Richard K. Mann et al.Download PDFPatent Trials and Appeals BoardDec 2, 201913018583 - (D) (P.T.A.B. Dec. 2, 2019) Copy Citation UNITED STATES PATENT AND TRADEMARK OFFICE UNITED STATES DEPARTMENT OF COMMERCE United States Patent and Trademark Office Address: COMMISSIONER FOR PATENTS P.O. Box 1450 Alexandria, Virginia 22313-1450 www.uspto.gov APPLICATION NO. FILING DATE FIRST NAMED INVENTOR ATTORNEY DOCKET NO. CONFIRMATION NO. 13/018,583 02/01/2011 Richard K. Mann 10284-077US1 8789 115453 7590 12/02/2019 Dow AgroSciences LLC Meunier Carlin & Curfman, LLC 999 Peachtree Street NE Suite 1300 Atlanta, GA 30309 EXAMINER HOLT, ANDRIAE M ART UNIT PAPER NUMBER 1616 NOTIFICATION DATE DELIVERY MODE 12/02/2019 ELECTRONIC Please find below and/or attached an Office communication concerning this application or proceeding. The time period for reply, if any, is set in the attached communication. Notice of the Office communication was sent electronically on above-indicated "Notification Date" to the following e-mail address(es): docketing@mcciplaw.com PTOL-90A (Rev. 04/07) UNITED STATES PATENT AND TRADEMARK OFFICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Ex parte RICHARD K. MANN and YI-HSIOU HUANG Appeal 2018-008624 Application 13/018,583 Technology Center 1600 Before ERIC B. GRIMES, RICHARD M. LEBOVITZ, and TAWEN CHANG, Administrative Patent Judges. CHANG, Administrative Patent Judge. DECISION ON APPEAL STATEMENT OF THE CASE Pursuant to 35 U.S.C. § 134(a), Appellant1 appeals from the Examiner’s decision to reject claims 4, 5, 7–9, 13, 14, and 18–20. We have jurisdiction under 35 U.S.C. § 6(b). We AFFIRM. 1 We use the word “Appellant” to refer to “applicant” as defined in 37 C.F.R. § 1.42. Appellant identifies the real party in interest as Dow AgroSciences LLC. Appeal Br. 3. Appeal 2018-008624 Application 13/018,583 2 CLAIMED SUBJECT MATTER The claims are directed to a method of controlling undesirable vegetation. Claim 4 is illustrative: 4. A method of controlling undesirable vegetation which comprises applying pre-emergently to the locus of the undesirable vegetation a synergistic herbicidal mixture comprising a herbicidally effective amount of (a) penoxsulam and (b) butachlor, wherein the weight ratio of butachlor to penoxsulam is from 10:1 to 40:1, and wherein the undesirable vegetation is winklegrass. Appeal Br. 14 (Claims App.). REJECTION The Examiner rejects claims 4, 5, 7–9, 13, 14, and 18–20 under pre- AIA 35 U.S.C. § 103(a) as being unpatentable over Breen,2 Johnson,3 the entries for penoxsulam4 and butachlor5 in The Pesticide Manual, and Mahajan.6 DISCUSSION A. Issue The Examiner finds that Breen teaches compositions comprising penoxsulam and butachlor in weight ratios of 1:50 and 1:33.3, the same two 2 Breen et al., JP2001-233718A, published Aug. 28, 2001. Our citations are to the English-language translation of record. 3 Johnson et al., U.S. Patent No. 5,858,924, issued Jan. 12, 1999. 4 BRITISH CROP PROTECTION COUNCIL, THE PESTICIDE MANUAL: A WORLD COMPENDIUM 874 (C. D. S. Tomlin ed., 15th ed. 2009). 5 BRITISH CROP PROTECTION COUNCIL, THE PESTICIDE MANUAL: A WORLD COMPENDIUM 117 (C. D. S. Tomlin ed., 12th ed. 2000). 6 Gulshan Mahajan et al., Performance of Penoxsulam for Weed Control in Transplanted Rice, 2 PEST TECHNOLOGY 114 (2008). Appeal 2018-008624 Application 13/018,583 3 compounds recited in the claim and in a ratio that overlaps with the claimed ratio. Ans. 6. Appellant contends that Breen does not suggest applying its herbicidal mixtures pre-emergently or to control winklegrass as recited in all the claims. Appeal Br. 8; Reply Br. 4–5. Appellant contends that, “[t]herefore, nothing in Breen would have suggested that penoxsulam and butachlor could produce synergistic results when applied pre-emergently to winklegrass.” Appeal Br. 8; see also Reply Br. 4–5. Appellant contends that the other cited references do not cure the deficiencies in Breen and that, if anything, “Mahajan . . . only serve[s] to reinforce the teachings of Breen that the compositions described therein should be applied post-emergently.” Id. at 8–9; see also Reply Br. 2–4. Thus, Appellant contends that a skilled artisan would not have had a reason to combine the cited references to arrive at the claimed invention, with a reasonable expectation of success. Appeal Br. 10; see also Reply Br. 4–5. In the Reply Brief, Appellant also contends that “Breen does not demonstrate that combinations of penoxsulam and butachlor exhibit any synergistic effects” and that, to the extent the Examiner has established a prima facie case of obviousness, the subject matter of the invention exhibits unexpected results. Reply Br. 3, 5. Appellant does not separately argue the claims. We therefore limit our analysis to claim 4 as representative. The issues with respect to this rejection is (1) whether a skilled artisan would have had reason to combine the cited prior art references to arrive at the invention of claim 4, with a reasonable expectation of success, and (2) if so, whether the subject matter of claim 4 exhibits unexpected results. Appeal 2018-008624 Application 13/018,583 4 B. Findings of Fact 1. Breen teaches herbicides of formula (I) , wherein Q may be C-H or N and R may contain one or more halogen or an oxygen atom, among other substituents. Id. ¶ 4. 2. Breen teaches compositions comprising herbicide A and herbicide B, wherein herbicide A is an herbicide of formula (I) and herbicide B is a “soil and . . . foliage applied herbicide.” Breen ¶ 6. 3. Breen teaches that herbicide A may be a compound of formula (I) wherein Q is C-H and R is CH2CHF2. Id. ¶ 9. The Examiner finds, and Appellant has not disputed, that this compound, designated A7 in Breen, is penoxsulam. Ans. 5. 4. Breen teaches that herbicide B may be “chosen from a publicly known weed killer,” including among others butachlor, designated compound B2 in Breen. Breen ¶ 10. 5. Breen teaches that its composition “is effective especially as a paddy field weed killer,” has a long period of residual activity, and is not harmful to crops such as paddy rice. Id. ¶ 7. 6. Breen teaches that when herbicide A is added to herbicide B there is “a surprising synergistic effect”: If each weed killer of these ingredients (B) is independent, the grass species of clo GUWAI and Ms. GAYATSURI which are the above-mentioned difficulty control cannot be controlled. . . . Appeal 2018-008624 Application 13/018,583 5 [B]y combining . . . ingredient (A), from the combination of a general active principle, the above-mentioned fault is improved to such an extent that it cannot predict, Effect continuation shows power to the paddy field difficulty control weeds which demonstrate a surprising synergistic effect, do not have a weed killer which can be controlled especially, and are expected the effective weed killer that the weeds which growth followed can also be withered in a long period of time. . . . Especially the width of processing time can extend an ingredient (A), the ingredient numbers 1, 2, 3, 7, 33, 38, 40, 44, 47, 49, 53, 57, 59, and 60, and by combining the ingredient (b) of 1, 2, 40, 49, 53, and 59 more preferably. Id. ¶¶ 11–13; cf. id. ¶ 33 (stating with respect to its invention that “[t]he outstanding feature that an extermination effect becomes good, so that he is surprised, a residual activity period becomes long further, and no medical harm is in crops, such as paddy rice, is shown”). 7. Breen teaches that the weight ratio of ingredient A to ingredient B in its composition is for example 1:0.1–100, preferably 1:0.1–50, and more preferably 1:0.1–5. Id. ¶ 14. 8. Breen teaches composition in its examples consisting of the combination of penoxsulam and butachlor at weight ratios of 1:50 and 1:33.3. Id. at ¶ 26, Table 1. 9. Johnson teaches using N-(Triazoloazinyl)arylsulfonamide compounds as herbicides. Johnson Abstract, 1:16–20. 10. Johnson teaches that one of the preferred compounds of its invention include 2-(2,2-difluoroethyoxy)-6-(trifluoromethyl)-N-(5,8- dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidin-2-yl)benxenesulfonamide, designated compound 190. Id. at 6:46–8:5. The Examiner finds, and Appellant does not dispute, that this compound is penoxsulam. Ans. 6–7. Appeal 2018-008624 Application 13/018,583 6 11. Johnson teaches “[t]he use of suitable compounds of the invention to achieve either total vegetation control or the selective control of weeds in wheat, rice and oil-seed rape crops.” Id. at 3:11–14. Johnson teaches that “[b]oth grassy and broadleaf weeds can be controlled.” Id. at 3:14–15; see also id. at 30:14–15, 20–22. Johnson teaches that “[c]ompounds of special interest for [the] purpose” of “control[ling] . . . [the] many broadleaf and grassy weeds in rice” include compound 190, i.e., penoxsulam. Id. at 30:39–43. 12. Johnson states that post-emergence applications of its compounds are generally preferred but teaches that the compounds of its invention “have been found to be useful preemergence (including pre-plant) and post-emergence herbicides.” Id. at 30:11–13; see also id. at 3:15–16, 30:58–61 (“Herbicidal activity is exhibited by the compounds of the present invention when they are applied directly to the plant or to the locus of the plant at any stage of growth or before planting or emergence.”), 31:3–5. 13. Johnson teaches that the compounds of its invention “are often applied in conjunction with one or more other herbicides to obtain control of a wider variety of undesirable vegetation,” that “[i]t is generally preferred to use the compounds in conjunction with other herbicides that have a similar crop selectivity,” and that “[i]t is further usually preferred to apply the herbicides at the same time, either as a combination formulation or as a tank mix.” Id. at 31:15–18, 38–42. 14. The entry for penoxsulam in The Pesticide Manual states that penoxsulam is “[a]pplied pre-emergence, post-emergence and water applied” and that its “[p]rimary use will be a post-emergence application in dry-seeded, water-seeded and transplanted rice.” Pesticide Manual 874. Appeal 2018-008624 Application 13/018,583 7 15. The entry for butachlor in The Pesticide Manual states that butachlor is “[u]sed pre-emergence for the control of annual grasses and certain broad-leaved weeds in rice, both seeded and transplanted.” Id. at 117. 16. Mahajan teaches that butachlor is used widely for weed control in transplanted rice and provides effective control of annual grasses. Mahajan 114, left column. 17. Mahajan teaches that “[p]enoxsulam is a post-emergence herbicide[ that] acts by inhibiting the acetolactate synthase enzyme and is registered for weed control in rice in the southern USA.” Id. at 114, right column. 18. Mahajan describes a field experiment using seven treatments consisting of two doses of penoxsulam (22 or 25 g/ha) applied to rice at 3 or 12 days after transplanting (DAT), butachlor (1500 g/ha) applied at 3 DAT, hand weeding (twice at 20 and 40 DAT) and weedy check (untreated control). Id. at 114–115. 19. Mahajan teaches that the main grassy weeds present in the field included Ischaemum rugosum. Id. at 115, right column. Ischaemum Appeal 2018-008624 Application 13/018,583 8 rugosum is winklegrass. Spec. 9:15. Tables 1 and 2 of Mahajan are reproduced below: Mahajan 115. Table 1 describes the “[e]ffect of weed control treatments on weed density (species wise) and their dry weight (DM) at harvest.” Id. Table 2 describes the “[e]ffect of treatments on plant height, weed control efficiency (%), yield components and yield of rice.” Id. 20. Mahajan states that “[t]he application of penoxsulam . . . proved more superior in terms of weed control when applied at 12 DAT than at 3 DAT.” Mahajan 115, right column. However, Mahajan also teaches that “[t]here was no phytotoxic effect on the crop due to application of penoxsulam at any of the doses applied at 3 or 12 DAT” and that “[a]ll weed control treatments increased grain yield over the untreated control . . . due to better control of weeds.” Id. 21. Mahajan teaches that “[i]t was observed that many weeds, especially sedges and broad-leaf weeds, emerged after the application of Appeal 2018-008624 Application 13/018,583 9 penoxsulam when applied at 3 DAT so that these weeds were not controlled when penoxsulam was applied at 3 DAT.” Id. at 116, left column. 22. Mahajan teaches that “penoxsulam provided excellent control over weeds in rice and could be used as an alternative herbicide to butachlor for weed control in rice,” and further teaches that, “[d]ue to its pre- and post- emergence activity, it provides more flexibility to farmers in terms of its time of application, if the farmers fail to apply pre-emergence herbicide in time.” Id. C. Analysis Except as otherwise noted, we adopt the Examiner’s findings of fact and reasoning regarding the scope and content of the prior art with respect to claim 4 (Final Act. 2–12; Ans. 3–15; FF1–FF24) and agree that claim 4 is obvious over the cited art. We address Appellant’s arguments below. Only those arguments made by Appellant in the briefs have been considered; arguments not presented in the briefs are waived. See 37 C.F.R. § 41.37(c)(1)(iv). Appellant contends that a skilled artisan would not have had a reason to combine the cited references to arrive at the claimed invention, with a reasonable expectation of success. Appeal Br. 10; see also Reply Br. 4–5. In particular, Appellant contends that “nothing in Breen would have suggested that penoxsulam and butachlor could produce synergistic results when applied pre-emergently to winklegrass” and that the other cited references do not cure the deficiencies in Breen. Appeal Br. 8–9; see also Reply Br. 2–5. We are not persuaded. Breen teaches an herbicide composition comprising penoxsulam and butachlor, including an embodiment that falls Appeal 2018-008624 Application 13/018,583 10 within the claimed weight ratio of butachlor to penoxsulam. FF1–FF4, FF6, FF8. While Breen does not appear to explicitly teach applying its composition pre-emergently to winklegrass, the entry for butachlor in The Pesticide Manual teaches that butachlor is “[u]sed pre-emergence for the control of annual grasses . . . in rice.” FF15. Similarly, the prior art teaches that penoxsulam may also be used as a pre-emergence, as well as a post- emergence, herbicide. FF10, FF12, FF14, FF22. Furthermore, the prior art teaches that penoxsulam may be used to control weeds in rice, and Mahajan teaches that one of the main grassy weeds that may be present in a rice field is winklegrass. FF5, FF11, FF14, FF17, FF19, FF22. Given these prior art teachings – i.e., Breen’s explicit teaching of a composition comprising penoxsulam and butachlor having the claimed weight ratio and the teachings from other prior art references that butachlor and penoxsulam may both be used as pre-emergent herbicide, that they are useful in controlling weeds in rice, and that winklegrass is one of the main grassy weeds in rice fields, we find that a skilled artisan would have had reason to apply a composition comprising butachlor and penoxsulam having a weight ratio within the claimed range pre-emergently to control winklegrass, with a reasonable expectation of success. Appellant disputes that other cited references suggest applying penoxsulam pre-emergently to winklegrass. Id. at 8–9; see also Reply Br. 2–4. In particular, Appellant contends that Johnson teaches that post- emergent application of its compounds is generally preferred and does not provide an example of applying penoxsulam pre-emergently, and The Pesticide Guide also states that penoxsulam’s “primary use will be a post- Appeal 2018-008624 Application 13/018,583 11 emergence application in dry-seeded, water-seeded and transplanted rice.” Appeal Br. 8. We are not persuaded. In evaluating obviousness “all disclosures of the prior art, including unpreferred embodiments, must be considered.” In re Lamberti, 545 F.2d 747, 750 (CCPA 1976). Thus, the teaching in Johnson that post-emergent application of its compound is preferred and the teaching in The Pesticide Guide that the primary use of penoxsulam is as a post-emergence herbicide do not render pre-emergent application of penoxsulam non-obvious, since both references also teach that penoxsulam may be applied as a pre-emergent herbicide. FF12, FF14. Moreover, Mahajan also teaches that penoxsulam may be used pre-emergently. FF22. Appellant contends that Johnson and The Pesticide Guide are both silent regarding “application of a herbicidal mixture comprising any combination of butachlor and penoxsulam or that the combination could control winklegrass.” Appeal Br. 8–9; see also id. at 10, 11. We are not persuaded. “Non-obviousness cannot be established by attacking references individually where the rejection is based upon the teachings of a combination of references. . . . [The reference] must be read, not in isolation, but for what it fairly teaches in combination with the prior art as a whole.” In re Merck & Co., 800 F.2d 1091, 1097 (Fed. Cir. 1986). In this case, not only does Breen teach the combination, but the combination is also obvious because prior art teaches both herbicides individually as useful for controlling weeds in rice. FF11, FF14, FF15, FF16, FF22. “It is prima facie obvious to combine two compositions each of which is taught by the prior art to be useful for the same purpose, in order to form a third composition which is to be used for the very same purpose. . . . [T]he idea of Appeal 2018-008624 Application 13/018,583 12 combining them flows logically from their having been individually taught in the prior art.” In re Kerkhoven, 626 F.2d 846, 850 (CCPA 1980). Indeed, Johnson explicitly suggests applying the compounds of its invention with other herbicides having similar crop selectivity. FF13. Likewise, with respect to the use of the composition to control winklegrass as required by claim 4, we agree with the Examiner that such use is obvious because the prior art teaches that penoxsulam and butachlor are useful for controlling weeds in rice and Mahajan teaches that winklegrass is one of the major grassy weeds present in the rice fields of its example and further teaches using penoxsulam for weed control in rice. FF18, FF19, FF20, FF22. Appellant contends that “Mahajan . . . serve[s] to reinforce the teachings of Breen that the compositions described therein should be applied post-emergently” because it “explicitly teaches that penoxsulam is a post- emergent herbicide” and “notes that the application of penoxsulam at 3 DAT proved to be most inferior among all the weed control treatments” because late emerging weeds “escape[d] [penoxsulam’s herbicidal] mechanism of [reducing] transport of photosynthate from source leaves to roots.” Appeal Br. 9–10, 12; Reply Br. 2–3. Appellant also contends that “Mahajan . . . relate[s] to the application of penoxsulam and/or butachlor individually.” Appeal Br. 10. We are not persuaded. While Mahajan does describe penoxsulam as a post-emergent herbicide and teaches that weed control was superior when penoxsulam was applied 12 DAT as compared to 3 DAT, Mahajan teaches that application of penoxsulam at 3 DAT also increased grain yield due to better weed control. FF17, FF20. Moreover, Mahajan explicitly teaches that Appeal 2018-008624 Application 13/018,583 13 penoxsulam also has pre-emergence activity, stating that “[d]ue to its pre- and post-emergence activity, [penoxsulam] provides more flexibility to farmers in terms of its time of application, if the farmers fail to apply pre- emergence herbicide in time.” FF22 (emphasis added). As discussed above with respect to Johnson and The Pesticide Guide, in evaluating obviousness “all disclosures of the prior art, including unpreferred embodiments, must be considered.” In re Lamberti, 545 F.2d at 750. We are likewise unpersuaded by Appellant’s argument that Mahajan relates to application of penoxsulam and/or butachlor individually, for the same reasons already discussed above with respect to Johnson and The Pesticide Guide. Thus, we agree with the Examiner that, in light of the combined teachings of the prior art, a skilled artisan would have had reason to combine penoxsulam and butachlor for pre-emergent application to control winklegrass, with a reasonable expectation of success.7 Appellant further contends that the prior art does not teach that the claimed herbicidal mixture would be synergistic, particularly when applied 7 In response to Appellant’s argument that Mahajan teaches that penoxsulam is a post-emergent herbicide, the Examiner notes that “the Mahajan reference was not relied upon to teach the application stage, but to [teach] the application of penoxsulam and butachlor to winkleweed.” Ans. 12. Appellant contends that the Examiner fails to consider Mahajan in its entirety. Reply Br. 2–3. To the extent the Examiner suggests that Mahajan’s statements regarding penoxsulam’s application stage are irrelevant because Mahajan was cited for another purpose, we disagree with the Examiner and do not adopt the Examiner’s position in this regard. “It is well settled that a prior art reference is relevant for all that it teaches to those of ordinary skill in the art.” In re Fritch, 972 F.2d 1260, 1264. However, as discussed above, we find that the prior art as a whole teaches that penoxsulam may be used as a pre-emergent herbicide. Appeal 2018-008624 Application 13/018,583 14 pre-emergently, and that a skilled artisan would not thus have a reasonable expectation of the claimed synergistic activity. Appeal Br. 10–11. We are not persuaded. Breen teaches that when its herbicide A (which includes penoxsulam) is added to its herbicide B (which includes butachlor), there is a “surprising synergistic effect.” FF6. More importantly, as discussed above, the combination of prior art suggests applying a composition of penoxsulam and butachlor as a pre-emergent herbicide to control winklegrass. Breen further discloses combining penoxsulam and butachlor at a weight ratio of 1:33.3, which falls within the weight ratio of claim 4. Thus, the limitation regarding “synergistic” herbicidal mixture is inherently met by the method suggested by the prior art combination. In re Woodruff, 919 F.2d 1575, 1578 (Fed. Cir. 1990) (explaining that “[i]t is a general rule that merely discovering and claiming a new benefit of an old process cannot render the process again patentable”); see also In re Best, 562 F.2d 1252, 1255 (CCPA 1977) (holding that “[w]here . . . the claimed and prior art products are identical or substantially identical . . . the PTO can require an applicant to prove that the prior art products do not necessarily or inherently possess the characteristics of his claimed product”). Appellant’s citation to Takeda Chemical is inapposite. Appeal Br. 10–11; Takeda Chemical Industries, Ltd. v. Alphapharm Pty., Ltd., 492 F.3d 1350, 1361 (Fed. Cir. 2001). In Takeda, the issue was whether a claimed compound was obvious over a prior art compound, compound b, that was alleged to be structurally similar. Id. at 1353–1354. In that case, the Court saw no error in the district court’s determination that “nothing in the prior art . . . suggest[s] making the specific molecular modifications to [prior art] Appeal 2018-008624 Application 13/018,583 15 compound b . . . necessary to achieve the claimed compounds,” given that there was no reasonable expectation in the art that the modification would have resulted in beneficial changes. Id. at 1360–1361. The Court also noted that the district court found the claimed compound to exhibit unexpectedly superior properties over the prior art compound b. Id. at 1361–1362. In contrast, in this case Breen explicitly suggests the composition used in the claimed method, and the combination of prior art also gives a skilled artisan a reasonable expectation that pre-emergent application of the composition will be useful in controlling winklegrass. Thus, unlike in Takeda, the prior art does suggest making the modifications necessary to achieve the claimed method, while the limitation regarding “synergistic herbicidal mixture” is inherently met by the method suggested by the prior art. Appellant contends that the prior art references are silent with respect to the ability of a composition comprising penoxsulam and butachlor in controlling winklegrass. Appeal Br. 11–12. In particular, Appellant contends that “Mahajan does not evaluate the herbicidal activity of penoxsulam and butachlor against individual weeds” but rather only “evaluates the effectiveness of penoxsulam and butachlor against classes of weeds (grasses, sedges, or broadleaf).” Id. Thus, according to Appellant, “Mahajan fails to provide any information about the effectiveness of penoxsulam and butachlor against any individual weed,” and “it is possible that the level of control exhibited by penoxsulam and butachlor against the grassy weeds in Table 1 [of Mahajan] could be due exclusively to control of [grassy weeds other than winklegrass].” Id. at 12. Appeal 2018-008624 Application 13/018,583 16 We are not persuaded. While it is true that Mahajan does not separately evaluate the effect of penoxsulam and butachlor against winklegrass, we find that Mahajan’s teachings that winklegrass was one of the main grassy weeds present in its field experiment, and that application of penoxsulam at 3 and 12 DAT and butachlor at 3 DAT controlled grassy weeds, provide a skilled artisan a reason to use penoxsulam and/or butachlor to control winklegrass, with a reasonable expectation of success. In this respect, we note that in the context of an obviousness rejection “expectation of success need only be reasonable, not absolute.” Pfizer, Inc. v. Apotex, Inc., 480 F.3d 1348, 1364 (Fed. Cir. 2007). Finally, citing to the Board’s decision in Suty-Heinze, Ex parte Suty- Heinze, Appeal No. 2012-012281, 2015 WL 1642091 (PTAB Mar. 12, 2015), Appellant argues that “synergism can overcome prima facie obviousness, even when the prior art broadly suggests synergism may be expected.” Appeal Br. 11. Similarly, Appellant contends in the Reply Brief that “Breen does not demonstrate that combinations of penoxsulam and butachlor exhibit any synergistic effects” and that, to the extent the Examiner has established a prima facie case of obviousness, the subject matter of the invention exhibits unexpected results. Reply Br. 3, 5. We are not persuaded. As already discussed above and as the Examiner points out, unlike in Suty-Heinze, in this case Breen teaches the claimed combination of the herbicides in the claimed weight ratio (FF8), and the combination of prior art also suggests that the composition may be applied pre-emergently to control winklegrass, as claimed. Thus, we find that the limitation regarding a “synergistic herbicidal mixture” is inherently met absent evidence to the contrary. In re Best, 562 F.2d at 1255. Appeal 2018-008624 Application 13/018,583 17 Finally, we are likewise unpersuaded by Appellant’s argument regarding unexpected results. Appellant cites to Table 3 of the Specification in arguing that a skilled artisan “would not have reasonably expected that the claimed method . . . would have the substantial herbicidal activity shown.” Appeal Br. 10. However, claim 4 encompasses weight ratios of butachlor to penoxsulam of from 10:1 to 40:1, whereas Table 3 describes the results of only a single composition (and thus a single weight ratio) of butachlor to penoxsulam (300 grams per hectare to 13 grams per hectare, or about 23:1). Spec. 9:7–15. Neither has Appellant persuasively explained why this composition is representative of compositions falling within the claimed range of weight ratios. One data point is insufficient “to ascertain a trend in the exemplified data which would allow [one having ordinary skill in the art] to reasonably extend the probative value thereof.” In re Kollman, 595 F.2d 48, 56 (CCPA 1979). Here, Appellant must, therefore, demonstrate or explain why the result of the single composition would establish the asserted unexpected result for the full scope of claim 4. We conclude Appellant has not done so. Appellant has not, therefore, shown unexpected results commensurate with the scope of the claim, as required of evidence presented to rebut a prima facie case of obviousness. In re Dill, 604 F.2d 1356, 1361 (CCPA 1979) (holding that “[t]he evidence presented to rebut a prima facie case of obviousness must be commensurate in scope with the claims to which it pertains”); In re Kao, 639 F.3d 1057, 1068 (Fed. Cir. 2011) (explaining that an applicant may establish that evidence of unexpected result is commensurate with the scope of the claim “[i]f an applicant demonstrates that an embodiment has an unexpected result and provides an Appeal 2018-008624 Application 13/018,583 18 adequate basis to support the conclusion that other embodiments falling within the claim will behave in the same manner”). Accordingly, we affirm the Examiner’s rejection of claim 4 as obvious over Breen, Johnson, the entries for penoxsulam and butachlor in The Pesticide Manual, and Mahajan. Claims 5, 7–9, 13, 14, and 18–20 fall with claim 4. CONCLUSION In summary: Claims Rejected 35 U.S.C. § Reference(s)/Basis Affirmed Reversed 4, 5, 7–9, 13, 14, 18–20 103(a) Breen, Johnson, the entries for penoxsulam and butachlor in The Pesticide Manual, Mahajan 4, 5, 7–9, 13, 14, 18–20 TIME PERIOD FOR RESPONSE No time period for taking any subsequent action in connection with this appeal may be extended under 37 C.F.R. § 1.136(a). See 37 C.F.R. § 1.136(a)(1)(iv). AFFIRMED Copy with citationCopy as parenthetical citation