 fil. 12M, 993 pub, 1MI93 pub.401994 fil 6113M994 fil, 615ý5 ML 1212/1993 ý 0&154.792 0&163,449 1 59310 08/4155ý251 081160295 1 SEQ 11) NO,8 SEQ ID NO:8 SEQ ID NO 1 SEQ 10 NO.8 SEQ ID NOI 13 G-- 13 G 13 G 1 cGT-- -T3 A --- 14 44 A 14 A 14 2 A Is C 15 C 15 c 3 c 15 68 16 A 16 A 16 A 4 A I A 1 69 17 T 17 T 17 T 5 -T T i 14 J, 7-1 "g 19 19 G 19 G 7 G 44G 19 72 C --7-3 21 C 21 G 21 C 9 G 6 G 21 G 74 G 1= 1 -G-- -7- 73 23 T 23 T 23 T 11 T 8 T m 7 24 G 24 24 G I G 2 7 25 C 26 C 25 C 13 -- c 10 - C 25 '13 11 A 26 79 zz A 26 A -26 -A M -A 1-4 A 6AW 27 G 27 G 27- G 1-5 G 12- G- 27 80 28 C 28 C 28 C 16 C 13 r 28 j `1 c vlýý' -29- C 29 C 17 C 4229 C 14 C 29 30 G -30 G -50- -G -IrS- -G -Tr -G 3-0 83 3 -- r-- 31 -A -31- -A 1-9 -A 1-6 3-2 - A 32 2-0- -A - 8532 A A 17 33 G 33- -G -33 G -- Tl-- G 18 G 33 86 34 G G 34 G 22 G 19 34 - G 34 87 35 A 35 A 35 A 23 A 20 A 35 88 36 G- -36 1- G 36 G -24 G I G 89 &Wo 37 A 37 A 37 A 25 A 22 37 90 A 1/8mr 38 C 38 C 38 C 26 C 23 C 38 39 G -39- -G 3-9 G 2-7 -G -- 2ý7 G 40 C 40- -C -40-- -C -C -25- C 93 41 T 41 T 41 T 29 14 T 2e T 41 42 G 4-2- -G -4-2 G 3-0 -G -2T- G 43 C 43 C 43 -C -31 -C -28 44 A 44 A 44 A 32 A - A 44 45 G 45 G 45 -G 33 -G 3-0 G 11 1 46 T - T -34 T I T 41 'FI, 9 47 T 47 T _ý7_ T --i-oo 5 T 32 T 47 46 1 3-6- G XT -0 48 "L 6 48 G 118 1 49 1 G 49 G 37 G 34 G 49 luz A -3S -A 103 51 g *1 39 G- 3-6 G 1 104 52 A 52 A 52 -A 4-0 A 37- -A 11 53 G 53- G -ý3- - G 41 G 38 G 13 ý-'J'--" rffý i66 --- 6-4- -C 6 -54 -C -42 -C -3ýF -C 54 C 1071 ""Wr 55 G 55 G 55 -G 43- -G 4-0 -G 55 8 56 C 56 C 56- -C 44 -C 4-1 C 56 14 9 -67- _5 -G 4-2 lit 57 G G 577 G 4 G 0 68 58 G 58 G 46 G 43 G 58 59 C 59- -C =9 -C 47- -C 4-4 C 121 C 5 C 1 , 3 60 c 60- -C 6-0 -C 48 1- -4 61 61 61 G 49 46 G 61 114 \197 62 A 76-2 A 50 A 47 A 62 115 -pý 63 G 63 G jjý -- r-63- G 5-1 G 4-8 G 1 6 4ý 64 G 64 1 G 1 64 -G -52- -G 4-0 -G 64 11 7- G 63- -T 5-0 -T _ 7J 65 T T 65 T lis I 66 C 66 C 1-1 -1 4- -1 1-1 -C -ffq I 67 G 67 G 67 G 55 G -52-- - G 1201 MER 68 G 68 G 68 -G 56 -G 5-3 G -12-1 ý 69 Iff- 6-9- -C -- 59- -C -57 -G 7R- C 122 r wz,ýR 70 -70- - T _70- --- 7-- 58- T 5 T 70 123 T _ýq T 12 71 T 71 T 5 :1 i 1214 31A -T2- -C -65- -C i 5 7, 72 (5 72 C 57 c 125 -TT -G 73 G _73 G 61 G 58 1 73 126 1ý' 74 T 74 T 74 T 62 T 59 T 71 1271_ý 75 G -7 U MIOý J" -75- G -T5- -G 63 -G so G -12-8-1 76; C 76 C -ýS - C -EF4- c 61 C 7 ci 7-7 G -77- G -6-5- G 62 G 7Z 78 78 C 78 C 6-6- C 61 -C 131 79 - r- 67- -54- -- T-- 79 'T_ 132 =0 T 68- -T 6-5- T 80 33 T -9- - -- A ilgit-:: =1 C 6 C 56 C 1 1 34 T 82 T 70 T 6-7 1 82 ý3 T ý3 T 83 T 71- T 68 T 136 -2- - -6- "PRA 84 T 84 T 84 T 7 T 9 T 73-7 85 C 85 C 85 c 73 C 70 85 86 A 88 A =8 A T4 A 71 A 86 f3-9 76-7 G 8-7- G -1-5 -G -7-281 -G 140 88 G 88 G 88 G 76 G 73 G 88 G 4' 89 G 89 G 89 G 77 G 74 G 1 2 90 C 90 C 90 C 78 C 75 C V ý 91 A 91 A 91 A 79- A 76 A 92 T 92 T 92 T 8-0- T 77 T ý A l '71 93 G 9-3 -G 9-3 G -81- G 76 G 74-6 94 C 94 C 94 - C 82 79 C -147 9-5 I-C 9-5 c 95 C uu C Pq- - , w 0 0 K.I.dý., Kotcdner Cell Cell rrmWm Kolodner I Kolodner I Chapelle #1 fil il/17193 fil, 1ý/1993 pub. 121919 pub NW1994 fil 611311994 1 fil. 615195 1 fil. 1201993 08/1ý,792 081163449 OM59 310 08/465.251 OM6029 SEQ ID NO 8 SEQ ID NO B SEQ ID NOA SEQ ID NO:6 SEQ ID NO 1 UQ G 96 G N G 84 G 81 G M WMýWIW 149 97 G Sl- -G 57- -G -&5- G 82 98 A 98 A 98 A 86 A 83 A 978- 151 -95T- -G 9-9 G 9-9 G 87 G 84 -5-9 -ý-oo -A -i-oo- -Woo -77-- -m- -A -a5 -A loo 153 -j-01- - A liý- A A -Az 101 A 01 A 86 101 154 102 G 102 G 102 G W G G T02 155 -TO-3 -C -TO-3- -C 7-0-3 -C _W1 M. 103 z, 156 104 104 1 104 89 92 C C -T5-7 -TO-5- G 105 G 105 G 9-3 G 90 - G 1 -1-58 1-0-6 -A 106 A 106 -A -A 9-1 -A 1 M 107 C 107 C 107 C 95 C 92 C 107 160 C 108 C 108 C 96 C 93 C 108 10-9 - A 1-0-9 1-0-9 -- 7 9- -97 A 94 A 109 162 A, 110 C 110 C 110 C 98 C 95 C 11 -163 -Ti -I - C -11-1 C ill C 99 C 96 C ill -164 -- -9-- 1-12 -9-- 71-2 -7- IM -- T- GiT -9-- 112 113 C 113 C 113 C 101 C 98 C 11 166 -74- -A -1-1 T -A 7-14- -A -TO-2- -A 9-9 -A 11 -167 115 G 115 G 115 G 103 G 100 G 115 11-8- T -1-1 -6 T -1-16- T -104 T 101 T lis Tý I 117 G 117 G 117 G 105 G -102 G -717- 1 - C 118 C 118 C 106 C 103 C 118 171 T1-9- G 1-19- G 119 G 107 G 104 G -Tig 172 T-20 -C 120 -C T2-0 -C 70-8 -C 105 C 120 73- 'A/6, V 7-2-1 C 121 C -T2-1 - C 70-9 - C Im C 121 174 C' -1-22- 122 T 122 110 107 U2 V-5 T", T T T T Q-3- T -123 T -123 T -11-1- -T -TO-8- -T U-3 17-6 T, 124 T 124 T 177 ppT M\ T2-4 --- r- 71-2 --- r-- _T09- 124 125 T 126 T 125 T 113 T -1-1-0 T -12-5 178 X -f2-6- -C -12-6 -C 72-6 C -1 U C ill C 126 W -9 t, 1271 G 1 1271 G 127 G 115 G 112 G 127 180 128 A 1281 A 1-2-8 - A --1-16 A 113 1 181 -W -C -12-9 - -117 1291 C C C -11-4 - C 1 182 -01-30- - C 130 C 130 -115- C 1 183 1-31- G -113-1 G 131 G 119 G 118 G 131 184 -1-ý-2 G G 132 G 120 G 117 G 132 185 13-3- - G -113-3 G 133 G 121 G 118LG 133 186 -1-3-4 G -1-3-4 G 134 G 122 G 1191 G 1 -18T (a, T3-5 -C -13-5 -C -1-3-5 C 123 C 12U 1 1 ý118-8 G 136 G -G 124 -G 121 G 136 9 -1-37- A 137 A -13-7 - A -125 A 122 A 1 1-3-8 C 138 C -'F3-8 C 126 C -123 - C 1 191 1-3-9 139 T 139 T 127 T i3g 19 -f4-0-1-T -140 19 T 140 T 128 T 125 T 140 931* -,,-' 141 -1 -4 - 70- - -126 1, C 141 C 1 C 2 C C i 1 44 -14-2- --- r 142 T 142 - 7- -1-3o ---- T- -127 - T i I T 143 A 7-43- -A -1-43- A 131 A -ý12-8 -A 96 ",vý -1-44- T 74-4 T -1-44- T 73-2 T - 29- T 1,4 145 A 74-5 -A U-5 A 1ý A 130 198 146 C ý6 C 146 -f4- C 1ý C 131 C 1 199 147 G 147 G 147 -T3-5 G 132 G 147 ýM 1-4-8 -G 74-8- G 148 G ' -1-3-6 -G 133 G 148 Am 149 C 149 C 149 C 137 C 134 C 149 SIR' 150 G 75-0 G 1 G -T3-8 G 1-35 - - -G---j 160 G,' ,i*ý 203 ý1)1 - C -T51- C 151 C 139 C 136 C 151 11,5 152 A 152 A 152 A 140 A - 137 A -- 7-5-2 -20-5153 C 141 -C- 73-8 1531 C 153 C 206 60 54 G 1ý I G 154 -f4-2- - G 73-9 G 154 207 w 158 -198 55 G 1551 GG 155 G 143 G 1 G 155 ma "6 C 156 C -144 C 1 1 -C- -1-56 162 214 1 6 C 156 -To-9 157 - 75-7- -G 157 G 145 142 G 15, , , I , 212 ;124 '-Ili A 158 A 158 A 146 A 143 A 211 9 G G -159- G -TV G 144 G -1-59 161 - 74-9 A 146 A - 1 1 z I G 160 G 160 G 148 - G 145 G A 161 A 161 A C 162 C 162 C -150 C 147 G 162 215 1-6-3 G - G 163 G 151 G 148 G 163 211 1,4 1 Mý U"7 164 C 164 C 164 C 152 C 149 C ... .... 21 165 G 165 G 165 G 153 G 1 G 165 18 166 C 166 C 166 C 154 - C 151 C 166 167 T 167 T 167 T 155 T 152 T 67 22( -1-6-8- G -1-6-8- G -TW i68 1681 G 153 6 4 21T '\,d 1-69- C 169 C 169 C 157 C 1ý C 169 -f7-- - -170 T 158 155 -T 170 171 G 171 G 171 G 159 G 156 G 171 172 G W2 G -f72 G 160 G 157 G 172 ýIpfQ 173 C 173 C 173 C 161 111 1 173 1-7-4 - C -- 4 C 174 C 1ý C 159 C 1 175 -G 175 ill -G -G 176 C C 176 C 164 C 1 1 C 176 OFF, _J16- - -I -1-77- -C C 177 -C -16-5 C 2 -C -1-7-7 C 178 C 166 c 1 71 z- Kalodw Kolodner Cell I Cell Erralu. K.I.drl.r I Kolodher I Chap. all 11117193 fil 1ý11993 pub, 12J9193 ub 4/WI994 fil 6/13M994 fil. 615M5 fil. 12IV1993 06/154,792 G&I 63,449 OW259 310 U&4b* 2*1 _ UW W2WD SEQ ID NO 8 SEC ID NO 8 SEQ ID NOA SEQ ID NO 8 SEQ ID NOA -1-- - G 1-67 G -T6-4 G -7-9- - Tý"' 232 Wý"50`, -TW- G 168 01 1W G -T8-O 43 81 G 181 G 181 G 169 G 66 181 234 182 A A 170 182 A 182 -16-7- - A 1 23-5- :'q [17 G g17G 79 1- RAM 11 , 8 -1-1 - -1-68 83 G 183 G 183 G 7 G ý6 , '4 18 7-84- -G 17-2 -G -169 -G 1 237 1 , ý86 - _T39 184 G 184 111L 1 T - -1--- - 1-- - iý 185 T 185 185 T 73 T 170 T 1 238 FF 86 G 1 G 186 G 174 G 171 G 1 187 187 T 187 T 175 T 172 1 T 187 240 188 T 1 -88 - T -T-8--888- T 176 T 173 T 188 241 189 C 189 C 189 C 17 C 174 C 189 242 190 A igo A 10 A 178 A 175 1 A 190 243 191 A ý-9-1 - A 79-1 - A 179 A 176 1 A 191 -f44- I@ 192 G -19-2- G 792- G 18 G 1 G 192 193 A 193 A 193 A 181 --- r- 178 A 193 I'Aýý 246 7-94 - C 194 C 194 -c- 182 C 179 1 -f4-7 79- 183 C 180 C 1 248 -C -Tw -C i -C 1 Wi- C 196 249 196 C 84 197 - A 197 A 197 A 18S A --ITB--22- A I 4WW I -- -1W G 186 G -i-83 G 1 -725, 198 G 198 199 G 199 G 199 G 187 G 184 G 1 199 tmý",P 252 2(X) G 200 G 200 G 188 185 G 1 2W 253 G A 1-8-6 ZuI 254 201 -G -2W -G -TOT G -1-89- G G 202 G To-2- -G -fo-2- -G 7-9-0 -G 187 G 202 203 T 203 T 203 T 19-1 T -Im T 203 256 204 G 204 G -204 G -1-92- G 1-89- -G T57- Aý' 20-5 A 205 A 205 A 1-93- - A 10 A 205 258 2ý T 206 T 206 T 194 T 191 zUt -TO-7 -C 207 C 207 -C -1-99- -C 79-2 -c tmý ";W"', To-a- -A -To8- -A -To8- -77- 7-96- --- 7- -19-3- -A 208 209 A 209 A 209 A 197 A 194 A -21-0 G 210 G 210 G 198 G 195 G 1 263 211 T 211 T 211 T 199 211 264 2-12 - A 2-12 - A 212 A 200 A 197 A 1 266 213 C 213 C 213 C 201 C 196 C 1 -0ý 214 A T14- - A -YI-4 - A -ff2- A 199 A 1 214 267 215 T 215 T 215 T 203 T 2DO T 215 268 16 3 -216 G 216 G 216 G -204- G 201 G GA, TI -7 G 217 G 217 G 205 G _202 G I 2V 270 -Ti-8 G 218 G 218 G 206 G 203 G 218 271 -T1-9 G -T1-9- G G -207- G 204 G -219 272 22-0- - C 220 - C -220 C 208 C 0, C 220 273 221 C 221 C 221 C 209 C 206 C 221 274 -T-- - _T22- G -fI 0- G 20-7- G 2222 G 22 G 75 223 G 223 G 223 G 211 G 208 M 276 224 C 224 C 224 C 212 C 2D9 C 224 277 -22-5- -A -22-5- -A -225 -A -T1 -3 -A -TIO- -A 278 IA'W M -G -226 -G -22-6- -G T1-4- -G 2-1 -1 -G 227 G 227 G M7 G 215 G 212 G 227 IMM 228 A ma -A MS -A -fl -6 A 2113 A 228 -281 229 G G 229 G 17 G 2 4 G 229 229 - 2- - M-2 230 C 230 C 230 C fi T C C 83 -231 -A -T31- -A -A I A 1 A 1 -401% M2 - A -232 A 232 A 220 A 2W I A 1 232 233 A M A 2n A 221 A 218 A 233 Q -nit - -234 -02 234 G G G G Mg -G 235 A 235 7- 2-35- -A 22-3- -A 72-0- A 235 - 23-6 -A 23-6- -A 2W -A 22-4 -A 221 A 89 -23-7 - T -T3-7 T 237 T M5- T 222 T 23-8 -C -Z3-8- -C -ff6- 223 C 2W 238 C C WZ' 291 239 T 239 T 239 T 227 T 224 292-2 & .... .. - - -T-0- - 2-- - G --- - -2f240 G 4 0 40 Z28 G 5 G 293 W."o, C Z29- -C -2ý 241 241 C 241 C C 241 242 A 242 A 242 A 230 A 227 A 242 'A 3- - -74-- G - G .- G 2-28 243 231 -24-4 --- 7 244 A 79- 297 244 A M2 A 22) 2" A`ý' G 245 G 233 298 245 245 a G G 01 'T OF wig 46 T 234 T 'j M TAW/f/I -246 -- T-- -T4- - -2 -299 i-O'D 247 G 247 247 G 235 G M G 247 248 T 248 T 248 T 236 T 2ý T 248 301 4 T 249 T -2W T -2-T7- -T ZU -T 302 2 0 G 25-0 -G -T50- -G -0-8 -G 23-5- G 2ý I T -T51- T -T5-1- T 23-9 T 2-36 -T I G T52- G -T5-2- G 240 G -ýZF -G M-6,,,, 2 C -2ý -C -253- -C -f4-1 -C -23-8 C 253 254 T 254 T 254 T 242 T 239 T 254 255 T T 243 T 240 T 2ý -A 2 25ý1 A 244 1ý1 x 256 26ý G 25 ý5 56 24-2 G T T 246 T 243 T 258 T 259 A 1 247 A 1 244 1 A 260 A 248 5 A 260 A 249 A K.I.dw KýI.dýe, C.11 Cell Ermtum Kolodner Kolo w Chape le # fil 11117193 fil 12(7/1993 pub 1ý9M pub.401994 fil 6/lWI994 fil, 6/5/95 fil. 12ý19 081154,792 0&163 449 081259310 OIV465,251 08116029 - SEQ -IDNO 8 SEQ -IDNO 8 - 5EQ ID NO 1 -SEQ -IDNO,8 - SEQ 10 NO -26-2 -T-- -Z6-2 -A -02 T5-0 -T4-7 --- A7- 26-2 ,ý, ' '\ 1 1 263 T T 248 2. > \0 263 T 251 T v,ý '-T,ý,Aa -26-4 G -264 -G -T6-4 G -f5-2- -G 249 G 317 265- -A -f6-5 -A M5 A -3- -A -TSO- A 265 'V, 318 26-6- A 266 A 266 A 254 A 25-1 - A -266 26-7- -T 26-7 T -267 T -05-5 T _T52- T -267 X6-8 -- 7-- --f6-8 -T 2-68- -T -256 --- r- 253- T 268 Rj 321 -T -T6-9 T 26-9- T -269 T -257- T -T -269 V-0 -T 1-77-0 IT -270 IT 1 ý58- T I-T5-5 IT 270 323 271 G L71 1 G 271 G 259 G 256 G 271 324 27ý A __ý72 A 260 2-72- A A 257 A 32 P-3- zfý I A -773- ý6- - -f58- -A , 326 A A 1 A A 11 "1 274 T 274 1 T 274 --- r- 26-2- 259 T 274 27 275 c 275 c 275 c 263 c C 27 -276 -T -276 -T -T7-6 T -T64- -T -f6-l T 2M, ",J"," K329% 277 T 277 T 27T -7- -265- --- r- -TS2- -T 2 30 278 T 278 T 278 T 266 T f6-3 T -278 3 1 j - -279 -T 27-9 T -f67- T -26-4- T 279 TI, 332 279 T M -G Z8-0 -G 2ý- --- 7- -T65- G -fs-o 280 G 281 - T 28-1- T 281 T 269 T 266 T -281 333 -33-4 M, 282 A 282 A 282 A 2T0- -A -T67- -A -282 A, 'W'-M-5 283 A 283 A 283 A 271 A 2681 A 283 336 A -fS4- -A -08-4 -A 2-84 A 272 A 269 A 284 285 A 28-5 -A -06-5 A 273 A _770- -A -285 -338 286 G 286 1 G 286 G 274 G 271 G 286 287 A 287 A 287 A 275 A 272 A 374-0 288 T 288 T 288 T -276 - T 273 T -U-1 M-9- -C -T89- -C -T89- -C -T77- -C -T74- c 289 _L42 Q 290 T 290 T 290 T 278 T 275 T 343 291 T 1 T 1 T f79 T 6 T I i -79-- - -T9-- -T7-- --T4-4 292 C -T92- c 292 c 280 c 277 c 292 1ý4 R-1, ,41C I 293 T 293 T 293 T 281 T 276 T 45 294 2-94- T -282 -T M -T 34]7111%%,&`ýý', 295 c 295 c 2951__qC__ f83 C --f-80- C 9 CW%%ýI% 348 96 T 296 T 296 284 T 1 281 1 T 296 349 2 7 G 2vt 291 T 1 228251211 U -29-7- 4ý -r5o 298 G 298 G 298 G 286 G 283 G 298 1ý 299 T 299 T 299 T 287 -T 284 T -299 352 3w T 70-0- -T -50-0 T -288 -T 28-5- T -ffo- Wr -S5-3- T 301 c Ml C -30-1 -C --f89- -C 286 c 301 354 302 G- 3ff -G 30-2 -G -ý9-0 -G -f8-7 -G 302 303 T 03 T 3-03 T -291- T -T -30 304 c 304 c 304 -C -292 -C _T89- -C 304 db/ Owl 305 A 305 A - A 293 A 290 A -305 358 306 G 306 G 306 G r G 294 - 291 G 306 359 T 307 T 307 T 295 T 292 T 307 308 A 308 A 308 A --:F96- -A -T93- -A -W8 -9 361 A% 309 T RO -T W9 T -29-7 T 2ý4 - T 30-9-9 aff al-o A 310 A 298 A 295 A 310 363 311 G 311 G 311 G 299 G 296 G 311- 364 312 A 312 A 312 A ýQO A 297 A -Yi 2 313 G -M -G -G -W-1- -G 2W G - 366 -3ý -T -fl-4- T 3-0-2 T 299 T 1 367 314 T - - 7-15 T -303 - T 30 T 315 315 T 315 T ,T 368 316 G 316 G 316 G - G 301 G 316 7--7r.7 31-7 - A 317 A 317 A 305 A 302 A ý17 A 318 1 A 71-8- -A 3-18- -A -3-0-6 -A 30-3- -A -S-1-8 1 A, 319 G 319 G 319 G 307 G -3w ý19 372 K-0 -T - -ý2- - -TO8- T 305 320 373 Mm 321 T 321 T 321 T 309 T 306 T 321 -374 32-2- 322 T 322 T ' 310 T 32 T 3-22- 375 _ý2 323 A 323 A 3 A 31, A ý0, A M 324 T 324 T 324 T T mg I T 325 A 325 --- 77- 325- -A -31-3 -A 310 325 378 326 A 326 A 328 A 314 A 311 A 326 327 G 327 G 327 G -Tl-5 G 312 G 621 380 328 A 328 A 328 A 316 A 313 A 328 381 329 A 329 A 329 A 317 A 314 A M -33Y -T 330 T 73-0- T -31-8 -T -3W T 330 331 331 A 331 A 319 A 316 A 331 384 X3-2 G 332 G 3-32- G 320 G 31-7 G -25-2 ' ' 6 ;Zy/ 333 A 333 A 333 A 321 A 318 A - -386 ý,A, 334 G 334 G 3ý4- -G -322 -G -31-9 G 3U 387 ý,G 335 c 335 c 33-5 - C -323 c 320 c 335 388 VC, 336 T 336 T 336 T -324 -T -ý32-1- - T 389 --ý37- -G 337 -G 33-7- -G M-5- G 322 1 G 390 337 90 338 G 336 G 33a G 326 G 323 G 3 190 3-9 339 -A -53-9 -A -T2-7 A 324 A U-0 A 1 340 1 - A -14-0- -3-28- A A 393 341 A 1 341 1 A 341 A 329 A A 3 394 U-2 - T 1 3421 T -34Y T -T3-0 T 327 1 T 3 -3-95 U3 31: 2ý8 A 396 ý344A ýA344 =7T= = -4 332 A 3ý 1 A 3" 39 Kolodner Kolodner I C.11 CV Ermtn I Kolodner _ Koldne5r+ _ Chapelle #1 94 iý71311994 fit /5ý SIF 1111-7193 - TI 1ý11993 1 pub 1 D9193 pub. 4 1 till fit IM1993 -Ta-/154792 . .... 03,ý4498 8/259,310 - - 08/4651251 _ OSM60295 SEQ ID NO a SEQ ID NO 8 1 SEQ ID NO 8 SEQ ID NO 1 - - - T -398-54-5 G J4ý I M G ,ý ýju', G 345 G 346 G 346 G 346 G 334 G 331 1 G 346 347 c 347 c 347 c M5 c 332 c 347 400 348 A 348 A 348 A ý6 A 3W -A 402 0 349 T 3-49 T 349 337 T 334 -350 - C __§5_0 c 3W c -335 -403 _,p, _El -c _ý557 c -C 3W C 1 ýfl' __04 a5_1 c 404 3ý -A 3_52 _ýPFO -A 33-7 A 352 352 A 405 ME 353 A 353 A 353 A 1 341 A X338- - A -406 75-4- G 3" G 354 EG 1 342 G ý33_9 _G -417 355 G 355 G 365 G 343 G 340 G M A 34-1 -A 356 A 356 A 356 A 344 A 10C 'If -41. 35- _G 357 G 357 GG -345 G -342 G V 1W b, 346_ 411 M-8 A 358 A 358 A A 3 358 412 359 A 359 A 359 A 347 359 360 T _ý5_9 -A A 344 ýA 4 3 _WD _T 360 T 348 T 5 361 G 361 G 361 G 349 G 34 t G 361 414 362 A 3U A 362 A 350 A 34 A 362 415 ýA -M-3 _T 36-3 _T 363 _T51 T P" 416 T T T &A 3ý __= ýW___444 364 352 T 349 T 364 T W-5 G 365 G 365 G 353 G 350 G 418 _M6 -_66- -41, 366 G 3 G 354 G 351 G 365 367 T 367 T 1 367 T 355 T 352 T 368 A 368 A 368 A 356 A 353 A A 421 70 7_69 T _T T _T57 _T _T54- T T 422 T -37C T 358 -T- m5- 37LO 4 3 T 369 371 3_5_9 71 371 T 371 T T T 358 T F 4 4 _37-2 G 372 G 372 G 360 G 35-77 _G 372 4 5 RG 372 T 374 C 3`9 _M3 G G 373 G 361 G 35-8 _G 373 4 6 374 C 374 c 362 c 3W - c 37 4 7 c 3-75- A 375 - A _37ý A 363 A 36-0 --- A---] 37EI 4 8 3m T 376 _T -376 T 364 T 361 T I 377 377 A 377 A 365 A 430 37-8 T 378 T 37 T 366 T 363 1 T 11 37 431 379 A 379 1 A 379 A 367 A 3ý A 3 380 A 380 A 380 A 368 A 365 A 380 "k." 433 381 _G 38-1 G 3_8_1 G -369 G 356 G wi 382 M-2 _ G _382 G 370 G 3:7 3382 435 pwý 383 c 383 c 371 383 436 6 _4 T _3 - 38--l I S A, 08 84 T 4 T 1 372 T 369 1 1 384 437 -- 7- 38-5 T 385 T 373 T 370 385 c 371 c 438 1 386 4319 386 c 386 c 374 c 316 78-- 38- - W7 - __d7_ Wo 372N T q387 01, :414 388 c _338 c 3m c 376 C 3-73- c 388 441 c 389 c 389 C 389 c 377 c 374 c 389 W90 T_ U-0 _T 3W T -378 T 375 T 390 - - - -57-9- _G -57-6 391 G 391 G 391 G 392 G 392 G 392 G 380 G 377 G 445 AM 99-3 c 393 c 393 c 381 c P-8 c 39_3 _ý94_ - A A 379 394 A 394 A 382 395 A 395 A 395 A 383 A 380 A 395 39-6 _T 3W T -396 T _W4 T _j8_1 T _jW6 T, _ýG_7 -C -39T -C 397 C 385 c 382 c 397 0 396 T 398 T 398 T 386 T 3 T 398 ;-,T, I 'T, c c 384 c 399 399 399 c 399 c 387 c 400 - -- 7- 4W T _41M _T 388 T 385 1 T 1 400 W 4oi 401 c 401 c 401 c 389 c 386 1 C 1 401 54ffý -TO-- - -4ff _T -402 T _ýqo T T 1 6 2 T 387 402 456 403 1 c 403 _;F03_ _ C 39_1_ c 388 c 403 456 404 3W - 3-- 457 404 A 404 A 2 A 89 A 404 M 'W o -40-5- G 1 4-05 JG _W5 G 393 G 39-0- _G 70-5- 45-8 I- 406 T 406 T 406 394 T 391 406 459 T 40-7 T -401 T -TOW 395 T V92 4W 460 70-8 __ T -Y93- -T -408- _"T III T 401 T 396 T 461 4" 40, -TO-9 G 397 G 394 4ff -A 777 TV 462 4101 A 410 398 A _396- -463 1 39V 1 0 -464 4_11 -A::- 11 411 A A 7-96- -A -412 _ G 412 G 1 400 1 U 397 G 412 465 'W" 98 A 4iý 413 1 4ni 413 A 466 A M3 414 T 414 T 414 T 402 T 399 T 414 T 467 c 415 A A A 5 OF 416 T 41611 416 T 404 1 1 1 41 6 1 9 'T"""o 4-17 417 T T 41 T 4 7 0 T T 417 4Ub 1 2fl -413 c 418 c 418 c 406 c 4031 c 418 471 419 T 419 T 419 T 407 T 404 T 419 472 pp T_ _T2_0 -C -C -c 40-8 c 4Ub C 2U [4q 3 72-1 _T 421 -T 1 _T 70-9- ___r_ 408 T 421 474 ffý, 407 T ý5,, :5 422 T 422 T T 10 7 - _411 T _4_R -423 T T T 476 -424 _G _G -- 7 6- 4-1-2- _G QW_ G 424 477 Z7 425 G 425 G 425 G 413 G 410 G 425 426 T 4 6 T T -414 T 0_1 T ___X- 4-1-5 _41-T A 0 0 Kolocner Kolocner Cell Cell Erratum Kolodne I K.I.dn., I Chape a fil 11117M fil 12011993 pub. IMM pýb. 4/811994 _ filL 611W1994 fil, &5/95 1 fil. 1201993 081154,792 081163.449 OMS9.310 1 1 08/160295 SEQ ID NO 8 SEQ ID NO.8 SEQ ID NO I SBQ-lD NO,8 SEG ID NO 1 428 A 428 A 428 A 416 A 413 A 428 'r mw A,ý, 429 C -429 -C 429 C 417 C 71-4 -C -429 482 rl,,6W, 430 A Z3-0 -A 43-0 A 4-18 --- T- -41-5 A 483 431 A 431 A 431 A 419 A 416 A IS 484 -AA- T 432 T 432 -T 420 T 417 T M R85 4W -G 733- -- =- -421 G 418 G - 433 486 434 A 434 A 434 A 422 A 419 -48-7 1435 T 435 T 435 T -423 -T-- -42-0 T -T8-8 436 A 1 436 1 A 436 A 424 A 421 1 A 489 437 T 437 T 425 T 422 1 437 T T 438 G 438 a 438 G 426 G 423 439 T 739 --- 7- -4W T 427 T 424 T 492 440 C 440 C 440 C 428 C 42 C -493 '4 441 A 441 A 441 A 429 A 425 A 1 442 G 442 G 442 G 430 G 427 G 443 C 443 C 443 C 431 C 428 C T 432 T T "S 444 T 444 T 444 497 -T45- -"5- 433 T 430 445 498 445 T 7- T , eý,T 446 C 446 c 446 C 434 C 431 C 447 C 447 C 447 C 435 c 432 C b ý,,,t"?x -goo 448 A 448 A 448 A 436 A 4133 A 448 501 A 449 T 449 T 449 T 437 T 434 T 49 450 T 450 T 450 T 438 T 435 T -45-0 451 G 451 G 451 G 439 G 4T6- --- = 451 '43 504 452 G 452 G 452 G 440 G ý7 G -452 555 453 T 453 T 453 T "i T 438 T 453 ým 506 454 G 454 G 454 G 442 G 439 454 ,Q, 507 455 T 455 T 455 T 443 T 440 T 'T 50-8 456 T 456 T 456 T 444 T 441 T VEMEN -6-09 457 G 457 G 457 G 445 G 442 457 V G 456 T 458 T 459- T 446 T 443 T 511 59 G 459 G 459 G 447 G 444 G 459 S ir 460 G 460 G 460 G 448 G 445 G 460 513 461 G 461 1 G 461 G 449 G ý446 IS 461 -51-4 462 T 462 T 462 T 450 T 7 T 462 T- 515 -463 -G 463 -G 463 -G -G 4W G 463 516 x 464 T 464 T 4" T 452 T 449 T 464 517 465 T 465 T 465 T 453 T 450 T 465 -ýl 8 466 A 466 A 466 A 454 A 451 A 466 519 467 A 467 A 467 A 455 A 4u --AT- -52-0 468 A 468 A 468 A 456 A 453 521 469 A 469 A 469 A 457 A -;f64 522 470 T 470 T 470 T 458 T 465 T 471 G 471 G 471 G 459 G 456 G 1 S24 472 T 472 T 472 T 460 T 457 T 472 525 473 C 473 c 473 c 461 C 458 C 626 474 C 474 1 C 474 c 462 C 459 C 474 ý52ff --ýPff -= 476 G 475 G 453 G 460 476 C 476 C 476 c 464 c 461 C 52-1 "c"', -TB-- Aý -53o 477 A 477 A 477 A 465 A 56-2 A 477 4 7-8 47-8 G 466 G 463 G 478 4 531 479 T 479 T 479 T 467 T 464 T 479 ýT...... 532 480 T 480 T 480 T 468 T 465 1 T I T -,, - 533 481 G 481 G 481 G 469 G 466 G 481 Q,ý 482 A 482 A 482 A 470 A 467 482 483 T 483 T 483 T 471 T 468 .. . 535 J, 484 G 464 4 G 472 G 469 G 484 P,,ý 537 ý ýq 485 G 485 G 485 G 473 G 470 G w ri -638 \\\,Nwe - 47- - ý, M 486 C 486 C 486 C 474 C 1 C 70 ý"ký'k 487 C 487 C 487 'r- 47-5 - C 77-2- c 48 40 488 A 488 A 488 A 476 A 473 A -641 0 489 G 489 G 489 G 477 G 474 G 542 490 A 490 A 490 A 478 A 475 A 490 543 X"' 491 G 491 G 491 G 479 G 476 G 491 544 492 A 492 A 492 A 480 A 477 --,T- 545 -493 -C -493 --- 7- -49-3 c 481 C 478 "o 494 A 494 A 494 A 482 A 479 A -647 A 495 G 495 G 495 G 483 G 480 G 495 548 496 G 496 G 496 G 484 G 481 G 496 549 497 T 497 T 497 T 485 T ZV8-2 T 550 498 T 498 T 498 T 486 T ----- TTTTT -95-1 T 499 G 499 G 499 G 487 G 484 G 500 G 500 G Soo G 4sa G 485 G 501 A 501 A 501 A 489 A 486 A 501 A,11, 502 G -5-02- --- '= -50-2 G 490 G .1 1 buz 503 T 503 T 503 T 491 T 488 T 503 *00 504 T 504 T 504 T 492 T 489 T 504 556 557 505 G 505 G 505 G 493 G 490 G 506 G 506 G 506 G 494 G 491 M59 =1 -4 492 G 507 G 7-07 G !:ZF 508 1 T bad I T 4 5 8 561 509 1 A 509 A we I A 1 4 494 A 56-2 510 1 T 510 1 blu I T -61-3 0 0 Kolodner Kolodne, C.11-ErmWm K.I.dn.r I Koiýner P. fil 11117193 fa, 12IT/1993 pub, 1219193 pub, ý811994 fil, 6/13/1994 fil. 615/95 fil 1ý1993 081154792 OW163449 M 59.310 1 081465.251 081160295 SEQ ID NO 8 SEQ 0 NO 8 10 NU I I SLU IU NU:d btu lu NOA 11 G 11 -T I i G 499 G 496 G 6 564 71 512 T 512 T 512 T 5w T 12 565 5 1 7 513 G -513- G 1 G 501 G 49 :5W13 - 6 10-1 51 3 5 3 1 4 5 4 q14-,/" Y, 567 M G ,ýg 5 G 4 G 1 502 G G 15 E4 I I ;q [5515 A 516 A 515 A 503 A bw A /ý,p 5 516 -5-6-9 5 504 T 501 T 516 51 6 5 5 6 1 7 5 7 T 502 T 517 1 8 c -618 T 7 T i `W 571 c 518 518 c 606 c 503 C 519 c 5191 c 619 1 c 507 c 504 c -519- 572 520 A 520 1 A 520 1 A 508 A 505 520 521 T 521 1 T 521 1 T 509 T 506 T 521 757- "N' 522 A 522 A 522 A 510 A ýýN A 523 c 523 C -923 c 5-11 - C 90-8 c 523 524 A 524 A 524 A 512 A 60--99- A 577 525 G 525 G 525 G 513 G 510 578 526 A 526 A -626 A 514 -611 A 526 579 527 G 527 G 527 G 515 G 512 G 527 528 G -32-8 G -628 G -9-16 G 513 G 581 529 A 529 A -529 A 5171 A 514 A 529 582 530 A 530 A 530 A 5181 A 515 583 531 A 531 A 531 A 519 A 5161 A 531 -684 532 c 532 c 532 C 520 c 517 c 532 533 T 533 T 533 T 521 T 518 T 533 A 534 A -62-2 - A -6-1-9 -ýSu ý,, ý'1'111, 5u A 534 934 A - 52 -G 535 G 535 G 5351 G 3 G 536 G 536 G 536 1 G 524 G G 589 537 A [537 A 537 A 525 A 522 A 590 538 c 538 c c 526 c 523 c 538 539 T 539 T 539 T 527 T 524 T 539 92 ýN' 540 G 540 G 540 G 528 G 525 GG -941 T 541 T 541 T 529 T 526 T S41 0 4 542 G 542 G 542 G 530 G 527 G 5 5 543 1 T 543 T 543 T 531 T 528 T 543 544 G 544 G 544 G 532 G 529 G 544 545 A 545 A 645 A 533 A A 545 646 546 A 546 -934 - A 7- -532 ---- 7-- 547 547 T 547 T 547 T 600 548 T 548 T 548 T 536 T 533 T 5 . .. .I 549 c 549 c 549 1 c 537 c 534 c 5ý49 550 c 550 c 550 1 538 c 535 c 551 c 551 c 551 c 539 c 536 c 1 604 V` 552 T 552 T 552 T 540 T 537 T 552 HO5-Z \f 553 G 553 G 553 G 541 G 538 G 553 554 A 554 A 554 A 542 A 539 A 607 1,Izz 555 T 555 T 555 T 543 T b4U T 556 A 556 A 556 A 544 A 541 A 556 557 A 557 A 557 A 545 A 542 TA ..... A 558 T 558 T 558 T 546 T 543 T 11 1 1 -6]5_9 -669 G 559 G 547 G 544 G 559 ,,"1 612 560 A 560 A 560 A 548 A 545 A 561 T 561 T 561 T 549 T 546 1 562 c 562 c 562 c 550 c c 815 563 A 563 A 563 A 551 A 548 A A -616 564 G 564 G 564 G 552 G 549 G 17 565 T 565 T 565 T 553 T 550 566 T 566 T 566 T 554 T 551 1 T 567 c 567 c 567 c 555 c 552 c T T 553 568 T 568 556 569 c 569 c 569 c 557 c 554 M9 570 c 570 c 570 c 558 c 555 c 570 m 571 A 571 A 571 A 559 A 556 624 5-- -625 572 A 572 A 572 A 560 A !T57 A 573 T 573 T 573 T 561 T - -ý66ý8 T -62-6 5-- 627 574 c 574 c 574 0 562 c 59 C 575 T 676 T 575 T 563 T 560 T 628 576 T 576 T 576 1 T 564 T W1 T 629 577 G 577 G 577 1 G 565 G 562 G 577 630 G 578 A 578 A 578 1 A 566 A 563 A 578 -63-1 579 G 579 G 579 G 567 G 564 G 532 633 Ir ,,G 80 G 580 G 580 G 568 G 565 G 5 1 c 581 c Sal c 569 c 566 c 1 634 2 T 582 T 562 T 570 T 567 T --188-02 -635 -683 - C -683 c 571 568 636 583 c c 583 T T 569 T -684 637 584 T 584 T 584 572 ýmm 585 c 585 c 585 c 573 c 570 c 63-8 586 c 586 c 586 c -674 - C -971 -639 587 T 587 T 587 T 575 T 572 T -587 640 R, 588 c 586 c 588 c 576 c 573 c 588 641 -989 A 589 A 577 A 1 5 4 A 589 ýA 642 590 T 590 T 590 T 578 T 575 590 591 c 591 c 591 c 711 576 c 591 644 -692 =92 u F55 577 c 592 645 59 -993 býJ JF77377ý1 3:11 A A AW Kotodnw Kolodner ce" Cell Ecratum Kolodner Ko odner -epe e NL11117M fil 1ý/1993 pub. 1219/93 _ pub, 4/8/1994 fil. 6113/1994 fil W5195 fil 1201993 081154.792 ON163,449 OM59,31 0 UbMý,ZW 08/160295 SEQ ID NO.8 SEQ ID NO 8 SEQ ID NO 1 SEQ ID NO 8 SEQ 0 NCA 594 G 594 G 594 G 582 G 579 G 594 595 A 595 A 99-5 A 58-3- --- r- 580 A 5ý 80 596 T 596 T 596 T 584 T 581 T 596 597 T 597 T 597 T 585 T 582 T 6ý 598 G 5-9-8 --- = -598 - G 586 G 583 G 598 ... ..... 4471 651 1 599 G 599 G 599 G W G M4 a 599 ý52 A A ý5 600 A 600 A wo 588 --65-3 ao-1 60, C 589 C ý6 C 601 654 601 C 6-55602 1 590 c M7 C 2 602 C 602 c C 603 A 603 A 603 A 591 A 588 A --T656 604 A 604 A 604 1 A 592 A 589 T- 604 657 605 A 605 A $05 A 593 A 590 A ý5 658 606 G 606 G 606 G 594 G 591 1 G -95--99 607 G G 60T G 595 G 592 G 608 A 608 A 608 59-3 A 609 A 609 A 609 A 597 A 594 A 609 610 T i -8il-o- -998 -ý95- T 610 ýuj 1: 611 G 611 G 611 G 599 G 596 G 11 664 I T 612 T 612 T 6M T 597 T 612 665 61 3 G 613 G 613 G 601 G 598 G i 614 T 614 T 614 T 602 T 599 614 667 'o ýwmw 615 T 615 T 615 T 603 T 6W 615 668 rA 77= -616 T 616 1 T -616 -- le- ON T 7ow -- 7- 616 6- 4, 617 T 617 T 617 T 605 T 602 T 1 70 618 A 618 A 618 A 606 A 1 603 A 618 ýq 672 \\\g 619 C 619 c 619 1 r 607 C 604 C 619 y 7 0 620 C ýo c 620 C 608 C 605 C 621 621 C C 6 8 C UNIME, 621 C c 609 -621 1 w 622 G -622 G 622 G 610 G 607 G 6m t,"'k ý 6fb 623 G 623 G 623 G 611 G G -676 fl if, 624 A 624 A U4 A 612 A - A 72-4 Al"'Al -677 625 G -625 G 62 G 613 G 610 G 625 -,G n M 626 G 626 G 626 G 614 G 611 G 626 679 627 A 627 627 A 615 A 612 A 627 680 M,ý,: A'42 628 G 628 G 628 G 616 G 613 G 629 A 829 A 629 A 617 A 614 A 682 630 G 630 G 630 G 618 G 615 G 630 631 A 631 --- T- 63-1 -- 7- 619 A 616 68 ý40 632 C 632 C 632 C 620 C (ýlff c 633 T 6n T 633 T 621 T 616 T 7N 634 G 6U G 634 G 622 G 619 G ý4 6w 635 C 6ý C 635 C 623 C 620 C --T21- T 636 T 636 T 636 T 624 T 637 G 637 G 637 G 625 G 622 G 63 638 G 638 G 638 G 626 G 623 G 638 691 639 A 639 A 639 A 627 A 624 A 639 640 1 G 640 G 640 G 628 G 625 641 A 641 A 641 A 629 A 626 A 1 694 642 C 642 C 642 c 630 C 627 C 643 A 643 A 6431 A 631 A 628 A 69 644 T 644 T 644 T 632 T 629 T 6-97 645 G 645 G 645 G 633 G 630 G 45 -- 698 "1 646 G 646 G 646 G 634 G 631 699 647 G 647 G U7 G 635 G 632 G 147 wo 648 G 648 G 648 G 636 G 633 G W -64-9 ---- T- 649 --- 7- 64-9 A 637 A 634 1 A 649 'A 01 -,Gýw 0 650 A 650 A ýo A 08 A 635 A -703 A`ý' 'k', -704 , , A x 651 A 651 A 651 A 639 A 636 652 C 652 C 652 C uo C 637 C 652 705 653 T 653 T 653 T 641 T 638 T 6 706 654 G 654 G 654 G 642 G 639 G 6 43 5 707 655 A 655 A 655 A 643 A EF40 A 708 A' 656 G 656 G 656 G 644 G 6411111 G n09 'ýW, 0 710 657 A 657 A 657 A 645 A 642 A 658 C 658 C 658 1 C 646 C 643 -712 659 A 659 A 659 A 847 A 644 A 660 G 6w G 660 G 648 G 645 G 713 661 A 661 A 661 A 649 A 646 A 661 71 15 662 T 662 T 6U T 650 T 847 T 7 663 A 663 A 663 A 651 A 648 A 716 664 A 664 A 664 A 652 A 049 A 664 665 T 665 T 665 T 653 T 6M T 66 718 666 T 666 T 666 T 654 T 651 T """R I 720 ý,,777 667 C 667 c 667 c 655 C 652 C T 667 668 A 668 A 668 A 656 A 653 A 6w 721 ,,,ý,,A 669 A 669 A 669 A 657 A -ý65ý4 -A 722 W&4 670 A --670 A - A A 655 A b/U AAMM 723 A 671 G 6 1 G 671 G 659 g G 656 G 671 672 A 672 A 672 A 660 A -65-7 - A 725 -7-2-6 6T-7-3 G 673 G 7' 1 6111 G 658 G 727 674 1 G 674 G i býz 1 u 659 G 675 A -728 I T7-61 G 1 676 1 G 1 676 1 G 1 664 1 u Ubi u blt 29 M - 0 0 K.I.d. Koloolner C.11 Cel Effaturn Koloomer Ko. ý.r a ele# ML 11117/93 fil 1WI1993 pub, 12/9M pub. 41611994 fil, 611 Wl 994 fit 615195 fil. 1201993 0&154.792 08/183,449 08/259,310 Oal465,251 - 081160295 SEQ ID NO,8 SEQ ID NO:8 SEQ ID NO I SEQ ID NO 8 SEQ ID NOA 677 G 677 G 677 G 665 G G 677 G 730 W VON 6 678 A 678 A 678 A 666 A 663 A 6 6 679 A 67-9- -A -679 -A 66-7- A 664 A 679 >,,; r 6 5 -73-3 680 T 680 T 680 T 668 T 65 T 680 8 T 681 T -06-6 T 681 [681 T 681 T 669 734 666 669 -6 6, - - - -682- -C -9-7-0- -C 66-7 c 682 c 682 '8 -T3-66, 683 7 682 83 T 683 T 683 T 671 T 8 T 6 670 669 684 6, -7T3--------77777777 "2 84 G 684 G 684 G 672 G - G [6 3 685 1 A 685 1 A 685 A _V-3- A 670 A 685 738; 6 686 T 686 T 666 T 1 674 T 1 T 686 73 T C 6 68T C 687 687 c 675 c 672 C 4 A 7 8 c ' 688 A 688 A 688 -67-6 - A A 68 A 67, 689 c 689 c 689 c 677 c 674 c C 674 689 690 A 690 A 690 A 678 A 675 A 90 .. 6 _0 691 G 691 G 691 G 679 G 676 G 691 VG 67' 692 A 692 A 692 A 680 A 677 A k 745 693 A 693 A 693 A M A 678 A 693 746 AN A 679 A 694 694 A 694 A 694 A ý2 695 G 695 G 695 G 683 G 680 G :4 ..... G 696 A 696 A 696 A 684 A 68111111 A A 697 A 69-7 A 685 A 682 1 A 697 750 IýV A, 698 A 698 A 898 A 686 A 683 1 A 1 98 751 699 A 699 A 699 A 687 A 684 A -752 k0o , IS 700 A -TW- -700 -A 6W A 685 701 A 701 A 701 A 689 A 686 A 701 75 702 A 702 A 702 A 6W A 687 A 702 703 G 703 1 G 703 G 1 691 G 688 G 0 704 c 704 c 704 0 692 c 689 G 757 705 T 705 T 705 T 693 T 60 T 705 758 770-6 -G -706 G 706 G 694 G 691 G 707 A 707 A 707 A 695 A 692 A 60 708 c 706 c 708 c 696 c 693 c 76-1 709 T 709 T 709 T 697 T 694 T 709 T 762 ýT 710 T 710 T 710 T 698 T 695 T 710 T, j T 1 711 T, -T64711 T 711 T 711 T 699 T 696 T .. \\\\ 712 T 712 T 712 T 700 T 697 712 t 713 c 713 c 713 c 701 c 698 c -766 714 c 714 c 714 c 702 c 699 c 1 767 715 A -715 A 703 A 7W - A 715 A- 758 716 c 716 c 716 c 704 c 701 c 716 769 717 A 717 A 717 A 705 A 702 A 71T 718 A 718 A 718 A 706 A 703 A 718 771 719 A 719 A 719 A 707 A 704 A T, 9 MR, 7-72 720 A 720 A 720 A 7M A 7M A TM-000 773 721 G 721 G 21 G 709 G 774 7-22- -7755 -775 722 A 722 A 722 A 710 A 707 A M ffw l T76723 723 723 711 70 G 723 724 A 724 A 724 A 712 A 709 A 725 T 725 T 725 T 713 T 710 T -725 77-8 725 T 726 T 726 T 714 T 711 -72-6 779 -727 --- r- -T2-7 --- r- 7-27- 7-15 1 727 rný,ý T 780 728 A 728 A 728 A 716 A 713 A - 8 ffi/; X'M -7 T 729 T 729 81 T -Yff T 714 T -729 729 T 782 730 c 730 c 730 c 718 c 15 C 730 C 78 731 A 731 A 731 A 719 A 716 1 A 1 731 A 'Z 7 732 G 732 G 732 G 720 G 717 G T3-2 0 78 733 G 733 G 733 G 721 G 718 G 7-33 fob wg/g 'o ut; 734 A 734 A 734 A 722 A 719 A 734 ý\1 787 735 1 c 735 c 735 c 723 1 c 720 c -T3-5 " M71bl 736 1 c 736 c 736 c 724 c 721 c 736 789 -'-V 737 T 737 T 737 T 725 T 722 T 70 X, 738 c 738 c 738 c -726 c 723 c M791.' CIA , 739 A 739 A 739 72T -- = - -72-4 792 ýS 740 A 740 A 740 A 728 A 7T-2-5- - A 793 741 c 741 c 741 c 729 c 726 c 0 1 M794 55"", 742 c 742 c 742 c c 727 c 742 W ý\ G 743 G 743 G 743 G 731 G 728 G 796 744 G 744 G 744 G 732 G 729 1 G I Jq -745 --- r- 745 1 T 745 7- 7-33- - T 730 T 745 798 746 T 746 1 T 746 T 734 T T 746 79 J"'4" 747 G 747 G 747 G 736 G 732 G 748 T 748 T 748 733 748 ýP,' T 801 gj 749 T 749 T 749 T 737 T 734 T_ 749 802* 0' ' 'T 750 G 750 G 750 G 738 G 735 G 750 11 103 GOP,` 751 A 751 A 751 A 739 A 736 A 751 &ýý 804 1ý,\ 752 A 752 A 752 A 740 A 737 A 752 @IMIM 805 753 A 753 A 753 A 741 A 738 A 753 806 754 G G 4 42 G 739 G 754 807 755 G 755 G 755 G 7ý G 740 G 755 808 756 c 756 c 756 c 744 c 741 c 757 A A A A 810 ',,A 758 A 758 A 758 1 746 A i A to 8il 759 A 759 A 759 Aý 14, 1 A F81 +2!kW1AA Kolhdýe, K.I.dw Cell Cell F"tum Kýlbdne, K.I.dý.r Chapelle #1 fil 11/17193 filL 1ý/1993 ýb, 1M/93 pub 4/8/1994 fl 611W1994 fil. 615195 ML 1ý1993 081154792 081163,449 OM59,31 a 081465,251 08/160295 SEQ ID NO 8 SEQ 10 NOS SEQ ID NOI SEG ID NO 8 SEQ ID NO 1 760 A 760 A 760 A 748 A 748 7-45 --- T- -T6-0 '13 761 A 761 A 761 A 749 A 746 A 761 -614- A 762 G 762 G 762 G 750 G 747 G 762 M 763 G 763 G 763 G4 751 G 748 INN 816 V, NN 764 G 764 G 764 G 752 G 749 G 764 .17 F/F/F/F/F/F/F/W-A 765 A 765 A 765 A 753 A 765 -754 -G 766 01 819 766 G 766 G 766 G "1 11 ' A 755 A 762 A ýgffi - A, 767 A 767 A 767 767 -62,, 768 G 768 G 768 G 766 .151 753 G -r6T -621 769 c 769 c 769 c 757 c 754 c 769 822 770 A 770 A 770 A 758 A 7-55- - A 7-70- M 823 A 771 G 771 G 771 G 759 G 756 G I G - 77T -EF2--4 772 A 772 A 772 -- 77- 760 A 757 A 772 825 773 7 773 T 773 T 761 T 758 T 73 82-1 7- 774 G 774 G 774 G 762 G 759 G 7774 K2-7 775 A 775 A 775 -- 7- 7-63- - A 760 A 775 828 'A - 7-7- _8 776 A 776 A 776 A 764 A 761 A 6 32:9:fZ"'\I` 777 T 777 T .. _777- --- T-- -T6-5- - T 762 T -77-7 830 778 A 778 A 778 -76-6 A 763 A 778 ýAýk'VMW 831 -1/1, A 779 G 779 G 779 G 767 G 764 G -779 632 r 780 T 780 T 780 T 768 T 765 T -780 781 G -W ---- = -78-1 G 769 G 766 G -781 77777 834 782 c 782 c 782 c ýo c 767 -T- 77URNp c 82 'C -635 C 'M 783 T 783 T 783 T 771 T 768 783 tMME M 784 G 784 1 G 784 g G 772 G TI, P' - M -G -784 G 837 G 785 T 785 T 785 T 773 T 770 T 786 A 786 A 786 A 774 A 771 A A 839 A,",,' T 787 T 787 T --- 7- 77-2 T 787 T 788 T 788 T 788 T 776 T 773 T 88 T 789 G 789 G 789 G 777 G 774 G -7w 842 - - - 7-- C -778 c 775 c 70 843 790 c 790 C 90 c 791 c 791 c 791 c 779 c 776 c -ý-91- &g am, -2 %//,"ýc 8414 FOR C A 780 1 A 777 A 'R 792 1 A 792 A 792 1 79 845 . .... A 793 1 G 793 G 793 G 781 1 G 776 G 846 794 A 794 A 794 A 782 A 779 A -84-7 A 795 A 795 A 795 A 783 A A -7ýTM-T- -F4-1 796 A 7W -A _79-6 A M-4 -A T8-1 A 796 849 797 T 797 T 797 T 785 T 782 T 797 798 G -7W G -79-8 KG -786 G 783 G - Ki" 1 7w G 799 G 799 G -T8-7 G -ý78U -G AA 852 Boo A 0 A >0 A 788 A 785 A --85-3 - -60- If 801 G --610-1 G 7§0_1 -95G 789 G 786 -90-2 A 802 A -602 70 A 7M-87- 855 ~ OVII 803 A 803 A 803 A 791 A 78S A 803 -656 804 T 804 1 T 1 804 T 792 T 789 T -9-5-7 C W-8 C, 805 c 805 c 1 805 c 793 c 790 c 806. A 806 A 8061 A 794 A 791 859 ý*r gg 807 G 807 G 807 G 795 G 792 G 807 -g-6-0 INN, M ; -3W -G -G -808 -- T- -79-6 -G -793 851 809 T 80-9 T 80-9 T 797 T 794 T 809 862 810 T -61-0 T 8-1-0 -T -79-8 T 795 T 1 3 -811- --- 7- 8-1 -1 -G -611 G 799 G TV9-6- -G 11 854 812 c 812 c 812 c Boo c 797 c 1 8m 813 A 813 A 813 A 801 A -ý79W -A 1 N86 814 G 814 G 814 G 802 - G -79-9 G 814 667 N 815 T 815 T 815 T 803 T 8W T 8 5 868 816 T 816 T 1 86-9 -9-16 T 804 T 801 T 8 6 A\WN 817 T 817 T 817 T 805 T 802 8 816 c 818 c 818 c 806 c 803 c % -671 yd 819 A 819 A 1 19 - A -FO-7- A 804 A 1 -9-72 820 T 820 T 820 T 808 - T -aw -- T 820 873 821 c R2-1 -C - c w-9 c 806 c 1 -U-4 822 A 522 A 822 A 810 A 807 A 823 c 823 c 823 - C -ýDa- c 823 824 T 824 T 824 T 812 T 809 T 625 6 825 G 825 G 813 G 810 G 825 878 826 T 826 T K6 -- T- 814 T 811 B79 827 c 827 c 827 c 816 c 812 c 827 828 T 880 -928 T -W2-8- T 81-6- T 813 T 1 829 G 829 G 829 G 817 G 814 G 8291 882 830 c 830 c 830 c 818 c 815 C; 3 831 G 831 G 331 G 819 G 816 G M4 832 G 832 G 832 G uo- G 817 G 832 885 833 T 833 T 833 T 821 T 818 T T 834 A 834 A 834 A 822 A 819 A -987- A 835 A 835 A "635 A -623 -82-0 835 888 A 837 c 837 c 825 c an c 90 36 836 T 836 T 836 T 824 T 821 T L 838 A 838 A 838 A 826 A 623 839 A 839 A 839 R g A 827 A 824 A 892 k , 'M 840 G 840 G 840 G 828 G 1 825 G 140 R-9-3 a W --- 7- 84-1 T 841 T -U-9 1 T 12,1 T 11 841 842 T 842 T 84 1 . - . I Kolodner Kolodner I Coll Cell Eýtum I Kolodner Kolodner ha el e #1 fil, 11/17193 fil. 12M1993 pub, 1219M pub. 418/1994 fl, 6113/1994 fil. 615/95 flLI IM-1993 081154792 081163 449 QW259,310 465.251 OW160295 SeQ ID NO 8 EQ ID NO 8 SEQ HD NO:1 SeQ ID NO:8 SEQ ID NO 1 -6-43- T -843-1 -343- --- Y- -991- -T EW -T --Mý4VY -ý4-4 -- T-- 64-4 -- T-- -8ý4-4 -- T'- -952- -- r-- 62-9 T U4 897 5 -gZ5- -T --P-5- -T M-5 T 833 T 830 T 898 C46 -A -W5 -A -946- -A -TM- -A -T3-1 -A E46 99 "."'Alm" 84-7 -G -F4-7- --- = -84-7- -G EM5- -G -6]3_2 G U - A, -94-8 A 836 A 833 A 848 001 !P9 -A -V49- -A -849 -A K-7 -A 8.14 - A 49 2 -6-50- -C --65-0 -950- -=- -9T8- -C -835- -C 850 f; 903 -85-1 - - -wi T 851 T 839 T 836 B 2 1 C 1 52 -992 840 C SW - C -W2 ýQff, 904 k653 T T 853 ao- - T -eas - T - -3 T" T -ý5 'I "I 54t _:::I -9-5-4 -T EWT -T 8a-9 T -854 T 854 855 A ass A -65-5 - 0, -ý25 - A -8-4-0 A 655 6b6 - T- 856 8W - T-- -84-4 841 T 656 T"- 909 -155-7 -C 8-57 ---- iý-- - -C -C 8-42 - Z"ýýA/ C 857 C 657 10 -ý5- - -856- -k -U-6 -A -84T -A A, 8 911 8759- -G -ý59- -G -859- -G -947- -G -844 G 859 912 AM -A -6-60- -A M-0 -A -6-48- -A -g-45- -A 860 9 -7 -661 1 -ffl- -17- 70 -T -646- -T 914 862- G -56-2 - G 862 G 850 -7- -64-7 - G 862 915 -816-0 A 863 A - A -85-1 A 845 A 3 916 664 T __664 ___T_ _6 . ... T_ --- T 64 652 T 84 T 8 4 17 -aiJ-5 - T -665- --- r- -865- T 353 -T 850 T 865 918 866 C 866 C 866 C 854 C _MT - C 919 -867- -C -85E- -C -857 -C 867 C 67 C 8 7 920 868 A $68 A 3158- -Mý - A -6-53 A 921 X, -8-6-9 - A -a69- ý A 869 A 857 A 854 A 8 87-0 -C a7-0- -C 70- -C -ýW -C 6-56 C -9-23 871 -tP-l T 871 T 65-9 --- T- -W5-6 T 871 924 -97-2 T -67-2 T 872 T 66-0 -T --45--7 -T 872 925 61-3 -- T--- -157-3- T 77-3 741- -T -65-8 -T 873 926 -97-4 -G -67-4 G 874 G 862 -65-9 -G -875 G -1375- - G 875 - G -863- G 860 G 875 618 8-76- A, -P-6- -A 676 -A A 6151 1 A 8 6 929 -87-7 - C -67-7 C 3-7-7 C 865 C i C 877 930 -87-B -ý7-8 -A [878 -A -866- -A 60 A 878 1 S-79- G -87-9 -G 879 -G 86-7 604 111 U U/ 880 T So 1ý 88-0 868 0 33 881 *T4 kZ91 ý -T 881 -T WM- -- TT-- §8:1 T 551 9ý -- 92-- 882 _ a 77-0 88 1 8 2 935 -aa-3 m U- T 883 - G -871- 86 G 883 ký'% 8 ' , ,q 935 A 884 A 4 A 872 A 669 \Ng"'APP ý - 7 A, 985- A-- "85 J- A -9M- -A _T73- -A 9-7-0 -A 8 5 ýj 9M ANNE;@ 886 886 886 % 93 C C - -- = -97-4 C 871 C 886 -F87- -T 887 T -887- -T -T P-2 -T 94 -68-8 -G Ba G -88-B- -G -876- -G -873- G I'll 4 88-9 - A 889 A -88!D- -- %-- -97-7- - A -874- -- 7-- 88 A7,,A 942 89-0 -0 ago C -89-0- -C -97-8- -C -875 1 C a 943 ...... -691 -T 91 T -T -67-9 -T -67-6 -T 1 944 89 8-- -A -W- -A -877- A, 22:ý A 892 A 92 892 945 893 c -893- -C; -9-81 -C -876- -C 893 946 894 1 T 894 T -694- -892- - T -b-79- - 7 Z 4 947 895 T 895 T BR5- T 883 T 88-0 1 T 895 948 896 T 896 T -696- -T 8-84 T 881 MM T 896 949 M KIM W7 -T 97 T -89-7 --- Y- 8T5 -T -69ý 1-!-- 8 7 950 89-8 G 898 G 898 G 886 -G 883 Q g5i 899 A -869- - A A A 8A A 899 952 96T -C sw -c -9w -G; a8a -C -a-BF 9 0 -go,- - T --- ,r- -90-1 899- --- r- -6-86- 954 --60-2 -T -CO2- -T -90-2 -T 890 -T -68-7- -T -ý5-5 -ýý-03- C -ýoa- -C -ff3- -C agi -C -8-84ý- C _g5_6 -90-4 -A -90-4 -A -904- 892 -A 889 A 90 905 -G-- -5-0-5 -G -90-5 -G 893 -G -M-0- -C; 905 95-1 90-6 -C -g-06- -C -C 894 -C -897 9 6 --65-9 9-07- -C -aUf -C -9-07- -C -C -99-2- 907 960 czz- 908 A- -9-08- -A -908- -A -A -993- -A 908 -§6_1 A z -965- G -J-0V -G -W9 -G -G -TD-A G -gay §i-o T lo T 910 T T allý! Tj --96-3 Ttt -vi 1- - A 911 A 11 'g A 89 A 91 WIT -T -ýTY -T --ýý1-2 T 900 -T 897 1 T -PaS -A 51-3 A 913 -A 901 B A 913 -ý-14- - T -ýl I- - T -914- - T -962- - T 899 T 91 -667- Týý,' -9-1-5- -G -9-1 -TI -5 G -953- -G W -G 1 --66-8 -A 916- -A 916 -A 9-0-4 -A -g01- A 916 -al-7 -A -ýl 7- -A -§'l 7- -A 905- -A 90-2 -A 917 J70 969 WB- - We A 71 - T -919 T --- r- -§T7- - T 904 T 919 1ý "T . ...... 920 T 920 -T- 75-20- T -§018- - T -966- T -ffl- -G 92-1 G 22' G §59 -G a G I -9-22- G 1 922 1 G 1 '22 1 U 9101 G 7 G 922 92-3 A- fl- A 1 A gob A 9 3 -9-P 1 IR224 T 9223Z T 1 T 9 4 9ýý ýb I A 1 u2b 1 A 1 913 1 A 1 91u A 92 0 fodneý Cell Eýtmm Kolodne o c ner Chep.lle #1 ill, 11117193 fil. 12MI993 pub, 1ý9193 _p.b, VW1 994 fill WN1994 _ fil, 615195 _ ML 1 =1 993 081154,792 08/163,449 - wr259 310 0814LS ý251 _ OW160295 SEQ ID NO 8 SEQ ID NO 8 SEQ ID NO:l 926 NO d SEQ 10 NOA 926 T 926 T -926 T 914 T 911 T _ ý P, 927 T 927 T 927 T 915 T 912 T 927 980 T m -628 - G -916 928 981 I'G,11G 928 G G 913 G C 929 C 917 C 914 C 929 930 A 930 -A 930 1 A 1 918 A 915 A 93-0 A, 931 G 931 G %31 G M G 916 G 931 -93-2 - C 932 C 9 i2 C 920 C 917 C 932 1933 A 933 A -933 A -92-1 - A 918 A -93-3 934 G 934 G 934 G 9m G 919 G 934 935 T T -1ý3-6 T 9m T T 988 936 C -C -936 C --92-4 -C 92-1 -C 937 A 937 A 937 7- 92-5- 70-2 A 937 990 93-8 G 93-6 G -53-8 G 926 G 923 G 93 5,,Pl -A -9-39- -A -92-7 -A -52-4 939 93 939 A 940 G 940 -G 94-0 G -92-8 -G GF25- -G 940 941 C 941 C 941 C 929 C 926 C 941 994 942 C -942 - C 942 C 9W- - C 927 C 942 995 943 C 943 -C 943 1 C 931 -C -928- -C 24Z3 996 T 932 T W-9 -T 944 1 T 944 T 944 0-3 T 930 T 2 4 T 997 '45 1 9 -99-8 "'A;' 1 1 945 T I r", 0 ! 946 A 946 946 A 1 934 1 A g3l I A 946 999 ra, 947 A 947 A 947 A 935 1 A 932 1 A 7 1000 948 C m - C 94 C 936 1 C 961 1 -10-01 9-49- -C 94T -C c 937 C 934 C 949 1002 -EF50- T 950- T 9w T 935 T To /Z T 950 -93-6 - - -T j 1 -1-000'4 95-1 T 951 T 951 T 939 T T. 952 T 952 T 952 -- 7- T 937 T 1 952 T 100 953 T 953 T 953 T 941 T 938 T T 1 954 T ý4 T 954 T 942 T 939 T 1 955 C 955 955 95- - -C -C 94-0 --- U- 955 956 A 956 A 956 A 944 A 941 A 956 1 957 G -7-5-7 G 967 G 945 G -94-2- G -9-5-7 1010 I - 943 -G 958 G 1 958 1 G 958 G 946 G - - 458 ol 1 959 G 959 G 959 G 947 G 944 G 959 09 121'M 960 T 960 1 11 Jbu T U46 T 945 T 960 1013 -96T T I --- ,r- 9 1 946 T 961 962 C 962 1 C 982 C 950 C 947 C 962 1 1 963 -963 T , 1'11,1'ý'1016 -913 T 92 T 9 J51 T 948 T E;6-4 -G 4 96 -G 52 G 949 1 G 964 ",A T 2112 -419111 IRM, AM 965 965 T 53 T 1 950 1 T 05 Ir T 966 T 966 - 954 T 1 961 1 T 96-6 1,01,9 -966 T Avt i"ýM' 967 96-7 -Q 967 RýI P68 T 968 T 968 T 956 A 953 A 968 T 1021 A 1-96FI A 969 A 957 j -gw W;;ý A 970 G 970 1 G 970 G 958 G 1 955 G 9 0 , 971 A 971 A 971 A 959 A A 1 972 T W-2 T 97-2 T 96-0 T 957 T 972 1 973 A -9-73- - 7- -973 - A D6-1- A 958 A 973 ý6 974 C 974 C 974 C 962 C 959 c 1 7 975 C 77-5 C 5 C 963 C 960 C 8 976 A 9-76- UJ A 964 A --961- - A 977 C 977 C 977 C 965 C 962 C 977 1030 -T7-8 963 T 978 978 T -T T 966 T I I 979 G 9-79- -G 979 G 967 G 964- -G 979 1032 980 G 968 G 965 G 103 G 980 G 980 E033 981 C 981 C 981 C 969 C 966 1 C 1 1034 982 T 982 T 962 T 970 T 987 T 982 983 C 983 C 983 C 971 C 968 C 1036 984 T 984 T 972 T - T 11111 5 "'T -ýsim -C C -57-3 -C 970 985 C 85 985 low 986 A 986 A 986 A 974 A 971 A 98-6- -1639 987 G 987 G 987 G 975 G 972 G -987 -1-W 98- T 9-76- --- T- -T 1041 988 T 88 989 C 989 C 989 C 977 C C 1042 990 T 69-0-0-0 -T T 978 T T 1043 991 C 991 C 991 C 979 C 976 C 1 1044 992 T MR9_2 T T 980 T 977 T 154-5 993 G 993 G 993 G 981 G 978 G 993 1045 994 G 994 G 994 G 982 G 979 G 1047 995 C 995 C C 983 C 8' 1 1048 996 T -ý799ý6 T T 9-84- T -111 T 49 99--- -G G 982 G 997 1050 997 G 197 G 985 998 C 998 C 998 C 986 C 983 C 998 1 1 999 C 999 C 999 C 987 C 984 C 1 Iwo T ýiow -10fZ -T -6-88 1001 T 1001 T 1001 T 989 T 986 T 1001 1002 G -TW-2 G G 990 G 98-7 G 1 IT- - --ý-91- -c --§8-a -c i 1003 C 003 1004 T 1004 T 1004 T 992 T 989 T 1 1005 G 1005 G 1 G 993 -T-- - 9-9---000- -G 1 A 1006 A 994 A 991 1 9W-7 10071 A 110071 A 1 lW( A 1 S95T A 992 A 1007 1008T T 1008 1 1 '.. 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I ý/1993 pub. lV9193 pub V&1994 fil, 6/13/1994 fil. 615195 1201993 08/154 792 08/163,449 0 59,310 - -08/465,251 160295 SEQ ID NO,8 SEO ID N0,8 SEQ ID NO 1 SEQ ID NO:8 Q ID NOA Tom -A To-cq -A Tm-9 -T97- - A 994 A 100 TOM Do -A TO 1-0 A A 998 A 995 A -101-1 G TO 1-1 G 1011 G -99-9 - G 990 G 1011 1064 1012 T 1012 T -101-2- -1-0-00 --- 7- 99-7 --- 7-- 1012 111"T 1065 98 G 013 1013 G 1013 G 1013 G 1001 G G 1 -10-1 - -11-01 - -1- -9900ý T 9 T 1 4 , ý11111111 TO 1-5 - A -150-15 A 1015 A 160 A low 0A aý,ý M 1068 ,,ý A"M 1016 A -1-01-6 -A -1-0-1 6 -A -150-0-4 A -1 G01 A 01 56 A 1:i 0=1 7 A - - -- 5 t *1017 11017 A 100 A 1002 A "A [Plý0ý718ý1--A joial A loi8 A 11wUl A IW3 A 1018 1071 lulgi G Ulu U 110191 U Iluu,'I U IW4 G 1019 110201 G 10201 U 110201 U 1 lQU81 c lQUb G 1020 1021 1022 1022 c 1022 1010 c 1W7 c 1022 c 1075 c I I I I-Wl I T 110081 T -imcý7 10241 c 110241 C 10241 c 11012 c 1ON c 1025 A 1025 A 1025 A 1013 A 1010 A 1 25 1 V A', 26 A 6 A 1026 A 1014 A 1 11 A 1026 1 1027 G 1-027 - G -TO-27 -= - -10-15 G 1012 G 10227 1080 1,21 08 0 8 % 1 1028 G 1028 G 1028 G 1016 G 1013 G 1 1029 "A 1,8 -1-02-9 -A -10-17 -A -fO-1-4 -A 1029 1029 A 1029 A ý082 lo3o -c -io3o -c Tow -c -To-1-8 -c -fo-1-5 c lo 3 1031 A 1031 A 1019 A 1016 A 1031 1031 A m R, -, 10 4 -70-32- -A M-2 -A -1632 -A -102-0 A To-1-7 -A 1032 5 TO-3-3 -A T03-3 -A IM -A 1-02-1 -A -i 0 1-8 -77- 1033 A 1086 ,A 1034 G T03-4 G 1-034- G -10-22 G -10-19 G M11 1087 1035 -A TO-3-5 -A -TO-35 -A -TO-23 -A -1-0-2-0 A T03-5 1 1 036 c 1036 c 1036 c 1024 C 1021 c 1036 089 -110--37- T 1 T -1-025 -1037 T T 1022 T 037 - - 1091 113.1 1 IWO I luý T 121 T 23 T 1038 10 iC39 -T 1039 C7-- 1 G -10-27 G 1024 G 1039 2 1040 T 1040 T 1040 T 1028 T 1025 T 1040 -3 109 TO4-1 -T -1 0ý -T I I T 1029 T 1025 T 1041 10904",",ýT -1542 -A 1-0-42 -A I A -10-30 A 1027 A 1 1042 1095 0ý A 1W -A TO4-3- -A I W 1031 A 1028 A I 1=0964" 1044 c 1044 c 1044 c T032 c 1029 c 1044 iO97 .1411, -1-0-45 -C _f0_45 -C 1 10-33 c 1030 c 1045 1046 A 046 A A 1034 A 1031 A 1046 099 -- - -1-- 1046 - 109 -TO-47 G V04-7 -G 1 G TO-35 G -TO-32- -G 1 110" V0-4-8 T 1048 1048 T 6 -1033 T 1048 1101 im G 1049 G 1049 G 1037 G 1034 G 1049 -1050 - -0-5 1102 Eý G 1 0 G 1 G 1038 G 1035 G 1050 1103 1051 A 1051 A7 i i A -1-0-39 -10-36 - A 1104 V p, A -1-052 T -1-052 T 1052 T -1-040 T 1037 1053 T T 1041 1 1 U35 T 1106 REP, T ',',a 1054 A 54 A A -TO- 1054 A -TO-4-2 A 1039 A 1 -1-107 " ý, 1055 A 1055 A 1055 A 1043 A 1040 A 1 'p, -70-56- G 1056 G 1 G -10-44 G -ýfRWT - G I -TI-0-9 1057 C 1TO-5-57-7 ----- CCCCC 1 c t0-45 -C 1042 -- C 1057 1110 1056 A 1058 A 1058 A 1046 A - A 1 -10-59 G 1059 G 1059 G 1047 G 1044 G 1059 1060 c 1060 c 1060 c 10481 c 1045 c 1061 c 1061 C -1661 c 1049 c 1046 c 1061 1062 T 1062 T 1062 T loso T 1w T 1062 1115 -1-06-3 c 1063 c 1063 c 1051 - C -1-048 -C 1063 1116 1064 T 1064 T 1064 T 1052 T 049 T 1064 1117 -70-53- - c -1-0-50 c 1065 1118 . .. .. 1065 c 1065 c 1066 c 1066 A -TO66 - A -1066 A -10-54 A 101 1067 T 1067 T 1067 T 1055 T 1052 T 067 1068 G 1068 G 1068 G 10-56 G lob3 G 1058 VýW -ff2l 1069 G 069 -11669 - 1-069- G 1057 G -iO-54 1069 1122 GfI.W11 -10-7-0 A 1070 A 11070 A 1058 A 1055 A 1070 MW 1123 1071 T 11071 T 11071 T 1 org T To 5-6 T "'T 1072 A 110721 A -11072 ilooo A 1057 A 1-07-2 1073 - A 110731 A 110731 ýI 1061 A 1058 A 1073 - 74: N 1 ýi U 1059 ]G 1= 112OZ7151 075 1 -fl -2 811 A 10 tA r1176 A 1 1 1,7, au UL 1078 A A 1078 A 1078 AA 1066 A 1063 A 1078 A 1131 A 3 i 10 9 132 10791 9 1 IL721 G 1079 G 1067 G m "Ill] -1 =1 5 080 A 1.. A 1080 A I.b A 110651 A a o AmM'"3 10811 A 110811 A 10811 A 1089 A 110661 A 1081 1134 1082 T 1082 T 1082 T 1070 T 1087 T 1 1 f3_5 -1-08-3 -A 10-83 -A -1083 -A -1-07-1 A 1068 A 1 - -11-36 -TO-84- -G IOU -G T08-4 -G 15-72 -G 1069 G 1084 1137 1085 A 1085 A 1086 A 1073 A 1070 A 1138 -1-08-6 G -f0-86 -G -16H G TM G -10-7-1 -G 1 10 wU 113-9 P4 rlý -1087 -G TO-87 -G -ý08-7- -G -10-7-5 -G 1-07-2 -G 1 li TOM - A -10-8-8 A 1088 A 1076 A 1073 A 1088 1141 -TO89 G T08-9 G TO-8-9 G l-W7 G 1074 G 1089 11 ý0 1096 A 090 A 090 A -1078 A 1075 A 1090 11 1091 G 1091 G 1091 G I G -10-76- G 1 1 11 Kolodner K.I.dner W C0 Er.Wý I Kolodner Kd.dw Ch.p.11. #1 -fiý 11117M id 1 /1993 - j.t:J:Wý9193 pýb, 4WW4 ftt. 61IN11994 -fil, _W5195 fil, 1ý1993 ... P_ _08 08/154,792 081163,"g 081259,310 1465 '251 0811 6029 8 -SG-Q DNO 8 - SEQ D NO I SEG ID NO,8 5FQ 10 NO 1 w92 A, IW2 - A -109-2 A -108-0 - A TO-7-7 -109-2 Mý1111' 1 -- T- -110-93 -T -fO9-3- --- r- TO-81 --- r-- ý(G-7-8 -- T-- TO-93 T09-4 T -1094 T 1094 T 1082 T 1079 T 1094 1147 - - -G -108-3 -G -10-80 log, 10 95 G W5 G 11 110 9-6 -A -109-6 -A -10-9 6 -A -108-4 -- X-- -10-81 A 1096 *1 1149 1097 A TO9-7- -A -fO-97 -A -108-5 -A -1082 -A 1097 -a --o - 1-096 -T '1-0-85 -T -10-83 --f- -- 9 11 1 98 1 98 T 39 AAkm 099 1099 - T T09-D 1-0-8-7 -fO-M T 1099 "",r'T 1152 1100 T 11W T 1100 T L1088 T 1085 T 11 5 4m -- k1101 A 11U A 1101 A 110891 A 110 ... .. 115 1-10-2 - G 1102 - G- 11021 G 110901 -7- _f0_87 1103 T 103 T 1103 1 Im T IGBE T T, - -- - TVF4 -G 1104 --- d-- 709-2 -G G 11 1104 G 1089 1157 G -T1 0-5 -11-0-5 -G 11 -G 1093 G Iý G 11 1158 1106 A 06 A 1106 1094 A 1091 A 1100 1159 "A If -1-10-7 - A -1-1 -07 - A 1107 A iOe5 A 1092 - 11 7 1 60 1108 G Tl 0-8 -G 11 -G -liO-9-6 G -TO-9a ---- = lios 1161 1109 c 1109 c 1109 C: 97 C -li0- - -TO-94 -C 1109 1162 1110 To 1110 -1 -To-% -T -fm ------- T - 163 1111 T 1111 T 7-11-1 --- r- -To-99 - T --10-96 --- T--- lill 1164 -1112 T -1-11-2 -T -fl-1-2 -T -11-0-0 -T -fO-9-7 -T Ill lies 1113 -11-13- _fTF3 -- y- -11-0 T T To-98 T ill 1166 11- G 1114 G 1102 G im G 1114 1167 1114 G 114 -11-1-5 T -11-1-5 V T JMý 100 T ill 1165 1-1-16 - 110 -1-11-6 -A -1-11-6 -A Illff --- A- lIC41 - A -111-7 - G -111-7 G 11171 G 11051 G 11021 0 1117 01 1118 A 1118 A 1118 A 1106 A 11031 A 1118 11 A, 1119 -A TI 1-9 -K-- 1-1-19 -A -A -fl- 0-4 t-A - 111 1172 -112-0 - G 72-0 -fl-2-0 -- -G- -11-0-8 G 5 112 1121 A 1121 A T1Y -A T1-6ý - A 411106 A 112-1 A I i -11-2-2 -- T- -11-2-2 -TT-2-2 1110 - T 107 -112-2 T 11 1 23 1176 vyý, M"Q'SQ, 1 G 1123 r 123 -- -T'- TI 1-1 G ilas G 1123 G ý,M 1 1124 c 1124 c -f-12-4 - C -11-1-2 - C 1109 c 1124 0, 1177 ýo 1-1 -1 - 1-fo -1112-5 11 78 1125 A 25 A 125 A TA 3 A I Aý ii A , , 1126 G Ti 2-6 - G -11-26 -T-11-4 - G 71-1 -1 1126 Q "U" 1179 1127 A le::o 1127 A 27 A 115 1112 1128 A 1128 A I 12B -1 11 81 A T1 I A IIJ3 1129 1129 1129 T 1117 T- -11-14 --- T- 1129 11,130 T 1130 T -f-13-o -T -T-11-B - T -i 11-5 -T Ti -3-6 1183 -11-31-1 -G Tl 3-1 -G -0 -111-6 -G lie 1131 G -11-31 1132 A 132 A i-132 -A ý-120 -A f-1-1-7 --- X11 3, - -- -17- - - -111-8 G 1T331133 G 1133 G 133 G 1121 - G ",4 - -1-1- - -113-4 -C3 -1-12-2 - G i 1 11 1134 G 54 G -G 11-19 1135 c 1135 c 135--F-- -1112-3 lub 1136 A 1136 A 1136 -A- -11-24 - A i-ii2-iT 1189 A, 1137 G 137 G 37 1126 G 1122 G 11-1-37 119 a 7138 -A 13-8 -A -T-138 -A -1-12-6 -A 1123 A 11-38 115, 1139 c 1139 c 713-9 -C -112-7 -C -11-24 -C 1139 1140 -T 7-14-0 -T -ý-140 -T Tiý 4" 1141 T 1141 T 1141 T 11291 T 1126 T 41 'T",,ý- 1194 --mm" T 1142 -5 1142 T 142 T 1142 T 1130 T 1127 119 1143 A -1114-3 - A -i-143 - A Tl -3 T -T-12-S 1-145 -11-9-6 kktý' A"YPM 1144 C 1U4 - C 7-1-4-4 - 7'-- -ýJ-32 - (7-- -i[-12g c ll" 1197 týZ,,ýo 1145 A 1145 A -1-14-5 -A -1-133- - A -f-M Tl 4-5 -11-9 8 1146 A -Ti 46 A `ý1-4-6 - A -VI-3-4 - A -f 13-1 _1_ -fl -9, 1"", 1147 G 11 G li 1-4-7 -- = Tl 3-5 T1-3-2 G 1147 A 11 A -11-14-8 A 1136 A -T-13-3 - A 1 48 1149 A 11 A 49 - A 71-3f A 1134 A 114 G _1160 G 1150 G 1138 G il-35 - G 115-0 1151 A 1161 F- A -1-1151 -A -TI-39- -A -fl 3-5 -A 11$1 -j-2Q4 11521 T , 1152 T 1140 -11-3-7 -T1152 T 1152 205 1153 7 115e 7 115ý T 11411 -111-38 T 1 1154 T 1164 T 54 11421 T 11- -T IlTg -T 117i - A -1T9-5 A 1155 A 11 4ý A 1140 1156 c 1156 c 1156 7C: -114-4 - C 1141 '11-57 -T -115-7 -T -1157 -T -1-14-5 T 1142 T 1157 -1-2-10 115 T 58 T 58 - -T- -7-4-5 - T -ý-14-3 1158 211 115e C 159 C 159 -- = - -1-14-7 - C -1-1 -4-4 1159 1212 -1116-0 G -116-0 G -116-0 -0 1-14-5 G -11-A-4-5 -G 1 6 12-13 li-- -1 61 -V-14 1161 T 161 T 161 T- 149 T 146 71-- - --- = 1-150 -C 162 -1215 1162 c 1162 c 1162 1163 G 1163 G 1163 G 1151 G 1146 G 11 1216 7-16-4 -A 11-64 -A -116-4 ------ -1-1-ff -A T149 -A 1217 1165 1165 T TI-6-5 -- - -1-153 --- "r- ffl-50- -- T- 1165 1218 1166 T 1168 T 166 T 154 T 151 T 1166 _11 57 c 1167 c 167 1 5 c 152 1 1168 C TI 6-ý 1168 c 11156 c 11 c 1 -1-16-9 c 1169 c 1169 c 11157 c llý c 1 1170 -A 1-170 -A -1170 A IT5e A "55 11-7-1 -G -117-1 -G 1171 G -77 =G -11 6 11! 77 117-2 -A ý-172 A '117-2 - A 1 -117-3 T -1-1 -7a -T -Tl 7-3 T 117 1-- c 1159 11174 1174 r 114 -C 7-4 K.l.d.a, Kotodner il Cell ErmWm Kolodner Kolodner I Chapelle #1 fil, 11/17193 fil. 12MI993 pub 1W9t93 pub. ý8/1994 fil. 6/1 W1 994 fil, W5195 fil, 1ý1993 OWI ý 792 081163.449 ý59,31 a 081465,251 081160295 SEC ID NO 8 SEQ ID NO:8 SEQ ID NO 1 SEQ ID NOiS SEQ ID NOA 1175 T 1175 T 1175 T 1163 T 1160 T 1175 1175 T 1176 T 1176 T 1164 T -ffff T 1176 -1229 kýý -11-7 7 - A A 1177 A 1165 A 1162 A 1177 1230 1178 A 1178 A 1178 A 1166 A 1163 A IM T2-3 1179 C 1179 G 1179 C 1167 c 7711164 C 11 9 -12-3 1:1 -80 7- -1180 C 1180 C 1168 C 1165 C 1160 12-1 G G 1169 G G 11 1 1234 1181 G 1181 1181 -1-168 a 13 1182 A 1182 A 1182 A 1170 A --Tý1-1-667 A 11.1 12ý 1183 C 11831 C 11831 C 1171 C 1168 C I ligg 1236 1,, 1184 T 1184 T 1184 T 1172 T 1169 T iiu -12-37 1173 T 1170 T &S 1238 1185 1185 1185 11 1186 G 11 -86 -- U-- -ff86 IM G 1186 1239 1187 C 1187 C 1187 C 1175 C 1172 c 11 1240 1188 c 1188 C 1165 C 1176 C 1173 C 11 12411 Q 1189 A 1189 A 1189 A 1177 A 1174 A 1 1189 241 All 1190 A 1190 A 1190 A 1178 A 1175 A 11190 1243 1191 G 1191 G 1191 G 1179 G 1176 G 1191 41' 1192 A 1192 A 1192 A 1180 A 1177 A 1192 1245; 1193 A 1ýn A 1193 A 1181 A 1193 2ý 1194 G 1194 G 1194 G 1182 G -TT11--79- G 11 4 124 1195 T 1195 T 1195 T 1183 T 1180 119 48 1196 T 11961 T 1196 T 1184 T 1181 T 9 1 N 1197 T 1197 T 1197 T 1185 T 1182 TT - 9 T2_50,11, =, - i 1198 C 1198 C 1198 C 1186 C 1183 C 1198 1251 1199 A A 1187 A 1184 A 1199 1199 A 1199 1252 -11--8-5- A12W A 12W A 12W A 1188 A 1253 1201 A 1201 A 1201 A 1189 A 1186 A 12-01 -12-54 A 1202 G 1202 G 1202 G 1190 G 1187 G lm 1255 1203 A 1203 A 1203 A 1191 A 1188 A 1 03 Q,,, A -125-6 1204 C 1204 c 1204 C 1192 - C _ff§9 C 1204 1205 A 1205 A 1205 A 1193 A 1190 A -1-205 -12- ý,y 1206 A 1206 A 1206 A 1194 A -11-9-1 - A 1206 725-9 M ýMý 12071 G 1207 G 12071 G 1195 G 1192 1208 C 1208 c 1208 C 1196 C 1193 1209 A 1209 A 1209 A 1197 A 1194 A 1 -126-2 1210 G 1210 G 1210 G 1198 G 1195 G 1211 C 1211 C 1211 C 1199 c 1196 C m 1212 A 1212 A 1212 A 1200 A 1197 A 1212 1 1213 A 1213 :2 6 , , a :6 - - -12-1-3 A -1201 - A -1198 1213 Xý""A 1 1199 A \ 7 f 1214 A 1214 A 1214 A 1202 A 1-214 IIWIMNIMMAý , ý 1 1215 C -1216 - -1-21 268 C 5 C 1203 C 12001 C 1ý 1268 -f2-16 72-1-6 T -1216 --- r- -f2-o4 --- 7- 1201 T 1216 -F2-7-0 1217 T 1217 T 1217 T 1205 T 1202 T 1217 1218 A --1-2-03 -A T12-18 1218 A 1218 A 121M. A IF-271 12191 C 1219 C 12191 C 1207 C 1204 C T2-ig 77777-r- - , I 1220 A 1220 A 1220 A 1208 A 1205 A -12-2-0 1273 1221 A 1221 A 1221 A 1209 A 1206 A 221 274 -//M-ýAMWý 1222 G 1222 G 1222 G 1210 G 1207 G T222 1275 " G" -, 1224 T 1224 T 1224 T 1212 T 1209 T 1224 1277 1223 A 1223 A 1223 A 1211 A 1208 A 1223 60 -12ý 7-22-5 - T -1225 1 1 T 1210 1225 127 1226 G 1226 G 1226 G 1214 G 1211 6 121 1227 T 1227 T 1227 T i i T 1212 T 1 1228 T im -- 7- -T2-2-s T 1216 T 1213 T T 1229 A 1229 A 1229 A 1217 A 1214 A 1 1282 1230 C 1230 C 1230 C c Q 1230 -1231 - C T23-1 C 1231 C 1219 C 1216 C X0 12321 G 1232 G 12321 Wzkllý, SEEM 1220 G 1217 63 IN 1233 A 112331 A 1233 A 1221 A 1218 A 123 1286 1234 C 1234 C 34 C 222 C 1219 - C 1234 -- 1; - - -12-35 P0011"'T" 1235 T 1235 T 1235 T 1223 T 1220 T 1236 C 1236 C -123-6 C 1224 C - 1221 - C -123-6 --- r- -12-3 1237 T 12V 7 T 1225 T 1222 --- 7- 1237 1 1238 A 1238 A 1238 A 1226 A 1223 A 1238 A 1291 1239 T 1239 T 1239 T 1227 T 1224 T 1 1239 T,5 ..... I 1240 C 1240 C 1240 C IM c 122 C 1240 r "'JW, 1293 'k 1241 A 1241 A 1241 A 1229 A 321 A 1241 129 1242 G 1242 G 1242 G 1230 G 227 T24-2 1 A 1243 G 1N3 - G 1-243 G 1231 G 1228 G 1243 129d ME 1244 G 1244 G 1244 G IM2 G 1229 G 1 1297 1245 T 1245 T 1245 T 1233 T 1230 T 1 1 1246 A 12461 A 1246 A 1234 A 1231 A 1246 1299 A, 1247 T 1247 T 1247 T 1235 T 1232 T 1247 -T-3m- "T""', 1248 A 1248 A 1248 A 1236 A 1233 A 1248 1301 1ý , 1249 A 1249 A 1249 A 1237 7- -1234 A 1249 1302 1250 A 1250 A 1250 A 1238 A 1235 A 1250 - 4% 1251 T 1251 T 1251 T 1239 T 1236 T 1 1 1252 C 1252 C 1252 C 12 1237 C 1 1253 A 1253 A 1253 A 1241 A 1238 A 1253 1254 A 1254 A 1254 A 1242 A - -fog -A 1 1255 C 1255 C 1255 C 1256 T 1256 T 1256 1 11244 1 11241 1 1 z0b 12571 A 1257 A 112571 A 112451 A 112ý2 A 12ý1 K.Idner Kolodner Cell Cell Erratum I Kolodner _ Kolodner _ Chapefie#1 fil il/17193 fil. 1ý11993 pub. 12J919 pub, 41WI994 _ fit 6/1311994 fil, 6/sms filL 1ý1993 OW1 54ý792 08/163ý449 - OBn59,310 _ 08/4L5 ý25 OW16IM5 SEQ 0 NO 8 SEQ ID NO 8 SEQ ID NO 1 ýhu ID Nol b 6tU ID NUA 1258 12-58 -- =- -12-5-8 -C -12-46 -C 12ý -- =- T25-8 -f3-11 1259 C 1259 C 1259 C 1247 C 1244 C 259 ýX 1312 'R, 1260 T T260- T -126-0 T 1248 T 1-24-5- -T T26-0 1313 -f2-61 A A 1261 T3-14 Aý, \1\1 1261 A 1261 A 1249 1246 -T31262 A -ý262 - A -f2-62 A 1250 A 1247 A 1262 15 1263 T 1263 T -1-263- T -12-51 T -124-8 T 1 ""1 G - -G -i- - U --- T- -12-4-9 -G 1264 1264 1264 264 G 252 1317 1 J&I 12ý T 1265 T 1265 T 1253 T T25-0 - T 129 WIS ....... 1=318 1266 A 1266 T 1266 A 1254 T 1251 T 1266 T 1319 T 1 1255 A 12 2i 1268 T 1268 T 12681 T !IZDUI 1 1 12w T 12 8 -726-9 - A . 1269 A .... 1 A I "ýý I A 11 13 U-7-0 - C T27-0 C 12701 C 112581 C 1255 c 127 1271 A 1271 A 1271 A 1259 A 1256 A 270 1 -T2-72- G 1272 G 1272 G 1260 G 1257 -G 12712', U-7-3 G 1 G ý273 G 1261 - G -12-58 G 730 1274 C 1274 C 1274 C 1262 C 1259 1274 4ý, -12-75 ----- TTTTT i -T -f2-75 T 63 T 1260 T 1275 1276 C 1276 C 76 C C 1264 1261 C 9 1277 T 1277 T 1277 T 1265 T 1282 T 127 1330 z T278 G 1278 G 72-78- gG 1266 -G 12W G 12/ 133110, a V2-79 -G 1279 --- 6- T2-7-9 G 1267 -G -12-6-4 -G 1332 ýýV, 12801 A 1280 A 1280 A 1268 A 1265 A 33 A- 7281 1269 -A P, 1281 A 1281 A 1266 A 12 A1334 E282 A 1282 A 1282 A 1270 A 112671 A 122:12 1 '41, 1283 A 1283 A 12831 A 1271 A A A 1 6 -ý2- -A -f2-84 -A T2-8-4[-A -T2-72 -A 126N A 1 TA 1285 C 1285 C 1285 C 1273 C 12701 C 1 j285 ffippv, ý332ai "'Ac;gs 1286 A 1286 A 1266 A 1274 A 1271 A 286 -1-2 _f2_87 T -1275 T 1272 T 87 T 1287 T i2lf 134 1288 1341 1288 G i2sa G ima G 1276 G 273 1342 1289 A 1289 A 1289 A 1277 A 1274 A 1289 -i-29O -127-8 -A -127-5 90 A 1 90 A A 1343 [2 RA 1291 G 1291 G 72- 1- G -1-27-9 - G Un G 1291 1344 'Q 5 "88 1 212 G 1214 A 1292 G 9 G 1292 G 1280 G -7-1--2-777 1 5 29' G 1 293 A 1 29, A -f-- -A -12-78- 1 -13-46 L'A IMM 1293 A A 1293 A 281 1294 A 9 7- -f294 A 12821 A 1 At 1347 1295 A 5 A 1295 A 1283 A - 1286 A 1 1348 -12-96- - A 1 96 A 1296 A 1284 A -11-2-M-1 A -134-9 P 1-2-9-7 C 1297 C 1ý217 C 1285 C -71T-22-8-2 C 1 1298 A 1298 11298 A 12136 A 1283 A 1 -13-11 T299 C 1299 C C - - 1255 -1-287 -C -12-8-4 -C 1 713--52 1-3-00 -C 1300 C 1300 C- 1288 - C 1285 C -13-0-1 -A -13-0-1 -A 1301 A -12-89 A 1286 A 1301 T3-54 A 1302 G = -150-2 G 1302 G 729-0 -G 728-7 G 1 1355 G' 1303 A 1303 A 1291 7- 1288 A 3 1304 A 1304 A 1292 A -12-8-9 - A 12312, -- A T2 9-0 -13-05 1357 13051 A 1305 A -f2-93 - A A r T358 -- I - ---- -13--1306 T 1506 T 1306 1294 T 1291 T 1306 1359 1-3-0-7 T 1307 T 1307 T 112951 T -1-n-2 T 307 M 1308 A 1308 A 1308 A 1296 A 1293 A 1-3W -13-61 JýK, 1309 T 309 1309 1297 T 1294 - T 131M -f2-98 -1-5 - -1-0 1310 T 1310 T 1310 T T 29 T 310 "t, -13-11 G -1-T1 -G -131-1 G -1299 G 1-129-6 G T3 -11 1 1364 1312 T T312 --- r'- 1312 T 1300 T 12971 T 1312 .. 1313 T -1313 T 1313 T 1301 T 1296 T 1 1 113N6T `5 1314 G 1314 G T31-4 G 1302 - G 1299 -G 1 1 1367 GT ýfi7 73-1-5 -G -1-315 -G -131-5 G -f3-03 -G 1300 G 1 31 N 1 -13-16 -C 1 ý1-6 -C _T3_16 C 1304 C 1301 C 13 ' 1369 17 A -i-3O5 -A 1317. A 7 A A1317 1370 6 T3-- zLIIA 1318 G 1318 G 1318 G -f3-O6 - G 1303 G 1318 13 T 3 t2 1 [138 G 1319 T 1319 T 1319 T 1307 T 1304 T 1319 1372 pl, 1 2' T 1320 T 1320 T 13081 T 1305 T 1320 1373 T,,, 1 4 1 '21 T 1321 T 1321 T 1309 T- 13M 1321 IW4 T37322 1322 T I 1322 T 1310 T 1307 323 T 3 T 1323 T 1311 T 1308 T 1376 I'M", 1 1 3 T G 1324 G 324 G 312 G 1309 G 1324 1377 325 T 1325 T 1325 T 1313 T 13101 T 1325 1378 IM, -T 1326 G 1326 G 13M G -13-14 - G 1 1379 13'7 A 1327 A 1327 A T31-5 A 13121 A 1327 1380 A 1328 C 1328 C 1328 C 1316 C 1313 C 1 1381 73-29 T -1-329 T 1329 T -1-317 -T i i -T I T3-1-2 330 C 1330 C 1330 C 1318 C 1315 C 13W 1383 -- C T3-31 - C 1331 C 1319 C 1316 C 1 1 3:88:4 851ý - i i38 7=1 ýý 21 T 1312 T 1320 T I i T 332 1333 C 1333 C 1333 C 13211 C 1 18 C 1333 1334 T T 1334 T 13 M1334 1 1335 T 1323ri l 1388 M35-5 T ---- T- 13351' CC T -- 11336 --- X- -1-32-4 A ýA 1 9 1-336 A 13361 A 1 1 A 36 1337 C 1337 C 3 7 C 1325 1 C 1333 0 131 UT8 T I ýg T -f-321 T 133 T391 1339 G T G 35 Z G 1327 G 1 G 1 1392 1340 A 134 A 1328 A 13251 A 134 K.1.0, K.I.dn., Cell Cell Ermtum K.I.&er Kolodner Chapelle#1 fil 11/17193 fil 1ý/1993 pub 12J9193 pub, 41811994 fil,6/1W1994 fil, 615/95 fil 1201993 OW1 54 792 0&163,449 Oat259,310 08/465.251 ON160295 SEC ID NO:8 SEQ 10 NO:B SEQ ID NO 1 SEQ ID NO:8 SEQ ID NO 1 1341 T 1341 T 1341 T 1329 T T32-6 T 1-341 777717-7 T39-4 -777ý 1342 C 1342 C 1342 c 1330 C 1327 C 1342 1395 M, 1343 T 1343 T 1343 T 1331 T 1328 T 1343 ... 1 1344 T 1344 T 1344 T 1332 T -13-29 T -1-344- 1397 1345 C 1345 C 1345 C 1333 C 1330 C 1345 139 41, R"I"'I"", 1346 G 1346 G 1348 G 13U G 1331 G 1346 1347 T 1347 T 1347 T 1335 T 332 T 13-47 1348 T 1348 T 1348 T -1336 --- T- -1333 --- r- 1348 T 1401 1349 C 13491 C 113491 C 13371 C 13341 C 1 1349 Pq 02 13ý T 1350 T 1350 T 1338 T 1335 T "13 ow",'r 1351 G 1351 G 13511 G 1339 G 1336 G 1351 1404 1352 A 1352 A 13521 A 1340 A 1337 A 1 1353 C 1353 C 13531 C 1341 C 13W38 C 1 -1354 -1354 T 13541 T 1-342 -----7r--- -133n T ý314W 2 %L 407 1355 T 1355 T 13551 1 3 T 340 T - 4 8 C 1356 C 13561 C 1344 C 41 C 1356, 09 1356 A14O9 M\ý\\ 13ý -1w T 13571 T 1345 T 1342 T 1ý7 14 1358 C 1358 C 13581 C 1346 C 1U3 C 1 0 1359 C 1359 C 13591 C 1347 C 1U4 C T559 QMCWA, 1 1 13601 A 1360 A 13601 A 1348 A 1345 A 1360 A 1413 1361 A 1361 A 1361 A 1349 A 1346 A 1361 1414 A 1362 G 1362 G 1362 G 1350 G 47 TS62 14S -13ý --- r- -1-363 T 1363 T 1351 T T363 1416 1364 T 1364 T 1364 T 1352 T 134 13" 1366 T 1365 T 1365 T 1353 T 351 T I Týý 1366 C 1366 C 1366 C 1354 C 1351 141 A 1367 A 1367 1367 W V1421 1355 A 1352 A -1-36-7 1368 G 1368 G 1368 0 1356 G 7353 1421 1369 G 1369 G 1369 G 1357 G 13U G 422 1370 A 1370 A 1376 A 1358 A 13ý A 1 1423 -1971 A 1371 A 1371 A 1359 A 1356 A 1371 1372 A 1372 A 1372 --- X- -13-eD - A -139 -A 1372 1425 13731 T 1373 T 113731 T 1361 T 1358 T 1373 1374 G 1374 G 1374 -1362 G 1359 G 1374 427 -13ý A 1375 A -1376 A -136-3 A 1360 A 1375 ýAv 1376 T 1376 T 1376 T 1364 T 1361 T V" 1376 T 1377 A 13 7 A 77 A 1365 A 3-62 A 1377 A 1 ý,,ýA 1378 G 1378 G 378 G 1366 G 1363 G 1 1376 1379 A 1379 A 1379 A 1367 A 1364 A 1379 U32 1380 A 1380 A 1380 A 1368 A 1365 A 1380 -1381 A 1381 A 1381 1369 A 1366 A 113131 38 1434 T3- -c -1382 -c 73-7-o C 1367 C 13822 1382 c a2 1435 13831 A 1383 A 1371 A 383 1383 1368 iý , 1384 A 13841 A 13M A 1372 -- r- 1369 A 1 4 1437 1385 C 1385 C 113861 C 1373 C 137-0 - C 1 1438 1M61 T 1386 T 1386 T 1374 T 1371 T 1- 1439 1387 T 1387 1387 T 1375 T 1372 T -14-40 1388 T 1388 T 1388 T -1376 T 1373 T 1 031, 1389 A 1389 A 1389 A 1377 - A -137-4 A 1389 1390 G 1390 G 1390 G 1378 G 1375 G 1390 1391 A 1391 A 1391 A 1379 A 1376 A 1391 1444 ý,A 1392 T 1392 T -1392 T T3-80 T 1377 T 1392 -130 A 1393 A -1-39-3 - A -1381 - A 1378 A 1 1393 1446 1394 T 1394 T 1394 T 1ý2 T 1379 T 1447 T"' 1395 G 13ý G _T__ 1395 G G 1380 G 1395 1448 OWN, -13W G 1396 G 1396 - G -139 G 1381 G 1396 44 1397 A 1397 A 1397 A 1385 A 1382 A 397 00,11, "-1449 C,,' 8fO " , A 13981 T 1398 T 13981 T 1386 T 1383 T 398 """tam" 141 1399 C 1399 C 1399 C 1387 C 1384 C 1399 1452 1400 A 1400 A 1400 A 1388 A -1-38-5 --- V- 1453 1, 10 1401 G 14 1 G 14W - G -1-38-9 G 1386 G -14-01 111 T40-2 G 1402 G 1402 G 1390 G 1387 G T4-02- Ir',I,,,Q'Mfrý, 1455 1403 T 1403 T 1403 T 1391 T 'M ..... -13M T -1-403 ý ' ýT,,',,g 1456 1404 G 1404 G 1404 G 139-2 G 1389 G "Al 1 1405 G 7-40-5 -G 14a -G T39-3 -G 13W G 1-406 U 'W 145B 1406 A 1406 A 1406 A 1394 A 1391 A -1-406 'Aý I 1407 A 1407 A 1407 - A T3-9-5 - A 13-92 A -1-407 1 "I'll "I'll ",1011 1408 A 1408 A 1408 7- 1-39-6 - A 1M 14-08 1461 , , A" 1409 A 1409 A 1409 A 1397 A 1394 A UCQ 1410 C 1410 C 1410 C "g 1398 C 1395 410 , 1 1 1 1411 C 1411 C C 1399 c 1396 C 1411 1464 1412 A 1412 A 1412 A 14W A 1397 - A 1 1 1413 T 1413 T 14131-T -140-1 T -T-398 T i i 1414 G 1414 G 14141 G 1402 G 1399 G 141 1415 A 1403 1415 A 14M A 1415 1415 A ýA 1416 A 1416 A 1416 A 1404 A 1401 A 1 1 kMB 1469 W -1417 T 1417 1417 T -14-05 - T 1402 T 1417 1470 T 1418 T 1418 T 1418 T 1406 T 1403 T 1418 1 1 1419 C 141g C 1419 C 1407 C -1-404 C 1472 1420 C 1420 C 1420 C 1408 C 1405 C M, 1421 T 1421 T 1421 T 1409 T 1406 T 11 1 1422 T 1422 T 221 T 1410 T 1407 T 14ý 147b G 14 423 14111 G 1408 u .147B. Kolcdner K.I.dý., Cell Cell Eatuý Kolodner Kolodner Chapelle 01 f1i 11117M fil 12f7/1993 pub. IMM _ pub. 4/8/1994 fil WlNI994 fil &5/95 - fil iDD1993 - -08-/1-54 7-92 - -5 a-/ 1-6 3 4-4 9 - -68/259-1310 - M1465 251 08/160295 SEQ ID NO 8 SEQ ID NO:8 SEQ ID NO 1 SEQ ID NO.8 SEQ ID NOI 1424 T 1424 T 1424 T 1412 T 409 T 1424 1417 1425 A 14ý -A T42-5 -A T4-1-3 -A 1410 -A -1-42-5 7= 0 1426 A -17426 - A T42-6 -- T- 74-14 A 1411 A T42B g&, 141 1427 A 1427 A 1427 A 1415 A 1412 A 1427 148; 6ý' 1428 A 1428 A 4=28 -A 41 -A 14 -A 428 "K, Aý,ý 1429 c -14-29 -C 142-9 -C -f4-17 -7- -14-14 C 1429 1482 C -14-30 - C 14W - C -141-8 C 1415 C 1430 1483 1430 T - - -1 - T U-31 T 1419 T -14-16 T i i 1431 1, 1 ý -ýf4134 1432 1432 T 1432 T 1420 T 14171 T 1432 -, X 1433 C 1-4-33- C C 1433 C 1421 C 141,11 C 1433 14 1434 A A 1422 A 41 A T1434 1434 A F1434 -1435 1435 2 T 14201 T 1435 14BB , 'R 1435 T 1436 T T 424 1436 1489 1436 1 1436 1 1421 1437 T -14-3-7 T 1437 T 1425 T 1 2 - T -143-7 ýM&\,%,T . .... 1490 -f438 -G -ý4-38 -G 1426 1423 - G 1438 1438 G , iWM 1491 1439 A 1439 A 1439 A 1427 A 1424 A T43-9 AMC 1 1492 1440 T 14ý -T -144-0 T 14-28 -T 1425 -T 14W T 1493 1441 C 441 C 441 -1- -1429 - C 1426 ---- = 14-41 14V4 1442 C 1442 C 1442 C 1430 C 1427 C 442 1496 rx, 1443 T 443 T -1443 T -114-31 -T 1428 -T T4-4-3 1444 W-_ U44.4ý A 1444 A 1432 A 1 A 44 M 1445ýý IN 1445 A 144 A 1445 A 1433 A 1 30 A 14 -1-446- T 1446 T 1446 T 1434 T 1 1 -T 1 14 14ý 1447 C 1447 E 14351 C 1432 c 1447 1500 1448 T 1448 T 1448 T 1436 T 1433 1448 1 1 1449 C 1449 C 1449 C -143-7 - C 1 4 c 1449 1 M-5-0 -A -A 1ý A -14-38 A 1435 A 14ý 1503 1451 G 1451 G 1451 G 1439 G 436 G 5 4 -1452 -T 1452 T -145-2 T -144-0 -T T43-7 -T T MM 14-5-3 -G 1453 -G -1453 G -1441 -G -1438 -G 1453 1506 A - U- :M7 1454 A 1454 A 1454 A 1442 A 1439 A 454 k, "8* 1455 A - A 140 A 1443 1455 - -IfUd - A -14-5-5 508 T 1510 14561 T 1456 14ý T 1444 T-- -T4-4i - T 1456 r4lý -T I & 1457 T 1457 T 1457 446 T 1442 T 149 -- A -1-446 -A -14-43 A 14a I ill 1458 A 1458 A 1458 1459 A -1-459 A 1459 -f4-47 --- r- 1-444 1459 1 1480 G 1460 G 1460 G 114481 G 1445 G 60 1513 1461 A 1 1 -A 1-461 A 14491 A -ýf4ý4ý6 -A 1 1 1 14 1462 G 1 G G 11 01 9 1 1417 1 G 1462 rrýl 462 - -1-46-2 S Ai ý,,W 145i A 44, -1463 A 1463 A 1463 A 1463 A 1516 1464 A 1464 A 14U - A lewl A le4al 1464 -1ýýl 7 1'1ý 1465 A 1465 A -1465- A 14531 A 1450 A 1465 lbld kNjýý 1466 T 1466 T 1468 T 1 1451 T 1466 ka, I 14-67 - A 1467 A 1467 A 1 11 A 14-52 41156161M,, I Dzu 'UN&\', A A 1468 1468 7- 1488 A 14561 A -1-45-3 --- 7- 1468 1 ý21 ",4 411 1469 T T 1457 T 1454 T 1469 5 2 - - ý'W -1- G -1-47-0 R -162-3 1470 G 14701 G 1470 G 1458 G 455 1-4-71 A 1471 A 1471 A -ý4-5-9 - A -14-56 - A 1524 Aý _i5 -f4- -A 25 1472 A 1472 A 1472 A 60 A 1457 T47-0 -T -1-473 T 1473 T 1461 -T 14M -T 15-2-6 -1474 -G -1-47-4 -G 1474 G 14ý G T45-9 -G 1527 1475 1475 A 1475 A 1463 A 460 -15-28 T4 -1461 -C 7-62 T4 7-6 -C 76- -C 1476 c 1464 C 1 9 -147 - r- -14" - T 1477 T 1465 T 1462 1 1 ý61J A T -11 -31 SWIT 1478 T 1478 T 1478 T 1466 T 1463 ' I -14-67 1464 G -- ý3- M's 1479 G -1479 -G -1-479 G -G 1 2 -5-80 - G 1480 G 1480 G 1468 G- 1465 G 14ý 1481 A 1481 A 1481 A 14691 A A 1481 1534 A A A 1470 1 8 1: Tý35 1482 A 1482 1482 A T4e7 A 1482 M', Aý -1468 -A 1483 1483 A 1483 A 1483 1471 A g 1484 A 1484 A 1484 A 1472 A 1 A -1-484 Z 1537 -T4-s5- -G -14 -a5 -G T4-85 -G -1473 -G 1470 G 1485 17938 1485 A U -86 -A -1486 -A -1474 A 14H -A T48-6 -T4-87 - A 1-487 A 1487 A 1475 A 1472 A 1 1488 G -5-88 -G -148-8 G -f4-76 G 1473 G 1488 1489 A 7-4-8-9 -A T4-8-9 -A -T4-7-7 -14-7-4 -A 1489 A 1490 T 490 T 49 T 1478 T 1475 T 1490 1 1491 G -W -G -14a G 114-79 G -1-476 G 1 4 1492 C 92 C 92 C 1480 1477 C 1492 1645 c" 1493 A 1493 A 1493 A 1481 A 1478 A 1493 1546 1494 G 1494 G 1494 G 1482 G 1479 G Z. -T-- -- --- r- -T4-8-o -T 1 1548 T I T 1495 T 495 i4s3 1496 C 1496 C 1496 C 1484 C 1481 c 1496 164-9 1497 A A -1497 A 1485 A 14132 A 1 9 50 -A -1-49-8 --- =- 1-4 -- R-- -ý4-83-A 1 -1-5-5-1 A 1499 C 1499 C -1499 C 1487 C 14-4-4-8-8-4-4-4 - C I T55-2 1500 A 1500 A 148-8 - A -14M A 1 1ý63 RA 1501 T i i T -f6ol - r--- -T4-89 14-86 - T 1502 T- 1502 T 1502 T 1490 T ý487 T 1503 A A 15031 A 1491 A 14M - A I 6041 A 114921 A 1 jý49 1 =IH I" M 5 1505 T I ýub i U5 3 55 A 49519 A ft 'Aý, ýuo A ý5-06 ýA l T ... Kolodner _ to err Cell Cell Erratum Kolodner Kolo ner Chapelle #1 fit 11/17/93 fit 1 11 ub, 4/8/1994 fil. 611311994 fil. 6/5195 fit 1M 1993 U81-154,792 - 81 , 08/259,310 081465251 08/160295 SEQ -IDNO,8 - SEG ID 06 SEQ ID NO 1 SEQ 10 NO:8 SEQ ID NO 1 1507 A 1 1507 A 1495 A 1492 A 1507 1ý0 ýZ,' A z -1558- G 1508 G 1508 1496 G 1493 G 1 1561 ... Gý -1-50-9- T T 1509 T -T4-97 T 1494 T 1 -15-6-2 T' 1w --- 7- -15-10 G 1510 G 1498 G 1495 G 1563 15ff - c -151-1 c 1511 c 1499 c 1496 c 1511 m b, ý-1612 - -1912 -1665 -,--A' A A 1512 A 15 A T49-7 15ý - G T51-3 G 1513 G 1501 G 8 - G 1513 1514 15--14- c -1614 c 15M c -fag - c Iffim SMý T lmvý" " " -C 1515 c 1515 c -1516 -C -T5-03 - C -1 5W c kmlý cmýw 1516 A 1516 A 1516 A 15-0-4 - A 151A - 77- 116 1517 - G 1517 G I G 1505 - 15 11, 110 >'I , 11 -15-70 1517 G 1502 G 17 15 8 - -1M -A 151-8 A 15(M -A -15-0-3 1518 A 1571 1519 G -15-1-9 - G 15% G 1507 G 1504 G 1519 \My" 1520 -A T52-0 A 15M A - -1-50-8 -A 15M.-A 1ý A 1573 1521 -T -1521 -T -15-21 T 1509 T 1506 T -1-521 im mftýW'& 1522 C 22 C 5ý C 510 c 1507 G 1522 1575 15- - -1- - -1-- toccoM -f- - T-o8 T 1ý -11-7-6 1523 T 1523 T 1523 T 511 T 5 T- - -1512 15n 1524 T 1524 T 524 T T 1509 T 1524 1 G -1625 G 1525 G 1513 G 1510 1 2 525 - -T514 1526 1526 G 1 G G 1511 G 1526 1579 15271 c 1527 c 1527 C -1-515 c 1 1 c 1527 75-8-0 1 1 C\ 1528 T 1528 T 1528 1516 T 1513 T 1528 1 t112/1""'A 1529 T 1529 T 1529 -T 161-7 T -1514 T 1 2"1121'2 \:&\\,\T, 7-5-30 G G 1518 G 583 -1630 -G 1530 530 T-53T - G 1 5ý3-1 - G 1 1 G 1519 G 1516 G 1531 1584 -1-532- A 1532 A 1532 A 1520 A 1517 A 1532 1585 -1633 T53-3- - C i - C t5-21 c 15181 c 1586 -1-5-3-4 -C -169 -C I -C 1-522 -C 1519 c 15U 1587 1535 c 1535 c 1535 G 1523 c 1520 c 1 -15-36 -T 16W -T I T -152-4 -T -152-1 -T 1536 -1-589 Tý"-' -15-37- - G -153-7 1537 G 1525 G7- 1522 G 1537 1590 75-3-8 G 5-38 -fý G 1538 G 1526 G 1523 G 1538 -1-53-9 - C 539 c 1539 - C -15-27 c 1524 c 1539 -1512 1540 A 1540 A 1 - A 528 A 1525 - X 41 111 //",A 1b93 1541 A 1541 A 1541 A 1529 A 1 1 A j1541 1542 A T1542 A 1 A 2 542 -15-30 A 1 A 1595 1543 C 1 S4-3 ---- CccC c 1531 c 1528 -C 1543 T54-4- -A T54-4 -A 1 A -153-2 -A 15ý -A VW 15-4-5 G T5-4-5 ----- GGGGG 1 G -1533 G 1530 G T620 1 7ý -A -15-46 -A 1 -- 7 X- -15-34 A 1531 A 1546 1599 ,A T 1547 T 1547 T 1535 T 1532 T 1 -1600 1647 1 , 'gý' -T5-48 -T 1648 -T 1 8 T -1536 T -1-533 T 1548 " wwr IMMýý'*' 1-549- - A -ý5-49 A 1549 A 1537 A 1534 A 1549 1602 -- AIIIý', 1550 A 1550 1550 1538 A T5 -fiiff 1551 A 1551 A -1T3 -A -1-536 -A 1604 1552 c 15521 c 1552 c -15-40 - C 1-53-7 - C 1552 Igg 1605 1553 T 1553 T 15ý T 1541 T 1538 T 1553 75-54- G -155-4 G -1-942 G 1539 G 1554 -15-5-5 -G -15-55 -G 15-55 G 1543 G 1540 G T-556- -A -15-56 A - - A T6-09 A 1556 A 1544 A 1541 1557 T 1557 T 1557 T 5 T 1542 11 ibbf 76-10- MEN, -1-558- 15-58 -T 75-58 T -15-46- -T -15Z- -T 1158 75-9- -15- - -1-5 T5T7 155 M -1-5 C 59 C 59 c c 1644 C 9 612 -7560- -c -156-0 -c 1-560 c 194-8 -C 75-4-5 -C 15 1613 T5-6-1 - A -1-56-1 - A -156-1 A -15-4-9 A 15461 A 5161 -1-562 G -T5-62 G 11562 G 1550 G 1547 G 62 -1663 - T 1563 T 1563 T T 1548 T 1563 1616 -T 15641 G 15641 G 1564 G -1-552 - G 1549 G 156 0 1617 G', 1565 15651 c 1565 c 1553 0 1550 Z565 1618 --654 - - 15 1566 A 1566 A 1566 A 1 A 1551 i566@&ýtt -16-19 1567 C 1567 C- 15671 G 155151 C 1552 C 1567 1ý62 6 -1653 -A -!-1568 A 1568 A Ibmi A ibb 1568 21 1569 G 1569 G 1569 G 1557 G 1554 G 1669 622 1570 T 1570 T iblu I 1ýbd -1-555 --- 7- 570 1623 56 T 71 624 5T 1571 T 1571 T 1571 T 1559 T 15 1572 -1672 T -1972 T 1 60 T -1557 T 1572 1625 ýQffl= - -1-- -G 75-7-3 1573 G 573 G 1561 G 1558 G 1573 1 626 1574 G -1-574 G 1574 G 1562 G 1559 G 157 BN27 1575 A 1575 -=I 1628 A 1575 A 1 s3 -A T58-o -A T5-7-,- 628 1576 --- r- -15-76 -T5-76 T 1554 --- 7- T5-6i - T 5746 1629 15771 A 1577 A 1577 A 1562 A An -T 75-78- T 75-78- T 4 66 -T 7W -T 15 1578 Mr La 1579 T 1579 -15-7-9 1567 --- 7- -15-6-4 T 1 9 T 'T -1-580- -A 75-80 -A 1580 ffAi R-8 A 1565 A 1560 ' - - %Mklý 1569[ c 1 1 1634 581 c 581 c 1565 c 58 "c 1582 T 1582 1582 1570 -15-6-7 - T 5 2 1635 ý'T " , 1583 T 3 T 1 71 T 568 T 15 3 "T' 1636 T 1584 T T584- T ý5 - T 5 4 T' -1637 48 T ;84 T -1672 T 1569 1585 T5-8-5 - C 1573 C 15701 c 5 5 1638 '\mq 1586 G G 11586 G 1574 G 1571 F G 1 16 0 1586 5 6 1639 Mlý \'15 U -_ 1587 - T T5- -7 52;7 T 1 75 T 1572 T 5 7 4 1 G G a G I G 1573 G 1588 ,,ý,,;ýg 1641 rý MM, 1589 T T 1577 T lb1411 1 1589 T',`M\0 16 2 T Kolodner Kolodner Ce I Call Err.tuý Kolodner ape e fil 11/17/93 fil 1ý/1993 pub. IMM Pý 994 fil. 6113/1994 fil 1ý1993 08/154,792 081163,449 08r259,310 08/1 6G295 SEQ ID NO 8 SEQ U NQ,8 SEQ ID NO 1 SEQ ID NO:l 1590 A 15W A 15BUl A 1578 A 1 A 1 1643 WWA,,, 1591 A 1591 1 A 1591 A 1579 A 1576 A 1591 1644 645 1592 c 1592 c 1592 c 1680 c --Tt-5-77-7 --- CC 1 1 11ý1%ý, -1-5-93 -C T59-3 c _j5 -C -1-581 -C TP-78 -C 1 1-6-46 9 5, -r- -f5-7-9 1594 -ý5-94 --- 7- 1594 T 1594 T 1582 1647 1-5-95 G 1595 G 1-59-5 G 1ý3 G 1580 G 1595 -1-148 -T5-9-6 T -15-96 T -15-96 T -1 W T -f5-8-l T 1 164 ý-5-97 -A T597- -A _j5_97 --- 7- -i-585- -A -f5-82 1597 -fw ý2ý 1651 1598 A 1598 A 1598 A 1586 A 1583 A 1598 illl[- -I T59-9- -G 111-9 G -1587 G 1584 G 159 1 1600 G 1600 =- T6-0-0 -G 158-8 -G T5-a G 16 1601 A -T6-01 A 1601 A 1589 A 1 6 A 1601 1854 A 1 A T60-2 - A -1-602 A 1590 A 1587 A 1602 Mý A 1603 G f6-O-3 T6-0-3 G 1591 G 158 1603 1604 A 041 A 041 A 1592 A 1589 A 1604 1657 'A 1605 - A 19605 A 11266S A 1593 A 159 1 165 1M6 A 1606 A 16GS1 A 1594 A 15911 1606 A A 1595 512 1607 A 1 16071 1 ... 1608 A 1608 A 16081 A 1596 A 1 5" A 1661 1609 G 1609 G 1609 G 1597 G 1594 G 160 16 0 15- 1595 T 1 1 1663 1 T 1610 T 1610 T 98 7611 c 1611 c c 1599 c 1596 1ý loll 1664 1612 c 1612 c -im-1-2- c 1-600 - C 1597 c 1612 166 1613 T 1613 T -fe-13 T 1601 T 1598 T 1 1 9, 1666 -1-614 T 1614 T -161-4 T -160-2 T 1599 T 1614 1667 -ýG- -16-03 1600 161 1615 c 1615 c is c 2 1616 G 1 1 G 16 G 1604 G 1601 G 1 1 1669 -1-6- T 161 T -16-17 T -1 -605- T 1602 T 1670 T -ýWA 1618 A 1618 A 18 A 1606 1603 A 1618 1619 A -1-619 - A -1-6-19 A 1607 1604 A 1619 1672 -1-82-0 c luo c -1-6-20 c 16W c 1605 c 1 1ý, -16-21 1621 A 11621 A 16091 A 1606 1621 ý,A 1674 1-6 , , Via 22 A 16ý2 A 1610 A 1607 A 1622 1676 22 A 1622 167 -1-6-2-3 T 16T3 T 1623 T 1611 TT i T 162 a 161766 16124 -A 1 24 1624 1612 1609 A 1624 625 1 - A 1610 613 1625 1678 1 6 - 1 u2. 16-14 -A -TWI -A 162 1679 [2 1 3 T 1 1 C -16 26 A 62 A A 1627 A 1627 A 1627 A 1615 A 1612 A 1628 A 1628 A 1628 A 1616 A 1613 A 1 1681 1629 C 62 c 62 c 1617 c 14 C 1629 1682 16-30 1630 ---- 7- 1630 -Tems -f6l--5 -- 7- 163o 1683 T -f6-31 T I i - T I I T 16-1-9 T 1 1 T 1631 76-8-4 168 1 IT 11 -1- -3 2 - 1 3 T -f-6-20 T l6l/ I 163ý 'A -15-3-ý - A 16 A 163$ A 1621 A 1618 A 1633 1-6-34 G -1-6-34 G -16-34 G 1622 G 161-9 G 1634 ...... W687 W," 16-35 T -163-6 IT -1-636 T 16M T 162-0 T 163 1," 1 1688 Mlý'T 1 (W6 A 1636 A 1636 A 1624 A 1621 -- -7- 1636 1689 M-3-7 c 1637 0 1ý c 1625 c 1622 c -16-37 -1-696 c 16-3-8 T 1638 T 16 T 1626 T 1623 T ma 1691 immi 1639 G 1639 G 1639 G 1627 -7- -1-624 - G 1 3 1692 SSfi-a 1640 T 1640 T 1640 T 1628 T 1ý5 T -7ý 1693 -f--6-441 -A 1641 A -f6-29 -A -16-Y -A 16-4-1 kl,,"-A --ý- 694 1641 A 1642 G 1642 G 1642 G 1630 G IU7 G 1642 1695 1 A 1643 A 1 4 A 1631 A 1628 A 1 1696 1-632 T 1620 1644 1 T 4 T I T T 1645 A 1645 A 164 A 16331 A 1630 A 164 1698 , A 1 T -1ý6a--46- T I T 1634 T 1631 T 1646 1699 16-77 -C 164 c 1-635 -C -16-32 -C 1-6-47 1700 1648 c 1648 C 1648 c 636 C 635 c 1646 1701 1649 A 1649 A 1649 A 1637 A 1634 A 16-49 -17-0-2 1650 G 1650 G 1660 G -1638 G 1635 G 1650 7=03 1651 A 1661 A 1651 A 1639 T- 1636 A 1651 -1-7-04 1652 A T652 A 1652 A -1640 - A 16-37 -A 17-0-5 -T6-53 G -16-53 G -16-53 G -16-41 G -T6-38 G 1 -1-170-6 165-4 A 1664 A 1654 A 1642 A 1639 A 1 -17-0-7 1655 A 1655 A 1 w5-6 A 1643 A 1640 A 1 1 A" -ý6-56 T T -656 T -f64-4 T i"i T 16M 76-57 -G -T6-57 -G 16-57 G 1645 G 1"211 G 1657 7 0 G -16-58 G 1 GG3 1658 G 1646 G 1643 G 1 7 1 W-5 9 T 1 1659 1647 1644 T 1 1711 -16-6-0 - G 1660 G 1660 G -1-64-8 - G -16-46 G 1,60 1713 -16-61 T 1661 T 1661 T 1649 T 1646 T 1661 714 ,,M 16-62 T 1662 T 1662 T 16-5-0 - T 1647 T 1 ýM;00 715 -A\glkT, 79- 1663 -16-51 --- r- -16-4-8 A 1663 1716 1663 A 1683 8, , 'MI - -- - 1649 A T7-17 - ,RE 1664 A I A 1664 A 1652 A Mm ML A 1664 1665 A 166 A 166 A 1653 A 1650 A 166 A 7 1666 T 1666 T 1666 T 1654 T 1651 T 1666 15"J 1719 L,' Al 1667 T 1667 T 1667 T 1655 T 1652 T 1667 1720 k -18-68- T 1-6-69 T 166 1656 T 16-63 T 1868 T 1721 ýWlxl -- 1657 T-- T6- - '66 T7 72:2 1669 A 1669 A 54 1670 c 1670 c c 570 1 23 no 1671 c 167 c lbill c 1671 1724 F/P 1672 --- A -*-IT6-7-2 I- A 116721 116601 ib(2 ý ,m it25 Kolodner Kolodner Celli Cell Erratum I Koladner fil 11/17133 fil 12J7/1993 pub 12/g/93 pub. 41811994 filL &13/1994 fil, 1M/1993 081154,792 0&11ý,449 5-8ý-ý59310 -0-&-16-0296- SEQ ID NO 8 SkQ ID NO 8 SFEQ ID NO 1 8 SFQ 10 NOA -1M A 6-73 A 1661 A 1658 A 1673 1 [673 A -16-74 -C -11M C 1662 -C -TTTT6--5--99 -- C 1 1727 167;4 C 1675 1675 9-- -16-7-55 A 1663 A 1660 A 1675 ý`1111 7 676 G 1676 G 1676 G 1664 G -1W G 1. *0 T67-7 C 1685 C 1662 Ilk, III 1677 C -16" -C C 1730 66 8 -1- -A T67-8 A ie-6-6 --- r- -1-66-3 1 1731 1679 A -1379 - A -1-679 A 1667 A 1664 1732 1 8, -1380 -A -IMO A T66-8 -A -1666 -A 1733 6 0 M A -13811- ie6g ýI :681 T T 11381 T T 1666 T 17U N12 i b.,i T 11582 T -T6-70 T 1667 T T73-5 6831 iudýj U I bud I G W 1671 G I G 1736 1684 A 1684 A 1684 A 1672 A 16691 A 1737 T685 C 1673 C 16701 C 1738 1685 C T16-85 CC IT T 1739 1686 1686 T -167-4 -T -1-7 --T-6--- - T 1675 T 1672 1740 1687 T 1TT687 1688 C 1688 C 1688 C 1676 C 1673 C 1 1 1689 T ý89 T T -167-7 -T -1M T 1 T T 1675 T 1690 TP, 1690 T T 1691 T 1691 -1-- T 1691 T 679 T 1676 T 1691 1 T'S ,Y, ,Y, , 74 A 1692 A -116-9-9-9-9-2 A 1 -A -1680 -A 1677 A 1692 1693 A -1-6-M-33 -A 1 -A -16-81 -A -11M A 1746 A, 1694 A 1694 - A 1694 A 16-8-2 A - A 1:9 1 -ý1ý -T i -T 1-68-3 T 1 T i 1695 695 1696 G 1696 G 1696 G 1684 G 1681 G 1 '96 5 1149 -16ý A 1697 A 1697 A 1682 A 09M -1750 -16w A 6" T751 1698 1698 A 86 1 A 1698 1699 G 1699 G 1699 G 1687 G -1684 ---- = 169u 1700 A 1688 A 1685 A 1700 175:3 A 1700 A 1700 1701 G 1 1 -G 1 1 G -16-89- -G M-6 -G -1-70-1 'Awn 1702 T 1702 - T T 1687 1702 T - 1756 -A- - -15- - - 1756 1703 1703 A 1703 A 91 A 16881 W03 -T704 T 1704 -T i -T - 1692 -T- T!F!JýT 17N -17-5-7 1705 1 -A 1705 A P3 160 A 1706 C 1706 C 1706 C 1694 C 1691 C 1 1759 1707 0 1707 C i C 76-95- - C 1692 C 1 ful 1760 1708 A 1708 A V08 A 1696 1693 A 1708 A A- -1- -A - ý ý,f, 1709 A 1709 A 1709 697 T69-4 - A 1709 1762 A 1710 A T71-o -A -fm -A -169-8 -A -169-5 -A 1763 &,;P/, A 1711 A 1711 A 17111 A 16991 A 1696 A 1 1 1712 A 1712 A 1712 A [177M A 1697 A 1712 1 1713 1713 T 1713 T 1701 T 13 1756 7- 1 1 A 1714 A 1702 -mg A 1 1714 17 1715 A 1715 A 1716 x 1703 A 1700 A I iflu 68 1716 A A 1 1 A 1704 A 1701 A fib 1 If, 41 1 ffigý 17 -17-0-2 A A- 17 A 1 1 A 0 1717 77 00 1718 C C 7 C 1703 Z77Z70 1 0 A 1 1 A 1 1 A 1717 A 04 A 1 1 1772 1 -1-7 R11 A ---- = 1 7 , - -T7-0-5 G 1720 3 S ...... \ 1720 G 1720 G 1720 0 G 1721 A 1721 A 1721 -A 171, - A -TT7-0-6 1721 Z77Z V-22 A 1722 A I -A 1 1 A -TIT-7-07 A 1 1775 1723 T 1 1711 1708 T 17M I flu ---- -1-77-7 1724 A A I A 1712 A 1709 A -17S T 172511 T 1725 T 1713 T 1710 T 1 1725 -17-78 1726 G 17261 G 11726 G -1714 - G 17111 G 1 1726 1 79 1727 A 1727 A 1727 A 1715 A 1712 A 1727 -1-780 "'A"A, -1 -7 A 1728 A 1728 A 171-6 - A 171-3 - A f , "' " I I , 1729 G 1729 - G 1729 G 1717 G 17U -- = 1729 1730 A 1730 - A 17M A 1718 A 1715 - A 1 73?390 17-83 1731 A -1716-A 1 1 -A W19 -A 17311' A 1784 1732 G 1732 1 -G -17-20 - G -17-17 G 1732 1185 1733 C 1733 C 1721 C 1716 1733 C 7:33f -17-3-4 C 1734 C 1 - C -17-22 1719 1 , , , -W87 788 'ýTor 989 94 1735 C 1 C i C 17231 C 731 1 G 1720 9' ' `- ý' A i7Z736 011 -1730 -A 1 -A 1 A 1724 A 1721 6 17 0 -17-37 G 1 -G i G 1725 G 1722 1 G 7317 17 1738 G 1738 G 1738 G -17-26- G 1723 G 1791 1739 A A 739 A 1727 A 1724 A _A 1739 T7-9-2 7740 T -17-401- T 77-4-0 T -17-28- 1 -17 2-5 1 -17-93 1741 G 1741 G 1741 G 1729 G 1726 G 1 1741 1794 1742 C 1742 C 1742 C 1730 C 1727 1 -1795 Q, 1743 C i C i C 31 C 1728 C 1796 77- --- r- -1-729 1744 A 1744 A A 32 1797 A T 1745 T 1 T i T 1733 T T7-30 TT 1 -17-9 8 -17-46 T i ----- TTTTT i T -17-34- -T W31 -T 1 -1-799 ýýhWAOM 1735 G 1800 ,ro, 1747 G 1 -G -- - -1732 -G lm T 1748 T 1748 T 1 1733 T 1 1801 1749 T 1749 T i -ý17ýM -T 1 -180-2 1750 A 1 A 1 A 1 1;31981 A 1735 A 1-80-4 1-751 A 1751 A 7 1 A A llýb A 1 T762 i A 7 2 11/4UI 1737 A 1 1805 1753 G 1753 f$ 31 1806 -ff54 1714 A 754 1807 T75-5 ,*bj A it b 1114ý1 7SS K.I.&e, Kolodner Cell Cell Eat.ý Kolodner .1. ýer Chape e fil 11117M fil. 121711993 ub 1 pub 4JWl 94 fil. 6/1311994 _ fil, 6/5/95 filL 1ý1993 08/154792 OW ý 449 OM69,310 M465,251 OW160ý5 SEQ ID NO 8 SEQ 0 NO 8 SEQ ID NO 1 0 NO 8 SEQ -IDNO 1 -T7-5-8 -T7-5-6 - ý7- -175-6 -A -174 - 77- -1-741 A 1756 "1I, :,", 1809 1- T 742 T -17-5 1757 T W57 T 757 T 1810 -- -1-758 --- -T -1743 -T 1756 758 T 1758 T 746 1759 G -f759 G V59 G -1747 - G 17-44 --- = 1759 1812 1760 T -17-60 T -1760 T 1748 T -1-7--4-5 T 1 . 1813 -1 T6-1 -G -1-76-1 -C -17-61 C -C -1746 -C i 1 -1614 -1-7-62 --- 7- -T7-62- - A -17-62- A -1-7-5-0 A -fn7 A 1762 1815 -1--6- 1763 A 1763 A 1751 A 1748 A 17 1816 1764 T 17641 T 1-764 IT 1-1-752 T 17491 T 1 1617 ION 1765 A 1765 A 17651 A - 1753 A 1750 A 1765 1818 1766 T 1766 T 1766 T 1754 T 1751 T 1 1819 -f7-67 T -1767 T -176-7 -T -175-5 T I Ibi T Ifbf 78-20 T -f7-68 - T -17-6-8 -- T-- -1756 T75-3 T 1 ýV,\, 1821 J, 17-69 -C -17-69 -C V69 C 1757 C -17-54 C 1769 1822 70 T 17 0 T , "I 1 -7- -7 T 1758 T 1755 - -f-- - -1 - -175-9 - T -1156 ---r- 1771 1824 V,,, 1771 T 771 T 771 T W, 1772 C 1772 C T772- - C 1-76-0 C 1757 c 1825 1 -- 7-- 1773 77-73- -A T7 6-1 - A -1-758 73 A A I T826 - W-7 - -1774 17-82 -G -1-75-9 -G 1 ..... 1827 1774 G 4 G G -f7-76 G -17-75 G 1775 G 1763 G 1760 G 1-7751764 '(01 17761 C 1776 C 776 C C 1777 T 1777 T 17771 T 1765 T 17621 T 1777 11 1830 -f7-78 - A 1778 A 1778 A 1766 A 17631 A A -1-831 1 - - -1-- T -T 1 6 T -- 6-V 1 763 ý79 T 779 7 7 17 4 T 1 1 1 1780 G 1780 G 1760 G 1 768 G 1765 G 1 1780 _1833 1781 T 1781 T 1781 T [17769 T 1766 T 1 1781 834 '01" T -1T8-2 -A 17-82 -A 1782 A 1770 A 1767 A 1 1 Ilk -T-7-8-3 G -f7-8-3 - G 1783 1771 G- 1768 G 1783 1836 -T7-84 - A -1784 A 1784 A 1772 A 1769 A 1 1837 1785 A 1785 A 1785 A 1773 A 1770 A 1 :1 B318 AS &r' 1786 C 1786 C 1786 C 1 774 C 17H C 1786 1839 1-787 -C -1-78-7 -C 1787 -C -1-775 'gZ C 1772 C 1787 0 1840 C -1f8S -A -f-78-8 A 1788 A -17-78 A 177-3 -A "ý " A 1789 A 1789 A 1789 A 1777 A 774 A 1789 q,ýký 1842 A, 1790 T 17ý T 17901 T 1778 T 1 T 1790 -1643 't 1791 G 1791 G 17911 G 1779 G .1 G M-971 1-844 1-7-9-2 C 1792 C 17921 C 1780 C 1777 C 1792 W romma, 1845 0 1793 A 1793 A 1793 A 81 A 1778 A 7,//, 1846 i , 1ý94 G 1794 G 17941 G 1782 G 1779 G 1ý -q ,--Z 1847 T795 - A 1795 A A 1783 A 1780 A 1795 1848 1 1796 C 1796 C 796 C 1784 C 17ý - C -1-796 1849 1w C -179-7 - A 1797 A 1797 A 1785 A 1782 - A T797 1 - -1- - -1-- T70 1851 1798 C 1798 C 1798 C 786 C M C 1852 1799 T 1799 T 1799 T 1787 T 1784 T 1799 -T788 -C -Tý -C -1 ý800- . . 1853 1800 C 1800 C 18M C V-8-6 - A 1801 1854 1801 A 1801 A 1801 A 17891 A 6 P , lW-2 - A 1802 A 1802 A 17901 A 1787 A 1 1a55 R, Ak ,\ -18-03 T 1803 T 1803 T 1791 T 17881 T I R 'm 1858 T'ý,\,Z ý G G -17ff G 1789 G 1804 1857 "'WI iauý A i8uýl A lduý A 1793 A 1790 A 18ý 1858 1806 T 1806 T 1806 -T T794 -T -179-1 -T 1 1859 180-7 G 1807 -G 18W G 179-5 - G 1792 G 1807 1860 'Z, 1808 T 1808 T 1808 T 1796 T 1793 T 1 1861 1 -1-- - -17-94 -G 1 -186-2 1809 G T809 G T809 G 797 G T8 vo --- 7- -Tamo -r-- 76-1-o --- 7- -T-79-8 -- T-- -T7-95 - T 1 1 1863 T81-1 T -161, T -1aff T 1799 T 1796 T 1811 T86-4 T 181-2 -A -1812 A 1812 A 1800 A -f797 -A 1 1 T8-6-5 ý-=,A 1813 G 1813 G 1813 G 1801 G 1798 G 1866 77ý7, 16141 G 1bI4 C 1814 C 1802 C 1799 C 1814 1867 161*1 1 ibib T 1815 T 118031 T 1800 T 1868 1816 C 1816 C 1816 C 11804 C 1801 C 1815 1817 A f81-7 -A 1817 A 1805 - A 1802 A 1806 G 1803 G 1818 1871 a 1 411 18-18- G -1818 G 1818 G 1819 C 1819 C - 18194 C 1804 C 1819 1820 T 1820 T 1820 T 1808 T 181M T 1 XX, T82-1 -A -182-1 -A -182-1 A -180-9 -A -18-0-6 -A 1821 1 'l 18-07 1822 1822 G 1822 G 1822 G isio G G 1823 A 1823 A 1823 A 1811 A -1608 A 1823 187 -18-2 -T -T 2 @ýT 4- -8-4- -18-2- -1- -18T 4 T 812 T 1 B09 T 24 -18-25 -G -f8-25 G 1825 G - 1878 1813 G 1810 G 1825 82 1814 1811 i8m -18-2-6 -C i -C C C C -TS-27- T 1827 1827 T 1815 T -T8--12 T T18-27 I , SIME, i8w NE T 1828r -G 1828 - 0 -1828 G -1816 G 1813 G- 1 1881 1829 T 1829 T 1829 T 1817 T 1814 T 1829 1-88-2 ýT -r- --Tiif8-l5 T -188-3 1830 T I oju T I.,. T 1818 T15 1831 G 18311 G 1831 G 1819 G 1-8-16 - G 1831 1884 1832 T 1832 T 1832 T 1820 T -T8-1-7 - T i8m 51' -T8-33- - C 1833 C 1833 C 1821 C 1818 C -T8-86 -j-834 -A 1834 -18-u A -1622 t8-1-9 -A 1 1w 1-83-5 G 1835 G 18M G 1823 G 1820 G 1 -1688 18-36 -C 1836 c 1838 c 1824 -C 1821 C I f837 T 1837 T 1837 T 1825 T 822 T 1 f8-38- T - MIA T 1826 T 1823 T 1 -18-91 0 0 K2 dýe, Cell Cell E,.W. Kolodner Kolýner Ch.,.11. Itl W11 M p.b 4/8/1994 fil 6/1311994 fil. 615195 - fil, 1M19931 08/154,792 1 08/163ý449 (W59,31 0 CFB/465,251 OW1 60295 SEC ID NO:8 I SEQ ID NO:8 SEQ ID NO:1 SEQ ID NO:B SEdTD No 1 1839 T 18391 UZ9 T 27 T 624 T 1839 70'7ý-ýT\ýW, -1-892 1840 G 18401 G 1840 G 1828 G -11M - G 4 1841 C 18411 C 1841 C 1829 C 1826 - C 1W T T 1821 1 -- T891842 T 18421 T 1842 1830 1842 5 1843 C 1843 C 1843 C 1831 C 1"3 1844 A 18,44 A 1844 A 1832 A -T8-29 A 1w 1697 1845 C I C 1845 C 1833 C 1830 C 18-45 f898 1846 -G -18-3-1 1846 G 1846 G G 834 G 1846 lbou 1847 T 1847 T 18471 T 1835 T 1832 T 1847 iwo 1848 G 1848 G 18481 G 1836 G -18-33 G 1848 1901 7-8-49 1849 T 18491 T -18-3-7 --- r- 1m4 - T 1849 1902 4 Ta-- C 1850 1850 C 50 C 18501 C 1838 C iM5 - 1-903 1851 A 19511 A 1839 A 1836 - A T661 -190-4 A.141 -18- - -1m7 -A -1-85-2 iqý 1852 A 1852 A 18521 A 40 A A 1853 A 853 A 18531 A 1841 A 1838 A 1 1 1854 T 1854 T 1864 T 1842 T 1839 T 1854 1907 -Aml 1655 G 855 -i- -1m5 G 1843 G -1-8884-60 - G 1 1908 855 G - 202 011, 1856 G 1856 G 1856 G 1844 G 1841 G 1856 1 1857 A A 18-57 A 1845 A -f8----4-2 -A 1 11 A, '58 1858 G .. -1 Bm G 1846 G 1843 G 1858 1911 1859 C 1859 C 1859 C 18471 C 1 B44 C -1912 z RIP 1860 A iaýR A 1860 A 1848 A 1845 A 1860 1861 C 1861 C 1861 C 1849 C 1846 C 1861 191 1862 C 1862 C 1862 C 1850 C 1847 C 862 1915 1863 T 1863 T 1863 T T8-4-8 T 463 1864 G 1864 G 1864 G 1852 G 1849 G 1BU 1917 1865 T 1865 T 1865 T 1853 T 1850 T I T 1866 T 1866 T 1854 T 1 1866 -1-- - -186-7 1855 C 1852 1867 C 867 C C 92U 1868 C 1868 C 1868 C 1856 C 1853 C 1 112 1869 A 1869 A 1869 A 1857 A lT8--54 A 1 1 q122 -i -s --- = --- 7- 1870 1870 T 7o 87o 1858 T 1855 1871 A 1871 A 1871 A 1859 A A 1871 1924 A 1872 T 1872 T 1872 T 1860 T 18571--- -T -1 1 1 1873 G 1873 G 1873 G 1861 G 1858 G 1 1874 T 1874 T 1874 T 1862 T 1859 T 1874 1927 A 1875 A 1875 A 1875 A 1863 A 1860 A 1 1 1876 C 1876 C 1876 1864 C 1861 C 1876 1929 1877 G 1877 G 1877 G 1665 G 1862 G 1 1930 1878 A 1878 A 1878 A 1866 A 1863 A 1878 Aý A 1879 C 1879 C 1879 C 1867 C -18-64 - C 1879 193 1680 C 1880 C 1880 C 1868 C 1865 C 1880 19 1881 A 1881 A 1881 A 1869 A 1866 A I I 1882 G TS-8-2 - G -1882 G 1870 G 1867 G 1882 1883 C 1883 C 1883 C 1871 C im - C I 1884 C 1884 C 1884 C 18721 C 1869 C 1884 1937 'CqWl 1885 A -168-5 --- T- 189 A 18731 A 18701 A 1 18135 A 1886 T 1886 T 1866 T 1874 T 18711 T 1 1886 1:33'1 1887 T 1887 T 1887 T 1875 T 1872 T 1887 1940 1- --- 7- -1873 1888 T 1888 T ism 876 1888 1889 T 1889 T 1889 T 1877 T 1 74 T 1942 1890 G 1890 G 1890 G 1878 G 1875 G 1590 -1-943 1891 G 1891 G 1891 G 1879 G 1876 G 1891 1$ 1944 -C, 1892 A 1892 A 1880 A 1877 A -1W 1892 k A' 1893 G 1893 G i8n G 1881 G 1878 G -1893 0 -f9-46 G 1894 A -1894 181M 1882 A -f8-7-9 - A Ta-94 A 1947 A 1895 A 1895 A 1896 A 1883 A 1880 A 1895 1948 A OR 1896 A 1896 A 1896 A 1884 A iMT - A T69-6 -1949 A,,"W* 1897 G 1897 G 1897 G Ism G 882 1897 1950 1898 G 1898 G 1898 G 1883 1898 1951 walc 1899 A 1899 A 1899 A 1887 A 18841 A TT9-9 1 qsý 1900 C 19M C 1900 C 1888 C 1885 1901 A 1901 A 1901 A 1889 A 1886 A 1 1 1 1902 A 1902 A 1902 A 1890 A 1887 A 1W2 . . 1955 , 1903 G 1903 G 1903 G 1891 G 1565 u 46, 1956 1904 G 1904 G 1904 G 1892 G 1889 G 1904 1957 1906 A 1905 A 1905 A 1893 A 1890 Rý1,111 ý'A -,-g-,-, 1906 A 1906 A 1906 A 1894 A 1891 A 1906 3 M"A", 1907 G 1907 G IW7 G 1695 G 1892 G T90-7 1960 1,Q 1908 A A 1908 A 1896 A A 1908 1908 1961 1893 1909 A 1909 A 1909 A 1897 A 18N 1910 T 1910 T 1910 T 1898 T T 1911 T 1911 T 1911 T 1899 T 1896 T 1911 1 1912 A 1912 A 1912 7- 1900 A 118971 A 1912 5 '-\\ýA T9ý3 1 6 118981 T 196 1913 T 1913 T 1913 T 1901 T 966 -94- 96 1914 A 1914 A 1914 A 1902 A 1899 A 1 IIN17 1915 T 1915 r[-- 1-91-5 1903 -T---- 1,2221 1 "15 1916 T 1916 T 1916 T 1914 T ol1 T 1916 1917 A 1917 A 1917 A IW5 A 1917 -1-8 - T918 A A 1903 A 1918 A 918 A 1906 1919 A 1919 A 1919 A 1907 A 19[A A 1920 A 9M A 1920 A 1 A 1ý0 A -T9-21- -G -1921 -G -1 92-IE G 1909 G 1906 G 1921 C 11 Cell Eýtum oo ner Kolodner Chapelle#l fil 11117193 fil, 12,711993 pýb lZ9193 pub.4/WI994 flL W 311994 'l 93 - -M, -615ffi5 fil 1=1993 08/154,792 OW 63 449 - OW259,310 0&4 251 WMW295 SEQ ID NO 8 SEQ ID NO b SEQ ID NO:l 3LU ID N d ýtu lu NU: I 19122 C 192-2 C 1910 C 1 C 1922 1975 9 -19ff -A 908 1923 A 1 23 A 1923 A 1923 922 C 1924 T 1924 T 1924 1-912 T 1909 T 1924 -19 - -f9-781925 C 1925 C 1925 C 1913 C lulu - , , %i 25 C - - - C l 9-25 1926 C -1526 - C -1926 C 1914 c 1911 C 1925 -1971 -T--7 - A -1-9-1-5 --- 77- T9-27 1927 A 1927 A 92 1 1912 1928 G 19ý G 1-926 G 1916 G 1913 9 8 1981 1929 G 1929 G 1929 G 1917 G 1914 G 1 1982 1930 C 1930 C 119301 C 19181 C 1915 C 1930 Ma 1983 1931 A 1931 A 19311 A 1919 A 1916 A 1-93-1 1984 -1-98-5 1932 T 1932 T 1932 T 1920 T 1917 T M2 1933 G 1933 G 19331 G 1921 G 1 18 G 1934 C 1934 C 1934 C 1922 C 1919 C l 9-3-4 1935 T 1935 T 1935 T 1923 T 1920 T 1935 -1-988 7-9-36 -?-- 19M -T T93-6- --- r- -1924 - T 7-9-2-1 1936 r,ý--,Tj A 1989 ýý14, 1937 G 37 G 1937 G 1925 G 1922 1 1938 T 1938 T 1938 T 1926 T T1923 I 1939 G -19-39 -G -19-3-9 -G 1927 G 1924 G 1939 1993 1940 T 1940 T 1940 T 1928 T 1925 T 1941 T 1941 T 1941 T 1929 T 926 T 1 1 1 1942 G 1942 G 1942 -7- -1930 - G -1-927 G 1942 9 5 1943 A 1943 A 1943 A 1931 A 19281 A 1943 1944 A 1944 A 1944 A 1932 A 1929 A 1944 1997 1945 G 1945 G 11945, G 1933 G 1930 G 1945 1998 a 1946 T 1946 T 19461 T 1934 T T93-1 T 1946 1-99-9 1947 T 1947 T 1947 T 1935 T 1932 T -1 W 20M .61 1948 C 1948 C 19481 C 1936 C 1933 C , AgA 6 1949 A 1949 A 1949 A 1937 A 1934 A 1 2002 1950 A 1950 A 1950 A 1938 A 1935 A 1950 2003 1951 G 1951 G 1951 G 1939 G 1936 G 1 1 004 MTMW 1952 A 1952 A 1952 A 1940 A 107 A 1 2DO5 A RU 1953 T 1953 T 1963 T 1941 T 1938 T 1 21-01 ýM 1954 G 199 -G -19-54 -=- -f9-42 -=- 193-9 -G 1954 2007 1955 A 1955 A 1955 A 1943 A 1940 A 199 1956 A 1956 A 1956 A 1944 A 1941 A 1-95-6 1957 A 1957 A 1957 A 1945 A 1942 A 1957 A 2010 1958 T 1958 T 1958 T95-8 T 1946 T 1943 T "T, 2011 Týl 1959 T 1959 T 1959 T 1947 T T959 -261-2 1,; 5 MG 2013 1960 G 1960 G 1980 G T96-0 1961 C 1961 C 19811 C 1949 C 1946 C 1 61 0 _f950 9 IN 1 1962 A 1962 A 1962 A A 1W A 19162 2015 1963 T 1963 T 1963 -19-5-1 --- r- T948 T 1963 2016 1964 T 1964 T 1964 T 1952 T 1949 T 1964 017 1965 T 1965 1 1955 T 1953 T 1950 T 1965 -1- -A lubi A 19W 1966 A 1966 A 1966 A 954 2Q19 1967 T 1967 T 1 M-7 T 1955 T 1952 T 7 MIM awn 1968 T 1968 T 1968 T 1956 T 19531 T 1946 -1569 C 1969 C 1969 C 1957 C 1954 C 1989 /e 2022 ýýG 1970 C 1970 C 1970 C 1958 C 1955 C , 2023 ýýo [H 1971 T 1971 T 1971 T -1959 T 1956 T 1971M 2024 - 9- - 1-2 1972 A 1 72 A 972 A 1M --- T- 1957 A A, 1973 A 1973 A 1973 A 1961 A 1958 A 1973 A 1974 T 1974 T 19741 T 1962 T 1959 T 1 1975 G 1975 G 19751 G 1963 190 G 1; 5 Aý, 1976 A 1976 A 19761 A 1964 A 1 1 A 2029 A 19771 C 1977 C IN5 C 1962 C 1977 1978 G 1978 1978 G 2031 7- 1966 G 1963 1979 T 1979 T 1979 T 1967 T 1964 T 1979 2032 1980 A -819 0 A 1968 A 1965 A 2033 1981 T 1981 98, T 1 2W4 im T 119681 1 1961 1982 A982 A 1982 A 1982 A 1970 A 7 A 982 2035 M -19-83 -C -19-7-1 -C 1963 C l9n C 1968 C 983 2036 19U --- r- T98-4 --- 7- T98-4 -T -f§72 ---- r- 1969 T 2037 1985 T 19ý T -19-85 T -T9-7-3 T 1970 T 1 2ý 1986 T T98-6 -T T98-6 T -1974 T 1971 T 1M -G -1-972 2039 1987 G 1987, G 1987 G 4u 1988 A 1 19M 1 A 1976 1988 A A 1973 A 9" ZIA 2UO-41 1989 A 1989 A- -, 9" A 1974 A ""I, 1989 A A 1989 1990 A 1990 1990 A 978 - A 1M -- T- 1990 2043 1991 A -19-9-1 -A 1M -A -19-7-9 A 1976 A 1991 2U4 1992 A -T992- - A -19-92 A 1980 A 1-977 A 1992 "I'l 2045 1993 G T99-3- - G 1M G 1981 G 1978 G 1993 q 2046 1994 A 1994 A 1994 A 1982 A 1979 A -1-994 A 1995 T 1995 T 1995 T 1983 T 1980 T 1996 "A IA 1996 A 1ý -199-6 A 1984 A 1981 A 1997 A 1997 A 1997 A 1985 A 1982 A 1 1998 A 1998 A 1998 A 1986 A 1983 A 199 1999 C -ým - C t9-9-9 C 1987 C 1984 C 1999 200 A 2000 A 2000 A 1988 A 1985 A 20M 2001 G 2001 G 2Wl G 1989 G 1986 G 2001 20021 A 20021 A 1 2W21 A -199o - A -Tg-87 -- 7 2uuj i 1 2UU31 1 1 2uw 1 1 1991 1 1986 T E2W3 ýW41 IZUU41 1 2uý 1 G 119921 G 1989 G 2W4 Kdbdý-, Kolodner Cell Cell Eýatum Kolodner Kolodner Ch.pelle #1 fil 11/17193 fil. 1WI1993 - pub, 1ý9193 ub. 41W1 994 M 611311994 fil. 615M5 fil, 1ý1993 081154792 OW 63,449 031259ý310 OW465,251 OaM60295 SEQ ID NO 8 SEQ 10 NO 8 SEQ ID NO 1 SEQ ID NO:S SEQ ID NOI 2005 T 2005 T 2005 T 1993 T 1990 T 20 2006 T 2006 T 2006 T 1994 T 1991 T 2W6 2059 2007 c ý07 2007 c 1995 c f9 T--G- - 20--60 -008 c 2W8 c _T9_96 -119903 c 2" 206 2008 C Fw A 2009 A 2W9 A 1997 A 1994 A 11031ý ", 2009 OZ62 2010 c 2010 c 2010 c 1998 c 1995 c I I I Cý W 2011 A 2011 A 2011 --- T- 1999 A 1996 A 2011 2064 2012 T 2012 T 2012 T 2WO m 1997 T 1 21ý 2013 c 120131 c 2013 c 2W1 c 1998 2013 -20-661 2D14 A 2014 A 2014 A 2W2 A -T9-9-9 2014 2067 2015 T 2015 T 2015 T 2003 T 2WO T 2015 2066 2016 T 2016 T 2016 T 2004 T NTOW-oi T 2016 2M9 T, w 2017 A -fo17 --- 7- n-17 --- 77- 2005 A 2002 A 2017 2070 A 2018 c 2018 c 2018 c 2006 c 2003 c 2018 2071 2019 T 2019 T 2019 T M07 T 2004 T I 2020 G 2020 G 2020 G 2008 G 2005 G 2020 2073 2021 G 2021 G 2021 G 2009 G 2006 G 1 -2074 2022 c 2022 c 2022 c 2010 c 2007 c 2075 2023 c 2023 c 2023 0 2011 c 2008 c 2009 c 2024 mc 2024 c 2024 c 2024 c 2012 c 77 2025 c 2025 c 2025 c 2013 c -2T1 0 c c -2678 0 2026 A 2028 A 2028 A 2014 A 2011 A I M26 A 2079 2027 A 2027 A 2027 A 2015 A 2012 A o" Iý 20W i -,r, 2028 2028 2028 T 2016 T 2m To-, 0 -20-17 2014 A 2029 2M2 2029 2029 2 29 2030 T 20M T 2030 T 2018 T 1 T 2031 G 31 G [2031 G 2019 G 2016 G 2wi F, 201M 2032 G 2032 G 2032 G 2020 G 2017 G 2032 2085 W I 0 33 2M G -20-86 2033 G 2033 G 2033 G 2021 G ýM I' I 'I 2034 A 2034 A 2034 A 2022 A 2019 A Z,ýR 20-8-7 A' 2035 G 2035 2,35 --- = 2023 G 20Z) G 2035 G- 2088 2036 G 2036 G 2036 G 2024 G 2021 G 2036 ;,s 2037 T 2037 T 2037 T 2025 T 2022 T 2ý T 2038 A 2038 A 2038 A 2026 A 2023 A 2038 ,A 2091 -;AI, I, 2039 A 2039 A 2039 A 2027 A 2024 -20-31 A,`IýA` W 2040 A 2040 A 2o4o A 2028 A 20251 A T2040 mw- --- T- -0- -T 2029 T 2041 ,T 2041 T 4 41 2026 2042 c 2042 c 2042 c 2030 c 2027 c lw 2043 A 2043 A 2M A 2031 A 2028 A 2043 2044 A 2044 A 2044 2032 A 20a A 2D" 2097 A 2045 c 2045 c 2045 c 2033 c 20M c 2045 2098 2046 A 2046 A 2046 A 2034 A -20-3-1 - A -20-46- I I I . 2047 T 2-0-47 20-47 2035 T 2032 T 2047 W- 2100 2048 A 2048 A 2048 A 2036 A 2033 A 210 2049 T 2049 T 2049 T 2037 T 20U T 2049 Il 2050 A 2050 A 2050 A 038 A 2035 A 20ý ýx 2051 T 2051 T 2051 T 2039 T 2036 T -ý00-61 1 2052 T 2052 T 2052 T 72UU 2052 2053 c 2053 c 2053 c 2041 c 20M c 2053 2054 G 2054 G 2054 a 2042 G 2039 2054 1 1 2M A 2040 2 2055 - 'I W", 2108 2055 A 2055 A 2055 A 2056 c 2056 c 2056 2044 c 20411 c 2056 ..... I ý,ýýMHM 2057 A 2057 A 2057 A 2045 A 2042 2058 A 2058 A 2056 A 2046 A 2043 A 21111 2059 A 2059 A 2059 A 2047 A 2044 A 2059 2112 2113 Aý 'I' 2060 c 2060 c 2MO c 2048 c 2045 14 2061 T 2061 T 12W1 1 T 2049 T 2046 T 2D61 2114 2062 G 20621 G 21M21 G -2650 -2047 G 2DU 5,,ý 2115 2063 G 2063 G 20631 G 2051 G G 20ý -fi 1-6"M 2064 G 2064 G 20641 G 2052 G 2049 G 2065 G 2065 G 20661 G 21ý3 G 2050 G 2066 2118 2066 T T 20661 T 21ý4 T 2051 T MR01 2119 2067 G 2067 G 20671 G 2ý5 G 2052 G I 2068 A 2068 A 20681 A 2056 A 205311 A M mNO 2069 T 2069 T 2069 T 2057 T 2054 T 2070 A 2070 A 2070 A 2058 A 2055 A 2071 G 2071 G 20711 G 2059 G 2056 G 2071 2124 2072 T 2072 T 2072 T 2060 T 2057 T 2072 21 ý 2073 A 2073 A 2073 A 2061 A 2058 A 2 73 72126 2074 c 2074 c 2ý --- = -20-62 c 2059 c 0 4 2075 T 2075 T 2b75 T 2063 T 2060 T 2075 2128 2076 0 2076 c 2076 c 2064 c 206111111111 c 2076 2129 2077 A 2077 A 2077 A 2ý 2131 2078 T 2078 T 2078 T 2066 T 2063 T rill 2079 G 2079 G 2079 G 2067 G 2064 G 2079 -Tff-l--3-2- G 2080 G 2080 G 2080 G 720ý - G 7209 G 2080 AA 2133 2081 c 2081 c 2081 c 2069 C 2066 c 1 'A 34 \M,"1 0"" 2062 c c A 71-352082 c 2082 2070 c 2067 c 2082 2083 c c 2071 c 068 C 20M 2136 A =101=777121 A 2072 A 2069 -A -20-84 721V 2085 A I ZU85 I A 12udbl A 3 A W-85 2 A 120651 A 120B61 207 32! ! - -20-71 - A 2M-6 2139 MWIA' 112117 T 120871 20f2 1 2w, 21401 Koiodner KcIodner Cell I Cell Erratum I K.lbdný, I Kolodner I Chapelle #1 fil lV17M fil, 12(7/1993 pub 12/9M3 pub. 4/a/1994 fil 6113/1994 fil. 6/W5 fil, 1201993 08/154,792 OW163,449 DBU59,310 M465,251 081160295 SEQ ID NO 8 SEQ 10 NO 8 SEQ ID NO 1 SEQ tD NO.8 SEQ ID NO.1 -fo-88 T T08-8 T 206 T M-76 -T 2073 T 7ýý -2-14-1 7M39ýTW -20-89 -G -209 -G -208-9 -G -20-77 -G 2074 -G S 2142 A,, -20-90 G 2090 G 2090 G 2078 G 2075 G 1 f0_91 -G -2091 -- - T--- 2M G Z0-79- -G 2076 -G I I m\ 2692 -20-92 080 -T -20-92 -T 2 2077 -- 7'- 2145 'T -20-93 G -2693 G -2-0-93 G 2081 G 2078 214z 0 -20-9-4 -T -2094 - -- T---- -Ma T _T082- -T 2079 T -20-95 - T -2096- 7- 2095 T 2083 T 20W 2148 T ........ _M96 T 120-961 2096 260:84 2081 T 2 .7 T T 2085 T 20821 2149 -20-9 - 6 T ONE zuv, 2udý I 50 ,T I `ýT 2098 G 2098 G 20981 G 2086 G 231 2 M98 2151 2-0-99 T T 20 mg I WT, 215 2099 T 20991 T 2087 -T1-0- 21M G 21 0 0 G 21 21M G G 2088 2 5 -21ý -C 210-1 -C 2101 c 2089 C 2086 C 2101 2154 ~C R, 2102 C -0 20-90 -C C UNER C 2102 2102 2087 -fl-55 ol 1 21703 A 2lM 1 A 1 A A 2 03 A 2 56 2jU -210-4 -T Ya i -T ým 4 2lbI 2 04 2089 0 -210-5 G 2105 G 1 G -20-9-3 G 2090 G -215-8 2106 T 2106 T 2106 T 2094 T T 2091 0 -fl 5-9 21071 G 210 - G 1 -G 2M G 1 7 fim 2 07 2092 0 i A 2108 A 2108 A 2096 A 2M --- A" 2108 1 1 2!W2 21 W G -71-09- G 2097- G 2M4 G 2109 1 2110 T 2110 T 2110 T 2098 F- T T 2110 2163 T 2M C 20991 C 2096 2111 -C -fl 1-1 -C c 2111 A 11 Y12 A -Tl 12- A 2112 A 21001 2097 A 2102 2095 -211-3 - G 2113 G 2113 G 2101 G 2098 G 2113 2114 C 2114 C 2114 C C 2099 C 11 2 67 T -211-5 -A -2115 -A -211-5 A -A T1 0-0 A 11 216 2116 G -211-6 - G 211-6 G 1 G 211M G 2116 R 2169 2171 2 04 A 2117 A 2105 A 2102 A 2117 -fl 1-7 - A -fl 1-7 2170 P,ýP A ý,z 2 11-8 - A 211-8 A 2118 A 2106 A 2103 A TI 1-8 1 G IN G 2119 2172 -21119 - G -211-9 G 2119 G 2 07 -a2O T 2120 T -2126 T 1 T 2105 T 212-0 217 -ffff G 21-21 G 21-21 G 2109 G 21M G -fl 2-1 2 7 21221 T 21221 T 2122 T 11 T 2107 T 2123 C 2123 c 2123 C 2111 c 2108 C 1 2176 -a24 -C -212-4 -C -71-2-4 - C 2112 C 2109 C 2124 WO"C', 2177 c C 2125 A 2ý A 2125 21131 A 2110 T -2 71-7- - -21-2 - T 2126 T 2126 T 2126 2114 T 21-1 -1 - T i ý179 2 T 7 T 21ý Ti 1-5 - T 2112 T 2121 218-0 2128 G TI 2-8 - G -21ý G Z1 1-6 211-3 G 21 4, -212-9 T -212-9 T V29 211-7 T 2114 T 129 182 ý,I 71-30- G -2135 G -2130 G 2118 G 2115 G 1 218-3 213-1 -G -21-31 -G -2131 21-1-9 -G -211-6 -G 2131 ..... . . .. "I A 218 2132 A 2132 A 2132 A 2120 A 2117 - A -2133 -C -213-3 -C -2-133 -2121 -C -2118 c 1 1 2--- -212-2 -T 211-9 -- T-- -ýFl 2134 T 21341 T 134 lu/ 2135 G 2135 G 2 5 G 2123 G 2120 Sq- -a -C -213-6 2- MIM 2136 C 36 C 2124 C 121 C :fl36 2189 -213-7 - A -213-7 A 2137 A 2125 A 211221 A 2137 A,,,,,, 2190 -213-8 T - 21-38 T 21381 1 2-12-6 T 21 ý,/,;,T Y39 - C -2139 C 2139 c 2127 c 2124 C 2139 219 21-40- -T -2-140 -T 21ý -- 7- 21-28 --- T- 2125 T 2140 3 2141 T 129 T 26 2141 T 2141 - 2-- ?2112 RE -1-14-2 -A 7a42 -A -214-2 A 2130 A -Tl--27- -A 5 ý7127 219 T 2-1-4-3 -G 1-4-3 -G 2iý -G -2131 -G 21-28 -G 2143 219 -2-14-4 - C 21-4-4 - C -2-144 C 2132 C 2129 c 1 21111 z 4 a45 -C -21-4-5 -C -21-45 -C -fl 3-3 -C 21W -C 1 2198 2 -a46 -C 213-4 C 2131 C 2146 C 2146 C 2146 99 -21-4-7 1 47 2W G -2135 G 213-2 G 1 ?21ý 21-4 =C =0 48 A Y36 A 2M -A 214 F A 220'10 2 48 2149 G_ 21491 G 2149 G 2137 - G 2134 2149 2202 C,-I 2150 T 2150 T --y- 213-8 T 2135 T "'T 2150 -215-1 - A 1 1 A 2151 A 2139 A 2136 - A 1 1 Z2-0-4 -21ý - G 2152 -21-4--00 G G 2152 G 2137 2153 G 2153 G 21153 G 2141 G 2138 G 1 -22-06 -215-4 G 2154 G 2154 G 2142 G 2139 G zlý -22-17 6 2 56 -2155 - -- 1 G -a43 -G -214-0 - 5 2 55 2155 G G 21 5 67 1 52 -22-09 2156 C 2156 C 2144 C 2141 c 1 6 21 4 -215-7 -T 2157 T -21-45 T i -T 21 -2ý2-10 21 58 59 2158 G 2158 G 214-6 - G 2ý G 2158 nil 21-59 G 2159 G 2159 G 2147 G -2144 G 1 dig 11[2 2-160 T i T 2160 T -21-48 -T -214-5 T 1 2-16-1 - G 2161 0- 2161 G 21491 G '-2-146 --- = 2161 2214 , -ýi 6-2 - A 2162 A 2162 A 2150 A 2147 A -2fl-6-2 22 5 1 -- - -21-6-3 -C 210 -C Z1-63 2216 2163 C 2151 -21ý -A -216-4 -A -fl 6-4 -A 2152 A 2149 A 21 64 1 A, 2165 G 2165 G 2165 G 2153 G 2150 G 2 65 8 -71-54- -T -Tl -5-1 -T 6 rooffmomm, -21-66 -T 66 T 2ý T 21 6 2M -21-67 -C -21-6-7 -215-5 -C 21K -C -fl 5-6 -A 21ý -A -ag -A -210 A 2168 A 2 21 Tl 6-9 - -fl 5-7 -A -a69 -A -2169 -A A 2 2 r2-170 r -T 2ý -T 2170 2 M 0 KýIbdý., I I Kolodner Cýll Cell Ert.. Kolodner Kolodner Cha ýe mu- --- rtj -6113J1994 fil, 6/5/95 ul 120-1993 fil. 11/17193 fil. lw/1993 pub 1MI9 b 4la/199A 06-IF154-7-92 OW63,449 GaI259 310 0814 S,2 1 081160295 SEQ-10 -NO 8 SEQ -IDNO 8 SEQ ID NOA SEQ N08 SEQ ID NO 1 2171 T 171 T 171 T 2IV9 - T -fl 5-6 T 2171 2224 21 G 2172 -G 217 -G -21-VO -G 2-15-7 -G 21 1 [217 2173 A 2173 A I A 61 A 5B A 217 2226 2174 A 2 74 A 2174 -2-1-62 2159 A 217A 2227 , 21 A 21 5 A 2)7 P, 21-63 - k 21 0 - A 217 2228 2176 G 2176 G 21 ' -G -2-1-6-4 G 216-1 G 217 2177 G 2177 G 2177 -G 2-16-5 -G 21-6-22 -- G-- 2177 2230 2178 -A 21 8 -A 2176 -A -A -2-IT3' -A 178 1 w. 21791 G 2179 G 2179 G 2167 - 1ý 2164 2179 21172611 T 21601-T 21-80 T 2168 -T 165 T I 218121bli 21 -61 -C -219 -C 21 6 c 18 2 18-2 T 2182 T 2170 -T 21671 T 2182 2235 2183 c 21431 c Yl -8-3 - C 21-7-1 - G 21081 C _ 2183 2236 -T-84- - - -, -7'-= IF -&-4 -C -211-2 -C -2T6q-C 21 72--3-7 2-18-5 A - 2165 A 2185 -fl 7-3 - A 2170 A -218-6 -C -216-6 -C -218-6 -C -217-4 -C fl 7-1 -C -223-9 21-87- -G T-B-7 -G TIST G -2M -G -2-IT2 G 1 -224-0 -21 -88 - T -216-8 -2-la-8 -2-17-6 2173 T 2188 2241 2189 -T-- -2169 T -0-89 T 2-177 T 1=74 - T 21 -2242 219 C 2190-j- - - - -2W -C -21 re -C -2M -C -221-3 -- 77- 2191 A 2191 A 2179 li A -2-17-6 -9- 2191 2244 -2-19-2 - T 2192 T 21 ý2 T ý2 12 2177 T 1 2245 719-0 G 219-3 G -2915F3 G 121 brl I -2-lT8 -G-j 1 3 -f2-4-8. -2-4 - -- g-- 2179 9 2 G 194 G 21W --G 21621 G -04-8 2195 c 2195 c 1 V5 - C 72163F- -C 218-0 2195 21-96 -7 -219-5 -T -PW -T 21841 T 2161 T 21 719-7 G 2197 G 2197 G 218S G 2182 -CF- 2197 GW 2196 A 2198 A 210-3 - A 21 8 -fl 9-8 -A 7fl 8-6 -A , , "IllsoMillip§ ' -2-199 -A -219-9 -A -2-15-9 -A 21-8-7 -A 1=64 -A 21 q -A 7aM- -A ý2-00 T19 -A fl-C5 A 2200 -ýý2-01 -T -Z2-01 -T ýi2-01 -T Tl 8-9 -T =86 T 01 2254 -22-02 -225-5 ý\\M, -G 2=02 -G 22-02 -- g- -21-93 -G -2Ar7 -G 2203 T -220-3 -- 7-- 02-0-3 219-1 - T 218-8 T noz 2256 2204 T YX4 -T 2=04 -T fl 9-2 n04 12257 -2:5 -2- T 2189 T 22 G -5 -G 205 fl-9-3 -G 2-19-0 -G 220 -225-8 2206 G T206 - G -22-0 1=94 G 2191 G 06 2259 ý2- 2260 z'Aý A 2207 A 07 A 1=95 -A -fl 9-2 A 07 2- -21-F3 -A 2261 220 k 2208 A 208 A 1=96 -A 2209 A 2209 - A 12209 A 2197 A 2104 Mg 2198 2195 22 2210 c 2210 c 2210 c c c 2263 Ml f T -20-1 -7 2211 2199 -T - 7f, 9-6 -T 2264 -22-12 -G -2212 -G 2=1 2 22-00 G - 2197 G 1 2265 22-13 -C 22-13- -C 71ý-i3 -C 2=01 -C -fl 9-8 ----- Ccccc ý2-68 22-14 -T -22-1-4 -T 2=1 4 --- T--- = -T 2-109 -T ý267 2-2-15 -- 7'- M-15 2=1 5 -- r- -ffM- -T 22-M T 22 -52S8 T,,e' gp 26 %& 22-16 -C T21-6 -C 22-16 -C 22-04 -C 22-01 -C Sk" -221-7 -T _r2-1-7 -T 2Tl-7 -T -22T5 -T -T27-2 -T 2270; 2218 i2-18 -A 2-21B --- =- 2-20-6 -A 2ý0-3 -A 18 ý11 ff 2272 2219 T 2=1 9 -T -0-1-P -T ffU-7 -T 0-4 -T 19 -T2-20 -C -22-20 -C 222-0 -0-0-8 c 2206 c 2 D-73 MI c _L221 ___C 2221 C - 2209 C 2206 c 222 -2274 2222 2222 T 2222 T 2210 T 22-0-7 - T 2 2 :ff7-S 2=2 3 c 22M c 222a c Z21-1 c 2208 c -Y2-7-6 2224 224 A 224 2 2 A 2209 A 2224 2277 -7- = - -- 77- -T-1- 2225 G 2=25 -G -f2-25 -G -22-13 G 22-10 -G 2225 2278 2226 - G 22-26 -G 22-26 2-2-14 G 22-1 -1 -G 279 '322-7 --- 7-- 2=27 -- T- -f2-27 --- r- Z2-15 2212 T - 280 -22-28 -C 2=28 -C -f2-28 -0 -22-18- c 22-13 -C 228- 2281 2=29 T -ý2-8-2 2=29 -T -2-22-9 -- T -22-1-7 T -221-4 -T - ZT- 21-8 G 2215 G 2230 431ý 228'a ývW, G 2230 G 22ý -ý2-30 2 ýc 2231 c 2231 c 2231 c 2219 c 2216 c a3i 2284 =2321-A -22T2 -A -2TS2 -A M22-0 A 2 17 A Ma2 285 2233 A 2233L A 2233 A 2221 A 21 A 223.1 ýZM ý,A 2234 c 2234 c 22 c 2222 c 19 c 22734 . ...... V ;,5 2235 5 c 2223 c 22201 c 35 -22rS 2236 A 2236 A W35 A 2ý26 2289 A A 2224 A 2221 2237 A 2237 A 25 -0-90 ý'-'ýA A ýn-35 -A -ý2-38 -0, -2ýg-6 2223 -A 38 -T29-1 - -ý2- W-39 -'F- 39 F7 G 2224 G 22 2292 2240 A 2240 A 2240 A 2228 A 25 A 2240 22-03 '11-ý,V " 1 T 24 T 241 T 22261 T--1 ý2 9-4 2242 22-42 - T -22- --- r'- -0-3-0 27 T 2242 22D5 M/ft 2243 C- -224-3 -C 22-4-3 -C 22-31 -- lC- 22128 43 72- -A ý2" -A -7.2-3-2 -23k, 2244 A 44 A, 2229 A 2 44 97 z , K 2246 2245 22 23 3 45 1 1 2298 2246 T 2248 T- T2T6 -T -223-4 T 31 T 22 -A 2AT -A -Ir3-5 -A 300 2247 A 247 A I 22-4-8 A 122481 A 22481 A p2mer A 2248 301 2249ý 2249 T 2237 T 2249 U 2 2 K-- J-22"O - A- 22501 A 1223581 A 235 50 -F3-0-3 2251 K-- 122511 A 2251 ý A 2239 A 1 2304 2252 122521 T 2;52 T 22 2 2305 T :22 T 2240 51 19 2-2-53 jzýjj 1 2ý. 1 2241 c 306 C" Ko lodher Kolodner Cell Cell Erratum Kolodner Kolodner Chapelle #1 -fil. 11/17193 fil. 12(711993 ub. 12/9193 pub 4/W1994 fil &1311994 fil. 6/5/95 fil. 1201993 OW154,792 08/163ý449 081259,310 081465.251 081160295 SEQ ID NO 8 SEQ ID NO 8 SEQ 10 NO.1 SEG ID NO.8 SEQ ID NO 1 2254 A 2254 A 2254 A 2242 A 2M 2254 2307 2255 T ý55 T 2255 T 2243 T 2240 T 2ý 2256 A 2256 A 2256 A 22" A -2W A 2256RON 2257 G 2257 G 2257 G 22ý - G 2M G 2257 2258 A 2258 A 2258 A 2246 A -22-43 - A 2MM 2259 T 2259 T 2259 T 2ý T 2244 T 2259 2260 G 2260 G 2260 2248 G 2245 G -n60 2261 A 2261 A 2261 A 2249 A 2246 A ;ý61 -23-14 A 2262 A 2262 A 2262 A 2250 A 22471 A 22-ý 23-15 2263 T 2263 T 2263 T 2248 T ý64 T 22U T 2252 T 2249 T 2 ý64 -232264 G n53 G n50 G ý65 17 2265 G 2265 G 2265 2318 2266 G 2266 G 2266 225-4 - G 2251 G 2266 2ý19 2267 G 2267 G 2267 G n55 G M52 2268 A 2268 A nlM A 2256 A 2253 FANW, 2269 A -fmý- A A 229 -A 22N 2322 2270 G 2270 G n70 G n58 G 2255 G 2270 2323 ,W 2271 A 2271 A 2271 A 2259 A 2256 A 2271 239 y 2M -G 2272 G 2272 -G 2260 G 2257 G 2272 2325 a-, 2273. G 2273 G 2273. G 2261 G 2258 G 2273 2326 2274 A 2274 A 2274 A 2262 A 2259 A 2275 A 2275 A 2275 A 2263 A 2260 A 2276 C 2276 C 2276 C 2264 C 2261 C 2277 T 2277 T 2277 T 2265 T 2262 T 2278 T 2278 T 2278 T- 2266 T 2263 T 2278 2279 C 2279 C 2279 C 32 -22-87 - C 2264 C 2279 _Z3 2280 T 2280 T 2280 T -T268- T -2265 T ... h -ý333 2281 A 2ý -- 77- -22-81 -A 2ý -A 22-66 A 2281 2334 2282 C 2282 C 2282 C 2270 C 2267 C 2282 2335 -2283 C 2283 C -22-83 C 2271 C 2268 C 2283 2336 -2264- -- T-- -:F28-4- - T 228-4 ---- = -22-7-2- M26-9 2284 337 2285 A 2285 ANNE A 2285 A 22731 A 2270 A 22MIM M E 2286 C 2286 C 22861 C 2274 C 2271 T28 2339 C --6 39 'W\0 2287 G 2287 G 22871 G 2275 0 2272 2288 A 2286 A a A 2276 A 2273 A 22M 2289 T -22-8 2M 1 T -2277 T 22-74 -T 2342 IMEM 9 T 221 MINE\ 2290 G 2290 G 22901 G 2278 G 2275 G 2290 -f2-91 G 2291 G 2291 G 2279 G 2276 G 2291 2292 A -2292 -A -22-9-2 -A 72280 A 2277 A 2293 T -ý2-9-3 -T -228-1 -T on --- T- n93 4 2294 T 2294 T 2294 T 2282 T 9 1 2294 INZ7 'M 22-95 T -22-95 T 2ý T -0-8-0 - T 2U 2295 T 2UB 2296 G 221M -G -22-9-8 -G 22-8-4 -G -0-8-1 -G 2296 2349 2297 G 2297 G 2297 G M5 G 2262 G 2297 2350 22981 G 2298 G n98 G 2286 G 2283 G 2298 2351 22991 T 2299 T M87- T 2284 T 2300 T 23M T 2300 T 2288 T 2285 T Z3-01 A 2301 A 23ul A a89 A A 1 Aý11'1 23-54 23ý G 23021 G - -2302 1 G 2290 G 2287 G 2W2 2355 2303 C 23031 C 123031 C 2291 C 2288 C -2356 2304 A 2304 A 23041 -A 22-92 A 2289 A 23ý T 2305 T 2305 T 2293 --- 7- -22-9-0 T M58 2306 G 2306 G 2306 G 2294 G 2291 G 231M 2307 G -2307 G T3 0-7 G 229-5 G 2292 G 2307 :ff-59 2308 G -230-8 - G -2308 --- 7- 2296 G 22wi u 26ud 5 10,01, 2361 2309 C 230-9 -C 2ý - - - r, "' ""' 23-62 C 2297 C 2294 C 2309 %W -T3-10 T 23ý T T mi-o2310 T f 21iff 2311 A 2311 A 2311 A 2299 A 2296 A 2311 Aý 2364 ýIfflA' 23121 T 12 T ý "w 23- - -Z3-12 T 23-M T 22ff T -:ffl-2- k R\,ý 2313 A 2313 A 2313 A 2301 A Z314 f 14 -T 23U -T -23-0-2 --- r- 2299 T 2314 2367 2315 C 23151 C 2315 C 2303 C 23M C 23-15- 2368 01' A 2316 A 2316 A 2316 A 2304 - A 2301 n16 -f 23ff G 2317 G 2317 G 2305 -(r- Z3-0-2 - G 2317 2318 A 2318 A 2318 A 2306 A 2303 A 18 2319 A 2319 A 2319 A 2307 A 4 A M19 2320 T 23ý -232-0 T 2308 T 231M -- T-- -2320 2d(j 2321 A 2321 A 2321 A 2309 A T3-06 - A 2321 A 2374 2322 0 2322 C 2322 C 2310 C 2307 C 2322 t Z375 2323 A 2323 A 2323 A 2311 A 23081 A 2323 2376 2324 T 2324 T 2324 T 2312 T 2309 T M24 23 TRý 77 2325 T 2325 T M-5 2313 T 2310 T 78 2326 G 23ý J- -23-26 G 2314 G 2311 2327 C 2327 C 2327 C 2315 C 2312 C 2327 2328 A 123281 A 2328 A 2316 A -f3-13 - A 2ý 2329 A 23291 A 123291 -- 7- 23-17 - A -23-1 -4 A 2329 2 82 2330 C 2330 C 2330 C 2318 C 2315 C 2330 2383 J/1 -23-31 A 2331 A 2331 A 2319 A 2316 A 3 23M 23ý A 2332 A 2332 A 2320 A 2317 x W, 2333 A 123331 A 2321 A 25U 2333 A 5 A 2333 386 MISS 2334 G 1ý1. I iJJ41 2322 G 2319 23-3-4 2335 A 2335 A 123351 23231 A - 23-20 -233-5 2388 ...... 4 T nýF-T l 2ý ýA-M/ 123361 T 1 2336 T 123351 T 232 21 n6 ,,,U23891 V11' K.I.fte, Kolodner Cell Cell Eýtum Kolodner Koloduer Chapells#1 fil 11117M3 fil 12U11993 pub, 12JM3 pub. 4/W1994 fil WN1994 fil. 615ý ML 1ý1993 081154792 OW 63 449 08/259,310 08/465.251 M160295 SEQ ID NO,8 SEQ 10 NO,8 SEQ ID NOA SEQ ID 1,40ý8 SEQ ID NOA 2337 T ý37 T 2337 T 2325 T 23n T 337 7,z, 2390 326 M 2391 2338 G 2338 G 23M G 23ý -G T3M -G 38 n92 2339 G M39 G 2339 G 2327 G 2324 G 2340 T M40 T 2340 T [23328 T 2325 T 11,!Iý .. 2341 G 2341 G 2341 G 2329 G 2M --- 7- -2341 7ý '4X-, 2394 W_ 2342 C 2342 c 2342 C 2330 C 2327 C 2342 lft,§ 96 II10AI CIýgffg 2343 T 2343 T 2343 T 2331 T 2328 T M43 "CT '3ý1011 -2396 WIM111, IT ý,Mhfi 23a --- r- -2344 T 2344 T 233ý2 29 2344 31`7 123451 2345 T 2333 T 23301 T 23 23451 T T 45 T,,' 2 98 2346 T 2346 T 2334 T 2399 2346 T M46 N 2347 T 2347 ---- r- 2W -T 2335 T 2332 T 2347 2348 G 2348 G 2348 G 2336 G 2333 2348 2401 2349 1 2UIff I W , C 2349 C M49 -C 2ý C 2334 Q 24-02 2350 A 23ý -A 50 -A r- Z335 A 2ý13 2403 2351 T 3 -2 ý51 T 23-5-1 T M39 T 2336 T 1 N04 -nn G 2352 G 23-52 G 2340 G 2337 G -f4O5 2 T 2338 T 2353 2353 353 -T 23ý -- T'- _Z341 - 24W 2364 T M54 T 2354 T 2342 T MID T 23M 2ý Wo ol 2355 T 2355 T 2355 T 2343 T 2340 T 4ý 2356 G 56 G 23ý G 2344 G 2341 G 23571 C 2357 C 2357 C 2345 C 2ý2 c -2410 2358 A 2358 A 2358 A 2346 A 2ý3 A 2411 2359 A 2ý -A -559 -A 2U7 A 2ý4 A 2412 2413 2360 c 2360 C 2360 C 2348 C 2U5 c Al 2361 c 2361 C 2361 C 234i - C 2346 C 1 -N-14 L, nu C 2362 C 2ý Z350 C 2U7 C 2363 A 63 A 63 A 2351 A 48 A TW3 A 2364 T 2364 T 2364 T 2352 T 23ý T 23U ý41 7 2365 T 2365 --- r- -f365 T 2353 T3 2365 2418 2366 T 2366 T 2366 T 2354 T -2351 1 P 1 2367 T 2367 T 2367 T 2355 T 7mý - I T, 2368 C 2368 c 23681 c 2356 c 2363 c 2421 23691 A 2369 A A 2354 2369 A 2357 2422 A 2370 T 2370 T 2370 T 2358 T 2355 T 2370 2371 G 2371 G 2371 G 2359 G 2356 G 1 2371 2424 G, 2372 A 2372 A 2372 A 2360 A 2357 A I Z372 2373 A 2JI3 A 2313 A 2361 A 2358 A 2ý C 2374 C 2ý c 2362 C 2369 C I M74 2427 2375 T 2375 T 2375 T Z363 T 2360 2375 2428 2376 T 2376 T 2376 T 2364 T 23-61 iT ZJ(U T 2377 A 2377 A Z377 A 239 -- - -r- M62 A 2377 2ýJU 'A 2378 C 2378 C 2378 C 2366 C 2363 C 2431 2379 T 2379 T 2 ý79 T ýM7 - T 2364 T 2432 23W -G Z380 -G 2M G 2368 G 2365 G 2433 23811 C n8i I C - 23811 C 2369 C 2356 c 1 1ý, 2434 SO 2382 C 23821 C 23821 C 2370 C 2387 C Cký, -2435 -2w 2383 T 23831 T 2371 Z368 - T 2436 2384 T 2384 T 2 T 2372 T 2369 T 7385 G 23NN 1 G -2373 G 737-0 -G 2385 G 2438 2386 G 2386 G 23861 G 2374 G G 2386 Q 2439 2387 C 2M7 2440 -k 2387 C C 23T5 C C 23U - Elk 2388 G 2388 C 23881 C 2376 C 23731 C 7441 2389 A 2389 A 23891 A 23T7 - A 2374 A 1 2389 2442 2390 A 2390 A 2390 A 2378 A 2375 A n9O 2443 T 23911 -2391 T -] 23919 2316 T q23901 T, NPý H2444 P, M12 2392 C 2392 c 23921 C 2380 c 2377 C I %, Iý ý,ý 44" 2393 A 2393 A 23931 A 2381 A 2378 A 1 M93 23941 G 2394 G 23941 2 G T23-79- G M94 [H2447 2395 A 2395 A 2395 A 23M A zwo A M95 zz\\NNA,ý, 1, 2448 449 [WIF 2396 T 2396 T 2381 T A 2396 T 2384 T - - -2396 A 244CI T/," 2397 A 97 A 7239T A 2365 A 2382 A Saff 2450 'kF% 2398 C 2398 C Z398 -C 2386 -C 2ý ---- = n98 2399 C 2399 c MWi C 2387 C 2384 C 2452 2400 A 400 A 61, 24W A 2385 A 24M 2401 A 2401 A 2401 A 89 -2386 A 2401 W/WMA 2454 2402 C 2402 c 2402 C 2390 C 2387 2402 56 2403 T 2403 T T -24 5-6 2403 T 2391 T 23M T 2403 2404 G 24041 G 2404 G 2M G 2389 G 2404 1.11 2405 T 2405 T 2405 T 2393 T 2390 T 2405 T 2458 2406 T 2406 T 2406 T 2394 T 2391 T 2406 .. 2407 A 2407 A 2407 A 2395 Z392 2407 A qII 2460 r/ A 2408 A 2408 A 2408 A 23961 A ý2393 A 2408 gq 2409 T 2409 T 2409 T 2397 T 2394 -fý- 74-09- ýT%\Mftý -f46-2 T 2410 A 24ý N-iO A 2398 A 2395 A 2410 2411 A 2411 A 2411 A 2399 A 2396 A Nff Qýll &fto 2412 T 2412 T 2412 T 2400 T -nR T 24U W 2ý -2413 c 2413 C 2413 C 398 --- = N13 .... 2466 23 2414 2414 T 2414 T 2402 T ýMg T T 2415 A 2415 A 2415 240 A 2400 1 -24-68 2416 C 2416 C 2404 C 2401 C 2416 2417 A 71 A 2417 A 2405 12416 2417 2416 1 124161 1 2418 T 2406 T T41-8 i (24191 G 124191 G 124191 G 2401 G T4-1 9 0 Kolcdner Kolodner CpII I Cell Ermtum I K.I.dne, ner Chapelle #1 - -fil 11117/93 fil 12f7/1993 pub. 1M/931 pub, 4/811994 fil, 6/1 W1 994 195 fil 1ý1993 08/1 b4.192 081183,449 08/259,310 251 08/160295 - S-- SE SEO ID NO 8 f Q ID NO 8 SEQ ID NO I NO:8 SEQ ID NO 1 -2426 T 2420 T 2420 T 2408 T 2405 T -973 ` 24WO6 C -27-7-4 74-2-1 C 2421 C 2421 -240 C 1 2422 A 2422 2422 A -2410 A 2ý 2422 2423 C 2423 2423 C 2411 C 2408 C -2476 -2424 - A 2424 A 2424 A 241f A 2409 A 2477 Z425 - G 2425 2425 G 2413 G 411 G 2425 2478 2426 C 2426 2426 C 2414 C 2411 C 2426 -2427 - A 2427 A 2427 A 24fý A f412 A T480 2428 C 2428 C 2428 C 2416 C 2413 C 2428 2429 T 24291 T 2429 T 2417 T -2414 T 1429 - - 2 24-30 - C 2430 C 2430 C 2418 C 241-5 1 74-3-0 2431 -A 2431 -A 24ý A 2419 A 2416 A 2431 2484 -2432 C 2432 C 2432 C 2420 C 2417 C 2ý Q 2485 C -f4-3-3 2ý 2433 C 24ý C 433 C 4=21 2418 C 2419 A 2434 ýý, W,ý-A- -2434 - A 2434 A 24u --- 77- -m2 ,: 2487 __ _ý4 _ ý4 2423 C 20 C 35 _t\ -2435 C 2435 2488 74-36- - T 2436 T 2436 T -2-42,f T 2421 T N36 T489 2437 G 2437 G 437 G 25 G 24ý 2437 24W 2438 A 2438 A 2438 A 2426 A -f423 - A m-8 2491 2439 A 2ý9 A 2439 A 2427 A 2424 A 2ý -T492- L A 2440 G 2440 G 2440 G 2428 G 24Z -2W A 2441 A -2441 A 2429 A 2426 A 2110' A -2442 .. 2495 G 2442 G 2442 G 2430 2443 A 24ý - A 2443 A 2431 A 2428 A 2496 2444 C 2444 C 2444 C 2432 C 2429 C M444 2497 244,[ -f- C 2430 -- C 2445 ý,7/Wý,5C 2498 2445 C 445 C 724Z C 2433 2446 T -2446 - T -24-4-6 T 2434 T 2431 T 244S6M/V,//" 249p, -24 N -25 -f447 T 47 T T 2435 T 32 T 2447 00 -4 - - 7 T44-8- - -2--4 - I A 4 8 A T4 -8 -A 24-3-6 -A 24-33 -A 2448 -24 A 43-4 -A 2449 -N49 --- R- -2449 -A 49 A 2437 -N50 C 2450 2450 2438 C 2435 245:OF T45-1 T 7451 T 4-39 T 43-6 2451 T 245 IZZ 2452 A 2452 A 2452 A 2"0 A 437 A 2411 2505 2453 T 2453 T M3 T 2441 T 2431 T 24535 -2454 G 2454 G 2442 G 5 2454 G 2454[ý 2455 C 2455 C 24M C 2443 C 2440 C 2456 T 2456 T 2456 T 2444 T 2441 T 245 -2457 T -245-7 - T 72457 T 2445 T Z442 T 2457 'g"' T, - - -24 T 2443 -T 245 -T458 -2458 - T 58 T 2446 8 2- A 2459 A 2447 A 2444 A 2459 2459 A 459 _Sil 2 2-46-0 -T 4=48 T --- 1 gg 2460 T ;F460 T 2445 T 2ý q2513 24-61 -C -N61 - 2514 461 C C 2449 C 2446 2461 2462 A 2462 A 2462 A 2450 A 2447 A f462 2515 ",\2 24-63 -G - -16 -2463 -G T46-3 -G G 2451 G T4 4-8 2464 - G 2464 G 2464 G 2452 -T- T44-9 G 2464 M301 2517 2465 T 2465 T 2465 T 24-53 T -N-50 T - ' ',(v ý; 2465 2518 -f4-66 G 2466 G- 2466 G 2454 G 2451 G 2468 2W --- r- -2467 --- 77- 2467 A 2455 A 2452 2467 2468 A 2468 A 2488 A 56 A A 2521 N 2453 2468 2469 -N-59 G 2469 G 2457 G 245A G -74-69 2522 -2476 -A -2476 -A 2W A 2458 A -N55 -A 2470 252 2 24 ýkO't` 2471 A 2471 A 2471 A 2459 A 2456 1 2471 ffi 5 ' 'M k -2-472 -A -24-72 -A -24-72 A 24-60 -A -24-57 q2472 Lkn,ý"",ý -2ý - """IbIL -24-73 G 24-73 -G -24-73 G 2461 G -24-56 -G 2473 a 2526 G, 2474 G 2474 G 2474 G 2462 G 2459 527 -2 T 2463 T 2460 T 475 475 -T 475 24751 1928 2476 G 2476 G 2476 G 2464 77- 2461 G 2476 2529 G -24-7-7 T 2477 T 2477 T 2465 T 2462 T 2477 2530 -24-78 -C 2478 2478 C 4=66 -C 24-63 C 2478 2479 Z479 --- T- -2479 T 2467 T 2464 2479 T "m N80 2480 G 2480 G 2468 G 2465 G 2480 2533 2W -T 2ý -T -2481 T 2469 T -2466 -T 2461 2- -G -2482 G 2470 G 2467 G 2 Q 2482 G 482 2483 A 2483 A 2483 A 2471 A 2468 A 24M 2484 T -2484 - T 84 T 2472 T 2469 2484 --- -f- - -2 - 2M -C 2485 2485 C 485 C 485 C 2473 T486 A - A 2- A -Nn -1 2486 - T4T6 A 486 A 2474 - - T48-7 -A 4=7 5 A 24n 24U -A 2487 A 2487 A 2488 A 2488 A 2488 A 2476 T471 A 248 2489 G 2489 G 2489 G 2477 G 474 G 2489 [ý, "I 74-90 T 2478 T 2475 T 2543 -N90 -T T490 -T 2490 F,', T 1 ..... -2491 -T 491 -T 491 T 2476 T 2491 -2-M T 2479 q,,c ýý T' Rl 7N" -T 2492 T -f492 2492 2492 T 2480 T 254 7-4-9-3 -T 9-3 -T 2493 T 4=81 T 24M -T 2493 T 2546 MIMMIS' -24-94 -G -f4 9-4 -G - - -= -24-82 -G -24-79 -G 2494 Z 2ý41 - G G -2495 -2495 2495 G 2495 G 2483 G 2480 2548 2496 GF- -2496 -G N-96 -G 4=84 G 2W -G Y49-6 - -9ff -A 2497 -r- 4=85 -2497 -A A 2ý -A 2497 Mo 2498 T 2498 T 2498 T 2486 T 24ý - T 418 255 2499 T 24-99 T -2499 T 4=87 -T 24-U -T T499 -24 - 2553 2500 C 85 -C 2500 2501 A -A -2486 -A 2501 25021 T 2*Q2 I I nuz 1 1 24vu T -24--8-7 - T 25-02 0 a Kolodner K.t.dý., C.11 Cell Eýtum I Kolodner Kolodner I Ch.pellý #1 fil 11/17/93 fil 12f7/1993 pub 12/9/93 pub ý&1994 1 fil, 611 ýl 994 1 fil. 615M5 1 fil 12M1993 OW 54,792 08/163,449 1 08ý59,310 1 06/465,251 1 OW 60295 SEQ JD NO 8 SEQ ID NO.8 SEQ ID NO I SEQ ID NO:8 SEQ ID NQ:l 2503 G 2503 G 2503 G 2491 G 2488 G 2503 ... l!' 2556 2504 T -ýý504 T -ýý-4- T -24-9-2 T 2489 2557 2ý05 T 2505 T 05 T 2493 T 24PO 72658 2506 G -f5O-6 -G -ý5-06 -G -5-9-4 -G 2491 G 2507 -ý-5-07 - C 2507 c 2495 c -Tif4-9-2 2-5-W -25-08 -A -2908 A -25-08 -A -4-9-6 A 2493 A I 2561 -25-09 -G 2-50-9 -550-9 -G -ýA-97 -G 24a G 2510 A 2510 A A 2495 A 2510 2511 G 2511 G 2511 0 2499 G 2496 G 11 -W*ýl 2564 2512 c 2512 c 2512 c 25M c 2497 c 2512 5 2513 T 2513 T 2513 T 2501 T 2498 T 1 -256 1& 29-1-4 T 1 T -ýý514 T -ý502 T 2499 -2 -256-7 WMISM/ftl 2FE-0-6- C 2516 c -Y5-16 c 2504 c 2501 c 2 16 569 251-5 -G 2515 -G -T5-15- G -ý - 3 G 2500 G 21 gý -M17 T 2 17 T 2517 T 2505 T T 1 2570 2-51-8 -A 2518 -A -ý5-1-8 -ý5-0-6 - - -r- 2503 A 18 2571 X -251-9 - A 2519 A 2519 A 2507 A 25N A 251 5721 2520 T 2 20 T I q2573 - 7520- T -0-08 T 250 -25-2-1 - T 2521 -ý5-2-1 -ý5-0-9 - T 2506 T 2ý21 I q 2b 25 2 T 2522 T 2522 T 2510 T 2507 T 267 ,QQT, , 2523 c 2523 c 2523 G 2511 C 2508 c 257 C, -25-24 --- C 2-52-4 r-- C 2524 -F5-1-2 - C 2509 c 2524 2525 c 125251 C 2525 C 2513 C 2510 C 2578 2526 T -f5-2-6 T T5-f4 T 2511 T 2526 2579 2521 A 2521 A 2ý21 A -F5-15 25121 A 252( illjMU 2*W "ggpA---ý 1 -25-21 2581 ',\"'A 252B 2 2 A 2528 A 2516 A A ?514' G 2529 2582 2"1 #1 G 25-29- G 2517 G 25 2530 c 25301 c -T5-3-0 c -ý5-18 c 2615 c 2530 2583 2531 A 2531 A 2531 A 2519 A 2516 A 2532 T 2 32 1 ýDjz T -ý5-2-0 T 2517 T 2532 2533 G 2 3 G 2533 G 25211 G 2518 G 2533 ' 3 2586 2534 T 2534 T 2534 T 2522 T 2519 T 2 3 2587 2535 A T53ý6 A 2535 A 2523 A 2520 A 2 3 H2MI - 6 -25 2536 A 2636 A 2536 A 24 - A 2521 A ' ' 2537 T 2531, T 2W, T 5 T 2622 - 0 -i5-- 2590 25-38- -A 2538 25-26 A 2523 A I 2539 G 2 39 G 2539 ý5-2-7- -RG 2 24 -G 2539 wR;-,Vý 2592 2540 A 2540 A 2540 A 2528 A 252 - 25939 -Y5-- - - 5, A 2 1t0M-", 2541 G 2T41 G 2541 G 29 G - 2526 G 2549 25194 W,ý, //§ 264-2 T 2542 -25-30 - T 2527 --- T- 2542 2595 ','ýA 5 a 25 8 frd 2596 25431 G 2543 G 2531 G 2 G 2 43 2,ý4 111111 T I-M 2594 7 V/4ý f /y -25-32 T 25ý 2545 G 2545 G 2545 G 2533 G 25M G 2545 G 2546 c c 2546 c -2534 c 2531 c 2546 T 26471 T 2547 T q254 2547 12535 T 2ý T 2547 2WO 2548 A 264ý A 2548 A 12536 A 2533 A 2548 26HOl 25491 A 2549 A -F-25-37 A 2534 A 254E 2602 2550 A 2550 A 2550 A 2538 A 2535 A 255C 2603 2551 G 2ý*l 1 c 2539 C 2536 C 2551 260 2552 A 2552 A 2552 A 2W A 2537 A 2552 2606 2553 R G -2T53 G 2553 G T541 P G -2538 G 2553 2 06 ýIha` 2554 A Tý5-4 - A 2554 A -ý5-42 A 2539 A 25 M A, 2555 A 2555 A 2555 A 2543 A 2540 A 2555 2549 A I A -26--56- A A 25-4-4 A 2541 A 2556 25 7 G -ý6-55--7777 G G 2545 G 2542 G 2557 wo" 13 2610 2ý6-58- -c C 25-43- -C 2558 gg 2546 OFF/, 2611 2559 c 2559 c 2559 c 25 7 C '0111" 2611:02 M" -f5-44 -C 8/0 c zag 2560 C 2560 c 2560 c 2548 -2545 2ýO 2613 ý% p/,,M, 2561 T 2561 T 2581 T 2549 T 2ý6 T 1 2614 5 2 G 2562 G 2562 G 2550 G 2547 G 2562 2615 25-63 G -256-3 -G 2563 -G 2 1 G 2 48 G 2564 A 2564 A 2564 A 2552 A 25491 A 2564 ;ý5-6-5 A 2565 A -ý5-65 - A 2553 A 2618 -f566 -C -ý5-6-6 -C -2566 -C 2 c 255 c 06: 2519 Celýw -25-6-7 T -25-6-7 T -256-7 T T 25 , Mis 26-20 jT 'ý Výýfi 25-6-8 T -256-8 T 2-56-8 T -T 2M8 I I ZM8 1 26-2-1 2-569 -G -25-6-9 --- = -:F56-9 G 2557 G- 2554 G 9 25-70 A 2570 A -55-7-0 - A 2558 A 2555 A 2570 2- k',9 -- 2- G - G -25-6 1 26 -2571 G 2571 G 57T G 7559 G 56 G 1 4 2572 G 2572 G 72 G 560 G 2567 G 2572 2625 2573 A 25-7-3 -A ý5-73 [-A 2561 A 25 257 2574 G 2574 G 2562 G 2559 G 2 27 -ý, a 2575 T Z7-5 -- 7- -- Y57-5 -- r- -ý5-63 --- T- 25-6-0 T 2575 8 T 2576 T 2576 T ýý5-76 T 2564 T 2561 T 2576 212 ýT 25 7 T 2P-7 T 25-77 T -56-5 T z5-6-2 T 2577 263 1'Q 2578 C --- -f578 C ýý5-78 -C -2566 - C 2563 c 2578 A 2579 A i5-79 -A -ý-567 A 2564 A 2579 2580 G 2 80 G 80 G 2568 G 2565 G 2581 T 25-8-1 - T 25-81 T 125691 T 2581 2582 A ZB-2 T 26-83 - I 2bdý I I 2D(l I I A 2bd4 Ublýj A T 15-85= F2521 T 125731 T Kotodner Kolodner Call ý11 Eatum Kolodner K.lodm Chapelle #1 fil, 1 1117M fii 1ý11993 pub 1 3 pub, 4/&1994 fil, 6M311994 fil. 615195 iii, 1=1993 081154792 081163,449 UM-5931 0 081465,251 - 081160295 SEQ ID NO 8 SEQ ID NO 8 SEQ ID NO 1 SEQ ID 1,10ý8 - SEQ -IDNO 1 2586 T 2586 T 2586 -T -25-7-4 - T -25-71 -T 25M 2587 G 2587 ------ T- 2587 --- T- 2575 --- 7- -557-2 -G 2587 2640 2588 G 2588 G 2588 G 2576 G 2573 G 2588 2641 2 89 -A 2589 -A 2W9 -A -25-77 -A -f5-74 -A 2-64-2 2590 G 2590 -G 2590 -G -25-7-8 -G -f57-5 -G 2643 U"' 2S91 A 2591 A 2591 A 25-79- -A 25-7-6 -A 1 2 92 A 592 A 2592 -A -f5-80 -A -f5-77 -A 2592 2593 2593 ------ ý7r 2593 --- r- -ýw 25941 C 2594 c 2594 C 2582 C 2579 C 2594 2647 2S95 G 2595 G 2595 G 12583 G 2580ý G IIIIII 25-96 - C 25-96 - C 2596 C 2584 C 25811 c 1 2596 2649 GI 2597 2-5-97 - A 25-97 A 2585 A 2582 A 2597 2650 26-9-8 -A Z-9-8 -A -25-99 A 2586 A 2583 A 2ý9-9 G -2599 G - -2600 G 2599 G 2587 -G 25-8-4 -G 2599 2 26W G 26W G 2588 G 2585 - 6 .. 2601 A -2601 -A 25-89 - A T58-6 - 60jr 2601 A 2601 , A-M -26-0-2 -T -ý6-02 -T 26-02 -- r- -ý5-90 -- -r- 25-87 -- T- 2:122 ,, , aZ 215J 2603 A 2603 A 2603 A 2591 A -ý5-88 - A 03 265 -ý6-04 T _T604- -T -f5-92 -T -T 604 ý\%j 7 Z6-0 25K M-1 2606 G -5605 G 5 G 2593 G T590 - G 2 4 2 7 , 2606 A 2606 A 2606 A 2594 A 2591 A ?2:616 '58 60'0' T9 Al -2-50-7 IT 1-ýý6-07 I- T 2607 T -T 25W T 6 59 , I 2595 q2617 Y6111 -",.A 2608 A 2608 A 2608 A 2596 A -ý5-0- 2608 'o' 2609 T 2609 T 2609 2597 T _T6 maw C 2598 c 2595 C 10 -2-6-10 -C -M-10 -C -261-0 T610 2663 26 1-1 -A -ý6-11 -A 26-11 -A -ý5-99- 2596 2 25 Aý, 2612 T 2 T 2612 T 2600 T 2597 T 2612 'T -2--1 2613 G 2613 G -fW-l -G f5 -g8 -G ý2ý XMIU -26 1-4 -G -M-14 G 2614 G -f6O-2- -G 250 -G 2614 667 2-6-15 A 2615 A 2615 A 2603 A - -26W A 26Z 66 2616 2616 A "g -A -f6O-4- -A 26U -A 2616 2616 q2 - - 36-1-7 c 2617 C 26051 2602 C 2617 F/ý, , 2670 2617 C C 2618 C 2618 C 26io I IbUbj c 2603 C -26-18- 26-71 2619 A 9 A 2619 A 26071 A - A 11ýmlg 76-72 2620 G 2620 G 2620 G 2608 G 2605 -G 26M 2673 2621 C _i621 M-1 -C 2621 C 2609 C 2606 -C 2674 2ý6-22 -A -M-22 -A -26-2-2 -A 26-10 -A 2ý -A N-2-2 ý675 2623 G Z6-23 -G 26-23 -G 2W G 2M8 G 2623 2676 2624 C 2624 C -2624 -C 2M - C 2609 c 2624 2677 2-6-25 A 2625 A 282-5 -A 2M -A -28-1-0 -A 2ý -26-78 2626 A 2626 A 2STS -A -f6-14 --- 77- ýýff -A 2626 2627 A -2627 -- A-- 2627 A 2615 A 2612 A 2627 -2680 78-2-8 G 2626 G 2628 G 2616 G ý2M G -T6-2-8 2629 A 2629 A 2629 A -26-17 -A 2ý -A 26-29 A 2682 g 2630 2630 - A 2630 A 2618 A 2615 A 2630 2683 -26 201 G 2631 G 76-1 -9 -G 2M -G A 'Jo 3-1 G i ýo MOR, ;' , 2632 T 2l532' T 263 T 2620 T 26177 2632 \\"\z 2685 2633 31 G 2633 G 2621 -G -f6-18 -G it-Ql - '3 26ý -2 1 -26-86 2MU -C z T6 2bJ41 U 2634 -26-22 - C -f6-19- C 21ý -67 2635 T 2635 T 2635 - T 2623 T 2620 T 2635 Tz 2688 2636 A 2636 A 26W -- A -269 - A 2621 ýA 2(KI6 2689 26ý -T T _f_ 6=7 T 6=37 T 26ý -262-2 07 260 -ý638 C 6=38 C 38 - --= 2C2-6 2623 C 208 2691 2639 T 2639 T -263-9 T 26V T -ýBý T 2692 G- 2 40 26Z 9W 640 G I 2M 640 G 2640 4ýý' M G M2-5 -G -f641 G 6=41 G 641 -- =- -2629 -G 2M -G 26411 2694 76-42- A 2642 A 2642 A 2630 A7- 26-27 - A 2642 A -f6-95 pffiik\ý 2543 -A 6=4 3 A - wffi:\\ý 2643 A 2631 A 2628 -f6-43 26-M Wt ý'A 2644 A -264-4 - A -f644- A 2632 A 2629 2697 2645 G 2645 G -- 5 10 2645 G 2633 G 264 2698 -A -2iM -G 5 1, ', 2646 A -26-46 A 2634 A T63-1 -A I , 'I 2646 - 2646 %fiWM122699 2647 G 2647 G 2647 G 2635 G 2632 G 2647 72700 ay 2648 A 6=48 -A 2648 A 2636 -A-- 2M -A 6=4 9 2"8 2701 A , 2649 G G 2649 G 2637 G 2ý4 -G -ý-U-g ý 270002 -W -R-50 -C T650 c 2650 c -26-3-8 -C -26-35 - C M50 IMF/P4W 2703 V, 2651 A 2651 A 3/ -26-5-1 -A 26ý -A -26-3-6 -A 26ý 2704 X6-5 - -652- - -26-4 - 6-3 05 2652 A f A 0 A 2 7 A 1652 [2H7 &-,-\\*, 2653 G 6=53 G 2653 G -f6-41 - G -26-38 G 2653 2706 U 2654 G 2654 G 2654 G 2642 G 2639 G 2707 T 2655 T 2643 T 2640 T 08 2655 T 6=55 27048 - - - -26 6561 G 2656 G 56 G 2644 G 2641 G 2(R56 fl9 27 910 A 2W 2657 .. ýE357 A 2657 A 2657 - A 2642 A 10 642 A 0 26b6i A 8 A 2646 A 2643 ýbbllj A 2711 2659 A 26591 A 26-59 - A N-47 A 2644 A A,ý 2712 2660 A 26601 A 2650 A 264-8 A 2645 -A 2222 2661 A M61 U -A 2M -A -26-49 A A 2661 2714 Z662 A 6=62 -- T 662 -A 26-5-0 -=- 2647 A 2662 2 ---- T 2663] 663 25031 T 2663 T 2651 T - T 2663 2716 2664 T 2664 T 26U T 2652 T 4 T IT6-4 717 -ý-6-65 - A 26651 A 2665 A 2653 A 2650 --- 7- 2665 2 2666 T 2W61 T 126:6 1 =6541--T 2651 T 26-66 19 M-7- 71ý 6 T 2bb/I I Jýb T 2655 1 2667 7 0 46-68 - c 26681 G 126681 U 126561 G 26ý -C 26-68 ýVOMIWII 2771 MMý , 0 0 Kolodý., I Kolodner Cell Cell Ermtum Kolodner I K.I.&.r .11. #1 fil, 11/17193 A ' b 1M193 ub WW1994 fil ý1311994 fil. 616M5 1993 OW154 792 'ýO 81116 3 494913 081259310 =465.251 160295 SEC ID NO 8 SEQ 10 NO 8 ý-EQ -IDNal - -ýEQ ID NO:8 ID NOI A 2669 A 2669 A 2669 A 2657 A 2654 A 2669 2722 A 2670 G 2670 G G 2658 G 2655 - -26 - -Z6 - 2656 2671 - G 2671 G 71 G 59 G G 2671 2672 A 2672 A 2672 A 2660 A 2657 A 2672 2673 G 2673 G 2673 G 2661 G 2658 G MG -T T6 7-4 -- Tý- 2662 2674 -f674 2674 2659 2675 T 2675 T 2675 T 2663 T 2660 T 2676 C 2676 - C C 2664 C 2661 C 2677 C 2677 0 2677 C 12665 0 2662 C 2677 2678 T 2678 T 2678 T 2666 T 2663 T 273 2679 G 26-79 G 2M G 26U/ u 2bM 1 2679 2680 T 2680 T 2680 2668 T 2665 T 26M 2681 C 2681 C 2681 C 2669 C 26M C 2734 -26-82 -C 26-82 C 2670 C 2667 C 2682 C -2383 A 2683 A 2671 A 26M A -2683 273 2684 A 2684 A 2684 A 2672 A 26ý A 2 84 2737 2685 G 2685 G 2685 G 2673 G 2670 G 2 5 2686 G 2686 G 2686 G -2674 --- T- -26n G 2686 2687 T 2687 T 2687 T 2675 T 2672 T 2740 -f6-8 - 2W G 2676 G 2673 G 2588 2689 A 2689 A 2689 A 12877 A 2674 A 2689 RV 'A, 2690 A 2690 A 2890 A 2678 A 2675 A W, A 2691 2679 2691 A 2691 2M -A 1 -26 214b gn' 2692 C 26921 C 2692 C 26W C T7 C 2692 2693 A 2693 A 2693 A 2681 A 2678 A 693 2694 A 2694 A 2694 A 2882 A 2679 A T6-9-4 ký, 2- -26W- 2695 A 2748 2695 A 26ý A 695 A 2683 A - -2749 2696 T 2696 T 2696 T 2684 T 2681 T 2697 G 2697 G 2697 G 2685 G 2682 G N97 275-0 ON 2698 - C 2696 C 2686 C 2683 C 2 8 2698 C 11 2699 C 2699 C 2699 C 2687 C 26M C -26-99 052 26-8-5 -C n70-0 :1753 2700 C 2700 C 2700 C 2688 C O F 2701 T 2701 T 2701 T 12689 T 26M T 2701 2754 2702 T 2702 T 2702 T 2690 T 2702 2755 2703 T 2703 T 2703 T 2691 T 26M T 27133 'ýT 2756 T 2704 A 2704 Va A 2692 A 2689 fk 21bt 2705 C 2705 C 2705 C 2693 C 2690 C 2706 T 270 T 270 T 2694 T 2691 T 2706 2707 G 2707 G 2707 G 2695 G 2692 G zw G" 276 2708 A 2708 A 2708 A 2696 A 2693 A 2708 T 2709 A 2709 A 2709 A 2697 A 2694 A 2709 2710 A 2710 A 2710 A 2698 A 2695 A 10 'WW, 2763 2711 T 2711 T 2711 2699 T -26-96 T 11 mowl' 2712 G 2712 G 2712 G 2700 G T697 G 27 2 .......... 2713 T 2713 T 2713 T 2701 T 2698 2714 C 2714 C 2714 C 2702 2699 C 2714 2767 2715 A 2715 2715 2703 27W A 27 5 68 2716 G 2716 G 2716 G 27N - G 27ff G 76 2717 A 27171 A 2717 A 2705 A 2702 A 2717 2770 2718 A A -777-1 2716 A 2718 2706 A 2703 A -777-1 2719 G 2719 G 2719 G 2707 G 2704 G 2719 2772 2720 A 2720 A 2720 A 2708 A 2705 A 2720 2773 2721 A 2721 A 2721 A 2709 A 2706 A 1 27n 2722 A 2722 A 2722 A 2710 A 2707 A 2722 2775 2723 A 2723 A 2723 A 2711 A 2708 A -2776 C 1 77-77 2724 C 2724 C 2724 2712 C 2709 C 2725 A 2725 A 2725 A 12713 A 27101 A 2725 2778 ýW 2726 T 2726 T 2726 T 2714 T 2779 2727 C 2727 C 2727 C 2715 C 271121 CT 2728 A -2728 - - - 7- -2728 A 2716 A 2713 A 27 8 , 2 1 2729 C 27291 C 2729 C 2717 C 2ý 27 9 27 2730 A 2730 A 2730 A 2718 A 2715 0 3 2ý - A 73-1 --- T- 27-31 A 2719 A 2716 A 2 31 .. . .2 2732 T 2732 T 2732 T 2720 T TION 2717 T 2732 2733 A 2733 A 33 A 2721 A 2ý A 2734 A 2734 A 2734 A 2722 A 2719 2787 L"i'a 2735 A 2736 A 2735 A 2723 A 20 A 2715 7 1 2736 G 2736 G 2736 G 2724 G 2721 G 2756 A2789 A 2737 T 2737 T 2737 T 2725 T 2722 T 2737 2790 m iT 2738 T 2738 T 2738 T 2726 T 2723 T 27 8 2791 2739 A 2739 A 2739 A 2727 A 2724 A -f7-9-2 2740 A 2740 A 2740 A 2728 A 2725 A 2793 2741 A 27411 A 2741 A 2729 A 2726 A 1 271M 2742 A 2742 A 2742 A 2730 A 2727 A 27156 2743 C 27ý -C 27ý -= Z7-31 -C 2M C 2796 2744 A 2744 A 2744 A 2732 A 2729 A 2797 2745 G 2745 G 2745 G 2733 G 2730 G 2798 27 - -27- -C 27ý -C 2731 C 2746 2799 2746 C 46 C 46 2747 T 2747 T 2747 T 2735 T 2732 T 28W 2748 A 2748 A 2748 A 2736 A 2733 A 2801 -2741 r 1 27-49 2 4 A 3 A 27 9 2802 =7=T:7:: 7 0 A 2750 2750 A 2136i A 2735 27 0 2803 2 7('5 T11 A 21W A I(w I A I Zjq A A 27 1 2804 0 0 Kolod,,e, Kotcdner Cell I Cell rrmtum Kolodner - 1 Kolodner Ch.pe e fil, 11/17193 fil 1ý/1993 pub. 1M/93 _ pub 41W 994 Til, 611 W1 994 Fl. W5195 11, OW154 792 08/163,449 08/259.310 08/465,251 OW 60295 SEC ID NO 8 SEQ ID NO:8 SEC ID NO 1 SEC ID NO:8 SEC ID NOI 2752 G T75-2 ---77- -952 G 2740 G 2737 2753 C 2753 C 2753 C 2741 C 273UB C 2754 7 -Z7-54 T -27-54 T 2742 T 2739 T 2754 -08-07 2755 G Z755 G -2755 G 2743 G 27-40 - G 2808 2756 A 2766 A 2756 A 2744 A 2741 A 2809 2757 A -2757 -2-75-7 A 2745 A --Y27-4-2 A Zz i 27-58 -G -2758 -G 2746 1 11 2810 mv 2756 G G 2743 G 2758 2811 2759 T 2759 T 2759 T 2747 T 2744 T 27 9 1 2760 A 27601 A 2760 A 2748 A 2745 2761 A 2761 A 2761 A 2749 A 2745 2761 A' 2814 2762 T 2762 T 2762 T 2750 T 2747 T 2815 2763 A 2763 A 2763 A 2751 A 274B A 2764 G G 27U G 2752 G 2749 G 1 2764 ' T ' 2764 2765 C 2765 C 2765 C 2753 C 2750 C , A 2766 A 2766 A Y76-6- 2754 A 2751 A 2W A 2755 A _Z7_52 --- r- 2767 2820 2767 A A A 2767 2768 A 2768 A 2768 A 2756 A 2763 A 2768 A 2821 2789 G 2769 G 2769 G 2757 G 2754 G 5 ,,il, 28-22- "ýwmfi 2770 A 2770 A 2770 2758 A A 2770 Aý 2771 A 2771 A 2771 A 2759 A 2756 A 2771 41Q 2772 T 2772 T 2772 T 2760 T 2757 T 2773 A 2773 A 2773 A 2761 A 2758 A 2826 W" A,, 2774 A 2774 A 2774 A 2762 A 2759 A 2774 mv 28-27 A 'PT 2775 T 2775 T 2775 T 27ý T 71ý2-7-6-O T 2828 2776 A 2776 A 2776 A 27" A 2761 A 1 2776 2829 2830 2777 G 2777 G 2777 G 2765 G 27U G I '(A 2778 C 2778 C 2778 C 2766 C 2tw C 2778 2-- -2779 2767 T 2764 T 2 9 2779 T 779 2760 T 2780 T 2780 T 2768 T 2765 T N 2781 T 2781 T 2781 T 2769 T --f7ffi T I 2782 G 2782 G 2782 G 2770 G 2767 G 2635 27831 T 2783 T 2783 T 2771 T 2m T 2784 A 2784 A 2784 R A 2772 A 2769 A 2784 2iff 2785 A 2785 A 2785 A 2M A 2770 A 2785 28M 2786 A 2786 A 2786 A 2774 A 2771 A W, 2787 T 2787 T 2787 T 2775 T 2T72 T 28-40 2768 G 2788 G 2788 G 2776 G G 2841 2789 A 2789 A 2789 A 2777 A 2ý4 A 2842 -28-43 2790 A 2790 A 2790 A 2778 A 2ý5 A 2791 A 2791 A 2791 A 2779 A 2ý6 A 1 2844 IM-A 2792 T 2M 2 7K2 T 2780 T T A, 2845 a 2793 C 2793 2781 - C -2646 2793 C C C -27- -27a A 2782 A 2779 A -fB 2795 T 2795 T 2795 T 2783 T 27W M I IF 2796 T 2796 T 2798 T 2784 T 2781 T 2797 T 2797 T 2797 T 2785 T 2 2798 C 2798 C 2798 C 2786 C 2783 C 28-51 2799 A 2787 -Tff8--52 2799 A 2799 A A 27M A 2800 C 28M C 28M C 27M C 27 C 2853 ?2 2801 G 2601 G 2801 G 2789 G 2802 A 2802 A 2802 A 2790 A A 280;j 2803 A 2803 A 2803 A 2791 A 27881 A 1 2803 2856 ,7 2804 T 2W4 T 2804 T 2792 T f, /070//r, T W lmwwr -f8-5-8 kýý',,Nffik 2805 A 2805 A 2805 A 2793 A 27901 A 2806 A -- 77- A 27941 A 2791 A ýrý/oAl";-,- 2859 2807 A 2807 A 2807 A 2795 A 2792 A 2860 28081 A 2808 A 2808 A 2796 A 2793 14" A 281M P 862 2809 G 2809 G 2809 G 2797 G 2794 G 2810 T 2810 T 2810 T 2798 T 2795 T Z113 2811 T 2811 T 2811 T 2799 T 2796 T 2864 2812 A 2812 A 2812 A 2800 A 2797 A 286 2813 C 2813 C 2813 C 2801 C 2798 C 2814 T 2814 T 2814 T 2802 T T 1 2815 A 2815 A 2815 A 2803 A 28M A 2868 C C Do M. 2:39 2816 2816 2816 C 2804 C 1 C 281' - 2870 2817 G 2817 G 2817 G 2805 G G -Mllfn 2818 T 2818 T 2818 T 2806 T 2819 G 2819 G 2819 G 2807 G 2804 G 2820 A 2820 A 2820 A 2808 A 2805 A 282 2821 A 28211 A 2821 A 2809 A 2806 A 2821 -2- 'A 2822 A 2822 A 2822 A 2810 A 2807 A 122 2876 A,; 2823 A 2823 A 2823 A 2811 A 2808 A 28ý 2824 A 2824 A 2824 A 2812 A 2809 A 2824 'A ...... 2825 T 2825 T 2825 T 2813 T M 1-0 T 2825 MMI/Z 2826 C 2826 C 2826 2814 C 2811 C 282 -28- -C 28V 2827 C 2827 C 2827 C 2815 C 12 2828 C 2828 C 2828 C 2816 C -fB13- - C 2828 T-44 A 2829 A 2829 A 2829 A 2817 A T8 2830 G 2830 G 28M G 2818 G 2105 -G 28-3o 7773-7 2831 T 2831 T 2831 T 2819 T 2816 T 2831 28-3 2832 A 2832 A 2832 A 2:2 A 2 28-1-8 2 833 A 33! 3 2 21 A 833 8 8W Ma MF T 28-11- T 283-4 2 3, F2834 lzdj4 T 1.1ý Kolodner K.I.dw pub Cell Cell Erratuý oo .r Kolodner le #1 fil, 11/17/93 fill 12J711993 1219M3 ýb, 41&1994 fil, 611 W1 P94 - filL 6/5/95 993 owlý,792 163,449 OM59,31 0 _ (T8-f465251 295 SEQ ID NO:1 SEQ -IDNO 8 NO.1 SEQ ID bLU IU W 1177 Sw2835 G 2835 G 28ý G 2623 G G M5 7 177ý\Twvw -28-36 - G 2836 G 2836 IS 2824 G 282 2836 - - 28-25 -A 2837 A 28-37- - A 2837 A A 2ý7 -28-38 -A M-8 -A -2838 A -Tý278-26 -A A 28-3-8 2839 839 T 2839 2827 T %4 2WU 2892 T-- - --- r i T -2840 G T8 4-0 G 284-0 G T8 G 2 2 G -284600 f8-41 -A -2841 -A T84-1 A --ý28-29 -A I A 08-4-1 A 2842 A A 2827 -= 2842 28-30 2842 2895 2843 G -2843 G 2M3 G M1 G 2828 G 2843 289 2844 G -2844 G -08-44 G T83-2 G 2-82-9 -G 2844 2897 G 2845 T 45 -28- 28-45 --- r- -28-33 T 2830 T 2M5 2846 A -f8-46 -A ý-84-6 A -ý8-34 -A -2831 -A 2899 2W -A ý-84-7 2- -A -2832 -A 2847 A A 835 -f-- -2848 -- T-- -f83-6 --- 7- -28-33 - T 2848 2901 kll,, 2848 T a 2849 A - 181489 A -A 2-83-7 -A -A 2849 2902 78-5-0 T 850 T 838 T T 28 0 M50 2903 2- - -fB- -f8-51 =T= -f8-51 -T 28ý -f8-39 -28-36 -T 28-51 - -28-7 G 28U 2852 G -28ff G -2-8-52 G 2840 G 3 2905 2853 A -2-85-3 -A -T8-53 -A -28 4-1 A 8 -A 2814 T 2854 1 28141 T 2842 - - T T 1 Mg T 2907 5] 28-41 A 2941 27 5 A ý5*0 A 285, T855 2908 L' 28-56 2856 A 26ýb A I 28ýO I ze4i 2857 F- G 2857 G 2857 G 2845 G 2842 G -28-57 2910 93 -T8-4-3 -C f858 W4, 2858 C 2858 C 2858 C 2846 C -T-4- - -f844- -T T85-9 2859 T 2859 T 2859 T 8 7 T 28-60 -28-6-0 28-4-8 --- r- f84-5 A 2860 ýe 2-86-1 T A-61 T 2861 T 2849 T 2846 T 2861 C 2862 T 2862 Ynsmo T 2847 2862 T 2862 ýil M.1 I 2863 G 2863 G G 2851-G 28-4-8 -G YB-63 2M4- T 2ý864 728ý T 2852 T 2849 865 C C NN-W C 2865 c 2dbO 1 1 2866 C 2853 2866 T 2866 T 2866 T -fM-4 ---- r- 2851 T 2866 2219 2867 G -Tý28-67 G G 2ý5 G 2852 G 2867 M M-6-8 T 2-86-8 T 2W T 28-5-6 -T -08-5-3 -T T8 6-8 1 m m22 fiý 2857 A 2854 A 2869 2870, A 2870 A 2870 A 2bbd A - 2855 A 59Jýý23 A ?2ý01 JW\ 2871 T -2S-59 T -TS56- -T _T924 2871 T T 12'711 OFF 24 2872 A 2872 A 872 A -fB-6-0 ý8-5-7 2872 2925 2ý73 G 9 2873 G 2873 2861 G 2858 G 2926 -5 2874 2874 T 2874 T 12874 1 21502 T 28 9 T q2927 2875 T 2875 T 2875 T 2863 T 2860 T 2875 2928 T 2884 T 2661 2929 2876 T 2676 T 2876 9 2877 T 28-77 T -2877 T 2865 T 28U T 28ý -2930 Im 2m- A 2878 28M -A 2863 A 2931 2878 A fffff 2879 T 28-79 T -287-9 T 2867 T -ý28M T < fý M2 w9 2880 A 2880 A 2868 A 2865 A "A" -293-3 2880 A A, "" ,, --- r- 2881 T 2869 T 2866 T 2881 J'-M, 2934 2881 T 2881 eý, 2882 T 82 T 2882 T 2870 T 2867 T Z882 2883 G 2883 G 2883 G 2W G 2868 G M3 i 2936 -28-84 -fB-U - -fB-- T 2 4 2884 T T 72 2885 T 2885 T 28M T 2873 T 2870 T 2885 29-38 2886 T 2886 T 2886 T -Tý28-74 I T 2886 -29-39 2887 T 2887 T 2887 T 2875 T 2872 T 218 29 2888 A A 2888 A 2876 A 2873 A 2888 T 2889 2889 T T 877 T 2890 A --- 7 9- 2M A 2878 A 2875 A 2890 2891 T 1 T 2891 T 2879 T 2876 T 2891 2944 2892 T T 2892 T 2880 T T 2892 "n, 'r 2893 A A 2893 A 2881 A 2878 2893 2894 A A 2894 A 2882 A 28791 A 2947 2895 C C 2895 C 2W G 26W 1 u 2895 2896 C 2896 C 2896 C 2884 C 2881 c 2896 -A;_*W, 2897 C 2897 C 2897 C 2886 C 2882 C 2898 T 2898 T 2898 T 2886 T 280 T T WIN 2899 T 2899 T 2899 T 2887 T 2W T IM7c 2900 T 29M T 2900 T 2888 T 2885 T 2900,,m , 2901 T 2901 T 2901 T 2889 T T ý d 2902 T 2W2 T 2902 T 2690 T 2887 T 2903 C 2903 C 2903 T 2891 C C 9 3 2904 C 2904 C 2904 C 2892 C C 9 4 2905 A 2905 A 2905 C 12893 A A 2905 2906 T 2906 T 290 A 12894 T 28-91 T 29071 A 2907 A 2907 T 12895, A 2M IN 2907 'A' 29081 IS 2908 G 2908 A 128961 G 28931 G 2908 2909 T 2909 T 2909 G 28971 T 2894 T 2909 \m 2910 G 29101 G T 289' G 2896 G 2910 291U 2911 1 T 1 T 2896 2911 G 289' 1 _Z9_12 T 9 T 2897 T 2 1 A 2913 T 9 A 2898 A I 29 T I 913 29- 4 02 A 2899 A 5 2go3 C 2900 C 01 221 go T T 211 i T 2916 C 2 4 2901 2917 G 2917 T 29 IA 2902 G T 1 G 2.ý , A -,I KcIod. Kolodnar 0.11 Cell Ermtum Kolodner Kolodner Chapelle #1 ill. 11/17193 fil. 12f7/1993 pub. 12/g/93 _ pub, V811994 _ fil, 6/1 VI 994 filL W5195 fil 1ý11?93 0&154 792 08/163.449 OM59,31 0 081465,251 08/160295 SEC ID NO.8 SEQ ID NO 8 SEQ ID NO 1 SEQ ID NO:8 I SEQ ID NO 1 2919 C 2919 C 291-9 T 2907 NIA 2904 C N19 2920 A 2920 A 2920 C N08 N/A 2905 A N20 2921 G 2921 G 2921 A 2909 NIA 2906 G ýez I 2922 T 2922 T 2922 G 2910 NIA N07 T N22 2923 G 2923 G 2923 T Nil NIA N08 G 2923 2924 C 2924 C 2924 G 2912 NIA 2909 C 2924 2925 C 2925 C 2925 C 2913 NIA 2910 C 2925 2926 C 2926 C 2926 C 2914 NIA Nil C 2927 A 29271 A A 129271 C 29151 WA 2912 29281 T 29281 T 2928 A 2916 NIA 2913 T yv2b 2929 G 29291 G 2929 T 2917 NIA 2914 G 2930 G 2930 G 2930 G 2918 NIA 2915 G 2931 G 2931 G 2931 G 2919 NIA 2916 G 2932 C 2932 C 2932 G 2920 NIA 2917 C N32 2933 T 2933 T 2933 C 2921 N/A 2918 T 2934 A 2934 A 2934 T 2922 N/A 2919 A 2934 2935 T 2935 T 2935 A 2923 N/A 2920 T 2935 All ' M" 2936 C N36 C 2936 T 2924 NfA 2921 2936 2937 A 2937 A 2937 C 2925 N/A 2922 A 2937 2938 A 2938 A 2938 A 2926 N/A 2923 A 2938 2939 C 2939 C 2939 A 2927 NIA 2924 C N39 M&I 2940 T N40 T 2940, C 29281 NIA 2925 T 1 2940 2941 T 2941 T 2941 T 2929 NIA 2926 T 41 2942 A 29421 A 2942 T 2930 NIA 292711 A 294 2943 A 2943 A 2943 A 2931 NIA 2928 A 2944 T 2944 T 2944 A 2932 NIA nN T N44 2945 A 2945 A 2945 T 2933 NfA 2930 A Z94b 2946 A 2946 A 2946 A 2934 N/A 2931 A N46 2947 G 2947 G 2947 A 2935 N/A 2932 G ýA7 2948 A 2948 A 2948 G 2936 N/A 3 A 2948 2949 T 2949 T 2949 A 2937 N/A 2934 T N49 2950 A 2950 A 2950 T 2938 NIA 2935 A 2950, 2951 T 2951 T 2951 A 2939 NIA 2936 T N51 2952 T 2952 T 2M2- T 2940 N/A 2937 T N52 - T N53, Mý, 2953 T 2953 T 2953, T 2941 NIA 2938 T 2954 A 2954 A 29ý T 2942 NfA 2939 A N54 2955 G 2955 G 2955 A 2943 NIA 2940 G 295511, 2956 T 2956 T 2956 G 2944 N/A 2941 T 295 K"ýy, 2957 A 2967 A 2957 T 2945 N/A 2942 A N57 2958 A 2958 A 29M A 2946 NfA 2943 A N58 2959 T 2959 T 29M) A 2947 NIA 2944 T 2960 A 2960 A 2960 T 2948 N/A 2945 A 2961 T 2961 T 2961 A 2949 N/A N81 2946 ;4 2962 T -29iff T 2962 'NUM& T 29501 N/A N47 T T 2963 T 2963 T 2963 T T 2963 T"ý 2951 N/A 2948 2964 T 2964 T 2964 T 2952 NtA -NO T N64 2965 A 2965 A 2965 T 2953 N/A 2950 A N65 2966 C 2965 C 290 A 2954 N/A 2951 C 2966 -29ff T 2967 T 12967 C 2955 NIA 2952 T 2916 1 2968 T 2968 T 2968 T 2956 N/A 2953 T 2Ubb 2969 T 296D T 2969 T 2957 NIA Nlý 2 6 2970 G G 2970 T 2958 NIA 2955 G 2971 A 2971 A 2971 G 2959 NIA 2956 A 2 71 2972 G 2972 G 2972 A 2960 TA 2957 G 2973 G N73 G 2973 G 2961 NVA 2958 G 2973 A N74 A 2974 G N62 NVA 2959 2975 C N75 C 2975 A 29631 N/A 60 C 1 2975 2976 A N76 A 2976 C 2964 NIA 2961 A 2977 T N77 T 2977 A 2965 NIA 2962 T 1.17 2978 T 2978 T 2978 T -ý966 NIA 2978, 2979 T 2979 T 297 T T 2967 N/A 2964 2979 2980 T 2980 T 2980 T 2968 N/A Nfl5 T 2980 2981 C 2981 11 C 112981 T 2969 N/A 2%6 C ZU61 Al 2982 A 29821 A 1 29821 C 2970 N/A 2967 A 2982 2983 A 2983 A 2983 A 2971 NIA 2968 A 2983 29841 A 2984 A 29841 A - WA 2969 2984 2985 G 2985 G 2985 A 2973 N/A 2970 G 2985 2986 A 2986 A 2986 G 2974 N/A 2971 A 2986 IN 2987 T 2987 T 2987 A 2975 NIA 29721 T 2988 T 2988 T 2988 T 2976 NIA 29731 T 2 8 - -29- - -292989 T 89 T 89 T 2977 MA 2974 T 2 8 2990 T 2990 T 2990 T 2978 NIA T 29DO 2991 T N91 T 2991 T 2979 WA 2976 T 2992 A 2992 A 2992 T 2980 WA 2977 A 2992 2993 T 2993 T 2993 A 2981 WA 2978 2994 T -- 29-94 T 29-94 T 2982 WA 2979 T 2994 2995 T 129951 T 2995 T 2983 WA 2980 T 2995 2996 T 2996 T 2996 T N84 NIA 29811111 T 2997 G 2997 G 299 T 2985 NIA 2982 G 2vu, -2-9-98 - A 2998 G 2986 N/A 2983 A 2 -29-99 - A 29991 A 2987 NIA 2984 A ee 30-00- - A 301DO 1 A 29681 N/A 2985 A WiM A 31MI A 129891 N/A 2966 A W-02 -A 3W21 A 29m 1 NIA 2987 "A 98B I T lodner Cý I Call raw. oo her Ko a ner Chapelle #1 fi 11 L1111 hLý 3 --- ýfil -12fM49'93 pub. 1219M3 pub, 4/8/1994 fil. 6/1311994 filL Uý95 fil, 1?Qfl993 08/154.792 1 081163,449 OM59,310 081465,251 081160295 SEQ ID NC,6 SEQ ID NO:B SEQ ID NOA SEQ ID NO 8 SEQ ID NOA 3004 3W4 T 2992 N/A 2989 G [004 010 005 3 A A 305 G 2993 N/A 2990 A 3W5 0,6 2994 3W6 -29 9-1 - 1 3006 G 3006 G A N/A 3 0, A -29-92 007 A 3W-7 G N/A A 3M7 3007 2995 3 00 3M-8 A - -29-93 008 G G N/A G 3W 3008 2996 3"9 3W-9 G -NIA 29-9-4 -C 3W9 30093009 2997 ý T 3010 TT 3-0--lo G 9 a N/A 2995 T 3010 -501-1 G 3011 G 3011 T -2 99 290 G 3 11 3013 3012 T 3012 T 012 G 3013 T 3 N;A -3013 - A 1 A 5 1 0 -2?91:8 A 321 3014 f9-9-9 3014 A 3014 A A A 01 3015 c 3015 C 3015 A 30031 N/A 3000 15 3016 T 3016 T 3016 G-- 3-00-4 7--N/A ]-ýM-01 T G 3017 G 3017 T 3005 F N/A 13002 3018 A 3018 A 3018 G - 300ý3 A 3019 G 30191 G 3019 A W071j:: ýIWIA J 3W4 G 3020 G 3020 G 3020 G 3008 N/A 3W5 G 302U F, 3021 A 3021 -A- 3-0-21 G 3009 NIA 3WS A 3021 30221 c 3022 c 3022 A 3010 N/A 3W7 C M 3023 T 3023 T 3023 c 3011 N/A 3WS T ýUý 3-0-12 -N/A 3WO 3024 G 3024 G 3024 T G ouzq 3025 T T 1-30ý -G 30-1 -3 -N/A -M-10 -T M", ý026 T 1$ 13026 T 3014 N/A 3011 Y- -M 3026 T W-27 T 3027 T 3027 T 30-15 NIA T 3027 3028 G 3028 3028 T 3016 N/A G 3029 c 3029 C 3029 G 3017 NIA 30-14 - C 30-2-9,' 3030 A 3030 A 3030 C 3018 NIA W15 ýs A M 3031 A 3031 A 3031 A 3019 NIA -ýo 1-6 - A qnql 3032 T 3032 T 3032 A 30201 NIA 3017 T T 3033 T 3033 T 3021 NIA 3018 T 3033 V 3034 G 30341 G 3034 T 3022 NIA 3019 G 3034 3035 30351 A 3035 G 23 N A -302'0 - A 3035 3036 c 30361 C 3036 A 3024 N/A 30211 c 3 3 3037 A 3037 A 3037 -C W-25 -NIA 30221 A 3038 T 3038 T 3038 A 3026 N/A 3023 T 3039 A 3039 T 3027 N/A 3024 A 3040 G G A 3028 NIA 3025 G 3041 G dual G JJU41 G 3029 NIA 3026 G 3041 3042 c 3042 c 3042 3030 NIA 3027 C 3043 A W43 A W43 c 3031 N/A 3... A A 3044 A -50-44 -A W-44 A W-32 -N/A -50-29 -A ý3fý0-4!4 -\.WM\\ý g" 3045 T 3045 T 3045 A 3033 NVA 3030 3046 A 3046 A 3046 T 3034 NIA -3031 3U6 3047 A 3047 A 3047 A 3W5 N/A 3032 A 3047 R4 3048 T 3048 A 3036 N/A 3033 T 3048 T" 'o a T JU4141 A 1ý4V A 4v4u T 3037 N/A 3034 A 1ý1. 3050 A 3050 A 3050 A 13038 1 N/A 30351 A 30ý 3051 G 3051 G 3051 A 3039 NIA 3036 G 4u*l 30- --- PTIA- 30-37 3052 T 3052 T 3052 G 40 3052 3053 G 3053 G 3053 T 3041 NIA 3038 G ... 30-5-4 A 3054 A 3054 G 3042 NIA W39 A 3054 A n-55- -T 3b6-5 -T 3CT5-5 A 3T43- -NIA W-40 T 3055 -M-55 G -3-0-56 G -305-6 T 304-4- -NIA W-4-1 G - 3-- - 3-0- W- - 3- 3057 T 057 T 57 G 45 WA 042 T 3 7 3058 G 3058 G _Y058 T 3046 NIA -50-43 G 3 8 - - 3-- - -30- -30- - 30 3059 C 059 C 59 G 47 N/A 44 C 3059 3060 T 3060 T 3060 C 3048 N/A 3045 T 30 3061 G 3061 G 3061 T 3049 N/A 3046 G 3 61 3062 A 3062 A 3062 G 3050 N/A 3047 A 306 5 ýVojl A ýUW A 300 A 3051, NwA_ 3048 A JUb4l I ýU*4 i 4u" A 3062 N/A 30-49 T 3065 T 3065 T 3065 1 1 ýbý NIA Uubu- i 3066 T 3066, T 3066 T 130541 N/A 3051 T 3067 T 3067 T 3067 T 3055 NIA 3052 T 3068 T 3068 T 3068 T 3056 WA 3053 A 3068 3069 A 3069 A 3069 T 3057 WA 3054 3070 T 3070 T 3070 A 3058 N/A 3055 A 3071 A 3071 A 3071 T 3059 N/A 3056 A 3071 0=72 -A X 7-2 -A -§0-72 A 3W-0 3W A 072 3073 A 3073 A 3073 A RO-61 30-58 T 3u1j.. -ý0-74 - A 3074 3074 3062 A u' A A N/A 3059 3W ý0-75- A 3075 A 3075 A - A 3060 3075, MM" 1, % -ý0-76 A 3076 A 3076 A 3061 A 3077 T 3077 T 3077 A 3062 A 3077 3078 -C 078 c 3078 T W63 T Mi. 30791 A A 3079 C 3064 c 3079 3110 T 3080 3065 A 3 3080 T 3081 3066 T 1 3082 A 3082 A G 3067 G We G 32 31 G W83 A 3068 T 3 8 G U69 A 52N T WN T 1111 1011L il 30857 T 3 85 T_ 30701 G "8, T 30861 T 3086 T 3071 T 3 6 3087 G 3088 G 6U881 U Judd 3073 T Kolodner Kol.dýu, Cell Cell rrmtum Kolodner fil 11117/93 fil, 1217/1993 pub. 1M/93 pub 4/WI994 fil 6/1311994 fil, 615195 fil, 1ý1993 0&154,792 081163,449 Oat259.31 0 081465,251 08/160295 SEQ ID NO 8 SEQ ID NO.8 SEC ID NOA SEO ID NO 8 SEC ID NO 1 3089 G 3089 G 3089 G 3W07-4 _G I 3090 A 3090 A 3090 G w-75- -T To -go ,"A ARM 3091 A 3091 A 3091 A 3076 G :ffg-l, wamawl 3092 A 3092 3092 A 3077 G W92 A ý' 3093 A 3093 3093 A 3078 3 3094 A 3094 3094 A 3079 3080 W94 3095 A 3095 3095 A A 3096 A 3096 3096 A 3081 W96 A 3097 A 3097, 3097 3082, - ý'A 3098 A 3098 1 3098 A 3083 3099 A 3099 3099 -A 3084 31001 A 3100 3100 A 3085 3100 3101 A 3101 3101 A 3086 3102 A 3102 3102 A 307 3102 3103 A 3103 3103 A 30-8 31-03 3104 A 3104 3104 A 309 3105 A 3105 3105 A 3M 3105 3106 A 3106 3106 A 3091 3107 A 3107 3107 A YOE 3092 3107 3108 A 3108 3108 A 3093 3108 3109 A 3-10-9 - 3109 A 3-- - -9- _____ý3094 3110 A 110 110 A, A 5 3110